Development Level

Tbio 982 | 11,178
Tchem 513 | 1,885
Tdark 217 | 6,569
Tclin 70 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Kinase: IDG Consortium (Comple... 36 | 37

IMPC Phenotype

preweaning lethality, complete... 125 | 979
preweaning lethality, incomple... 79 | 499
embryonic lethality prior to t... 42 | 278
embryonic lethality prior to o... 39 | 239
abnormal behavior 36 | 298
abnormal bone structure 33 | 187
abnormal embryo size 32 | 220
decreased bone mineral content 27 | 151
decreased total body fat amoun... 24 | 207
enlarged heart 24 | 210
increased lean body mass 22 | 172
decreased body weight 21 | 161
increased bone mineral content 20 | 108
decreased bone mineral density 19 | 126
increased total body fat amoun... 18 | 134
male infertility 18 | 123
decreased lean body mass 17 | 135
abnormal heart morphology 16 | 162
abnormal seminal vesicle morph... 16 | 114
decreased vertical activity 16 | 208
decreased body length 15 | 101
embryonic growth retardation 15 | 106
hypoactivity 15 | 132
decreased circulating glucose ... 14 | 126
decreased prepulse inhibition 13 | 82
increased bone mineral density 13 | 72
increased mean corpuscular vol... 13 | 92
increased startle reflex 13 | 112
decreased lymphocyte cell numb... 12 | 83
hyperactivity 12 | 148
increased circulating alkaline... 12 | 122
abnormal spleen morphology 11 | 55
decreased leukocyte cell numbe... 11 | 73
increased circulating HDL chol... 11 | 80
increased monocyte cell number 11 | 63
increased or absent threshold ... 11 | 101
short tibia 11 | 97
decreased blood urea nitrogen ... 10 | 51
decreased circulating serum al... 10 | 82
decreased fasted circulating g... 10 | 65
decreased startle reflex 10 | 75
abnormal gait 9 | 69
abnormal kidney morphology 9 | 65
abnormal lens morphology 9 | 81
abnormal skin morphology 9 | 50
cataract 9 | 92
decreased circulating alanine ... 9 | 47
decreased circulating choleste... 9 | 93
decreased grip strength 9 | 116
decreased hemoglobin content 9 | 68
decreased mean corpuscular vol... 9 | 79
enlarged spleen 9 | 41
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
abnormal behavioral response t... 8 | 66
decreased circulating HDL chol... 8 | 68
decreased circulating alkaline... 8 | 46
decreased neutrophil cell numb... 8 | 42
female infertility 8 | 60
impaired glucose tolerance 8 | 75
increased fasted circulating g... 8 | 76
increased mean platelet volume 8 | 45
small testis 8 | 58
abnormal coat-hair pigmentatio... 7 | 64
abnormal eye morphology 7 | 68
abnormal retina morphology 7 | 71
increased circulating sodium l... 7 | 71
increased mean corpuscular hem... 7 | 96
thrombocytopenia 7 | 56
tremors 7 | 39
abnormal epididymis morphology 6 | 42
abnormal neural tube closure 6 | 46
abnormal sleep behavior 6 | 70
decreased circulating creatini... 6 | 39
decreased circulating fructosa... 6 | 30
decreased heart left ventricle... 6 | 28
decreased red blood cell distr... 6 | 41
edema 6 | 59
enlarged lymph nodes 6 | 37
improved glucose tolerance 6 | 79
increased blood urea nitrogen ... 6 | 48
increased body length 6 | 32
increased circulating calcium ... 6 | 34
increased circulating triglyce... 6 | 42
small superior vagus ganglion 6 | 74
abnormal testis morphology 5 | 43
abnormal tooth morphology 5 | 24
abnormal vibrissa morphology 5 | 25
decreased caudal vertebrae num... 5 | 53
decreased circulating LDL chol... 5 | 38
decreased circulating calcium ... 5 | 36
decreased circulating total pr... 5 | 49
decreased hematocrit 5 | 46
decreased mean corpuscular hem... 5 | 50
hydrometra 5 | 53
increased hematocrit 5 | 46
increased prepulse inhibition 5 | 32
microphthalmia 5 | 26
persistence of hyaloid vascula... 5 | 33
prenatal lethality prior to he... 5 | 87

