Development Level

Tdark 429 | 6,593
Tbio 153 | 11,651
Tclin 11 | 612
Tchem 7 | 1,388

Collection

GPCR: IDG Consortium (Targets) 23 | 126
Ion Channel: IDG Consortium (T... 3 | 99
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal coat-hair pigmentatio... 3 | 64
abnormal retina morphology 3 | 71
decreased leukocyte cell numbe... 3 | 73
decreased vertical activity 3 | 208
hyperactivity 3 | 148
hypoactivity 3 | 132
increased leukocyte cell numbe... 3 | 47
increased or absent threshold ... 3 | 101
limb grasping 3 | 41
preweaning lethality, complete... 3 | 979
shortened RR interval 3 | 17
abnormal behavioral response t... 2 | 66
abnormal heart morphology 2 | 162
abnormal sleep behavior 2 | 70
abnormal vibrissa morphology 2 | 25
absent startle reflex 2 | 24
convulsive seizures 2 | 13
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
impaired pupillary reflex 2 | 26
increased circulating alkaline... 2 | 122
increased heart rate 2 | 23
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
prolonged PR interval 2 | 15
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal iris pigmentation 1 | 4
abnormal iris transilluminatio... 1 | 2
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal pupil morphology 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
enlarged thymus 1 | 5
enlarged uterus 1 | 11
female infertility 1 | 60
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
shortened PR interval 1 | 6
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 433 | 11,493
diabetes mellitus 87 | 1,728
psoriasis 66 | 6,694
medulloblastoma, large-cell 63 | 6,241
osteosarcoma 62 | 7,950
Retinitis Pigmentosa 61 | 226
ovarian cancer 57 | 8,520
Autosomal recessive predisposition 51 | 1,442
Nystagmus 45 | 317
Night Blindness 44 | 101
Electroretinogram abnormal 42 | 95
Kidney cancer 42 | 2,613
Photodysphoria 42 | 121
Photophobia 42 | 121
adult high grade glioma 41 | 3,801
Difficulties with night vision 40 | 87
Fundus dystrophy 40 | 83
Abnormality of retinal pigmentation 39 | 111
Obesity 39 | 678
Retinal Degeneration 39 | 106
Retinal pigment epithelial abnormality 39 | 111
lung cancer 39 | 4,740
Blindness 38 | 88
Cataract 38 | 297
group 3 medulloblastoma 37 | 4,104
Intellectual disability 36 | 1,016
Cone dystrophy 35 | 71
Lens Opacities 35 | 231
Low Vision 35 | 174
Visual Impairment 35 | 174
atypical teratoid / rhabdoid tumor 34 | 5,112
ependymoma 33 | 4,679
Dull intelligence 32 | 645
Glaucoma 32 | 239
Low intelligence 32 | 645
Mental Retardation 32 | 645
Mental deficiency 32 | 645
Poor school performance 32 | 645
glioblastoma 32 | 5,792
Reduced visual acuity 31 | 63
Blind Vision 29 | 111
Blindness, Legal 29 | 110
Congenital hypoplasia of penis 29 | 176
Hypogonadism 29 | 173
Keratoconus 29 | 113
Optic Atrophy 29 | 242
Sensorineural Hearing Loss (disorder) 28 | 284
lung carcinoma 26 | 2,843
Abnormality of the retinal vasculature 25 | 59
Anteverted nostril 25 | 191
Broad flat nasal bridge 25 | 236
Nasal bridge wide 25 | 236
Ophthalmoplegia 25 | 106
cone-rod dystrophy 25 | 59
Atypical scarring of skin 24 | 62
Conductive hearing loss 24 | 123
Congenital anomaly of testis 24 | 52
Hyperinsulinism 24 | 133
Night blindness, progressive 24 | 51
Breast cancer 23 | 3,578
Myopia 22 | 176
astrocytic glioma 22 | 2,597
Color vision defect 21 | 33
oligodendroglioma 21 | 2,850
primitive neuroectodermal tumor 21 | 3,035
Abnormal color vision 20 | 31
Color vision defect, severe 20 | 31
Leber congenital amaurosis 20 | 69
lung adenocarcinoma 20 | 2,716
Astrocytoma, Pilocytic 17 | 3,081
pituitary cancer 17 | 1,972
Pick disease 16 | 1,894
Melanoma 15 | 711
cystic fibrosis 14 | 1,696
interstitial cystitis 14 | 2,312
malignant mesothelioma 14 | 3,232
Congenital stationary night blindness 13 | 29
Hemolytic anemia 13 | 77
Skin cancer 13 | 469
group 4 medulloblastoma 13 | 1,855
non-small cell lung cancer 13 | 2,890
Abnormality of macular pigmentation 12 | 16
Cone/cone-rod dystrophy 12 | 20
Hyperopia 12 | 70
Macular pigmentary changes 12 | 16
Night blindness, congenital stationary 12 | 16
Visual field constriction 12 | 36
invasive ductal carcinoma 12 | 2,951
non primary Sjogren syndrome sicca 12 | 891
Epilepsy 11 | 792
Liver cancer 11 | 604
Severe myopia 11 | 22
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
pancreatic cancer 11 | 2,398
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
Asthma 10 | 385
Schizophrenia 10 | 1,160
Strabismus 10 | 270

Tissue

Endocrine System 262 | 18,159
Female tissues 176 | 17,400
Male tissues 167 | 17,142
Blood and immune system 164 | 16,909
Digestive Tract 158 | 17,369
Nervous System 154 | 16,725
Skin and soft tissues 154 | 17,230
Urinary Tract 140 | 16,678
Liver and Pancreas 134 | 16,750
Respiratory system 123 | 16,393
Cardiovascular System 92 | 15,192

Target Family

oGPCR 420 | 421
Non-IDG 74 | 12,091
GPCR 43 | 408
Enzyme 22 | 4,145
Ion Channel 16 | 344
Transcription Factor 9 | 1,400
Transporter 8 | 473
Kinase 6 | 634
Nuclear Receptor 2 | 48

UniProt Keyword

Sensory transduction 600 | 600
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2
Phosducin PDC Tbio Non-IDG -2.36871 242.5 78
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
Olfactory receptor 5B21 OR5B21 Tdark oGPCR 0.00000 4
Opsin-5 OPN5 Tbio GPCR -1.19753 14.2 151
Oxygen-regulated protein 1 RP1 Tbio Non-IDG 0.30 0.88 40
Olfactory receptor 1A2 OR1A2 Tdark oGPCR -0.35218 1.89 21
Odorant-binding protein 2a OBP2A Tdark Non-IDG -1.05436 11.3 41