Development Level

Tdark 430 | 7,003
Tbio 144 | 10,625
Tchem 15 | 1,890
Tclin 11 | 602

Collection

GPCR: IDG Consortium (Targets) 23 | 128
Ion Channel: IDG Consortium (Targets) 3 | 102

IMPC Phenotype

preweaning lethality, incomple... 4 | 260
abnormal coat-hair pigmentatio... 3 | 54
abnormal retina morphology 3 | 100
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
hypoactivity 3 | 89
increased grip strength 3 | 83
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
preweaning lethality, complete... 3 | 633
abnormal behavioral response t... 2 | 52
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal vibrissa morphology 2 | 17
absent startle reflex 2 | 15
convulsive seizures 2 | 11
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased lean body mass 2 | 195
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
hyperactivity 2 | 108
impaired pupillary reflex 2 | 14
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
mydriasis 2 | 9
shortened RR interval 2 | 19
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal gait 1 | 51
abnormal iris pigmentation 1 | 3
abnormal iris transilluminatio... 1 | 1
abnormal kidney morphology 1 | 30
abnormal liver morphology 1 | 5
abnormal pelvic girdle bone mo... 1 | 11
abnormal retinal blood vessel ... 1 | 18
abnormal seminal vesicle morph... 1 | 47
abnormal testis morphology 1 | 30
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased body temperature 1 | 2
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased coping response 1 | 5
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased leukocyte cell numbe... 1 | 54
decreased respiratory quotient 1 | 12
enlarged liver 1 | 3
enlarged thymus 1 | 4
female infertility 1 | 34
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased cellular hemoglobin ... 1 | 2
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased prepulse inhibition 1 | 21
increased startle reflex 1 | 38
macrophthalmia 1 | 2
short tibia 1 | 82
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

diabetes mellitus 83 | 1,663
psoriasis 66 | 6,685
medulloblastoma, large-cell 63 | 6,234
osteosarcoma 62 | 7,933
ovarian cancer 55 | 8,491
Retinitis pigmentosa 54 | 156
Blindness 38 | 84
Fundus dystrophy 38 | 77
Carcinoma 36 | 2,147
Cone dystrophy 32 | 59
adult high grade glioma 31 | 2,148
atypical teratoid / rhabdoid tumor 31 | 4,369
glioblastoma 31 | 5,572
lung carcinoma 26 | 2,844
cone-rod dystrophy 24 | 60
Night Blindness 23 | 39
group 3 medulloblastoma 23 | 2,254
Leber congenital amaurosis 22 | 72
Retinal Degeneration 21 | 49
astrocytic glioma 21 | 2,241
oligodendroglioma 21 | 2,849
primitive neuroectodermal tumor 21 | 3,031
lung adenocarcinoma 20 | 2,714
lung cancer 18 | 4,473
Breast cancer 17 | 3,098
pilocytic astrocytoma 17 | 3,086
pituitary cancer 17 | 1,972
Obesity 16 | 616
Pick disease 16 | 1,893
medulloblastoma 15 | 1,524
posterior fossa group B ependymoma 15 | 1,530
cystic fibrosis 14 | 1,670
ependymoma 14 | 2,514
group 4 medulloblastoma 14 | 1,875
malignant mesothelioma 14 | 3,163
Hemolytic anemia 13 | 70
interstitial cystitis 13 | 2,299
non-small cell lung cancer 13 | 2,798
Ciliopathy 12 | 57
Congenital stationary night blindness 12 | 28
Night blindness, congenital stationary 12 | 14
invasive ductal carcinoma 12 | 2,950
non primary Sjogren syndrome sicca 12 | 840
pediatric high grade glioma 12 | 2,712
posterior fossa group A ependymoma 12 | 1,511
Age related macular degeneration 11 | 84
Intellectual disability 11 | 573
Myopia 11 | 99
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 2,087
Achromatopsia 10 | 14
Bardet-Biedl Syndrome 9 | 40
Bardet-Biedl syndrome 1 9 | 22
Polydactyly 9 | 93
colon cancer 9 | 1,475
tuberculosis 9 | 1,563
adrenocortical carcinoma 8 | 1,427
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Atopic dermatitis 7 | 944
Cancer 7 | 2,346
Cataract 7 | 104
Usher syndrome 7 | 34
active Crohn's disease 7 | 918
gastric carcinoma 7 | 832
pancreatic cancer 7 | 2,300
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
Acquired metabolic disease 6 | 267
Atrial Fibrillation 6 | 110
Chronic heart failure 6 | 46
Myocardial Perfusion Imaging Adjunct 6 | 25
Partial central choroid dystrophy 6 | 12
Platelet Aggregation Inhibition 6 | 22
Prevention of Cerebral Thrombosis 6 | 29
Rheumatoid Arthritis 6 | 1,170
Uveitis 6 | 103
atypical teratoid/rhabdoid tumor 6 | 1,095
breast carcinoma 6 | 1,614
chronic rhinosinusitis 6 | 512
cutaneous lupus erythematosus 6 | 1,056
ductal carcinoma in situ 6 | 1,745
fibroadenoma 6 | 557
Asthma 5 | 349
Bradyopsia 5 | 10
Endometriosis 5 | 535
Fundus Albipunctatus 5 | 8
Glaucoma 5 | 135
Macular degeneration 5 | 44
Pelvic inflammatory disease 5 | 21
Retinal detachment 5 | 33
Schizophrenia 5 | 503
Sensorineural hearing loss 5 | 107
active ulcerative colitis 5 | 477
aldosterone-producing adenoma 5 | 664
inflammatory breast cancer 5 | 404
non-small cell lung carcinoma 5 | 413
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Female tissues 485 | 18,646
Urinary Tract 460 | 18,443
Nervous System 407 | 18,560
Endocrine System 406 | 18,511
Digestive Tract 378 | 18,472
Skin and soft tissues 344 | 18,114
Liver and Pancreas 279 | 18,135
Blood and immune system 276 | 17,994
Cardiovascular System 263 | 17,957
Male tissues 233 | 17,968
Respiratory system 207 | 17,483

Target Family

oGPCR 420 | 421
Non-IDG 74 | 11,969
GPCR 43 | 408
Enzyme 22 | 4,146
Ion Channel 16 | 341
Transcription Factor 9 | 1,400
Transporter 8 | 473
Kinase 6 | 634
Nuclear Receptor 2 | 48

UniProt Keyword

Sensory transduction 600 | 600
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.84429 67.5 71
Olfactory receptor 11H12 OR11H12 Tdark oGPCR 0.00000 18
Alpha-crystallin A chain CRYAA Tbio Non-IDG -2.83468 658.4 164
R-spondin-3 RSPO3 Tbio Non-IDG -1.18455 17.3 94
Membrane-associated transporter protein SLC45A2 Tbio Transporter -2.44017 262.3 79
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H Tclin Enzyme -0.84634 7.12 33
Sodium/potassium/calcium exchanger 5 SLC24A5 Tbio Transporter -1.59093 38.9 49
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C Tclin Enzyme -1.38423 22.7 78
Amiloride-sensitive sodium channel subunit beta SCNN1B Tclin Ion Channel -1.73185 46.7 245
Retinitis pigmentosa 1-like 1 protein RP1L1 Tbio Non-IDG -1.26662 19.3 0