Development Level

Tbio 125 | 11,445
Tdark 77 | 6,588
Tchem 13 | 1,598

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

male infertility 11 | 123
preweaning lethality, incomple... 6 | 499
abnormal behavior 4 | 298
female infertility 4 | 60
small testis 4 | 58
abnormal bone structure 3 | 187
enlarged heart 3 | 210
increased bone mineral content 3 | 108
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
decreased body length 2 | 101
decreased body weight 2 | 161
decreased lean body mass 2 | 135
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
preweaning lethality, complete... 2 | 979
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal esophagus morphology 1 | 5
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased B cell number 1 | 5
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased cardiac muscle contr... 1 | 8
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened RR interval 1 | 17
shortened ST segment 1 | 10

Disease

Carcinoma 137 | 11,493
osteosarcoma 74 | 7,950
medulloblastoma, large-cell 67 | 6,241
ovarian cancer 64 | 8,520
psoriasis 60 | 6,694
glioblastoma 52 | 5,792
atypical teratoid / rhabdoid tumor 46 | 5,112
Kidney cancer 44 | 2,613
Male infertility 43 | 206
ependymoma 42 | 4,679
group 3 medulloblastoma 39 | 4,104
lung cancer 35 | 4,740
adult high grade glioma 33 | 3,801
Infertility 31 | 188
primitive neuroectodermal tumor 29 | 3,035
malignant mesothelioma 26 | 3,232
Astrocytoma, Pilocytic 24 | 3,081
oligodendroglioma 24 | 2,850
Breast cancer 23 | 3,578
astrocytic glioma 23 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
non-small cell lung cancer 23 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
lung adenocarcinoma 20 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
lung carcinoma 19 | 2,843
Azoospermia 18 | 110
subependymal giant cell astrocytoma 17 | 2,287
Cancer 16 | 2,499
nasopharyngeal carcinoma 16 | 1,058
tuberculosis 15 | 2,010
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 13 | 1,855
Melanoma 12 | 711
Pick disease 12 | 1,894
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057
interstitial cystitis 12 | 2,312
pancreatic cancer 12 | 2,398
ulcerative colitis 12 | 1,819
Schizophrenia 11 | 1,160
Skin cancer 11 | 469
Endometriosis 10 | 540
Multiple myeloma 10 | 1,332
juvenile dermatomyositis 10 | 1,187
pituitary cancer 10 | 1,972
Oligospermia 9 | 36
Rheumatoid arthritis 9 | 1,191
breast carcinoma 9 | 1,638
chronic rhinosinusitis 9 | 512
medulloblastoma 9 | 720
pediatric high grade glioma 9 | 1,064
adrenocortical carcinoma 8 | 1,428
non primary Sjogren syndrome sicca 8 | 891
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
spina bifida 8 | 1,074
Autosomal recessive predisposition 7 | 1,442
Bipolar Disorder 7 | 666
Liver cancer 7 | 604
Sertoli cell-only syndrome 7 | 37
cystic fibrosis 7 | 1,696
hepatocellular carcinoma 7 | 547
progressive supranuclear palsy 7 | 676
Obesity 6 | 678
Premature ovarian failure 6 | 65
Primary ciliary dyskinesia 6 | 76
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,728
sonic hedgehog group medulloblastoma 6 | 467
tuberculosis and treatment for 6 months 6 | 409
Alzheimer's disease 5 | 658
Klinefelter's syndrome 5 | 56
Varicocele 5 | 26
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis and chronic rhinosinusitis 5 | 214
gastric carcinoma 5 | 807
posterior fossa group A ependymoma 5 | 468
posterior fossa group B ependymoma 5 | 416
primary Sjogren syndrome 5 | 735
primary pancreatic ductal adenocarcinoma 5 | 1,109
Amenorrhea Secondary to Ovarian Dysfunction 4 | 8
Atrophic vaginitis 4 | 14
Attention deficit hyperactivity disorder 4 | 278
Contraception 4 | 15
Dysfunctional uterine bleeding 4 | 9
Endometrial Hyperplasia Prevention 4 | 9
Endometrial carcinoma 4 | 15
Hypogonadism 4 | 173
Infertility Secondary to Progesterone Deficiency 4 | 8
Intellectual disability 4 | 1,016
Menopausal flushing 4 | 17
Prevention of Premature Labor 4 | 9
Secondary malignant neoplasm of kidney 4 | 9
Secondary physiologic amenorrhea 4 | 32
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
head and neck cancer 4 | 271
pancreatic carcinoma 4 | 562

Tissue

Endocrine System 207 | 18,159
Digestive Tract 165 | 17,369
Female tissues 163 | 17,400
Skin and soft tissues 162 | 17,230
Blood and immune system 156 | 16,909
Male tissues 155 | 17,142
Nervous System 150 | 16,725
Liver and Pancreas 147 | 16,750
Urinary Tract 146 | 16,678
Respiratory system 143 | 16,393
Cardiovascular System 114 | 15,192

Target Family

Non-IDG 141 | 12,091
Enzyme 28 | 4,145
Epigenetic 13 | 242
Transcription Factor 12 | 1,400
Kinase 9 | 634
Transporter 5 | 473
Ion Channel 4 | 344
GPCR 2 | 408
Nuclear Receptor 1 | 48

UniProt Keyword

Spermatogenesis 215 | 215
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Testis anion transporter 1 SLC26A8 Tbio Transporter -0.96605 9.56 60
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
T-complex protein 11 homolog TCP11 Tbio Non-IDG -1.26152 18.0 80
HORMA domain-containing protein 1 HORMAD1 Tbio Non-IDG -1.44656 27.9 135
Tubulin delta chain TUBD1 Tbio Non-IDG -1.28681 18.5 57
Testis-specific serine/threonine-protein kinase 3 TSSK3 Tbio Kinase -0.52985 3.86 47
Sperm-associated antigen 8 SPAG8 Tbio Non-IDG -0.96272 9.29 158
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
Sperm protamine P1 PRM1 Tbio Non-IDG -2.17603 144.2 30