Development Level

Tbio 3 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
edema 1 | 59
increased circulating bilirubi... 1 | 16
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
thrombocytopenia 1 | 56

Disease

Autosomal recessive predisposition 3 | 1,442
Epilepsy 3 | 792
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Seizures 3 | 596
Serine deficiency 3 | 9
ependymoma 3 | 4,679
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
psoriasis 3 | 6,694
Cancer 2 | 2,499
Carcinoma 2 | 11,493
Carcinoma, Non-Small-Cell Lung 2 | 107
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Dull intelligence 2 | 645
Global developmental delay 2 | 608
Hypoplastic mandible condyle 2 | 275
Infantile onset 2 | 238
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Micrognathism 2 | 275
Muscle Hypertonia 2 | 88
Neu Laxova syndrome 2 | 2
Neu-Laxova syndrome 2 | 2
Neu-Laxova syndrome 1 2 | 2
Orbital separation excessive 2 | 244
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Reduced fetal movement 2 | 51
Short neck 2 | 140
Sloping forehead 2 | 46
Small head 2 | 374
Uranostaphyloschisis 2 | 167
Vertical Talus 2 | 25
colon cancer 2 | 1,478
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung carcinoma 2 | 317
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
pancreatic carcinoma 2 | 562
subependymal giant cell astrocytoma 2 | 2,287
Acquired metabolic disease 1 | 336
Acquired scoliosis 1 | 281
Adducted thumb 1 | 22
Adenocarcinoma of lung 1 | 142
Breast Neoplasms 1 | 445
Byzanthine arch palate 1 | 194
Cardiovascular system disease 1 | 246
Congenital Bilateral Cataracts 1 | 50
Congenital cataract 1 | 50
Contracture of joint of hand 1 | 30
Curvature of spine 1 | 282
Decreased platelet count 1 | 111
Disease Models, Animal 1 | 155
Exophthalmos 1 | 112
Foramen Ovale, Patent 1 | 10
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hypsarrhythmia 1 | 25
Ichthyoses 1 | 41
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Lissencephaly 1 | 69
Liver neoplasms 1 | 130
MYELODYSPLASTIC SYNDROME 1 | 53
Macrotia 1 | 87
Mammary Neoplasms 1 | 425
Melanoma 1 | 711
Polyhydramnios 1 | 108
Poor growth 1 | 114
Prenatal onset 1 | 139
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Short cord 1 | 5
Small placenta 1 | 4
Spastic Quadriplegia 1 | 42
Syndactyly of the toes 1 | 45
Thrombocytopenia 1 | 197
Very poor growth 1 | 114
X-linked cerebral adrenoleukodystrophy 1 | 116
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
atypical teratoid/rhabdoid tumor 1 | 357

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Enzyme 3 | 4,145

UniProt Keyword

Serine biosynthesis 3 | 3
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252
Phosphoserine aminotransferase PSAT1 Tbio Enzyme -2.25926 176.4 136