Development Level

Tbio 1,435 | 10,625
Tdark 649 | 7,003
Tchem 189 | 1,890
Tclin 36 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 103 | 633
preweaning lethality, incomple... 42 | 260
embryonic lethality prior to t... 36 | 187
decreased lean body mass 29 | 195
decreased total body fat amoun... 27 | 186
abnormal behavior 26 | 226
embryonic lethality prior to o... 26 | 148
decreased body weight 24 | 174
abnormal bone structure 22 | 131
decreased body length 22 | 108
abnormal embryo size 20 | 112
decreased bone mineral content 20 | 157
decreased bone mineral density 17 | 126
increased or absent threshold ... 17 | 128
increased bone mineral content 16 | 92
decreased circulating choleste... 15 | 85
decreased circulating triglyce... 15 | 83
increased circulating alkaline... 15 | 119
increased mean corpuscular vol... 15 | 91
abnormal retina morphology 14 | 100
hyperactivity 14 | 108
decreased circulating HDL chol... 13 | 77
decreased circulating glucose ... 13 | 121
decreased grip strength 13 | 123
short tibia 13 | 82
decreased circulating serum al... 12 | 79
hypoactivity 12 | 89
increased lean body mass 12 | 107
increased mean corpuscular hem... 12 | 93
increased sacral vertebrae num... 12 | 62
decreased caudal vertebrae num... 11 | 49
decreased hemoglobin content 11 | 53
decreased leukocyte cell numbe... 11 | 54
decreased lumbar vertebrae num... 11 | 62
prenatal lethality prior to he... 11 | 64
decreased erythrocyte cell num... 10 | 43
enlarged heart 10 | 111
abnormal bone mineralization 9 | 55
abnormal eye morphology 9 | 38
abnormal gait 9 | 51
abnormal lens morphology 9 | 73
decreased circulating alkaline... 9 | 41
decreased prepulse inhibition 9 | 52
increased circulating sodium l... 9 | 71
increased grip strength 9 | 83
thrombocytopenia 9 | 46
abnormal cornea morphology 8 | 24
abnormal neural tube closure 8 | 37
abnormal retinal pigmentation 8 | 61
decreased circulating insulin ... 8 | 75
increased bone mineral density 8 | 52
increased circulating choleste... 8 | 53
increased total body fat amoun... 8 | 57
abnormal hindbrain development 7 | 24
abnormal sleep behavior 7 | 63
abnormal tooth morphology 7 | 24
decreased circulating LDL chol... 7 | 37
decreased circulating total pr... 7 | 41
decreased rib number 7 | 59
increased B cell number 7 | 23
increased circulating triglyce... 7 | 24
increased fasted circulating g... 7 | 68
increased startle reflex 7 | 38
abnormal coat/hair pigmentatio... 6 | 54
abnormal forebrain development 6 | 18
decreased T cell number 6 | 31
decreased blood urea nitrogen ... 6 | 31
decreased circulating alanine ... 6 | 53
decreased circulating creatini... 6 | 31
decreased circulating fructosa... 6 | 31
decreased eosinophil cell numb... 6 | 41
decreased hematocrit 6 | 25
decreased mean corpuscular vol... 6 | 50
increased body weight 6 | 42
increased circulating HDL chol... 6 | 63
increased mean corpuscular hem... 6 | 25
abnormal heart morphology 5 | 51
abnormal locomotor activation 5 | 26
abnormal midbrain development 5 | 22
decreased Ly6C low monocyte nu... 5 | 23
decreased circulating free fat... 5 | 39
decreased effector memory CD8-... 5 | 24
decreased fasted circulating g... 5 | 49
decreased mature B cell number 5 | 25
decreased threshold for audito... 5 | 32
hydrops fetalis 5 | 22
impaired glucose tolerance 5 | 52
increased circulating chloride... 5 | 43
increased circulating creatini... 5 | 29
increased exploration in new e... 5 | 56
increased hemoglobin content 5 | 45
male infertility 5 | 62
tremors 5 | 34
vertebral transformation 5 | 12
cardiovascular system phenotyp... 4 | 35
decreased circulating calcium ... 4 | 33
increased body length 4 | 20
increased respiratory quotient 4 | 12
persistence of hyaloid vascula... 4 | 22
vertebral fusion 4 | 23

