Development Level

Tbio 1,539 | 11,651
Tdark 610 | 6,593
Tchem 151 | 1,388
Tclin 36 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 164 | 979
preweaning lethality, incomple... 69 | 499
embryonic lethality prior to t... 50 | 278
abnormal embryo size 39 | 220
embryonic lethality prior to o... 37 | 239
abnormal behavior 35 | 298
abnormal bone structure 29 | 187
decreased total body fat amoun... 28 | 207
decreased body weight 27 | 161
decreased vertical activity 27 | 208
increased lean body mass 25 | 172
enlarged heart 22 | 210
hypoactivity 22 | 132
abnormal heart morphology 20 | 162
increased total body fat amoun... 20 | 134
decreased lean body mass 19 | 135
increased startle reflex 19 | 112
increased bone mineral content 18 | 108
increased circulating alkaline... 18 | 122
decreased circulating glucose ... 17 | 126
embryonic growth retardation 17 | 106
male infertility 17 | 123
abnormal seminal vesicle morph... 15 | 114
decreased bone mineral density 15 | 126
decreased circulating serum al... 15 | 82
decreased prepulse inhibition 15 | 82
hyperactivity 15 | 148
increased bone mineral density 15 | 72
increased mean corpuscular hem... 15 | 96
increased or absent threshold ... 15 | 101
abnormal gait 14 | 69
decreased circulating triglyce... 14 | 79
decreased leukocyte cell numbe... 14 | 73
prenatal lethality prior to he... 14 | 87
short tibia 14 | 97
decreased circulating choleste... 13 | 93
impaired glucose tolerance 13 | 75
increased mean corpuscular vol... 13 | 92
decreased body length 12 | 101
decreased bone mineral content 12 | 151
decreased caudal vertebrae num... 12 | 53
decreased erythrocyte cell num... 12 | 62
decreased grip strength 12 | 116
decreased lymphocyte cell numb... 12 | 83
small superior vagus ganglion 12 | 74
thrombocytopenia 12 | 56
abnormal retina morphology 11 | 71
cataract 10 | 92
decreased hemoglobin content 10 | 68
improved glucose tolerance 10 | 79
increased circulating HDL chol... 10 | 80
decreased blood urea nitrogen ... 9 | 51
decreased circulating HDL chol... 9 | 68
female infertility 9 | 60
hydrometra 9 | 53
increased circulating sodium l... 9 | 71
abnormal bone mineralization 8 | 38
abnormal cornea morphology 8 | 31
abnormal eye morphology 8 | 68
abnormal kidney morphology 8 | 65
abnormal lens morphology 8 | 81
abnormal neural tube closure 8 | 46
decreased circulating insulin ... 8 | 76
increased circulating choleste... 8 | 66
increased fasted circulating g... 8 | 76
increased monocyte cell number 8 | 63
abnormal retinal blood vessel ... 7 | 26
abnormal tooth morphology 7 | 24
decreased heart left ventricle... 7 | 28
decreased mean corpuscular vol... 7 | 79
edema 7 | 59
increased body length 7 | 32
increased circulating triglyce... 7 | 42
increased hemoglobin content 7 | 45
increased mean platelet volume 7 | 45
increased neutrophil cell numb... 7 | 46
tremors 7 | 39
abnormal behavioral response t... 6 | 66
abnormal coat-hair pigmentatio... 6 | 64
abnormal embryo turning 6 | 31
abnormal forebrain development 6 | 20
abnormal sleep behavior 6 | 70
abnormal spleen morphology 6 | 55
decreased circulating LDL chol... 6 | 38
decreased circulating alanine ... 6 | 47
decreased circulating alkaline... 6 | 46
decreased circulating total pr... 6 | 49
decreased mean platelet volume 6 | 25
decreased neutrophil cell numb... 6 | 42
increased circulating chloride... 6 | 41
increased mean corpuscular hem... 6 | 36
abnormal skin morphology 5 | 50
cardiovascular system phenotyp... 5 | 36
decreased circulating creatini... 5 | 39
decreased circulating fructosa... 5 | 30
decreased fasted circulating g... 5 | 65
decreased startle reflex 5 | 75
increased body weight 5 | 25
pale yolk sac 5 | 25
small testis 5 | 58

