Development Level

Tbio 285 | 10,625
Tdark 96 | 7,003
Tchem 58 | 1,890
Tclin 13 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 7 | 633
preweaning lethality, incomple... 7 | 260
decreased body weight 6 | 174
decreased lean body mass 6 | 195
decreased body length 5 | 108
decreased circulating triglyce... 5 | 83
abnormal behavior 4 | 226
abnormal bone structure 4 | 131
increased circulating alkaline... 4 | 119
increased or absent threshold ... 4 | 128
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased heart weight 3 | 44
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
hyperactivity 3 | 108
increased red blood cell distr... 3 | 21
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal eye morphology 2 | 38
abnormal retina morphology 2 | 100
abnormal tibia morphology 2 | 14
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to o... 2 | 148
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
increased sacral vertebrae num... 2 | 62
short tibia 2 | 82
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal esophagus morphology 1 | 4
abnormal gait 1 | 51
abnormal hair growth 1 | 8
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal tail movements 1 | 12
abnormal thyroid gland morphol... 1 | 3
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
absent adrenal gland 1 | 1
absent lymph nodes 1 | 3
absent vibrissae 1 | 14
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased IgG1 level 1 | 4
decreased KLRG1-positive NK ce... 1 | 9
decreased circulating calcium ... 1 | 33
decreased circulating glycerol... 1 | 19
decreased circulating phosphat... 1 | 15
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased pulmonary respirator... 1 | 4
decreased threshold for audito... 1 | 32
embryonic lethality prior to t... 1 | 187
enlarged thymus 1 | 4
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
pallor 1 | 13
prolonged RR interval 1 | 2
short tail 1 | 4
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

ovarian cancer 215 | 8,484
osteosarcoma 210 | 7,933
psoriasis 184 | 6,685
glioblastoma 147 | 5,572
medulloblastoma, large-cell 143 | 6,234
lung cancer 122 | 4,466
atypical teratoid / rhabdoid tumor 119 | 4,369
pilocytic astrocytoma 107 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 105 | 2,988
lung carcinoma 104 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 101 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 99 | 2,956
invasive ductal carcinoma 97 | 2,950
lung adenocarcinoma 93 | 2,713
interstitial cystitis 92 | 2,299
Breast cancer 89 | 3,094
pancreatic cancer 87 | 2,300
malignant mesothelioma 83 | 3,162
pituitary cancer 77 | 1,972
ulcerative colitis 77 | 2,087
non-small cell lung cancer 76 | 2,798
primitive neuroectodermal tumor 68 | 3,031
pediatric high grade glioma 66 | 2,712
cystic fibrosis 65 | 1,665
adult high grade glioma 62 | 2,148
oligodendroglioma 60 | 2,849
posterior fossa group A ependymoma 58 | 1,511
ductal carcinoma in situ 57 | 1,745
subependymal giant cell astrocytoma 55 | 2,287
group 4 medulloblastoma 54 | 1,875
active Crohn's disease 53 | 918
ependymoma 51 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
tuberculosis 50 | 1,557
Cancer 48 | 2,346
Rheumatoid Arthritis 48 | 1,160
group 3 medulloblastoma 47 | 2,254
astrocytic glioma 43 | 2,241
breast carcinoma 41 | 1,614
astrocytoma 40 | 1,493
colon cancer 40 | 1,475
cutaneous lupus erythematosus 40 | 1,056
posterior fossa group B ependymoma 39 | 1,530
diabetes mellitus 38 | 1,663
Carcinoma 36 | 2,147
Pick disease 36 | 1,893
sonic hedgehog group medulloblastoma 36 | 1,482
nasopharyngeal carcinoma 35 | 1,056
primary pancreatic ductal adenocarcinoma 35 | 1,271
adrenocortical carcinoma 33 | 1,427
primary Sjogren syndrome 32 | 789
Multiple myeloma 30 | 1,327
Atopic dermatitis 29 | 944
active ulcerative colitis 29 | 477
esophageal adenocarcinoma 29 | 737
atypical teratoid/rhabdoid tumor 28 | 1,095
juvenile dermatomyositis 28 | 1,189
medulloblastoma 28 | 1,524
gastric carcinoma 27 | 832
aldosterone-producing adenoma 26 | 664
non primary Sjogren syndrome sicca 25 | 840
tuberculosis and treatment for 6 months 25 | 686
fibroadenoma 23 | 557
spina bifida 23 | 1,064
mucosa-associated lymphoid tissue lymphoma 22 | 480
IGA Glomerulonephritis 21 | 454
acute quadriplegic myopathy 21 | 1,157
hepatocellular carcinoma 21 | 532
Duchenne muscular dystrophy 20 | 602
pancreatic carcinoma 20 | 567
acute myeloid leukemia 19 | 780
Multiple Sclerosis 18 | 498
dermatomyositis 18 | 933
non-small cell lung carcinoma 18 | 413
Chronic Lymphocytic Leukemia 16 | 242
Hypertension 16 | 287
Obesity 16 | 616
Prostatic Neoplasms 16 | 471
periodontitis 15 | 269
Muscular dystrophy 14 | 48
Waldenstrons macroglobulinemia 14 | 765
gastric cancer 14 | 430
sarcoidosis 14 | 358
Amyotrophic Lateral Sclerosis 13 | 431
Anemia 13 | 252
Alzheimer's disease 12 | 644
Kidney disease 12 | 396
Neurodegenerative disease 12 | 383
progressive supranuclear palsy 12 | 674
Atherosclerosis 11 | 275
Endometriosis 11 | 535
Human immunodeficiency virus infectious disease 11 | 92
Intellectual disability 11 | 573
Polycystic Ovary Syndrome 11 | 332
glioblastoma multiforme 11 | 347
tuberculosis and treatment for 3 months 11 | 327
Crohn's disease 10 | 304
Down syndrome 10 | 548
inflammatory breast cancer 10 | 404
nephrosclerosis 10 | 329

Tissue

Digestive Tract 441 | 18,473
Nervous System 441 | 18,561
Endocrine System 437 | 18,512
Female tissues 437 | 18,647
Urinary Tract 436 | 18,444
Cardiovascular System 434 | 17,958
Skin and soft tissues 434 | 18,115
Blood and immune system 433 | 17,995
Liver and Pancreas 433 | 18,136
Male tissues 433 | 17,969
Respiratory system 429 | 17,484

Target Family

Enzyme 283 | 4,146
Non-IDG 152 | 11,971
Transcription Factor 9 | 1,400
Transporter 7 | 473
Kinase 1 | 634

UniProt Keyword

Signal-anchor 452 | 452
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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