Development Level

Tbio 326 | 11,445
Tdark 79 | 6,588
Tchem 40 | 1,598
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 10 | 499
abnormal behavior 7 | 298
abnormal bone structure 7 | 187
hypoactivity 6 | 132
abnormal seminal vesicle morph... 5 | 114
decreased body length 5 | 101
decreased body weight 5 | 161
decreased lean body mass 5 | 135
enlarged heart 5 | 210
abnormal eye morphology 4 | 68
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
abnormal QT variability 3 | 10
abnormal embryo size 3 | 220
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased mean corpuscular hem... 3 | 96
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
abnormal bone mineralization 2 | 38
abnormal esophagus morphology 2 | 5
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal locomotor behavior 2 | 24
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
abnormal tibia morphology 2 | 14
abnormal vibrissa morphology 2 | 25
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased cardiac muscle contr... 2 | 11
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating phosphat... 2 | 27
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to t... 2 | 278
enlarged kidney 2 | 14
female infertility 2 | 60
hyperactivity 2 | 148
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased heart weight 2 | 62
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
pallor 2 | 34
prolonged QRS complex duration 2 | 8
small kidney 2 | 16
thrombocytopenia 2 | 56
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal pancreas morphology 1 | 13
abnormal retinal vasculature m... 1 | 27
abnormal thyroid gland morphol... 1 | 3
abnormal vertebrae morphology 1 | 18
absent adrenal gland 1 | 2
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
cystolithiasis 1 | 3
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
enlarged urinary bladder 1 | 8
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating lipase l... 1 | 3
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
small testis 1 | 58

Disease

Carcinoma 302 | 11,493
ovarian cancer 218 | 8,520
osteosarcoma 211 | 7,950
psoriasis 186 | 6,694
glioblastoma 150 | 5,792
medulloblastoma, large-cell 143 | 6,241
atypical teratoid / rhabdoid tumor 136 | 5,112
lung cancer 126 | 4,740
ependymoma 119 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 106 | 2,989
Astrocytoma, Pilocytic 105 | 3,081
lung carcinoma 105 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 101 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 100 | 2,955
Breast cancer 99 | 3,578
invasive ductal carcinoma 96 | 2,951
lung adenocarcinoma 94 | 2,716
adult high grade glioma 92 | 3,801
interstitial cystitis 91 | 2,312
pancreatic cancer 90 | 2,398
group 3 medulloblastoma 84 | 4,104
non-small cell lung cancer 84 | 2,890
malignant mesothelioma 83 | 3,232
pituitary cancer 77 | 1,972
tuberculosis 72 | 2,010
cystic fibrosis 68 | 1,696
ulcerative colitis 68 | 1,819
primitive neuroectodermal tumor 67 | 3,035
oligodendroglioma 60 | 2,850
Kidney cancer 59 | 2,613
ductal carcinoma in situ 55 | 1,745
subependymal giant cell astrocytoma 55 | 2,287
active Crohn's disease 54 | 922
group 4 medulloblastoma 54 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
astrocytic glioma 52 | 2,597
Cancer 51 | 2,499
Rheumatoid arthritis 46 | 1,191
breast carcinoma 41 | 1,638
cutaneous lupus erythematosus 41 | 1,057
Autosomal recessive predisposition 40 | 1,442
active ulcerative colitis 40 | 764
colon cancer 40 | 1,478
diabetes mellitus 38 | 1,728
Pick disease 36 | 1,894
pediatric high grade glioma 35 | 1,064
nasopharyngeal carcinoma 34 | 1,058
adrenocortical carcinoma 32 | 1,428
astrocytoma 32 | 1,146
primary pancreatic ductal adenocarcinoma 32 | 1,109
Liver Cirrhosis, Experimental 31 | 769
esophageal adenocarcinoma 30 | 737
non primary Sjogren syndrome sicca 30 | 891
Atopic dermatitis 29 | 952
Multiple myeloma 29 | 1,332
juvenile dermatomyositis 29 | 1,187
aldosterone-producing adenoma 26 | 665
gastric carcinoma 26 | 807
primary Sjogren syndrome 26 | 735
acute quadriplegic myopathy 22 | 1,158
fibroadenoma 22 | 559
posterior fossa group A ependymoma 22 | 468
spina bifida 22 | 1,074
Duchenne muscular dystrophy 21 | 601
acute myeloid leukemia 21 | 783
hepatocellular carcinoma 21 | 547
mucosa-associated lymphoid tissue lymphoma 21 | 484
pancreatic carcinoma 21 | 562
Hypertension 20 | 396
Multiple Sclerosis 19 | 540
dermatomyositis 19 | 966
medulloblastoma 19 | 720
Melanoma 18 | 711
Schizophrenia 18 | 1,160
Epilepsy 17 | 792
Obesity 17 | 678
Prostatic Neoplasms 17 | 495
Short stature 17 | 531
Anemia 16 | 365
Chronic Lymphocytic Leukemia 16 | 262
Muscular dystrophy 16 | 75
Alzheimer's disease 15 | 658
Cognitive delay 15 | 608
Global developmental delay 15 | 608
Intellectual disability 15 | 1,016
Mental and motor retardation 15 | 608
Muscle hypotonia 15 | 571
Amyotrophic lateral sclerosis 14 | 451
gastric cancer 14 | 459
periodontitis 14 | 293
Neurodegenerative disease 13 | 414
Seizures 13 | 596
Waldenstrons macroglobulinemia 13 | 765
sarcoidosis 13 | 370
Barrett's esophagus 12 | 182
Common variable immunodeficiency 12 | 101
Kidney disease 12 | 430
progressive supranuclear palsy 12 | 676
Bipolar Disorder 11 | 666
Endometriosis 11 | 540

Tissue

Endocrine System 444 | 18,159
Female tissues 437 | 17,400
Digestive Tract 435 | 17,369
Skin and soft tissues 430 | 17,230
Blood and immune system 424 | 16,909
Male tissues 424 | 17,142
Liver and Pancreas 422 | 16,750
Urinary Tract 421 | 16,678
Nervous System 410 | 16,725
Respiratory system 406 | 16,393
Cardiovascular System 361 | 15,192

Target Family

Enzyme 283 | 4,145
Non-IDG 158 | 12,091
Transcription Factor 9 | 1,400
Transporter 7 | 473
Kinase 1 | 634

UniProt Keyword

Signal-anchor 458 | 458
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Beta-1,3-N-acetylglucosaminyltransferase radical fringe RFNG Tdark Enzyme -0.37913 1.57 92
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 Tchem Enzyme -1.80418 63.8 91
Collagen alpha-1(XXIII) chain COL23A1 Tbio Non-IDG -0.49550 1.85 112
C-type lectin domain family 4 member D CLEC4D Tbio Non-IDG -1.43609 25.1 193
Alpha-(1,3)-fucosyltransferase 5 FUT5 Tbio Enzyme -1.52044 31.5 32