Development Level

Tbio 27 | 11,178
Tchem 8 | 1,885
Tclin 4 | 612
Tdark 4 | 6,569

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal sensory capabilities-... 1 | 8
cardiovascular system phenotyp... 1 | 36
decreased circulating alkaline... 1 | 46
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased heart rate variabili... 1 | 13
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating total pr... 1 | 28
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased startle reflex 1 | 112

Disease

medulloblastoma, large-cell 26 | 6,086
Carcinoma 25 | 11,192
osteosarcoma 24 | 7,766
atypical teratoid / rhabdoid tumor 23 | 4,971
glioblastoma 23 | 5,635
ependymoma 20 | 4,559
group 3 medulloblastoma 18 | 4,002
psoriasis 18 | 6,514
Astrocytoma, Pilocytic 17 | 3,006
adult high grade glioma 17 | 3,701
ovarian cancer 17 | 8,297
Breast cancer 15 | 3,469
primitive neuroectodermal tumor 14 | 2,957
astrocytic glioma 12 | 2,530
lung adenocarcinoma 11 | 2,627
Kidney cancer 10 | 2,548
colon cancer 10 | 1,428
cystic fibrosis 10 | 1,629
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,204
lung cancer 10 | 4,607
oligodendroglioma 10 | 2,768
Autosomal recessive predisposition 9 | 1,407
acute quadriplegic myopathy 9 | 1,133
invasive ductal carcinoma 9 | 2,867
lung carcinoma 9 | 2,755
pancreatic cancer 9 | 2,322
subependymal giant cell astrocytoma 9 | 2,230
Malignant hyperthermia 8 | 26
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,872
malignant mesothelioma 8 | 3,135
pituitary cancer 8 | 1,915
Pick disease 7 | 1,856
juvenile dermatomyositis 7 | 1,147
Heart disease 6 | 288
Myopathy 6 | 185
adrenocortical carcinoma 6 | 1,385
interstitial cystitis 6 | 2,237
non-small cell lung cancer 6 | 2,799
Cancer 5 | 2,388
Catecholaminergic polymorphic ventricular tachycardia 5 | 12
Liver cancer 5 | 589
Proximal muscle weakness 5 | 47
Proximal neurogenic muscle weakness 5 | 47
active ulcerative colitis 5 | 736
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 492
diabetes mellitus 5 | 1,683
ductal carcinoma in situ 5 | 1,686
primary pancreatic ductal adenocarcinoma 5 | 1,071
tuberculosis 5 | 1,963
Atopic dermatitis 4 | 915
Creatine phosphokinase serum increased 4 | 110
Duchenne muscular dystrophy 4 | 587
Elevated creatine kinase 4 | 110
Endometrial cancer 4 | 301
Epilepsy 4 | 775
Myocardial Infarction 4 | 142
Neuropathy 4 | 254
Renal Cell Carcinoma 4 | 211
Seizures 4 | 584
active Crohn's disease 4 | 882
breast carcinoma 4 | 1,589
dermatomyositis 4 | 941
group 4 medulloblastoma 4 | 1,806
non primary Sjogren syndrome sicca 4 | 861
pediatric high grade glioma 4 | 1,035
Amyotrophic lateral sclerosis 3 | 437
Anemia 3 | 353
Becker muscular dystrophy 3 | 184
Bipolar Disorder 3 | 646
Brody myopathy 3 | 3
Cardiomyopathy 3 | 116
Centronuclear myopathy 3 | 27
Dizziness 3 | 26
Liver Cirrhosis, Experimental 3 | 733
Muscle Cramp 3 | 55
Muscle Weakness 3 | 168
Muscle hypotonia 3 | 562
Myocardial Ischemia 3 | 162
Myopathies, Structural, Congenital 3 | 15
Polycystic ovary syndrome 3 | 348
Primary cutaneous amyloidosis 3 | 28
Rheumatoid arthritis 3 | 1,156
Schizophrenia 3 | 1,136
Slow progression 3 | 88
Sudden death 3 | 15
Syncope 3 | 22
Tachycardia, Ventricular 3 | 22
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) 3 | 5
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy 3 | 4
Vertigo 3 | 29
astrocytoma 3 | 1,113
cystic fibrosis and chronic rhinosinusitis 3 | 211
esophageal adenocarcinoma 3 | 696
interstitial lung disease 3 | 287
ulcerative colitis 3 | 1,765
Highly variable clinical phenotype 2 | 147
Highly variable phenotype and severity 2 | 147
Infantile onset 2 | 236
Phenotypic variability 2 | 147

Tissue

Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Male tissues 42 | 17,142
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Blood and immune system 41 | 16,909
Liver and Pancreas 41 | 16,750
Nervous System 41 | 16,725
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 26 | 12,091
Enzyme 6 | 4,145
Ion Channel 4 | 344
Kinase 4 | 634
Transporter 3 | 473

UniProt Keyword

Sarcoplasmic reticulum 43 | 43
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Sarcolipin SLN Tbio Non-IDG -2.17996 148.2 53
Ryanodine receptor 3 RYR3 Tclin Ion Channel -2.15460 142.3 16
Sarcalumenin SRL Tdark Non-IDG -2.06462 109.4 22
Kelch-like protein 41 KLHL41 Tbio Non-IDG -1.26172 19.8 167
Calsequestrin-1 CASQ1 Tbio Non-IDG -1.96476 86.8 103
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Junctophilin-1 JPH1 Tbio Non-IDG -1.77250 56.2 92
Nucleolar protein 3 NOL3 Tbio Non-IDG -2.32204 197.6 271
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504