Development Level

Tbio 781 | 10,625
Tchem 511 | 1,890
Tdark 233 | 7,003
Tclin 67 | 602

Collection

Eligible Kinase Proteins 121 | 134

IMPC Term

preweaning lethality, complete... 72 | 633
preweaning lethality, incomple... 33 | 260
abnormal behavior 29 | 226
decreased bone mineral content 25 | 157
embryonic lethality prior to t... 25 | 187
decreased lean body mass 24 | 195
decreased total body fat amoun... 23 | 186
embryonic lethality prior to o... 22 | 148
decreased body weight 18 | 174
abnormal embryo size 16 | 112
abnormal bone structure 14 | 131
decreased circulating glucose ... 13 | 121
decreased grip strength 13 | 123
increased or absent threshold ... 13 | 128
decreased body length 12 | 108
decreased bone mineral density 12 | 126
decreased circulating serum al... 12 | 79
increased bone mineral content 12 | 92
increased grip strength 12 | 83
increased lean body mass 12 | 107
abnormal retina morphology 11 | 100
hypoactivity 11 | 89
increased total body fat amoun... 11 | 57
short tibia 11 | 82
decreased circulating HDL chol... 10 | 77
decreased circulating choleste... 10 | 85
male infertility 10 | 62
increased sacral vertebrae num... 9 | 62
abnormal gait 8 | 51
abnormal lens morphology 8 | 73
abnormal retinal pigmentation 8 | 61
abnormal seminal vesicle morph... 8 | 47
decreased circulating alanine ... 8 | 53
enlarged heart 8 | 111
hyperactivity 8 | 108
increased mean corpuscular hem... 8 | 93
abnormal rib morphology 7 | 28
abnormal tooth morphology 7 | 24
decreased circulating alkaline... 7 | 41
decreased fasted circulating g... 7 | 49
decreased rib number 7 | 59
increased circulating alkaline... 7 | 119
increased circulating choleste... 7 | 53
increased circulating sodium l... 7 | 71
increased mean corpuscular vol... 7 | 91
small testis 7 | 37
abnormal behavioral response t... 6 | 52
decreased circulating LDL chol... 6 | 37
decreased circulating fructosa... 6 | 31
decreased heart weight 6 | 44
decreased lumbar vertebrae num... 6 | 62
decreased neutrophil cell numb... 6 | 37
decreased prepulse inhibition 6 | 52
increased circulating HDL chol... 6 | 63
thrombocytopenia 6 | 46
tremors 6 | 34
abnormal kidney morphology 5 | 30
abnormal sleep behavior 5 | 63
abnormal spleen morphology 5 | 36
decreased blood urea nitrogen ... 5 | 31
decreased circulating aspartat... 5 | 27
decreased circulating triglyce... 5 | 83
decreased eosinophil cell numb... 5 | 41
decreased hemoglobin content 5 | 53
decreased leukocyte cell numbe... 5 | 54
decreased startle reflex 5 | 48
decreased threshold for audito... 5 | 32
enlarged lymph nodes 5 | 27
female infertility 5 | 34
increased bone mineral density 5 | 52
increased circulating chloride... 5 | 43
increased circulating triglyce... 5 | 24
increased exploration in new e... 5 | 56
increased fasted circulating g... 5 | 68
increased heart weight 5 | 37
abnormal bone mineralization 4 | 55
abnormal coat/hair pigmentatio... 4 | 54
abnormal epididymis morphology 4 | 31
abnormal eye morphology 4 | 38
abnormal hindbrain development 4 | 24
abnormal midbrain development 4 | 22
abnormal neural tube closure 4 | 37
abnormal tail movements 4 | 12
abnormal testis morphology 4 | 30
cardiovascular system phenotyp... 4 | 35
decreased NK T cell number 4 | 28
decreased circulating calcium ... 4 | 33
decreased circulating creatini... 4 | 31
decreased circulating glycerol... 4 | 19
decreased circulating total pr... 4 | 41
decreased mean corpuscular vol... 4 | 50
impaired glucose tolerance 4 | 52
increased NK cell number 4 | 19
increased blood urea nitrogen ... 4 | 44
increased circulating aspartat... 4 | 17
increased circulating calcium ... 4 | 32
increased circulating iron lev... 4 | 25
increased hemoglobin content 4 | 45
increased mean platelet volume 4 | 19
increased prepulse inhibition 4 | 21