Disease

Carcinoma 1,259 | 11,192
ovarian cancer 945 | 8,297
osteosarcoma 881 | 7,766
psoriasis 662 | 6,514
medulloblastoma, large-cell 651 | 6,086
glioblastoma 594 | 5,635
atypical teratoid / rhabdoid tumor 528 | 4,971
lung cancer 481 | 4,607
ependymoma 463 | 4,559
group 3 medulloblastoma 413 | 4,002
adult high grade glioma 377 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 367 | 3,204
Breast cancer 365 | 3,469
malignant mesothelioma 357 | 3,135
Cancer 345 | 2,388
primitive neuroectodermal tumor 318 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 316 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 315 | 2,902
Astrocytoma, Pilocytic 311 | 3,006
Kidney cancer 310 | 2,548
non-small cell lung cancer 282 | 2,799
invasive ductal carcinoma 277 | 2,867
oligodendroglioma 263 | 2,768
astrocytic glioma 260 | 2,530
pancreatic cancer 251 | 2,322
lung carcinoma 249 | 2,755
lung adenocarcinoma 243 | 2,627
subependymal giant cell astrocytoma 236 | 2,230
pancreatic ductal adenocarcinoma liver metastasis 217 | 1,911
tuberculosis 214 | 1,963
Pick disease 210 | 1,856
group 4 medulloblastoma 207 | 1,806
interstitial cystitis 196 | 2,237
Autosomal recessive predisposition 183 | 1,407
pituitary cancer 179 | 1,915
ulcerative colitis 175 | 1,765
cystic fibrosis 166 | 1,629
Multiple myeloma 156 | 1,296
Intellectual disability 151 | 998
ductal carcinoma in situ 150 | 1,686
adrenocortical carcinoma 147 | 1,385
diabetes mellitus 138 | 1,683
breast carcinoma 136 | 1,589
spina bifida 133 | 1,053
colon cancer 132 | 1,428
juvenile dermatomyositis 131 | 1,147
Rheumatoid arthritis 130 | 1,156
Schizophrenia 127 | 1,136
acute quadriplegic myopathy 120 | 1,133
astrocytoma 120 | 1,113
pediatric high grade glioma 111 | 1,035
primary pancreatic ductal adenocarcinoma 107 | 1,071
Epilepsy 103 | 775
Dull intelligence 102 | 634
Low intelligence 102 | 634
Mental Retardation 102 | 634
Mental deficiency 102 | 634
Poor school performance 102 | 634
dermatomyositis 97 | 941
active Crohn's disease 93 | 882
Cognitive delay 90 | 596
Global developmental delay 90 | 596
Mental and motor retardation 90 | 596
Waldenstrons macroglobulinemia 88 | 742
acute myeloid leukemia 88 | 760
Muscle hypotonia 87 | 562
Seizures 86 | 584
primary Sjogren syndrome 84 | 710
cutaneous lupus erythematosus 82 | 1,016
medulloblastoma 82 | 702
nasopharyngeal carcinoma 81 | 1,024
Atopic dermatitis 80 | 915
Renal Cell Carcinoma 80 | 211
progressive supranuclear palsy 80 | 656
non primary Sjogren syndrome sicca 79 | 861
active ulcerative colitis 77 | 736
gastric carcinoma 76 | 781
esophageal adenocarcinoma 75 | 696
Melanoma 73 | 689
Obesity 70 | 655
aldosterone-producing adenoma 70 | 646
Prostatic Neoplasms 69 | 472
hepatocellular carcinoma 69 | 536
Alzheimer's disease 67 | 640
Breast Neoplasms 67 | 423
Liver Cirrhosis, Experimental 67 | 733
Short stature 67 | 514
Bipolar Disorder 66 | 646
Liver cancer 65 | 589
Mammary Neoplasms 62 | 403
Small head 62 | 366
Amyotrophic lateral sclerosis 54 | 437
Chronic Myelocytic Leukemia Accelerated Phase 54 | 59
Neurodegenerative disease 54 | 402
Blastic phase chronic myeloid leukemia 53 | 58
Failure to gain weight 53 | 359
Pediatric failure to thrive 53 | 359
Down syndrome 52 | 480
tuberculosis and treatment for 6 months 52 | 399
Micrognathism 49 | 273

Tissue

Endocrine System 1,727 | 18,159
Digestive Tract 1,701 | 17,369
Female tissues 1,701 | 17,400
Skin and soft tissues 1,691 | 17,230
Male tissues 1,687 | 17,142
Liver and Pancreas 1,683 | 16,750
Urinary Tract 1,672 | 16,678
Blood and immune system 1,668 | 16,909
Nervous System 1,666 | 16,725
Respiratory system 1,642 | 16,393
Cardiovascular System 1,585 | 15,192

Target Family

Enzyme 976 | 4,145
Kinase 592 | 634
Non-IDG 117 | 12,091
Epigenetic 71 | 242
TF/Epigenetic 17 | 38
Transcription Factor 8 | 1,400
Ion Channel 1 | 344

UniProt Keyword

Transferase 1,782 | 1,782
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 GCNT4 Tdark Enzyme -1.56850 33.7 45
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Serine/threonine-protein kinase N1 PKN1 Tchem Kinase -2.03368 117.6 153
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159
E3 ubiquitin-protein ligase MARCH1 MARCH1 Tbio Enzyme -2.08811 122.3 133
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242