Development Level

Tbio 1,484 | 10,625
Tdark 663 | 7,003
Tchem 192 | 1,890
Tclin 36 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 107 | 633
preweaning lethality, incomple... 42 | 260
embryonic lethality prior to t... 39 | 187
decreased lean body mass 30 | 195
embryonic lethality prior to o... 29 | 148
decreased total body fat amoun... 28 | 186
abnormal behavior 27 | 226
decreased body weight 25 | 174
abnormal bone structure 23 | 131
decreased body length 23 | 108
abnormal embryo size 21 | 112
decreased bone mineral content 20 | 157
increased bone mineral content 18 | 92
decreased bone mineral density 17 | 126
increased or absent threshold ... 17 | 128
increased circulating alkaline... 16 | 119
decreased circulating choleste... 15 | 85
decreased circulating triglyce... 15 | 83
increased mean corpuscular vol... 15 | 91
abnormal retina morphology 14 | 100
hyperactivity 14 | 108
decreased circulating HDL chol... 13 | 77
decreased circulating glucose ... 13 | 121
decreased circulating serum al... 13 | 79
decreased grip strength 13 | 123
increased lean body mass 13 | 107
increased mean corpuscular hem... 13 | 93
increased sacral vertebrae num... 13 | 62
short tibia 13 | 82
decreased lumbar vertebrae num... 12 | 62
hypoactivity 12 | 89
decreased caudal vertebrae num... 11 | 49
decreased erythrocyte cell num... 11 | 43
decreased hemoglobin content 11 | 53
decreased leukocyte cell numbe... 11 | 54
prenatal lethality prior to he... 11 | 64
enlarged heart 10 | 111
increased grip strength 10 | 83
abnormal bone mineralization 9 | 55
abnormal eye morphology 9 | 38
abnormal gait 9 | 51
abnormal lens morphology 9 | 73
abnormal retinal pigmentation 9 | 61
decreased circulating alkaline... 9 | 41
decreased prepulse inhibition 9 | 52
increased circulating sodium l... 9 | 71
thrombocytopenia 9 | 46
abnormal cornea morphology 8 | 24
abnormal neural tube closure 8 | 37
decreased circulating insulin ... 8 | 75
decreased rib number 8 | 59
increased bone mineral density 8 | 52
increased circulating choleste... 8 | 53
increased total body fat amoun... 8 | 57
abnormal hindbrain development 7 | 24
abnormal sleep behavior 7 | 63
abnormal tooth morphology 7 | 24
decreased circulating LDL chol... 7 | 37
decreased circulating total pr... 7 | 41
increased B cell number 7 | 23
increased circulating triglyce... 7 | 24
increased fasted circulating g... 7 | 68
increased startle reflex 7 | 38
abnormal coat/hair pigmentatio... 6 | 54
abnormal forebrain development 6 | 18
decreased T cell number 6 | 31
decreased blood urea nitrogen ... 6 | 31
decreased circulating alanine ... 6 | 53
decreased circulating creatini... 6 | 31
decreased circulating fructosa... 6 | 31
decreased eosinophil cell numb... 6 | 41
decreased fasted circulating g... 6 | 49
decreased hematocrit 6 | 25
decreased mean corpuscular vol... 6 | 50
increased body weight 6 | 42
increased circulating HDL chol... 6 | 63
increased mean corpuscular hem... 6 | 25
male infertility 6 | 62
tremors 6 | 34
abnormal heart morphology 5 | 51
abnormal locomotor activation 5 | 26
abnormal midbrain development 5 | 22
decreased B cell number 5 | 30
decreased Ly6C low monocyte nu... 5 | 23
decreased circulating free fat... 5 | 39
decreased effector memory CD8-... 5 | 24
decreased mature B cell number 5 | 25
decreased threshold for audito... 5 | 32
hydrops fetalis 5 | 22
impaired glucose tolerance 5 | 52
increased circulating chloride... 5 | 43
increased circulating creatini... 5 | 29
increased exploration in new e... 5 | 56
increased hemoglobin content 5 | 45
vertebral transformation 5 | 12
cardiovascular system phenotyp... 4 | 35
decreased circulating calcium ... 4 | 33
decreased startle reflex 4 | 48
increased respiratory quotient 4 | 12
vertebral fusion 4 | 23

