Development Level

Tbio 11 | 11,445
Tchem 11 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased mean platelet volume 1 | 25
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hydrometra 1 | 53
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 14 | 8,520
osteosarcoma 13 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Carcinoma 10 | 11,493
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
malignant mesothelioma 10 | 3,232
psoriasis 10 | 6,694
ductal carcinoma in situ 9 | 1,745
active Crohn's disease 8 | 922
interstitial cystitis 8 | 2,312
medulloblastoma, large-cell 8 | 6,241
oligodendroglioma 8 | 2,850
Pick disease 7 | 1,894
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
Antley-Bixler syndrome 6 | 16
Breast cancer 6 | 3,578
Cognitive delay 6 | 608
Epilepsy 6 | 792
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Mental and motor retardation 6 | 608
Seizures 6 | 596
Smith-Lemli-Opitz syndrome 6 | 9
astrocytic glioma 6 | 2,597
ependymoma 6 | 4,679
group 4 medulloblastoma 6 | 1,855
Autosomal recessive predisposition 5 | 1,442
Cataract 5 | 297
Dull intelligence 5 | 645
Failure to gain weight 5 | 365
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Small head 5 | 374
chronic rhinosinusitis 5 | 512
lung carcinoma 5 | 2,843
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
Chondrodysplasia punctata 4 | 41
Congenital Epicanthus 4 | 177
Congenital ichthyosiform erythroderma 4 | 28
Lens Opacities 4 | 231
Mevalonic aciduria 4 | 16
Muscle hypotonia 4 | 571
Nystagmus 4 | 317
Porokeratosis of Mibelli 4 | 4
Strabismus 4 | 270
esophageal adenocarcinoma 4 | 737
group 3 medulloblastoma 4 | 4,104
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Anteverted nostril 3 | 191
Atopic dermatitis 3 | 952
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Cancer 3 | 2,499
Carcinoma, Hepatocellular 3 | 228
Chagas disease 3 | 39
Congenital deafness 3 | 185
Deafness 3 | 198
Disseminated superficial actinic porokeratosis 3 | 4
Downward slant of palpebral fissure 3 | 158
Hearing Loss, Partial 3 | 185
Hydrolethalus syndrome 3 | 128
Hydronephrosis 3 | 89
Hyperkeratosis 3 | 50
Hypoplastic mandible condyle 3 | 275
Liver carcinoma 3 | 240
Low set ears 3 | 181
Mandibular hypoplasia 3 | 275
Methemoglobinemia 3 | 17
Micrognathism 3 | 275
Multiple myeloma 3 | 1,332
Photosensitivity of skin 3 | 51
Porokeratosis, Disseminated Superficial Actinic 3 | 4
Posteriorly rotated ear 3 | 61
Short stature 3 | 531
Stippled epiphyses 3 | 28
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
atypical teratoid / rhabdoid tumor 3 | 5,112
hearing impairment 3 | 199
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
Alzheimer's disease 2 | 658
Curvature of spine 2 | 282
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Hepatomegaly 2 | 285
Small nose 2 | 132
breast carcinoma 2 | 1,638
nasopharyngeal carcinoma 2 | 1,058
tuberculosis 2 | 2,010

Tissue

Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Blood and immune system 24 | 16,909
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678

Target Family

Enzyme 21 | 4,145
Kinase 3 | 634
Non-IDG 1 | 12,091

UniProt Keyword

Sterol biosynthesis 25 | 25
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NADH-cytochrome b5 reductase 2 CYB5R2 Tbio Enzyme -0.96076 7.49 58
NADH-cytochrome b5 reductase 1 CYB5R1 Tbio Enzyme -0.95573 7.22 142
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Phosphomevalonate kinase PMVK Tchem Enzyme -1.96385 92.3 144
Lathosterol oxidase SC5D Tbio Enzyme -1.42233 28.3 26