Development Level

Tdark 473 | 6,588
Tbio 173 | 11,445
Tchem 145 | 1,598
Tclin 96 | 613

Collection

GPCR: IDG Consortium (Targets) 124 | 126
RFA-RM-18-021 100 | 328
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

decreased vertical activity 16 | 208
enlarged heart 12 | 210
preweaning lethality, complete... 12 | 979
abnormal behavior 11 | 298
preweaning lethality, incomple... 10 | 499
hyperactivity 9 | 148
abnormal heart morphology 8 | 162
increased lean body mass 8 | 172
decreased bone mineral content 7 | 151
decreased bone mineral density 7 | 126
decreased total body fat amoun... 7 | 207
abnormal bone structure 6 | 187
increased total body fat amoun... 6 | 134
decreased body weight 5 | 161
decreased lean body mass 5 | 135
decreased startle reflex 5 | 75
small superior vagus ganglion 5 | 74
abnormal gait 4 | 69
abnormal kidney morphology 4 | 65
abnormal seminal vesicle morph... 4 | 114
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
improved glucose tolerance 4 | 79
increased circulating creatini... 4 | 38
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
increased or absent threshold ... 4 | 101
increased startle reflex 4 | 112
abnormal behavioral response t... 3 | 66
abnormal epididymis morphology 3 | 42
abnormal skin coloration 3 | 25
abnormal skin morphology 3 | 50
decreased circulating insulin ... 3 | 76
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
embryonic lethality prior to t... 3 | 278
female infertility 3 | 60
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased circulating calcium ... 3 | 34
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 92
male infertility 3 | 123
short tibia 3 | 97
abnormal eye morphology 2 | 68
abnormal liver morphology 2 | 17
abnormal sleep behavior 2 | 70
absent startle reflex 2 | 24
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
hydrometra 2 | 53
impaired pupillary reflex 2 | 26
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
microphthalmia 2 | 26
polycystic kidney 2 | 15
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small kidney 2 | 16
abnormal embryo turning 1 | 31
abnormal lymph node morphology 1 | 3
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
enlarged uterus 1 | 11
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating magnesiu... 1 | 10
limb grasping 1 | 41
prenatal lethality 1 | 28
scaly skin 1 | 4
small thymus 1 | 16
thick skin 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 655 | 11,493
psoriasis 201 | 6,694
osteosarcoma 171 | 7,950
medulloblastoma, large-cell 158 | 6,241
ovarian cancer 147 | 8,520
glioblastoma 129 | 5,792
diabetes mellitus 125 | 1,728
lung cancer 120 | 4,740
atypical teratoid / rhabdoid tumor 117 | 5,112
ependymoma 117 | 4,679
adult high grade glioma 109 | 3,801
lung carcinoma 93 | 2,843
interstitial cystitis 87 | 2,312
Astrocytoma, Pilocytic 86 | 3,081
Schizophrenia 83 | 1,160
group 3 medulloblastoma 82 | 4,104
Kidney cancer 77 | 2,613
lung adenocarcinoma 77 | 2,716
Breast cancer 75 | 3,578
invasive ductal carcinoma 74 | 2,951
primitive neuroectodermal tumor 70 | 3,035
oligodendroglioma 68 | 2,850
malignant mesothelioma 66 | 3,232
non-small cell lung cancer 63 | 2,890
Cancer 60 | 2,499
astrocytic glioma 58 | 2,597
Bipolar Disorder 56 | 666
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
ulcerative colitis 56 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,955
pituitary cancer 51 | 1,972
tuberculosis 51 | 2,010
Obesity 50 | 678
ductal carcinoma in situ 50 | 1,745
subependymal giant cell astrocytoma 48 | 2,287
Depressive disorder 47 | 409
colon cancer 46 | 1,478
pancreatic cancer 46 | 2,398
breast carcinoma 45 | 1,638
Alcoholic Intoxication, Chronic 40 | 289
Asthma 36 | 385
Mood Disorders 36 | 184
group 4 medulloblastoma 36 | 1,855
Mental Depression 35 | 333
Major Depressive Disorder 34 | 301
cutaneous lupus erythematosus 34 | 1,057
adrenocortical carcinoma 32 | 1,428
cystic fibrosis 31 | 1,696
Melanoma 30 | 711
primary Sjogren syndrome 30 | 735
Epilepsy 29 | 792
Multiple Sclerosis 29 | 540
Pick disease 29 | 1,894
Parkinson's disease 28 | 392
Rheumatoid arthritis 28 | 1,191
astrocytoma 28 | 1,146
Autosomal recessive predisposition 25 | 1,442
Hypertension 24 | 396
Skin cancer 24 | 469
Unipolar Depression 24 | 250
Allergic rhinitis 23 | 94
Attention deficit hyperactivity disorder 22 | 278
Liver cancer 22 | 604
Migraine 21 | 83
mucosa-associated lymphoid tissue lymphoma 21 | 484
Alcohol dependence 20 | 107
Atopic dermatitis 19 | 952
Autistic Disorder 19 | 364
Common cold 19 | 67
Substance Withdrawal Syndrome 19 | 55
active Crohn's disease 19 | 922
Cocaine-Related Disorders 18 | 92
Nasal congestion 18 | 21
Nasal discharge 18 | 24
Pain 18 | 103
Pain agnosia 18 | 104
Seizures 18 | 596
pediatric high grade glioma 18 | 1,064
primary pancreatic ductal adenocarcinoma 18 | 1,109
Liver Cirrhosis, Experimental 17 | 769
esophageal adenocarcinoma 17 | 737
gastric carcinoma 17 | 807
medulloblastoma 17 | 720
active ulcerative colitis 16 | 764
non primary Sjogren syndrome sicca 16 | 891
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Acquired metabolic disease 15 | 336
Alzheimer's disease 15 | 658
Status Epilepticus 15 | 98
fibroadenoma 15 | 559
hepatocellular carcinoma 15 | 547
Endometriosis 14 | 540
Hypertensive disease 14 | 292
Hypotension 14 | 82
Intellectual disability 14 | 1,016
Vascular disease 14 | 319
acute myeloid leukemia 14 | 783
juvenile dermatomyositis 14 | 1,187
pancreatic carcinoma 14 | 562

Tissue

Endocrine System 518 | 18,159
Female tissues 426 | 17,400
Digestive Tract 405 | 17,369
Nervous System 401 | 16,725
Male tissues 399 | 17,142
Blood and immune system 392 | 16,909
Skin and soft tissues 392 | 17,230
Urinary Tract 361 | 16,678
Liver and Pancreas 359 | 16,750
Respiratory system 344 | 16,393
Cardiovascular System 299 | 15,192

Target Family

oGPCR 421 | 421
GPCR 405 | 408
Non-IDG 46 | 12,091
Enzyme 15 | 4,145

UniProt Keyword

Transducer 887 | 887
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Olfactory receptor 5B2 OR5B2 Tdark oGPCR 0.00000 1
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248