Development Level

Tbio 29 | 11,445
Tdark 7 | 6,588
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal heart morphology 1 | 162
abnormal ovary morphology 1 | 7
abnormal thymus morphology 1 | 7
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased food intake 1 | 13
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged thymus 1 | 5
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
male infertility 1 | 123
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 29 | 11,493
ovarian cancer 23 | 8,520
osteosarcoma 21 | 7,950
medulloblastoma, large-cell 13 | 6,241
psoriasis 11 | 6,694
Cancer 8 | 2,499
Kidney cancer 8 | 2,613
atypical teratoid / rhabdoid tumor 8 | 5,112
lung cancer 8 | 4,740
Breast cancer 7 | 3,578
Intellectual disability 7 | 1,016
Pick disease 7 | 1,894
Dyskeratosis congenita 6 | 24
astrocytic glioma 6 | 2,597
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
non primary Sjogren syndrome sicca 6 | 891
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Short stature 5 | 531
Small head 5 | 374
adult high grade glioma 5 | 3,801
pancreatic cancer 5 | 2,398
Ataxia telangiectasia 4 | 34
Autosomal recessive predisposition 4 | 1,442
Cerebellar Ataxia 4 | 304
Decreased platelet count 4 | 111
Dry skin 4 | 75
Glioma 4 | 74
Hereditary Breast and Ovarian Cancer Syndrome 4 | 14
Hereditary Melanoma 4 | 12
Liver cancer 4 | 604
MELANOMA, CUTANEOUS MALIGNANT, 1 4 | 13
Thrombocytopenia 4 | 197
Xerosis 4 | 75
juvenile dermatomyositis 4 | 1,187
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Abnormality of the lymphatic system 3 | 14
Aplastic Anemia 3 | 21
Bone marrow hypocellularity 3 | 20
Cerebral atrophy 3 | 178
Cognitive delay 3 | 608
Cryptorchidism 3 | 296
Fanconi anemia 3 | 56
Fetal Growth Retardation 3 | 189
Freckles 3 | 33
Global developmental delay 3 | 608
HOYERAAL-HREIDARSSON SYNDROME 3 | 6
Hair shaft abnormalities 3 | 30
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hydronephrosis 3 | 89
Hypoplastic myelodysplasia 3 | 18
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Lung Neoplasms 3 | 232
Lymphatic Diseases 3 | 14
MYELODYSPLASTIC SYNDROME 3 | 53
Melanocytic nevus 3 | 43
Melanoma 3 | 711
Mental and motor retardation 3 | 608
Microcephaly 3 | 166
Nevus 3 | 19
Nijmegen breakage syndrome 3 | 24
Osteoporosis 3 | 363
Phenotypic variability 3 | 150
Rheumatoid arthritis 3 | 1,191
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
familial melanoma 3 | 10
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
hair abnormalities (non-specific) 3 | 30
interstitial lung disease 3 | 298
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
medulloblastoma 3 | 720
pancreatic carcinoma 3 | 562
periodontitis 3 | 293
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
tuberculosis and treatment for 6 months 3 | 409
Alopecia 2 | 115
Coagulation abnormalities 2 | 27
Dystrophia unguium 2 | 53
Frequent fractures 2 | 53
Hemorrhagic Disorders 2 | 30
Hyperhidrosis disorder 2 | 81
Increased fracture rate 2 | 53
Sweating 2 | 81
Varying degree of multiple fractures 2 | 53

Tissue

Endocrine System 40 | 18,159
Blood and immune system 39 | 16,909
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678
Nervous System 37 | 16,725
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 24 | 12,091
Enzyme 10 | 4,145
Transcription Factor 6 | 1,400

UniProt Keyword

Telomere 40 | 40
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Telomerase protein component 1 TEP1 Tbio Enzyme -1.74492 50.6 71
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Telomere repeats-binding bouquet formation protein 1 TERB1 Tdark Transcription Factor -0.45230 3.56 26
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.75509 5.75 308
Structural maintenance of chromosomes protein 6 SMC6 Tbio Non-IDG -1.42371 20.0 115
Telomere length regulation protein TEL2 homolog TELO2 Tbio Non-IDG -0.93554 9.48 94
CST complex subunit CTC1 CTC1 Tbio Non-IDG -1.74818 54.2 49
Telomere repeats-binding bouquet formation protein 2 TERB2 Tdark Non-IDG 0.60 0.26 6
Zinc finger and SCAN domain-containing protein 4 ZSCAN4 Tbio Transcription Factor -1.44000 29.0 220