Development Level

Tdark 477 | 7,003
Tbio 181 | 10,625
Tchem 132 | 1,890
Tclin 96 | 602

Collection

Eligible non-olfactory GPCR Proteins 141 | 143

IMPC Term

decreased bone mineral content 8 | 157
decreased bone mineral density 8 | 126
preweaning lethality, complete... 8 | 633
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
preweaning lethality, incomple... 7 | 260
decreased body weight 6 | 174
hyperactivity 6 | 108
increased or absent threshold ... 6 | 128
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
decreased grip strength 4 | 123
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
improved glucose tolerance 4 | 56
increased circulating calcium ... 4 | 32
increased circulating creatini... 4 | 29
increased grip strength 4 | 83
increased heart weight 4 | 37
increased total body fat amoun... 4 | 57
abnormal behavioral response t... 3 | 52
abnormal epididymis morphology 3 | 31
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
hypoactivity 3 | 89
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal seminal vesicle morph... 2 | 47
abnormal skin coloration 2 | 18
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
decreased B cell number 2 | 30
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased hematocrit 2 | 25
decreased leukocyte cell numbe... 2 | 54
decreased mature B cell number 2 | 25
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
enlarged epididymis 2 | 27
female infertility 2 | 34
impaired glucose tolerance 2 | 52
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 27
small kidney 2 | 10
small superior vagus ganglion 2 | 20
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal lymph node morphology 1 | 3
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
convulsive seizures 1 | 11
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
oligodactyly 1 | 14
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

psoriasis 201 | 6,685
osteosarcoma 171 | 7,933
medulloblastoma, large-cell 159 | 6,234
ovarian cancer 146 | 8,484
diabetes mellitus 122 | 1,663
glioblastoma 120 | 5,572
atypical teratoid / rhabdoid tumor 103 | 4,369
lung carcinoma 93 | 2,844
lung cancer 88 | 4,466
interstitial cystitis 87 | 2,299
pilocytic astrocytoma 87 | 3,086
lung adenocarcinoma 77 | 2,713
invasive ductal carcinoma 74 | 2,950
Carcinoma 71 | 2,147
primitive neuroectodermal tumor 70 | 3,031
adult high grade glioma 68 | 2,148
oligodendroglioma 68 | 2,849
malignant mesothelioma 65 | 3,162
ulcerative colitis 63 | 2,087
Breast cancer 62 | 3,094
ependymoma 62 | 2,514
pediatric high grade glioma 60 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
non-small cell lung cancer 56 | 2,798
Cancer 55 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,956
Schizophrenia 52 | 501
pituitary cancer 51 | 1,972
ductal carcinoma in situ 50 | 1,745
Obesity 49 | 616
astrocytic glioma 49 | 2,241
subependymal giant cell astrocytoma 48 | 2,287
colon cancer 46 | 1,475
posterior fossa group A ependymoma 46 | 1,511
breast carcinoma 45 | 1,614
pancreatic cancer 45 | 2,300
group 3 medulloblastoma 41 | 2,254
astrocytoma 37 | 1,493
medulloblastoma 37 | 1,524
tuberculosis 37 | 1,557
Asthma 36 | 349
group 4 medulloblastoma 35 | 1,875
cutaneous lupus erythematosus 34 | 1,056
adrenocortical carcinoma 32 | 1,427
primary Sjogren syndrome 30 | 789
Pick disease 29 | 1,893
cystic fibrosis 29 | 1,665
sonic hedgehog group medulloblastoma 29 | 1,482
Parkinson's disease 28 | 364
Rheumatoid Arthritis 28 | 1,160
Epilepsy 26 | 346
Allergic rhinitis 25 | 91
Multiple Sclerosis 25 | 498
atypical teratoid/rhabdoid tumor 24 | 1,095
posterior fossa group B ependymoma 24 | 1,530
Attention deficit hyperactivity disorder 21 | 156
Migraine 21 | 79
Nasal congestion 21 | 24
mucosa-associated lymphoid tissue lymphoma 21 | 480
Alcohol dependence 20 | 107
Common cold 20 | 63
Major Depressive Disorder 20 | 106
Nasal discharge 20 | 26
gastric carcinoma 20 | 832
Atopic dermatitis 19 | 944
Bipolar Disorder 19 | 266
active Crohn's disease 19 | 918
Autistic Disorder 18 | 320
Cocaine-Related Disorders 18 | 88
Pain 18 | 70
non-small cell lung carcinoma 18 | 413
primary pancreatic ductal adenocarcinoma 18 | 1,271
Pain agnosia 17 | 99
Substance Withdrawal Syndrome 17 | 52
esophageal adenocarcinoma 17 | 737
Hypertension 16 | 287
Hypertensive disease 16 | 193
glioblastoma multiforme 16 | 347
non primary Sjogren syndrome sicca 16 | 840
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Status Epilepticus 15 | 85
fibroadenoma 15 | 557
hepatocellular carcinoma 15 | 532
Alzheimer's disease 14 | 644
Asthma management 14 | 20
Endometriosis 14 | 535
Vascular disease 14 | 281
acute myeloid leukemia 14 | 780
juvenile dermatomyositis 14 | 1,189
pancreatic carcinoma 14 | 567
Acromegaly 13 | 40
Adenoma 13 | 165
Atherosclerosis 13 | 275
Bronchitis 13 | 44
Hemolytic anemia 13 | 66
Pulmonary emphysema 13 | 34
Seizures 13 | 95
head and neck cancer 13 | 270
spina bifida 13 | 1,064

Tissue

Female tissues 756 | 18,647
Urinary Tract 727 | 18,444
Nervous System 675 | 18,561
Endocrine System 673 | 18,512
Digestive Tract 645 | 18,473
Skin and soft tissues 606 | 18,115
Liver and Pancreas 533 | 18,136
Blood and immune system 510 | 17,995
Cardiovascular System 509 | 17,958
Male tissues 476 | 17,969
Respiratory system 443 | 17,484

Target Family

oGPCR 421 | 421
GPCR 403 | 406
Non-IDG 47 | 11,971
Enzyme 15 | 4,146

UniProt Keyword

Transducer 886 | 886
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Inactive phospholipase C-like protein 2 PLCL2 Tbio Enzyme -0.27372 2.11 81
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
Olfactory receptor 2T1 OR2T1 Tdark oGPCR 0.00000 38
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.29395 203.8 55
Neuropeptides B/W receptor type 1 NPBWR1 Tchem GPCR -1.34565 19.5 151
Neuropeptides B/W receptor type 2 NPBWR2 Tbio GPCR -1.14202 8.84 57
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96