Development Level

Tchem 269 | 1,890
Tbio 86 | 10,625
Tdark 20 | 7,003
Tclin 13 | 602

Collection

Kinase: IDG Consortium (Targets) 102 | 125
Kinase: IDG Consortium (Complete/Control) 35 | 37

IMPC Phenotype

preweaning lethality, complete... 16 | 633
preweaning lethality, incomple... 10 | 260
decreased body weight 6 | 174
decreased lean body mass 6 | 195
abnormal behavior 5 | 226
decreased body length 5 | 108
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
decreased bone mineral content 4 | 157
decreased circulating glucose ... 4 | 121
embryonic lethality prior to o... 4 | 148
increased bone mineral content 4 | 92
abnormal gait 3 | 51
abnormal retina morphology 3 | 100
decreased blood urea nitrogen ... 3 | 31
decreased fasted circulating g... 3 | 49
decreased neutrophil cell numb... 3 | 37
increased circulating LDL chol... 3 | 15
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased erythrocyte cell num... 3 | 26
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal eye morphology 2 | 38
abnormal joint morphology 2 | 14
abnormal kidney morphology 2 | 30
abnormal maxilla morphology 2 | 16
abnormal pelvic girdle bone mo... 2 | 11
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal tooth morphology 2 | 24
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
enlarged heart 2 | 111
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating aspartat... 2 | 17
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mature B cell number 2 | 12
increased mean corpuscular hem... 2 | 93
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
male infertility 2 | 62
microphthalmia 2 | 15
short tibia 2 | 82
small superior vagus ganglion 2 | 20
small testis 2 | 37
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
convulsive seizures 1 | 11
decreased Ly6C high monocyte n... 1 | 18
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
enlarged spleen 1 | 26
female infertility 1 | 34
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating triglyce... 1 | 24
increased eosinophil cell numb... 1 | 9
lethargy 1 | 5
long tibia 1 | 13
small thymus 1 | 11
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 217 | 8,491
osteosarcoma 212 | 7,933
medulloblastoma, large-cell 175 | 6,234
psoriasis 161 | 6,685
glioblastoma 146 | 5,572
atypical teratoid / rhabdoid tumor 127 | 4,369
lung cancer 115 | 4,473
Cancer 99 | 2,346
malignant mesothelioma 98 | 3,163
primitive neuroectodermal tumor 91 | 3,031
pilocytic astrocytoma 89 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,289
Carcinoma 87 | 2,147
Breast cancer 86 | 3,098
ependymoma 83 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 82 | 2,988
oligodendroglioma 80 | 2,849
pediatric high grade glioma 78 | 2,712
non-small cell lung cancer 75 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 72 | 2,956
invasive ductal carcinoma 70 | 2,950
lung carcinoma 67 | 2,844
astrocytic glioma 64 | 2,241
Pick disease 61 | 1,893
lung adenocarcinoma 60 | 2,714
adult high grade glioma 57 | 2,148
subependymal giant cell astrocytoma 57 | 2,287
group 3 medulloblastoma 56 | 2,254
medulloblastoma 53 | 1,524
pancreatic cancer 51 | 2,300
group 4 medulloblastoma 49 | 1,875
interstitial cystitis 46 | 2,299
ulcerative colitis 46 | 2,087
Renal Cell Carcinoma 44 | 199
cystic fibrosis 44 | 1,670
posterior fossa group B ependymoma 43 | 1,530
astrocytoma 42 | 1,493
pituitary cancer 42 | 1,972
adrenocortical carcinoma 41 | 1,427
Rheumatoid Arthritis 40 | 1,170
diabetes mellitus 39 | 1,663
ductal carcinoma in situ 37 | 1,745
sonic hedgehog group medulloblastoma 37 | 1,482
breast carcinoma 36 | 1,614
colon cancer 35 | 1,475
posterior fossa group A ependymoma 34 | 1,511
acute quadriplegic myopathy 33 | 1,157
Gastrointestinal stromal tumor 32 | 61
tuberculosis 32 | 1,563
Pancreatic Neuroendocrine Tumor 31 | 45
juvenile dermatomyositis 31 | 1,189
spina bifida 30 | 1,064
atypical teratoid/rhabdoid tumor 28 | 1,095
nasopharyngeal carcinoma 27 | 1,056
primary pancreatic ductal adenocarcinoma 26 | 1,271
dermatomyositis 25 | 966
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
Multiple myeloma 23 | 1,327
progressive supranuclear palsy 23 | 674
Chronic Myelocytic Leukemia Accelerated Phase 22 | 59
Parkinson's disease 22 | 364
acute myeloid leukemia 22 | 785
Blastic phase chronic myeloid leukemia 21 | 58
IGA Glomerulonephritis 20 | 454
Amyotrophic Lateral Sclerosis 19 | 432
Atopic dermatitis 19 | 944
Down syndrome 19 | 548
Hamman-Rich syndrome 19 | 35
Intellectual disability 19 | 573
Vascular disease 19 | 281
aldosterone-producing adenoma 19 | 664
tuberculosis and treatment for 6 months 19 | 686
Alzheimer's disease 18 | 644
Endometriosis 18 | 535
esophageal adenocarcinoma 18 | 737
primary Sjogren syndrome 18 | 788
Obesity 17 | 616
Prostatic Neoplasms 17 | 471
Mammary Neoplasms 16 | 410
Peripheral Neuropathy 16 | 303
Schizophrenia 16 | 503
Waldenstrons macroglobulinemia 15 | 764
cutaneous lupus erythematosus 15 | 1,056
Hypertension 14 | 293
pancreatic carcinoma 14 | 567
Lung Neoplasms 13 | 171
chronic lymphocytic leukemia 13 | 244
glioblastoma multiforme 13 | 347
Colorectal Neoplasms 12 | 217
Kidney disease 12 | 397
Melanoma 12 | 261
Neurodegenerative disease 12 | 383
Philadelphia chromosome-positive acute lymphoblastic leukemia 12 | 47
hepatocellular carcinoma 12 | 550
non-small cell lung carcinoma 12 | 413
Asthma 11 | 349
active Crohn's disease 11 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
gastric carcinoma 11 | 832
non primary Sjogren syndrome sicca 11 | 840

