Development Level

Tbio 309 | 11,178
Tdark 79 | 6,569
Tchem 57 | 1,885
Tclin 13 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 10 | 499
abnormal behavior 7 | 298
abnormal bone structure 7 | 187
hypoactivity 6 | 132
abnormal seminal vesicle morph... 5 | 114
decreased body length 5 | 101
decreased body weight 5 | 161
decreased lean body mass 5 | 135
enlarged heart 5 | 210
abnormal eye morphology 4 | 68
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
abnormal QT variability 3 | 10
abnormal embryo size 3 | 220
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased mean corpuscular hem... 3 | 96
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
abnormal bone mineralization 2 | 38
abnormal esophagus morphology 2 | 5
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal locomotor behavior 2 | 24
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
abnormal tibia morphology 2 | 14
abnormal vibrissa morphology 2 | 25
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased cardiac muscle contr... 2 | 11
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating phosphat... 2 | 27
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to t... 2 | 278
enlarged kidney 2 | 14
female infertility 2 | 60
hyperactivity 2 | 148
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased heart weight 2 | 62
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
pallor 2 | 34
prolonged QRS complex duration 2 | 8
small kidney 2 | 16
thrombocytopenia 2 | 56
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal pancreas morphology 1 | 13
abnormal retinal vasculature m... 1 | 27
abnormal thyroid gland morphol... 1 | 3
abnormal vertebrae morphology 1 | 18
absent adrenal gland 1 | 2
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
cystolithiasis 1 | 3
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
enlarged urinary bladder 1 | 8
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating lipase l... 1 | 3
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
small testis 1 | 58

Disease

Carcinoma 267 | 11,192
ovarian cancer 196 | 8,297
osteosarcoma 187 | 7,766
psoriasis 164 | 6,514
glioblastoma 138 | 5,635
medulloblastoma, large-cell 128 | 6,086
atypical teratoid / rhabdoid tumor 121 | 4,971
lung cancer 111 | 4,607
ependymoma 107 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 96 | 2,902
Astrocytoma, Pilocytic 93 | 3,006
lung carcinoma 93 | 2,755
intraductal papillary-mucinous adenoma (IPMA) 90 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,204
lung adenocarcinoma 85 | 2,627
Breast cancer 84 | 3,469
adult high grade glioma 82 | 3,701
invasive ductal carcinoma 81 | 2,867
group 3 medulloblastoma 79 | 4,002
interstitial cystitis 79 | 2,237
pancreatic cancer 79 | 2,322
malignant mesothelioma 75 | 3,135
non-small cell lung cancer 72 | 2,799
pituitary cancer 69 | 1,915
tuberculosis 69 | 1,963
ulcerative colitis 63 | 1,765
primitive neuroectodermal tumor 62 | 2,957
cystic fibrosis 58 | 1,629
oligodendroglioma 55 | 2,768
subependymal giant cell astrocytoma 51 | 2,230
group 4 medulloblastoma 50 | 1,806
astrocytic glioma 48 | 2,530
Kidney cancer 47 | 2,548
pancreatic ductal adenocarcinoma liver metastasis 47 | 1,911
active Crohn's disease 45 | 882
ductal carcinoma in situ 45 | 1,686
Cancer 44 | 2,388
Rheumatoid arthritis 42 | 1,156
Autosomal recessive predisposition 37 | 1,407
cutaneous lupus erythematosus 37 | 1,016
diabetes mellitus 37 | 1,683
breast carcinoma 35 | 1,589
active ulcerative colitis 34 | 736
colon cancer 34 | 1,428
Pick disease 32 | 1,856
pediatric high grade glioma 32 | 1,035
adrenocortical carcinoma 29 | 1,385
astrocytoma 29 | 1,113
nasopharyngeal carcinoma 28 | 1,024
primary pancreatic ductal adenocarcinoma 28 | 1,071
Multiple myeloma 26 | 1,296
non primary Sjogren syndrome sicca 26 | 861
Liver Cirrhosis, Experimental 25 | 733
primary Sjogren syndrome 25 | 710
Atopic dermatitis 24 | 915
aldosterone-producing adenoma 24 | 646
juvenile dermatomyositis 24 | 1,147
gastric carcinoma 22 | 781
esophageal adenocarcinoma 21 | 696
hepatocellular carcinoma 21 | 536
pancreatic carcinoma 21 | 555
posterior fossa group A ependymoma 21 | 456
fibroadenoma 20 | 538
mucosa-associated lymphoid tissue lymphoma 20 | 473
Duchenne muscular dystrophy 19 | 587
Multiple Sclerosis 19 | 527
acute quadriplegic myopathy 18 | 1,133
dermatomyositis 18 | 941
spina bifida 18 | 1,053
Epilepsy 17 | 775
Melanoma 17 | 689
Schizophrenia 17 | 1,136
Muscular dystrophy 16 | 75
acute myeloid leukemia 16 | 760
medulloblastoma 16 | 702
Chronic Lymphocytic Leukemia 15 | 254
Cognitive delay 15 | 596
Global developmental delay 15 | 596
Hypertension 15 | 372
Intellectual disability 15 | 998
Mental and motor retardation 15 | 596
Muscle hypotonia 15 | 562
Obesity 15 | 655
Short stature 15 | 514
Seizures 13 | 584
gastric cancer 13 | 445
periodontitis 13 | 280
Amyotrophic lateral sclerosis 12 | 437
Prostatic Neoplasms 12 | 472
sarcoidosis 12 | 357
Anemia 11 | 353
Bipolar Disorder 11 | 646
Neurodegenerative disease 11 | 402
Waldenstrons macroglobulinemia 11 | 742
Walker-Warburg syndrome 11 | 20
Alzheimer's disease 10 | 640
Atherosclerosis 10 | 276
Endometriosis 10 | 521
Polycystic ovary syndrome 10 | 348
progressive supranuclear palsy 10 | 656

Tissue

Endocrine System 444 | 18,159
Female tissues 437 | 17,400
Digestive Tract 435 | 17,369
Skin and soft tissues 430 | 17,230
Blood and immune system 424 | 16,909
Male tissues 424 | 17,142
Liver and Pancreas 422 | 16,750
Urinary Tract 421 | 16,678
Nervous System 410 | 16,725
Respiratory system 406 | 16,393
Cardiovascular System 361 | 15,192

Target Family

Enzyme 283 | 4,145
Non-IDG 158 | 12,091
Transcription Factor 9 | 1,400
Transporter 7 | 473
Kinase 1 | 634

UniProt Keyword

Signal-anchor 458 | 458
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 GCNT4 Tdark Enzyme -1.56850 33.7 45
Probable maltase-glucoamylase 2 MGAM2 Tdark Enzyme 0.60 0.20 3
Heparan-sulfate 6-O-sulfotransferase 1 HS6ST1 Tbio Enzyme -1.74222 59.7 70
Fukutin-related protein FKRP Tbio Non-IDG -2.01629 107.6 173
Semaphorin-5B SEMA5B Tbio Non-IDG -0.93332 8.55 54
Transmembrane protease serine 11D TMPRSS11D Tchem Enzyme -2.30083 201.8 97
C-type lectin domain family 1 member B CLEC1B Tbio Non-IDG -1.92806 93.6 224
Putative signal peptidase complex catalytic subunit SEC11B SEC11B Tdark Enzyme -0.76426 10.7 0
Chondroitin sulfate glucuronyltransferase CHPF2 Tbio Enzyme -0.51521 3.67 74