Disease

ovarian cancer 827 | 8,484
osteosarcoma 788 | 7,933
psoriasis 613 | 6,685
medulloblastoma, large-cell 590 | 6,234
glioblastoma 521 | 5,572
atypical teratoid / rhabdoid tumor 417 | 4,369
lung cancer 412 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 340 | 3,289
malignant mesothelioma 326 | 3,162
Cancer 305 | 2,346
Breast cancer 294 | 3,094
primitive neuroectodermal tumor 291 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 288 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 288 | 2,988
pilocytic astrocytoma 287 | 3,086
non-small cell lung cancer 265 | 2,798
invasive ductal carcinoma 259 | 2,950
pediatric high grade glioma 253 | 2,712
ependymoma 244 | 2,514
oligodendroglioma 242 | 2,849
lung carcinoma 232 | 2,844
Carcinoma 230 | 2,147
lung adenocarcinoma 227 | 2,713
group 3 medulloblastoma 223 | 2,254
pancreatic cancer 215 | 2,300
astrocytic glioma 210 | 2,241
subependymal giant cell astrocytoma 202 | 2,287
Pick disease 192 | 1,893
adult high grade glioma 189 | 2,148
ulcerative colitis 186 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 185 | 1,795
interstitial cystitis 179 | 2,299
group 4 medulloblastoma 176 | 1,875
pituitary cancer 167 | 1,972
medulloblastoma 160 | 1,524
cystic fibrosis 152 | 1,665
tuberculosis 149 | 1,557
ductal carcinoma in situ 140 | 1,745
astrocytoma 139 | 1,493
adrenocortical carcinoma 138 | 1,427
posterior fossa group B ependymoma 138 | 1,530
Multiple myeloma 136 | 1,327
diabetes mellitus 129 | 1,663
posterior fossa group A ependymoma 129 | 1,511
colon cancer 123 | 1,475
primary pancreatic ductal adenocarcinoma 117 | 1,271
spina bifida 117 | 1,064
breast carcinoma 116 | 1,614
sonic hedgehog group medulloblastoma 112 | 1,482
Rheumatoid Arthritis 109 | 1,160
juvenile dermatomyositis 109 | 1,189
acute quadriplegic myopathy 103 | 1,157
atypical teratoid/rhabdoid tumor 99 | 1,095
Intellectual disability 84 | 573
dermatomyositis 83 | 933
active Crohn's disease 80 | 918
Waldenstrons macroglobulinemia 78 | 765
acute myeloid leukemia 78 | 780
nasopharyngeal carcinoma 78 | 1,056
primary Sjogren syndrome 76 | 789
Renal Cell Carcinoma 74 | 199
cutaneous lupus erythematosus 74 | 1,056
Atopic dermatitis 73 | 944
progressive supranuclear palsy 72 | 674
non primary Sjogren syndrome sicca 71 | 840
esophageal adenocarcinoma 69 | 737
gastric carcinoma 69 | 832
tuberculosis and treatment for 6 months 65 | 686
Prostatic Neoplasms 64 | 471
aldosterone-producing adenoma 63 | 664
Obesity 60 | 616
IGA Glomerulonephritis 59 | 454
Alzheimer's disease 58 | 644
Mammary Neoplasms 58 | 410
hepatocellular carcinoma 57 | 532
Chronic Myelocytic Leukemia Accelerated Phase 54 | 59
Down syndrome 54 | 548
Blastic phase chronic myeloid leukemia 53 | 58
Schizophrenia 52 | 501
Amyotrophic Lateral Sclerosis 49 | 431
Peripheral Neuropathy 48 | 303
Gastrointestinal stromal tumor 47 | 61
fibroadenoma 47 | 557
non-small cell lung carcinoma 46 | 413
pancreatic carcinoma 45 | 567
Neurodegenerative disease 42 | 383
Pancreatic Neuroendocrine Tumor 42 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 42 | 47
Chronic phase chronic myeloid leukemia 40 | 45
Endometriosis 40 | 535
Parkinson's disease 40 | 364
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 40 | 45
gastric cancer 40 | 430
active ulcerative colitis 38 | 477
Hamman-Rich syndrome 35 | 35
Melanoma 34 | 261
autosomal dominant Emery-Dreifuss muscular dystrophy 34 | 499
Multiple Sclerosis 32 | 498
mucosa-associated lymphoid tissue lymphoma 32 | 480
tuberculosis and treatment for 3 months 32 | 327

Tissue

Digestive Tract 1,554 | 18,473
Liver and Pancreas 1,551 | 18,136
Urinary Tract 1,551 | 18,444
Endocrine System 1,549 | 18,512
Female tissues 1,548 | 18,647
Nervous System 1,548 | 18,561
Blood and immune system 1,546 | 17,995
Cardiovascular System 1,532 | 17,958
Male tissues 1,532 | 17,969
Skin and soft tissues 1,531 | 18,115
Respiratory system 1,515 | 17,484

Target Family

Enzyme 837 | 4,146
Kinase 592 | 634
Non-IDG 78 | 11,971
Epigenetic 63 | 242
TF/Epigenetic 17 | 38
Transcription Factor 4 | 1,400
Ion Channel 1 | 341

UniProt Keyword

Transferase 1,592 | 1,592
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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