Development Level

Tbio 2,219 | 11,651
Tdark 867 | 6,593
Tchem 293 | 1,388
Tclin 182 | 612

Collection

RFA-RM-18-021 51 | 328
Ion Channel: IDG Consortium (T... 29 | 99
GPCR: IDG Consortium (Targets) 19 | 126
GPCR: IDG Consortium (Complete... 8 | 25
Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, incomple... 91 | 499
preweaning lethality, complete... 81 | 979
decreased vertical activity 67 | 208
enlarged heart 55 | 210
abnormal heart morphology 43 | 162
abnormal behavior 39 | 298
abnormal seminal vesicle morph... 36 | 114
decreased total body fat amoun... 29 | 207
abnormal bone structure 28 | 187
embryonic lethality prior to t... 28 | 278
decreased circulating glucose ... 24 | 126
decreased grip strength 24 | 116
increased lean body mass 24 | 172
short tibia 24 | 97
small superior vagus ganglion 24 | 74
decreased bone mineral content 23 | 151
increased total body fat amoun... 23 | 134
hypoactivity 22 | 132
abnormal embryo size 21 | 220
abnormal kidney morphology 21 | 65
decreased lean body mass 20 | 135
hyperactivity 20 | 148
abnormal sleep behavior 17 | 70
decreased body weight 17 | 161
decreased lymphocyte cell numb... 17 | 83
decreased startle reflex 17 | 75
hydrometra 17 | 53
improved glucose tolerance 17 | 79
abnormal eye morphology 16 | 68
decreased circulating insulin ... 16 | 76
embryonic lethality prior to o... 16 | 239
increased bone mineral content 16 | 108
increased circulating alkaline... 16 | 122
decreased bone mineral density 15 | 126
decreased circulating choleste... 15 | 93
decreased mean corpuscular vol... 15 | 79
impaired glucose tolerance 15 | 75
increased circulating choleste... 15 | 66
increased startle reflex 15 | 112
abnormal gait 14 | 69
decreased circulating serum al... 14 | 82
increased circulating HDL chol... 14 | 80
increased mean corpuscular vol... 14 | 92
prolonged ST segment 14 | 36
abnormal coat-hair pigmentatio... 13 | 64
abnormal testis morphology 13 | 43
cataract 13 | 92
decreased body length 13 | 101
decreased fasted circulating g... 13 | 65
decreased prepulse inhibition 13 | 82
increased circulating triglyce... 13 | 42
increased monocyte cell number 13 | 63
small testis 13 | 58
decreased circulating HDL chol... 12 | 68
decreased circulating triglyce... 12 | 79
decreased leukocyte cell numbe... 12 | 73
increased heart weight 12 | 62
increased leukocyte cell numbe... 12 | 47
increased or absent threshold ... 12 | 101
abnormal retina morphology 11 | 71
abnormal skin morphology 11 | 50
increased bone mineral density 11 | 72
increased fasted circulating g... 11 | 76
abnormal epididymis morphology 10 | 42
decreased circulating total pr... 10 | 49
embryonic growth retardation 10 | 106
increased blood urea nitrogen ... 10 | 48
increased lymphocyte cell numb... 10 | 32
increased neutrophil cell numb... 10 | 46
limb grasping 10 | 41
abnormal spleen morphology 9 | 55
decreased blood urea nitrogen ... 9 | 51
decreased erythrocyte cell num... 9 | 62
decreased heart weight 9 | 27
increased circulating sodium l... 9 | 71
increased hematocrit 9 | 46
increased mean corpuscular hem... 9 | 96
male infertility 9 | 123
prolonged QT interval 9 | 38
thrombocytopenia 9 | 56
tremors 9 | 39
abnormal behavioral response t... 8 | 66
abnormal lens morphology 8 | 81
abnormal tail morphology 8 | 25
decreased circulating creatini... 8 | 39
decreased neutrophil cell numb... 8 | 42
enlarged epididymis 8 | 31
increased circulating total pr... 8 | 28
increased mean platelet volume 8 | 45
persistence of hyaloid vascula... 8 | 33
abnormal locomotor behavior 7 | 24
abnormal vibrissa morphology 7 | 25
decreased eosinophil cell numb... 7 | 24
decreased hemoglobin content 7 | 68
enlarged lymph nodes 7 | 37
impaired pupillary reflex 7 | 26
impaired righting response 7 | 26
increased circulating iron lev... 7 | 30
increased erythrocyte cell num... 7 | 39
increased vertical activity 7 | 24

