Development Level

Tbio 347 | 10,625
Tdark 111 | 7,003
Tchem 46 | 1,890
Tclin 31 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 45 | 633
embryonic lethality prior to o... 15 | 148
embryonic lethality prior to t... 13 | 187
abnormal embryo size 9 | 112
abnormal retina morphology 7 | 100
abnormal behavior 6 | 226
abnormal lens morphology 6 | 73
decreased body weight 6 | 174
decreased bone mineral content 6 | 157
embryonic growth retardation 6 | 28
preweaning lethality, incomple... 6 | 260
decreased total body fat amoun... 5 | 186
prenatal lethality prior to he... 5 | 64
abnormal bone structure 4 | 131
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
hypoactivity 4 | 89
increased fasted circulating g... 4 | 68
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
abnormal neural tube closure 3 | 37
abnormal vertebrae morphology 3 | 14
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased fasted circulating g... 3 | 49
decreased mean platelet volume 3 | 12
decreased rib number 3 | 59
increased NK cell number 3 | 19
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased heart weight 3 | 37
increased lean body mass 3 | 107
increased startle reflex 3 | 38
pallor 3 | 13
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal clavicle morphology 2 | 5
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo turning 2 | 15
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal heart morphology 2 | 51
abnormal limb bud morphology 2 | 15
abnormal liver size 2 | 4
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal skin coloration 2 | 18
abnormal tail bud morphology 2 | 6
abnormal testis morphology 2 | 30
decreased CD4-positive, alpha ... 2 | 19
decreased Ly6C low monocyte nu... 2 | 23
decreased T cell number 2 | 31
decreased body length 2 | 108
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased monocyte cell number 2 | 28
decreased red blood cell distr... 2 | 11
decreased startle reflex 2 | 48
decreased vertical activity 2 | 22
female infertility 2 | 34
hyperactivity 2 | 108
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased circulating free fat... 2 | 17
increased circulating iron lev... 2 | 25
increased circulating phosphat... 2 | 24
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
male infertility 2 | 62
polydactyly 2 | 22
prenatal lethality 2 | 16
short tibia 2 | 82
small testis 2 | 37
thrombocytopenia 2 | 46
abnormal coping response 1 | 12
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased exploration in new e... 1 | 9
decreased gamma-delta T cell n... 1 | 18
decreased thoracic vertebrae n... 1 | 7
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased circulating creatini... 1 | 29
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9

Disease

ovarian cancer 308 | 8,484
osteosarcoma 234 | 7,933
psoriasis 163 | 6,685
lung cancer 159 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 148 | 1,795
medulloblastoma, large-cell 142 | 6,234
glioblastoma 105 | 5,572
Multiple myeloma 90 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,289
atypical teratoid / rhabdoid tumor 82 | 4,369
malignant mesothelioma 79 | 3,162
non-small cell lung cancer 70 | 2,798
Breast cancer 66 | 3,094
astrocytic glioma 66 | 2,241
ependymoma 58 | 2,514
invasive ductal carcinoma 56 | 2,950
ulcerative colitis 56 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,956
lung adenocarcinoma 55 | 2,713
group 3 medulloblastoma 54 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 52 | 2,988
oligodendroglioma 52 | 2,849
Pick disease 51 | 1,893
primitive neuroectodermal tumor 49 | 3,031
non primary Sjogren syndrome sicca 46 | 840
Leigh disease 45 | 81
adult high grade glioma 43 | 2,148
interstitial cystitis 42 | 2,299
pediatric high grade glioma 41 | 2,712
subependymal giant cell astrocytoma 41 | 2,287
lung carcinoma 40 | 2,844
group 4 medulloblastoma 38 | 1,875
Cancer 37 | 2,346
medulloblastoma 37 | 1,524
colon cancer 36 | 1,475
pancreatic cancer 36 | 2,300
Waldenstrons macroglobulinemia 34 | 765
acute myeloid leukemia 32 | 780
ductal carcinoma in situ 32 | 1,745
pilocytic astrocytoma 32 | 3,086
adrenocortical carcinoma 31 | 1,427
tuberculosis 31 | 1,557
breast carcinoma 30 | 1,614
pituitary cancer 30 | 1,972
diabetes mellitus 29 | 1,663
Obesity 28 | 616
Neurodegenerative disease 27 | 383
astrocytoma 27 | 1,493
aldosterone-producing adenoma 26 | 664
dermatomyositis 26 | 933
cystic fibrosis 24 | 1,665
gastric carcinoma 22 | 832
posterior fossa group B ependymoma 21 | 1,530
Diabetes mellitus type 2 20 | 69
Rheumatoid Arthritis 20 | 1,160
Treatment Refractory Type 2 Diabetes Mellitus 20 | 53
atypical teratoid/rhabdoid tumor 20 | 1,095
primary pancreatic ductal adenocarcinoma 20 | 1,271
Lactic acidosis 19 | 42
MITOCHONDRIAL COMPLEX I DEFICIENCY 19 | 37
Methylmalonic acidemia 19 | 39
acute quadriplegic myopathy 19 | 1,157
juvenile dermatomyositis 19 | 1,189
nephrosclerosis 19 | 329
sonic hedgehog group medulloblastoma 19 | 1,482
hereditary spastic paraplegia 18 | 313
nasopharyngeal carcinoma 17 | 1,056
tuberculosis and treatment for 6 months 17 | 686
Cardiomyopathy 16 | 110
Maple syrup urine disease 16 | 25
Multiple acyl-CoA dehydrogenase deficiency 16 | 26
Stomach Neoplasms 16 | 282
active Crohn's disease 16 | 918
Degenerative polyarthritis 15 | 93
Disease Progression 15 | 125
posterior fossa group A ependymoma 15 | 1,511
3-methylglutaconic aciduria 14 | 29
Hypoglycemia 14 | 81
esophageal adenocarcinoma 14 | 737
primary Sjogren syndrome 14 | 789
NADH:Q(1) Oxidoreductase deficiency 13 | 20
Parkinson's disease 13 | 364
inflammatory breast cancer 13 | 404
Atopic dermatitis 12 | 944
Myocardial Ischemia 12 | 169
Propionic acidemia 12 | 20
cutaneous lupus erythematosus 12 | 1,056
pancreatic carcinoma 12 | 567
spina bifida 12 | 1,064
Glycine encephalopathy 11 | 28
Mitochondrial encephalomyopathy 11 | 18
Pyruvate decarboxylase deficiency 11 | 15
Sideroblastic anemia 11 | 18
Alzheimer's disease 10 | 644
Epilepsy 10 | 346
Intellectual disability 10 | 573
Mammary Neoplasms 10 | 410
Neuropathy 10 | 210
Polycystic Ovary Syndrome 10 | 332
Schizophrenia 10 | 501

Tissue

Female tissues 528 | 18,647
Nervous System 528 | 18,561
Endocrine System 527 | 18,512
Blood and immune system 526 | 17,995
Cardiovascular System 526 | 17,958
Digestive Tract 526 | 18,473
Liver and Pancreas 526 | 18,136
Urinary Tract 526 | 18,444
Skin and soft tissues 524 | 18,115
Male tissues 523 | 17,969
Respiratory system 520 | 17,484

Target Family

Enzyme 336 | 4,146
Non-IDG 171 | 11,971
Kinase 16 | 634
Transporter 6 | 473
Epigenetic 4 | 242
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

UniProt Keyword

Transit peptide 535 | 535
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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