Development Level

Tchem 261 | 1,388
Tbio 93 | 11,651
Tdark 20 | 6,593
Tclin 14 | 612

Collection

Kinase: IDG Consortium (Target... 102 | 125
RFA-RM-18-021 102 | 328
Kinase: IDG Consortium (Comple... 35 | 37

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 20 | 499
embryonic lethality prior to o... 10 | 239
abnormal bone structure 9 | 187
embryonic lethality prior to t... 9 | 278
abnormal embryo size 8 | 220
abnormal behavior 6 | 298
enlarged heart 6 | 210
decreased circulating glucose ... 5 | 126
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
increased bone mineral content 5 | 108
increased or absent threshold ... 5 | 101
abnormal behavioral response t... 4 | 66
decreased blood urea nitrogen ... 4 | 51
decreased body weight 4 | 161
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
increased mean corpuscular vol... 4 | 92
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal spleen morphology 3 | 55
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
enlarged lymph nodes 3 | 37
enlarged spleen 3 | 41
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating iron lev... 3 | 30
increased circulating sodium l... 3 | 71
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
male infertility 3 | 123
small superior vagus ganglion 3 | 74
abnormal clavicle morphology 2 | 6
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal pelvic girdle bone mo... 2 | 12
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal spinal cord morpholog... 2 | 9
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating magnesiu... 2 | 13
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased hematocrit 2 | 46
decreased large unstained cell... 2 | 11
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
edema 2 | 59
enlarged epididymis 2 | 31
increased blood urea nitrogen ... 2 | 48
increased circulating aspartat... 2 | 15
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
microphthalmia 2 | 26
pallor 2 | 34
short tibia 2 | 97
small testis 2 | 58
thrombocytosis 2 | 27
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal optic disc morphology 1 | 10
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 13
decreased circulating triglyce... 1 | 79
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating triglyce... 1 | 42
increased red blood cell distr... 1 | 34
long tibia 1 | 25
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 327 | 11,493
ovarian cancer 222 | 8,520
osteosarcoma 213 | 7,950
medulloblastoma, large-cell 176 | 6,241
psoriasis 161 | 6,694
glioblastoma 158 | 5,792
atypical teratoid / rhabdoid tumor 150 | 5,112
ependymoma 139 | 4,679
lung cancer 125 | 4,740
adult high grade glioma 111 | 3,801
group 3 medulloblastoma 109 | 4,104
Cancer 107 | 2,499
Kidney cancer 107 | 2,613
malignant mesothelioma 102 | 3,232
Breast cancer 98 | 3,578
primitive neuroectodermal tumor 93 | 3,035
Astrocytoma, Pilocytic 90 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 82 | 2,989
oligodendroglioma 81 | 2,850
non-small cell lung cancer 76 | 2,890
astrocytic glioma 74 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 72 | 2,955
invasive ductal carcinoma 71 | 2,951
lung carcinoma 68 | 2,843
Pick disease 62 | 1,894
lung adenocarcinoma 61 | 2,716
subependymal giant cell astrocytoma 59 | 2,287
pancreatic cancer 57 | 2,398
group 4 medulloblastoma 56 | 1,855
Renal Cell Carcinoma 47 | 214
interstitial cystitis 47 | 2,312
cystic fibrosis 46 | 1,696
tuberculosis 46 | 2,010
pituitary cancer 43 | 1,972
adrenocortical carcinoma 42 | 1,428
Schizophrenia 41 | 1,160
breast carcinoma 41 | 1,638
diabetes mellitus 41 | 1,728
Rheumatoid arthritis 40 | 1,191
ulcerative colitis 40 | 1,819
ductal carcinoma in situ 38 | 1,745
colon cancer 36 | 1,478
Autosomal recessive predisposition 33 | 1,442
Intellectual disability 33 | 1,016
acute quadriplegic myopathy 33 | 1,158
astrocytoma 33 | 1,146
Gastrointestinal stromal tumor 32 | 62
Pancreatic Neuroendocrine Tumor 31 | 45
juvenile dermatomyositis 31 | 1,187
spina bifida 30 | 1,074
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,962
nasopharyngeal carcinoma 28 | 1,058
Liver cancer 26 | 604
pediatric high grade glioma 26 | 1,064
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Multiple myeloma 25 | 1,332
Poor school performance 25 | 645
dermatomyositis 25 | 966
Parkinson's disease 24 | 392
acute myeloid leukemia 23 | 783
progressive supranuclear palsy 23 | 676
Chronic Myelocytic Leukemia Accelerated Phase 22 | 59
Epilepsy 22 | 792
Melanoma 22 | 711
primary pancreatic ductal adenocarcinoma 22 | 1,109
Alzheimer's disease 21 | 658
Blastic phase chronic myeloid leukemia 21 | 58
medulloblastoma 21 | 720
Amyotrophic lateral sclerosis 20 | 451
Endometriosis 20 | 540
Hypertension 20 | 396
Prostatic Neoplasms 20 | 495
Short stature 20 | 531
Small head 20 | 374
Atopic dermatitis 19 | 952
Hamman-Rich syndrome 19 | 34
Hypoplastic mandible condyle 19 | 275
Mandibular hypoplasia 19 | 275
Micrognathism 19 | 275
Vascular disease 19 | 319
aldosterone-producing adenoma 19 | 665
Bipolar Disorder 18 | 666
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Hypertensive disease 18 | 292
Mental and motor retardation 18 | 608
esophageal adenocarcinoma 18 | 737
primary Sjogren syndrome 18 | 735
Breast Neoplasms 17 | 445
Down syndrome 17 | 499
Mammary Neoplasms 17 | 425
Obesity 17 | 678
Depressive disorder 16 | 409
Endometrial cancer 16 | 311
Chronic Lymphocytic Leukemia 15 | 262
cutaneous lupus erythematosus 15 | 1,057

Tissue

Endocrine System 383 | 18,159
Digestive Tract 376 | 17,369
Female tissues 375 | 17,400
Male tissues 375 | 17,142
Skin and soft tissues 375 | 17,230
Liver and Pancreas 372 | 16,750
Blood and immune system 370 | 16,909
Nervous System 370 | 16,725
Urinary Tract 370 | 16,678
Respiratory system 367 | 16,393
Cardiovascular System 357 | 15,192

Target Family

Kinase 383 | 634
Enzyme 2 | 4,145
Non-IDG 2 | 12,091
Ion Channel 1 | 344

UniProt Keyword

Serine-threonine-protein kinas... 388 | 388
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase DCLK2 DCLK2 Tchem Kinase -0.89222 8.01 148
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Serine/threonine-protein kinase DCLK3 DCLK3 Tchem Kinase -2.33084 205.9 71
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Striated muscle preferentially expressed protein kinase SPEG Tbio Kinase -2.50316 309.8 65
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405