Development Level

Tclin 17 | 613
Tbio 7 | 11,445
Tchem 5 | 1,598

Collection

Ion Channel: IDG Consortium (T... 6 | 99

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased circulating alkaline... 2 | 46
decreased vertical activity 2 | 208
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal pelvic girdle bone mo... 1 | 12
decreased body length 1 | 101
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 25 | 11,493
Kidney cancer 14 | 2,613
Epilepsy 13 | 792
ependymoma 13 | 4,679
glioblastoma 13 | 5,792
medulloblastoma, large-cell 13 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
lung carcinoma 12 | 2,843
psoriasis 12 | 6,694
adult high grade glioma 11 | 3,801
osteosarcoma 11 | 7,950
Astrocytoma, Pilocytic 10 | 3,081
Atrial Fibrillation 10 | 124
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 27
lung cancer 10 | 4,740
oligodendroglioma 10 | 2,850
Breast cancer 9 | 3,578
group 3 medulloblastoma 9 | 4,104
Anesthesia for cesarean section 8 | 8
Bipolar disorder in remission 8 | 19
Major Nerve Block for Surgery 8 | 8
Regional Anesthesia for Labor Pain 8 | 9
Regional Anesthesia for Postoperative Pain 8 | 9
Regional Anesthesia for Surgery 8 | 9
Simple partial seizure 8 | 26
Tonic-clonic seizure 8 | 11
lung adenocarcinoma 8 | 2,716
primitive neuroectodermal tumor 8 | 3,035
Administration of Local Anesthetic Nerve Block 7 | 14
Administration of Regional Anesthesia 7 | 7
Infantile onset 7 | 238
Local Anesthesia for Ophthalmologic Procedure 7 | 7
Local anesthesia, by infiltration 7 | 14
Local anesthetic intrathecal block 7 | 7
Melanoma 7 | 711
Postherpetic neuralgia 7 | 11
Premature ejaculation 7 | 16
Prevention of Seizures following Cranial Trauma or Surgery 7 | 7
Seizures 7 | 596
Seizures in Neurosurgery 7 | 7
Status Epilepticus 7 | 98
interstitial cystitis 7 | 2,312
Administration of Corneal Anesthesia 6 | 6
Autosomal recessive predisposition 6 | 1,442
Brugada syndrome 6 | 29
Hemorrhoids 6 | 13
Infestation by Phthirus pubis 6 | 7
Infestation by Sarcoptes scabiei var hominis 6 | 7
Liver cancer 6 | 604
Local Anesthesia for Endotracheal Intubation 6 | 6
Local Anesthesia for Urethral Pain 6 | 6
Neuralgia 6 | 20
Paroxysmal atrial fibrillation 6 | 14
Pediculosis capitis 6 | 7
Pruritus ani 6 | 14
Regional Anesthesia for Ophthalmologic Surgery 6 | 6
Skin cancer 6 | 469
Urethritis 6 | 10
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
ovarian cancer 6 | 8,520
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 5 | 21
Autistic Disorder 5 | 364
Brugada Syndrome (disorder) 5 | 15
Cognitive delay 5 | 608
Constipation 5 | 181
Diarrhea 5 | 253
Dyschezia 5 | 135
Familial atrial fibrillation 5 | 23
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Parkinsonism 5 | 18
Spasticity 5 | 26
Tremor 5 | 113
cystic fibrosis 5 | 1,696
non-small cell lung cancer 5 | 2,890
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Endocrine System 28 | 18,159
Nervous System 27 | 16,725
Skin and soft tissues 26 | 17,230
Digestive Tract 25 | 17,369
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Respiratory system 25 | 16,393
Urinary Tract 24 | 16,678
Blood and immune system 23 | 16,909
Liver and Pancreas 23 | 16,750
Cardiovascular System 20 | 15,192

Target Family

Ion Channel 29 | 344

UniProt Keyword

Sodium channel 29 | 29
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Acid-sensing ion channel 5 ASIC5 Tbio Ion Channel -0.41218 3.22 86
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Sodium channel protein type 3 subunit alpha SCN3A Tclin Ion Channel -1.98160 87.0 76
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121
Acid-sensing ion channel 3 ASIC3 Tchem Ion Channel -2.28745 195.8 130
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.46568 276.3 60
Sodium channel subunit beta-4 SCN4B Tbio Ion Channel -1.42029 24.1 85
Sodium channel protein type 8 subunit alpha SCN8A Tclin Ion Channel -2.54867 340.7 156