Tissue

Endocrine System 385 | 18,511
Blood and immune system 384 | 17,994
Digestive Tract 384 | 18,472
Female tissues 384 | 18,646
Liver and Pancreas 384 | 18,135
Nervous System 384 | 18,560
Urinary Tract 384 | 18,443
Male tissues 383 | 17,968
Cardiovascular System 382 | 17,957
Respiratory system 378 | 17,483
Skin and soft tissues 377 | 18,114

Target Family

Kinase 383 | 634
Enzyme 2 | 4,146
Non-IDG 2 | 11,969
Ion Channel 1 | 341

UniProt Keyword

Serine-threonine-protein kinas... 388 | 388
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-interacting serine/threonine-protein kinase 3 RIPK3 Tchem Kinase -2.11581 129.5 456
Serine/threonine-protein kinase LMTK3 LMTK3 Tbio Kinase -1.18725 16.9 129
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.58792 56.8 175
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.24881 21.2 139
Testis-specific serine/threonine-protein kinase 3 TSSK3 Tbio Kinase -0.53305 3.86 46
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Testis-specific serine/threonine-protein kinase 6 TSSK6 Tchem Kinase -1.32403 18.5 110
Testis-specific serine/threonine-protein kinase 1 TSSK1B Tchem Kinase -1.41882 23.1 26
Cyclin-dependent kinase-like 1 CDKL1 Tchem Kinase -0.74791 5.41 233
TP53-regulating kinase TP53RK Tbio Kinase -1.17233 16.8 178