Development Level

Tbio 50 | 11,445
Tchem 26 | 1,598
Tclin 10 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 50 | 8,520
Carcinoma 49 | 11,493
osteosarcoma 39 | 7,950
psoriasis 37 | 6,694
medulloblastoma, large-cell 31 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
malignant mesothelioma 27 | 3,232
glioblastoma 26 | 5,792
lung cancer 26 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
atypical teratoid / rhabdoid tumor 22 | 5,112
Autosomal recessive predisposition 21 | 1,442
ependymoma 21 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Obesity 20 | 678
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
lung carcinoma 19 | 2,843
Cancer 18 | 2,499
astrocytic glioma 18 | 2,597
diabetes mellitus 18 | 1,728
Atherosclerosis 17 | 291
ductal carcinoma in situ 17 | 1,745
group 3 medulloblastoma 17 | 4,104
interstitial cystitis 17 | 2,312
oligodendroglioma 17 | 2,850
pancreatic cancer 17 | 2,398
Breast cancer 16 | 3,578
Lipid metabolism disorder 16 | 114
invasive ductal carcinoma 16 | 2,951
active Crohn's disease 15 | 922
Epilepsy 14 | 792
Pick disease 14 | 1,894
subependymal giant cell astrocytoma 14 | 2,287
Intellectual disability 13 | 1,016
Kidney cancer 13 | 2,613
adrenocortical carcinoma 13 | 1,428
Seizures 12 | 596
group 4 medulloblastoma 12 | 1,855
Alzheimer's disease 11 | 658
Astrocytoma, Pilocytic 11 | 3,081
Cognitive delay 11 | 608
Coronary artery disease 11 | 268
Global developmental delay 11 | 608
Hepatomegaly 11 | 285
Mental and motor retardation 11 | 608
Schizophrenia 11 | 1,160
primitive neuroectodermal tumor 11 | 3,035
tuberculosis 11 | 2,010
Atopic dermatitis 10 | 952
Carcinoma, Hepatocellular 10 | 228
Dull intelligence 10 | 645
Hypercholesterolemia 10 | 44
Hypertension 10 | 396
Liver carcinoma 10 | 240
Liver disease 10 | 237
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
adult high grade glioma 10 | 3,801
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
Cholestasis 9 | 155
Failure to gain weight 9 | 365
Hypercholesterolemia, Familial 9 | 23
Hypertensive disease 9 | 292
Pediatric failure to thrive 9 | 365
Splenomegaly 9 | 190
active ulcerative colitis 9 | 764
astrocytoma 9 | 1,146
esophageal adenocarcinoma 9 | 737
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 1,819
Cardiovascular system disease 8 | 246
Fatty liver disease 8 | 103
Hyperlipidemia 8 | 43
Kidney disease 8 | 430
chronic rhinosinusitis 8 | 512
Chemical and Drug Induced Liver Injury 7 | 195
Cushing's syndrome 7 | 48
Insulin Resistance 7 | 72
Liver Cirrhosis, Experimental 7 | 769
Muscle hypotonia 7 | 571
Neurodegenerative disease 7 | 414
Polycystic ovary syndrome 7 | 360
Prostatic Neoplasms 7 | 495
Smith-Lemli-Opitz syndrome 7 | 9
spina bifida 7 | 1,074
Cataract 6 | 297
Cerebrovascular disease 6 | 238
Down syndrome 6 | 499
Heart disease 6 | 306
Increase in blood pressure 6 | 119
Short stature 6 | 531
Small head 6 | 374
Strabismus 6 | 270
Vascular disease 6 | 319
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
posterior fossa group B ependymoma 6 | 416

Tissue

Digestive Tract 86 | 17,369
Endocrine System 86 | 18,159
Female tissues 84 | 17,400
Male tissues 84 | 17,142
Blood and immune system 83 | 16,909
Liver and Pancreas 83 | 16,750
Skin and soft tissues 83 | 17,230
Urinary Tract 81 | 16,678
Nervous System 77 | 16,725
Respiratory system 77 | 16,393
Cardiovascular System 72 | 15,192

Target Family

Enzyme 53 | 4,145
Non-IDG 28 | 12,091
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 1 | 473

UniProt Keyword

Steroid metabolism 87 | 87
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.31570 219.0 131
Vigilin HDLBP Tbio Non-IDG -2.01228 106.9 233
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Niemann-Pick C1-like protein 1 NPC1L1 Tclin Non-IDG -2.33312 222.7 139
NADH-cytochrome b5 reductase 1 CYB5R1 Tbio Enzyme -0.95573 7.22 142