Development Level

Tbio 84 | 11,651
Tdark 10 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal retina morphology 3 | 71
abnormal behavior 2 | 298
decreased grip strength 2 | 116
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
improved glucose tolerance 2 | 79
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased bone mineral content 1 | 108
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 64 | 11,493
ovarian cancer 59 | 8,520
psoriasis 43 | 6,694
osteosarcoma 42 | 7,950
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
medulloblastoma, large-cell 37 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
atypical teratoid / rhabdoid tumor 34 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
invasive ductal carcinoma 33 | 2,951
non-small cell lung cancer 33 | 2,890
ependymoma 32 | 4,679
glioblastoma 31 | 5,792
interstitial cystitis 30 | 2,312
lung adenocarcinoma 28 | 2,716
Breast cancer 27 | 3,578
ductal carcinoma in situ 26 | 1,745
group 3 medulloblastoma 25 | 4,104
lung cancer 24 | 4,740
pancreatic cancer 21 | 2,398
Cancer 20 | 2,499
Astrocytoma, Pilocytic 19 | 3,081
adult high grade glioma 19 | 3,801
lung carcinoma 18 | 2,843
primitive neuroectodermal tumor 18 | 3,035
spina bifida 18 | 1,074
subependymal giant cell astrocytoma 18 | 2,287
oligodendroglioma 17 | 2,850
Kidney cancer 16 | 2,613
malignant mesothelioma 16 | 3,232
pituitary cancer 16 | 1,972
breast carcinoma 14 | 1,638
active Crohn's disease 13 | 922
astrocytic glioma 13 | 2,597
cystic fibrosis 13 | 1,696
nasopharyngeal carcinoma 12 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
ulcerative colitis 11 | 1,819
primary pancreatic ductal adenocarcinoma 10 | 1,109
active ulcerative colitis 9 | 764
esophageal adenocarcinoma 9 | 737
group 4 medulloblastoma 9 | 1,855
Atopic dermatitis 8 | 952
Autosomal recessive predisposition 8 | 1,442
Pick disease 8 | 1,894
Prostatic Neoplasms 8 | 495
adrenocortical carcinoma 8 | 1,428
gastric carcinoma 8 | 807
Schizophrenia 7 | 1,160
cutaneous lupus erythematosus 7 | 1,057
Intellectual disability 6 | 1,016
acute myeloid leukemia 6 | 783
astrocytoma 6 | 1,146
diabetes mellitus 6 | 1,728
non primary Sjogren syndrome sicca 6 | 891
tuberculosis 6 | 2,010
Diarrhea 5 | 253
Down syndrome 5 | 499
Endometriosis 5 | 540
Inflammatory bowel disease 5 | 151
Kidney disease 5 | 430
Liver Cirrhosis, Experimental 5 | 769
acute quadriplegic myopathy 5 | 1,158
colon cancer 5 | 1,478
dermatomyositis 5 | 966
fibroadenoma 5 | 559
interstitial lung disease 5 | 298
medulloblastoma 5 | 720
mucosa-associated lymphoid tissue lymphoma 5 | 484
pediatric high grade glioma 5 | 1,064
periodontitis 5 | 293
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676
Bipolar Disorder 4 | 666
Breast Neoplasms 4 | 445
Dull intelligence 4 | 645
Leber congenital amaurosis 4 | 69
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nephrocalcinosis 4 | 35
Nystagmus 4 | 317
Polycystic ovary syndrome 4 | 360
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
aldosterone-producing adenoma 4 | 665
chronic rhinosinusitis 4 | 512
sarcoidosis 4 | 370
urothelial carcinoma 4 | 318
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Duchenne muscular dystrophy 3 | 601
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Pediatric failure to thrive 3 | 365
Prostate cancer 3 | 175
Seizures 3 | 596
juvenile dermatomyositis 3 | 1,187
nephrosclerosis 3 | 333

Tissue

Digestive Tract 92 | 17,369
Endocrine System 92 | 18,159
Female tissues 92 | 17,400
Urinary Tract 91 | 16,678
Skin and soft tissues 90 | 17,230
Male tissues 89 | 17,142
Nervous System 87 | 16,725
Respiratory system 87 | 16,393
Blood and immune system 86 | 16,909
Liver and Pancreas 86 | 16,750
Cardiovascular System 82 | 15,192

Target Family

Non-IDG 86 | 12,091
Enzyme 6 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242

UniProt Keyword

Tight junction 95 | 95
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Claudin-8 CLDN8 Tbio Non-IDG -1.50382 29.7 184
Claudin-6 CLDN6 Tbio Non-IDG -1.76879 66.0 370
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Cingulin-like protein 1 CGNL1 Tbio Non-IDG -0.84049 8.54 64
Blood vessel epicardial substance BVES Tbio Non-IDG -1.50394 37.0 168
Protein POF1B POF1B Tbio Non-IDG -0.76627 6.14 74
Rho GTPase-activating protein 17 ARHGAP17 Tbio Enzyme -1.81816 63.6 121
Probable ATP-dependent RNA helicase DDX58 DDX58 Tbio Enzyme -2.96494 922.1 422