Disease

osteosarcoma 1,129 | 7,933
ovarian cancer 1,118 | 8,484
psoriasis 799 | 6,685
medulloblastoma, large-cell 786 | 6,234
glioblastoma 676 | 5,572
lung cancer 618 | 4,466
atypical teratoid / rhabdoid tumor 567 | 4,369
malignant mesothelioma 445 | 3,162
Cancer 434 | 2,346
Breast cancer 419 | 3,094
primitive neuroectodermal tumor 417 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 366 | 3,289
oligodendroglioma 349 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 340 | 2,988
group 4 medulloblastoma 332 | 1,875
group 3 medulloblastoma 331 | 2,254
invasive ductal carcinoma 331 | 2,950
pediatric high grade glioma 324 | 2,712
ependymoma 323 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 320 | 2,956
Carcinoma 306 | 2,147
non-small cell lung cancer 279 | 2,798
pilocytic astrocytoma 276 | 3,086
astrocytic glioma 261 | 2,241
lung adenocarcinoma 254 | 2,713
Pick disease 243 | 1,893
lung carcinoma 243 | 2,844
pancreatic cancer 241 | 2,300
subependymal giant cell astrocytoma 234 | 2,287
pituitary cancer 233 | 1,972
adult high grade glioma 222 | 2,148
interstitial cystitis 219 | 2,299
astrocytoma 217 | 1,493
sonic hedgehog group medulloblastoma 216 | 1,482
Rheumatoid Arthritis 197 | 1,160
ductal carcinoma in situ 194 | 1,745
medulloblastoma 194 | 1,524
breast carcinoma 193 | 1,614
ulcerative colitis 190 | 2,087
adrenocortical carcinoma 182 | 1,427
tuberculosis 182 | 1,557
Multiple myeloma 180 | 1,327
cystic fibrosis 173 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 169 | 1,795
spina bifida 168 | 1,064
juvenile dermatomyositis 166 | 1,189
acute quadriplegic myopathy 162 | 1,157
diabetes mellitus 160 | 1,663
posterior fossa group A ependymoma 160 | 1,511
colon cancer 153 | 1,475
primary pancreatic ductal adenocarcinoma 145 | 1,271
acute myeloid leukemia 140 | 780
dermatomyositis 133 | 933
posterior fossa group B ependymoma 130 | 1,530
atypical teratoid/rhabdoid tumor 127 | 1,095
tuberculosis and treatment for 6 months 118 | 686
Intellectual disability 108 | 573
cutaneous lupus erythematosus 105 | 1,056
aldosterone-producing adenoma 103 | 664
non primary Sjogren syndrome sicca 99 | 840
Waldenstrons macroglobulinemia 97 | 765
primary Sjogren syndrome 96 | 789
nasopharyngeal carcinoma 92 | 1,056
Mammary Neoplasms 87 | 410
hepatocellular carcinoma 85 | 532
progressive supranuclear palsy 85 | 674
Atopic dermatitis 84 | 944
active Crohn's disease 81 | 918
gastric carcinoma 80 | 832
Prostatic Neoplasms 75 | 471
Obesity 73 | 616
gastric cancer 72 | 430
Alzheimer's disease 71 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 69 | 499
Endometriosis 67 | 535
Amyotrophic Lateral Sclerosis 63 | 431
pancreatic carcinoma 63 | 567
esophageal adenocarcinoma 59 | 737
Down syndrome 56 | 548
fibroadenoma 56 | 557
inflammatory breast cancer 55 | 404
Stomach Neoplasms 54 | 282
Craniofacial Abnormalities 53 | 147
Crohn's disease 52 | 304
Acquired metabolic disease 51 | 267
active ulcerative colitis 51 | 477
Schizophrenia 49 | 501
Multiple Sclerosis 48 | 498
Polycystic Ovary Syndrome 48 | 332
glioblastoma multiforme 48 | 347
Melanoma 46 | 261
chronic rhinosinusitis 46 | 512
Duchenne muscular dystrophy 44 | 602
sarcoidosis 43 | 358
Liver carcinoma 42 | 217
Cleft palate 39 | 125
chronic lymphosyte leukemia 39 | 232
facioscapulohumeral dystrophy 39 | 286
non-small cell lung carcinoma 39 | 413
Prostate cancer 38 | 172

Tissue

Female tissues 2,322 | 18,647
Nervous System 2,317 | 18,561
Digestive Tract 2,310 | 18,473
Endocrine System 2,310 | 18,512
Urinary Tract 2,297 | 18,444
Liver and Pancreas 2,287 | 18,136
Blood and immune system 2,283 | 17,995
Male tissues 2,283 | 17,969
Skin and soft tissues 2,275 | 18,115
Cardiovascular System 2,270 | 17,958
Respiratory system 2,202 | 17,484

Target Family

Transcription Factor 1,260 | 1,400
Non-IDG 671 | 11,971
Enzyme 171 | 4,146
Epigenetic 148 | 242
Nuclear Receptor 48 | 48
Kinase 39 | 634
TF/Epigenetic 34 | 38
Transporter 3 | 473
Ion Channel 1 | 341

UniProt Keyword

Transcription 2,375 | 2,375
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0