Disease

Carcinoma 1,995 | 11,493
psoriasis 1,479 | 6,694
ovarian cancer 1,310 | 8,520
osteosarcoma 1,195 | 7,950
glioblastoma 1,082 | 5,792
medulloblastoma, large-cell 1,016 | 6,241
lung cancer 940 | 4,740
ependymoma 859 | 4,679
atypical teratoid / rhabdoid tumor 858 | 5,112
lung carcinoma 806 | 2,843
Breast cancer 772 | 3,578
Cancer 767 | 2,499
Astrocytoma, Pilocytic 755 | 3,081
adult high grade glioma 736 | 3,801
lung adenocarcinoma 704 | 2,716
non-small cell lung cancer 703 | 2,890
interstitial cystitis 700 | 2,312
invasive ductal carcinoma 676 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 667 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 657 | 3,291
malignant mesothelioma 634 | 3,232
group 3 medulloblastoma 624 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 622 | 2,989
pancreatic cancer 617 | 2,398
Kidney cancer 600 | 2,613
ulcerative colitis 527 | 1,819
oligodendroglioma 508 | 2,850
cystic fibrosis 493 | 1,696
diabetes mellitus 490 | 1,728
pituitary cancer 482 | 1,972
primitive neuroectodermal tumor 455 | 3,035
tuberculosis 436 | 2,010
subependymal giant cell astrocytoma 433 | 2,287
breast carcinoma 428 | 1,638
ductal carcinoma in situ 420 | 1,745
astrocytic glioma 414 | 2,597
Autosomal recessive predisposition 371 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 369 | 1,962
colon cancer 333 | 1,478
cutaneous lupus erythematosus 330 | 1,057
Schizophrenia 320 | 1,160
group 4 medulloblastoma 318 | 1,855
adrenocortical carcinoma 312 | 1,428
primary pancreatic ductal adenocarcinoma 312 | 1,109
Atopic dermatitis 285 | 952
Rheumatoid arthritis 282 | 1,191
Pick disease 246 | 1,894
gastric carcinoma 244 | 807
Melanoma 239 | 711
juvenile dermatomyositis 236 | 1,187
Liver Cirrhosis, Experimental 230 | 769
active Crohn's disease 230 | 922
nasopharyngeal carcinoma 227 | 1,058
Duchenne muscular dystrophy 220 | 601
astrocytoma 217 | 1,146
Kidney disease 216 | 430
pediatric high grade glioma 212 | 1,064
esophageal adenocarcinoma 204 | 737
Multiple Sclerosis 197 | 540
Obesity 191 | 678
Arthritis 186 | 290
Skin cancer 186 | 469
Hypersensitivity reaction type II disease 185 | 253
Liver cancer 181 | 604
fibroadenoma 181 | 559
Bipolar Disorder 180 | 666
primary Sjogren syndrome 172 | 735
Asthma 171 | 385
active ulcerative colitis 170 | 764
Hypertension 165 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 165 | 510
dermatomyositis 165 | 966
non primary Sjogren syndrome sicca 163 | 891
Alzheimer's disease 162 | 658
acute quadriplegic myopathy 159 | 1,158
Atherosclerosis 158 | 291
mucosa-associated lymphoid tissue lymphoma 157 | 484
Epilepsy 152 | 792
Multiple myeloma 148 | 1,332
Coronary artery disease 145 | 268
Endometriosis 141 | 540
Anemia 137 | 365
Prostatic Neoplasms 135 | 495
Intellectual disability 129 | 1,016
spina bifida 129 | 1,074
Down syndrome 127 | 499
Autistic Disorder 125 | 364
Liver disease 124 | 237
posterior fossa group A ependymoma 121 | 468
medulloblastoma 120 | 720
periodontitis 120 | 293
Osteoporosis 117 | 363
Depressive disorder 115 | 409
Breast Neoplasms 114 | 445
aldosterone-producing adenoma 113 | 665
Cerebrovascular disease 112 | 238
Mammary Neoplasms 111 | 425
Seizures 111 | 596
Vascular disease 111 | 319
Heart disease 110 | 306

Tissue

Endocrine System 3,077 | 18,159
Digestive Tract 2,983 | 17,369
Female tissues 2,977 | 17,400
Skin and soft tissues 2,922 | 17,230
Male tissues 2,913 | 17,142
Blood and immune system 2,853 | 16,909
Liver and Pancreas 2,820 | 16,750
Urinary Tract 2,793 | 16,678
Nervous System 2,738 | 16,725
Respiratory system 2,698 | 16,393
Cardiovascular System 2,359 | 15,192

Target Family

Non-IDG 2,648 | 12,091
Enzyme 635 | 4,145
GPCR 92 | 408
Ion Channel 90 | 344
Kinase 79 | 634
Transporter 15 | 473
Transcription Factor 2 | 1,400

UniProt Keyword

Signal 3,561 | 3,561
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
T-cell surface glycoprotein CD4 CD4 Tchem Non-IDG -2.62762 407.9 4422
Mast/stem cell growth factor receptor Kit KIT Tclin Kinase -3.80501 6371.9 4098
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859
T-cell surface glycoprotein CD8 alpha chain CD8A Tbio Non-IDG -2.37172 222.6 3514
CD44 antigen CD44 Tbio Non-IDG -3.85987 6832.7 3401
B-lymphocyte antigen CD19 CD19 Tclin Non-IDG -3.54335 3206.2 2794
Amyloid-beta A4 protein APP Tchem Non-IDG -3.99225 9853.3 2781
Mucin-1 MUC1 Tbio Non-IDG -3.54835 3730.1 2598
T-cell surface glycoprotein CD5 CD5 Tbio Non-IDG -3.41577 2574.0 2481