Disease

Carcinoma 1,585 | 11,493
osteosarcoma 1,112 | 7,950
ovarian cancer 1,105 | 8,520
psoriasis 790 | 6,694
medulloblastoma, large-cell 779 | 6,241
glioblastoma 701 | 5,792
lung cancer 647 | 4,740
atypical teratoid / rhabdoid tumor 631 | 5,112
group 3 medulloblastoma 614 | 4,104
ependymoma 510 | 4,679
Breast cancer 487 | 3,578
Cancer 466 | 2,499
malignant mesothelioma 455 | 3,232
primitive neuroectodermal tumor 413 | 3,035
adult high grade glioma 388 | 3,801
Kidney cancer 371 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 369 | 3,291
oligodendroglioma 352 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 342 | 2,989
invasive ductal carcinoma 327 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 319 | 2,955
astrocytic glioma 298 | 2,597
non-small cell lung cancer 285 | 2,890
Astrocytoma, Pilocytic 278 | 3,081
group 4 medulloblastoma 271 | 1,855
pancreatic cancer 257 | 2,398
lung adenocarcinoma 246 | 2,716
lung carcinoma 241 | 2,843
Pick disease 237 | 1,894
pituitary cancer 234 | 1,972
tuberculosis 233 | 2,010
subependymal giant cell astrocytoma 232 | 2,287
interstitial cystitis 220 | 2,312
Rheumatoid arthritis 196 | 1,191
breast carcinoma 195 | 1,638
ductal carcinoma in situ 191 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 188 | 1,962
adrenocortical carcinoma 183 | 1,428
astrocytoma 182 | 1,146
Multiple myeloma 176 | 1,332
cystic fibrosis 176 | 1,696
Intellectual disability 175 | 1,016
juvenile dermatomyositis 169 | 1,187
spina bifida 168 | 1,074
ulcerative colitis 168 | 1,819
diabetes mellitus 165 | 1,728
acute quadriplegic myopathy 164 | 1,158
colon cancer 151 | 1,478
pediatric high grade glioma 151 | 1,064
acute myeloid leukemia 141 | 783
dermatomyositis 133 | 966
primary pancreatic ductal adenocarcinoma 131 | 1,109
Schizophrenia 127 | 1,160
Dull intelligence 112 | 645
Low intelligence 112 | 645
Mental Retardation 112 | 645
Mental deficiency 112 | 645
Poor school performance 112 | 645
cutaneous lupus erythematosus 104 | 1,057
aldosterone-producing adenoma 102 | 665
non primary Sjogren syndrome sicca 101 | 891
Short stature 100 | 531
Waldenstrons macroglobulinemia 100 | 765
medulloblastoma 98 | 720
Autosomal recessive predisposition 96 | 1,442
Breast Neoplasms 95 | 445
Obesity 95 | 678
Mammary Neoplasms 89 | 425
nasopharyngeal carcinoma 87 | 1,058
primary Sjogren syndrome 87 | 735
Cognitive delay 85 | 608
Global developmental delay 85 | 608
Mental and motor retardation 85 | 608
hepatocellular carcinoma 85 | 547
Atopic dermatitis 84 | 952
Bipolar Disorder 84 | 666
Prostatic Neoplasms 84 | 495
Epilepsy 83 | 792
Liver cancer 82 | 604
Muscle hypotonia 82 | 571
progressive supranuclear palsy 82 | 676
active Crohn's disease 81 | 922
gastric carcinoma 81 | 807
Melanoma 78 | 711
gastric cancer 75 | 459
sonic hedgehog group medulloblastoma 75 | 467
tuberculosis and treatment for 6 months 75 | 409
Alzheimer's disease 73 | 658
active ulcerative colitis 73 | 764
Small head 69 | 374
autosomal dominant Emery-Dreifuss muscular dystrophy 69 | 510
Seizures 68 | 596
Endometriosis 67 | 540
Cryptorchidism 66 | 296
Amyotrophic lateral sclerosis 65 | 451
Cleft Palate 65 | 271
Acquired metabolic disease 62 | 336
Strabismus 62 | 270
esophageal adenocarcinoma 60 | 737
pancreatic carcinoma 59 | 562

Tissue

Endocrine System 2,252 | 18,159
Digestive Tract 2,174 | 17,369
Skin and soft tissues 2,173 | 17,230
Female tissues 2,165 | 17,400
Male tissues 2,152 | 17,142
Blood and immune system 2,125 | 16,909
Nervous System 2,125 | 16,725
Liver and Pancreas 2,100 | 16,750
Urinary Tract 2,097 | 16,678
Respiratory system 2,069 | 16,393
Cardiovascular System 1,966 | 15,192

Target Family

Transcription Factor 1,261 | 1,400
Non-IDG 670 | 12,091
Epigenetic 149 | 242
Enzyme 130 | 4,145
Nuclear Receptor 48 | 48
Kinase 39 | 634
TF/Epigenetic 35 | 38
Transporter 3 | 473
Ion Channel 1 | 344

UniProt Keyword

Transcription regulation 2,336 | 2,336
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
Transcriptional repressor scratch 2 SCRT2 Tdark Transcription Factor 0.22 1.09 25
Zinc finger homeobox protein 2 ZFHX2 Tdark Transcription Factor -0.50515 3.13 28
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53