Development Level

Tbio 52 | 11,445
Tchem 52 | 1,598
Tdark 27 | 6,588
Tclin 11 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 8 | 499
abnormal embryo size 4 | 220
decreased bone mineral content 4 | 151
abnormal behavior 3 | 298
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal limb bud morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
male infertility 2 | 123
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal placenta size 1 | 20
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased B cell number 1 | 5
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased heart rate 1 | 18
decreased leukocyte cell numbe... 1 | 73
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged ST segment 1 | 36
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 84 | 11,493
psoriasis 66 | 6,694
ovarian cancer 48 | 8,520
osteosarcoma 45 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
Cancer 34 | 2,499
pancreatic cancer 34 | 2,398
cystic fibrosis 30 | 1,696
lung adenocarcinoma 30 | 2,716
lung cancer 30 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
medulloblastoma, large-cell 27 | 6,241
Breast cancer 26 | 3,578
glioblastoma 26 | 5,792
adult high grade glioma 24 | 3,801
diabetes mellitus 24 | 1,728
invasive ductal carcinoma 24 | 2,951
Autosomal recessive predisposition 23 | 1,442
ependymoma 23 | 4,679
lung carcinoma 22 | 2,843
non-small cell lung cancer 21 | 2,890
atypical teratoid / rhabdoid tumor 20 | 5,112
interstitial cystitis 20 | 2,312
malignant mesothelioma 19 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Astrocytoma, Pilocytic 18 | 3,081
Atopic dermatitis 18 | 952
Hypertension 18 | 396
group 3 medulloblastoma 17 | 4,104
cutaneous lupus erythematosus 16 | 1,057
oligodendroglioma 16 | 2,850
ulcerative colitis 16 | 1,819
pituitary cancer 15 | 1,972
Kidney cancer 14 | 2,613
Pancreatitis 14 | 123
primary pancreatic ductal adenocarcinoma 13 | 1,109
subependymal giant cell astrocytoma 13 | 2,287
tuberculosis 13 | 2,010
Cerebrovascular disease 12 | 238
breast carcinoma 12 | 1,638
nasopharyngeal carcinoma 12 | 1,058
Kidney disease 11 | 430
colon cancer 11 | 1,478
esophageal adenocarcinoma 11 | 737
group 4 medulloblastoma 11 | 1,855
Alzheimer's disease 10 | 658
Prostatic Neoplasms 10 | 495
Schizophrenia 10 | 1,160
astrocytic glioma 10 | 2,597
Atherosclerosis 9 | 291
Hypertensive disease 9 | 292
Thrombophilia 9 | 38
active Crohn's disease 9 | 922
fibroadenoma 9 | 559
gastric carcinoma 9 | 807
primitive neuroectodermal tumor 9 | 3,035
spina bifida 9 | 1,074
Coronary artery disease 8 | 268
Diarrhea 8 | 253
Heart disease 8 | 306
Liver Cirrhosis, Experimental 8 | 769
Pulmonary embolism 8 | 55
Rheumatoid arthritis 8 | 1,191
adrenocortical carcinoma 8 | 1,428
Angioedema 7 | 38
Exocrine pancreatic insufficiency 7 | 32
Multiple Sclerosis 7 | 540
Netherton syndrome 7 | 15
Obesity 7 | 678
Thromboembolism 7 | 15
Thrombosis 7 | 46
Venous Thrombosis 7 | 47
active ulcerative colitis 7 | 764
ductal carcinoma in situ 7 | 1,745
Bipolar Disorder 6 | 666
Disseminated intravascular coagulation 6 | 38
Duchenne muscular dystrophy 6 | 601
Factor XII deficiency 6 | 13
Hemorrhage 6 | 19
Myocardial Infarction 6 | 151
Partial thromboplastin time increased (finding) 6 | 11
Prostate cancer 6 | 175
Vascular disease 6 | 319
acute quadriplegic myopathy 6 | 1,158
head and neck cancer and chronic obstructive pulmonary disease 6 | 239
periodontitis 6 | 293
primary Sjogren syndrome 6 | 735
Arthritis 5 | 290
Brain Ischemia 5 | 110
Epilepsy 5 | 792
Lipid metabolism disorder 5 | 114
Lung disease 5 | 142
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
dermatomyositis 5 | 966
limb girdle muscular dystrophy 2A 5 | 213
mucosa-associated lymphoid tissue lymphoma 5 | 484
nephrosclerosis 5 | 333
pancreatic carcinoma 5 | 562

Tissue

Endocrine System 134 | 18,159
Skin and soft tissues 133 | 17,230
Female tissues 132 | 17,400
Digestive Tract 131 | 17,369
Blood and immune system 123 | 16,909
Liver and Pancreas 123 | 16,750
Male tissues 123 | 17,142
Urinary Tract 121 | 16,678
Nervous System 115 | 16,725
Respiratory system 115 | 16,393
Cardiovascular System 87 | 15,192

Target Family

Enzyme 131 | 4,145
Non-IDG 11 | 12,091

UniProt Keyword

Serine protease 142 | 142
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Neuroendocrine convertase 2 PCSK2 Tchem Enzyme -2.00248 109.8 132
Transmembrane protease serine 11E TMPRSS11E Tbio Enzyme -0.90309 9.71 126
Atrial natriuretic peptide-converting enzyme CORIN Tbio Non-IDG -2.14443 144.4 221
Rhomboid-related protein 2 RHBDL2 Tbio Enzyme -0.71201 6.19 56
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100
Serine protease 44 PRSS44 Tdark Enzyme 0.00000 0
Serine protease 27 PRSS27 Tbio Enzyme -2.20602 159.4 151