Disease

osteosarcoma 1,096 | 7,933
ovarian cancer 1,082 | 8,484
psoriasis 781 | 6,685
medulloblastoma, large-cell 766 | 6,234
glioblastoma 661 | 5,572
lung cancer 595 | 4,466
atypical teratoid / rhabdoid tumor 554 | 4,369
malignant mesothelioma 437 | 3,162
Cancer 430 | 2,346
Breast cancer 411 | 3,094
primitive neuroectodermal tumor 408 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 362 | 3,289
oligodendroglioma 344 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 335 | 2,988
group 4 medulloblastoma 327 | 1,875
invasive ductal carcinoma 324 | 2,950
group 3 medulloblastoma 321 | 2,254
ependymoma 316 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 316 | 2,956
pediatric high grade glioma 313 | 2,712
Carcinoma 297 | 2,147
pilocytic astrocytoma 274 | 3,086
non-small cell lung cancer 273 | 2,798
astrocytic glioma 254 | 2,241
lung adenocarcinoma 246 | 2,713
lung carcinoma 238 | 2,844
pancreatic cancer 238 | 2,300
Pick disease 237 | 1,893
pituitary cancer 233 | 1,972
subependymal giant cell astrocytoma 229 | 2,287
adult high grade glioma 219 | 2,148
interstitial cystitis 217 | 2,299
astrocytoma 213 | 1,493
sonic hedgehog group medulloblastoma 207 | 1,482
Rheumatoid Arthritis 196 | 1,160
ductal carcinoma in situ 190 | 1,745
medulloblastoma 190 | 1,524
breast carcinoma 189 | 1,614
ulcerative colitis 188 | 2,087
tuberculosis 181 | 1,557
adrenocortical carcinoma 180 | 1,427
Multiple myeloma 171 | 1,327
cystic fibrosis 170 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 168 | 1,795
spina bifida 165 | 1,064
juvenile dermatomyositis 164 | 1,189
acute quadriplegic myopathy 158 | 1,157
posterior fossa group A ependymoma 155 | 1,511
diabetes mellitus 153 | 1,663
colon cancer 148 | 1,475
primary pancreatic ductal adenocarcinoma 145 | 1,271
acute myeloid leukemia 138 | 780
dermatomyositis 130 | 933
posterior fossa group B ependymoma 125 | 1,530
atypical teratoid/rhabdoid tumor 124 | 1,095
tuberculosis and treatment for 6 months 118 | 686
Intellectual disability 105 | 573
cutaneous lupus erythematosus 104 | 1,056
aldosterone-producing adenoma 101 | 664
Waldenstrons macroglobulinemia 96 | 765
non primary Sjogren syndrome sicca 93 | 840
primary Sjogren syndrome 93 | 789
nasopharyngeal carcinoma 88 | 1,056
Mammary Neoplasms 86 | 410
Atopic dermatitis 83 | 944
hepatocellular carcinoma 82 | 532
progressive supranuclear palsy 82 | 674
active Crohn's disease 80 | 918
gastric carcinoma 80 | 832
Prostatic Neoplasms 75 | 471
Obesity 72 | 616
Alzheimer's disease 71 | 644
gastric cancer 71 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 69 | 499
Endometriosis 66 | 535
Amyotrophic Lateral Sclerosis 63 | 431
pancreatic carcinoma 60 | 567
esophageal adenocarcinoma 59 | 737
Down syndrome 56 | 548
fibroadenoma 56 | 557
inflammatory breast cancer 54 | 404
Crohn's disease 52 | 304
Stomach Neoplasms 52 | 282
Acquired metabolic disease 51 | 267
Craniofacial Abnormalities 51 | 147
active ulcerative colitis 51 | 477
Multiple Sclerosis 48 | 498
Schizophrenia 48 | 501
glioblastoma multiforme 48 | 347
Polycystic Ovary Syndrome 47 | 332
Melanoma 45 | 261
chronic rhinosinusitis 45 | 512
Duchenne muscular dystrophy 44 | 602
sarcoidosis 43 | 358
Liver carcinoma 42 | 217
chronic lymphosyte leukemia 39 | 232
facioscapulohumeral dystrophy 39 | 286
Prostate cancer 38 | 172
head and neck cancer 38 | 270
non-small cell lung carcinoma 38 | 413

Tissue

Female tissues 2,256 | 18,647
Nervous System 2,251 | 18,561
Digestive Tract 2,245 | 18,473
Endocrine System 2,245 | 18,512
Urinary Tract 2,231 | 18,444
Liver and Pancreas 2,221 | 18,136
Blood and immune system 2,217 | 17,995
Male tissues 2,217 | 17,969
Skin and soft tissues 2,211 | 18,115
Cardiovascular System 2,204 | 17,958
Respiratory system 2,137 | 17,484

Target Family

Transcription Factor 1,257 | 1,400
Non-IDG 652 | 11,971
Epigenetic 147 | 242
Enzyme 128 | 4,146
Nuclear Receptor 48 | 48
Kinase 39 | 634
TF/Epigenetic 34 | 38
Transporter 3 | 473
Ion Channel 1 | 341

UniProt Keyword

Transcription regulation 2,309 | 2,309
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0