Development Level

Tbio 90 | 11,445
Tchem 34 | 1,598
Tdark 23 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
decreased lean body mass 7 | 135
abnormal behavior 6 | 298
decreased bone mineral content 4 | 151
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased circulating glucose ... 4 | 24
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal gait 2 | 69
abnormal spine curvature 2 | 9
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased startle reflex 2 | 112
long tibia 2 | 25
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart position or ori... 1 | 1
abnormal hindlimb morphology 1 | 2
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
cataract 1 | 92
corneal opacity 1 | 32
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased basophil cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased erythrocyte cell num... 1 | 62
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased basophil cell number 1 | 7
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 108 | 11,493
ovarian cancer 77 | 8,520
osteosarcoma 66 | 7,950
medulloblastoma, large-cell 50 | 6,241
glioblastoma 49 | 5,792
atypical teratoid / rhabdoid tumor 39 | 5,112
psoriasis 37 | 6,694
lung cancer 33 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
malignant mesothelioma 30 | 3,232
Cancer 28 | 2,499
adult high grade glioma 28 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
Breast cancer 24 | 3,578
ependymoma 24 | 4,679
diabetes mellitus 23 | 1,728
subependymal giant cell astrocytoma 23 | 2,287
Kidney cancer 22 | 2,613
group 3 medulloblastoma 21 | 4,104
lung carcinoma 21 | 2,843
non-small cell lung cancer 20 | 2,890
juvenile dermatomyositis 19 | 1,187
primitive neuroectodermal tumor 19 | 3,035
Astrocytoma, Pilocytic 18 | 3,081
oligodendroglioma 18 | 2,850
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
lung adenocarcinoma 16 | 2,716
invasive ductal carcinoma 15 | 2,951
tuberculosis 14 | 2,010
spina bifida 13 | 1,074
ulcerative colitis 13 | 1,819
Atopic dermatitis 12 | 952
adrenocortical carcinoma 12 | 1,428
cystic fibrosis 12 | 1,696
group 4 medulloblastoma 12 | 1,855
interstitial cystitis 12 | 2,312
pancreatic cancer 12 | 2,398
Multiple myeloma 11 | 1,332
Pick disease 11 | 1,894
cutaneous lupus erythematosus 11 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Parkinson's disease 10 | 392
Rheumatoid arthritis 9 | 1,191
acute myeloid leukemia 9 | 783
pituitary cancer 9 | 1,972
Alzheimer's disease 8 | 658
Liver Cirrhosis, Experimental 8 | 769
colon cancer 8 | 1,478
dermatomyositis 8 | 966
esophageal adenocarcinoma 8 | 737
Bipolar Disorder 7 | 666
active ulcerative colitis 7 | 764
acute quadriplegic myopathy 7 | 1,158
primary Sjogren syndrome 7 | 735
progressive supranuclear palsy 7 | 676
tuberculosis and treatment for 6 months 7 | 409
Autosomal recessive predisposition 6 | 1,442
Neurodegenerative disease 6 | 414
active Crohn's disease 6 | 922
aldosterone-producing adenoma 6 | 665
breast carcinoma 6 | 1,638
gastric carcinoma 6 | 807
hereditary spastic paraplegia 6 | 318
Amyotrophic lateral sclerosis 5 | 451
Arthritis 5 | 290
Chronic hepatitis C 5 | 12
Melanoma 5 | 711
Myocardial Reperfusion Injury 5 | 37
Schizophrenia 5 | 1,160
Stomach Neoplasms 5 | 300
Vascular disease 5 | 319
hepatocellular carcinoma 5 | 547
pancreatic carcinoma 5 | 562
pediatric high grade glioma 5 | 1,064
Asthma 4 | 385
Carcinoma, Hepatocellular 4 | 228
Dementia 4 | 175
Duchenne muscular dystrophy 4 | 601
Fascioliasis 4 | 17
Infertility 4 | 188
Intellectual disability 4 | 1,016
Leukemia, Myelocytic, Acute 4 | 120
Leukemia, Myeloid, Acute 4 | 105
Liver carcinoma 4 | 240
Multiple Sclerosis 4 | 540
Obesity 4 | 678
Waldenstrons macroglobulinemia 4 | 765
astrocytoma 4 | 1,146
medulloblastoma 4 | 720
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Mental Depression 3 | 333
Type 2 diabetes mellitus 3 | 272
chronic rhinosinusitis 3 | 512
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
non diabetic and post-ischemic heart failure 3 | 200
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 131 | 18,159
Blood and immune system 129 | 16,909
Female tissues 129 | 17,400
Digestive Tract 128 | 17,369
Skin and soft tissues 128 | 17,230
Male tissues 127 | 17,142
Respiratory system 126 | 16,393
Liver and Pancreas 125 | 16,750
Nervous System 125 | 16,725
Urinary Tract 125 | 16,678
Cardiovascular System 118 | 15,192

Target Family

Enzyme 117 | 4,145
Non-IDG 30 | 12,091

UniProt Keyword

Thiol protease 147 | 147
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.64460 44.9 288
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 USP17L3 Tdark Enzyme -0.71476 13.1 15
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
Calpain-14 CAPN14 Tdark Non-IDG -0.55232 4.56 19
Ubiquitin carboxyl-terminal hydrolase 40 USP40 Tbio Enzyme -0.38917 2.14 68
Ubiquitin carboxyl-terminal hydrolase 29 USP29 Tbio Enzyme -1.22772 15.2 111
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Ufm1-specific protease 2 UFSP2 Tbio Enzyme -0.58306 3.98 69