Development Level

Tbio 57 | 11,445
Tclin 34 | 613
Tchem 25 | 1,598
Tdark 15 | 6,588

Collection

Ion Channel: IDG Consortium (T... 7 | 99

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 7 | 499
abnormal bone structure 5 | 187
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
impaired glucose tolerance 4 | 75
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased circulating alkaline... 3 | 46
decreased circulating serum al... 3 | 82
decreased hemoglobin content 3 | 68
decreased prepulse inhibition 3 | 82
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased monocyte cell number 2 | 63
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal iris morphology 1 | 13
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged thymus 1 | 5
eyelids fail to open 1 | 3
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
kyphosis 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
small heart 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 108 | 11,493
glioblastoma 50 | 5,792
medulloblastoma, large-cell 50 | 6,241
osteosarcoma 48 | 7,950
atypical teratoid / rhabdoid tumor 47 | 5,112
ependymoma 45 | 4,679
ovarian cancer 42 | 8,520
psoriasis 42 | 6,694
Kidney cancer 35 | 2,613
adult high grade glioma 35 | 3,801
lung cancer 35 | 4,740
group 3 medulloblastoma 33 | 4,104
lung carcinoma 31 | 2,843
Epilepsy 30 | 792
primitive neuroectodermal tumor 30 | 3,035
Astrocytoma, Pilocytic 27 | 3,081
oligodendroglioma 27 | 2,850
Breast cancer 25 | 3,578
pituitary cancer 25 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
subependymal giant cell astrocytoma 24 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
astrocytic glioma 21 | 2,597
malignant mesothelioma 21 | 3,232
Autosomal recessive predisposition 20 | 1,442
Seizures 20 | 596
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
lung adenocarcinoma 20 | 2,716
Atrial Fibrillation 18 | 124
Pick disease 18 | 1,894
interstitial cystitis 17 | 2,312
invasive ductal carcinoma 17 | 2,951
pancreatic cancer 17 | 2,398
Metabolic acidosis 16 | 90
non-small cell lung cancer 16 | 2,890
Bipolar Disorder 15 | 666
Hypertension 15 | 396
Melanoma 15 | 711
Schizophrenia 15 | 1,160
colon cancer 15 | 1,478
cystic fibrosis 14 | 1,696
ductal carcinoma in situ 13 | 1,745
Chronic heart failure 12 | 46
Cognitive delay 12 | 608
Diarrhea 12 | 253
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
Skin cancer 12 | 469
non primary Sjogren syndrome sicca 12 | 891
Autistic Disorder 11 | 364
Cancer 11 | 2,499
Edema 11 | 81
Epilepsy characterized by intractable complex partial seizures 11 | 28
Infantile onset 11 | 238
Intellectual disability 11 | 1,016
Itching of skin 11 | 18
Kidney disease 11 | 430
Life-Threatening Ventricular Tachycardia 11 | 15
Local anesthesia 11 | 40
Status Epilepticus 11 | 98
Ventricular arrhythmia 11 | 27
nephrosclerosis 11 | 333
ulcerative colitis 11 | 1,819
Constipation 10 | 181
Cough 10 | 23
Dysuria 10 | 26
Lennox-Gastaut syndrome 10 | 34
Liver cancer 10 | 604
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Parkinson's disease 10 | 392
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
active Crohn's disease 10 | 922
diabetes mellitus 10 | 1,728
tuberculosis 10 | 2,010
Cerebellar Ataxia 9 | 304
Congestive heart failure 9 | 113
Depressive disorder 9 | 409
Dyschezia 9 | 135
Hypertensive disease 9 | 292
Hypertensive disorder 9 | 56
Muscle hypotonia 9 | 571
Simple partial seizure 9 | 26
active ulcerative colitis 9 | 764
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Alzheimer's disease 8 | 658
Failure to gain weight 8 | 365
Mental Depression 8 | 333
Pediatric failure to thrive 8 | 365

Tissue

Endocrine System 127 | 18,159
Digestive Tract 120 | 17,369
Female tissues 119 | 17,400
Urinary Tract 119 | 16,678
Liver and Pancreas 117 | 16,750
Male tissues 117 | 17,142
Nervous System 117 | 16,725
Skin and soft tissues 117 | 17,230
Respiratory system 114 | 16,393
Blood and immune system 109 | 16,909
Cardiovascular System 88 | 15,192

Target Family

Transporter 94 | 473
Ion Channel 31 | 344
Non-IDG 4 | 12,091
Enzyme 2 | 4,145

UniProt Keyword

Sodium 131 | 131
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 Tbio Transporter -2.63743 436.2 124
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Sodium bicarbonate cotransporter 3 SLC4A7 Tbio Transporter -1.82039 64.7 133
Acid-sensing ion channel 5 ASIC5 Tbio Ion Channel -0.41218 3.22 86
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.37125 226.3 178
Solute carrier family 13 member 4 SLC13A4 Tbio Transporter -1.55886 37.5 50
Sodium-dependent phosphate transport protein 1 SLC17A1 Tbio Transporter -1.73498 53.1 39