Development Level

Tbio 162 | 11,178
Tchem 27 | 1,885
Tdark 27 | 6,569
Tclin 9 | 612

Collection

Ion Channel: IDG Consortium (T... 4 | 99
Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased body weight 8 | 161
preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 7 | 979
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
increased lean body mass 5 | 172
abnormal seminal vesicle morph... 4 | 114
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased hemoglobin content 4 | 68
decreased total body fat amoun... 4 | 207
decreased vertical activity 4 | 208
small testis 4 | 58
abnormal testis morphology 3 | 43
decreased bone mineral content 3 | 151
decreased mean corpuscular hem... 3 | 50
hypoactivity 3 | 132
increased blood urea nitrogen ... 3 | 48
increased circulating sodium l... 3 | 71
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal maxilla morphology 2 | 17
abnormal skin morphology 2 | 50
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating free fat... 2 | 31
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased exploration in new e... 2 | 11
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
enlarged lymph nodes 2 | 37
increased circulating alkaline... 2 | 122
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal locomotor activation 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal vibrissa morphology 1 | 25
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cystolithiasis 1 | 3
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean platelet volume 1 | 45
increased vertical activity 1 | 24
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small kidney 1 | 16
small superior vagus ganglion 1 | 74
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 189 | 11,192
osteosarcoma 120 | 7,766
ovarian cancer 109 | 8,297
glioblastoma 100 | 5,635
medulloblastoma, large-cell 95 | 6,086
psoriasis 92 | 6,514
atypical teratoid / rhabdoid tumor 81 | 4,971
ependymoma 73 | 4,559
lung cancer 71 | 4,607
adult high grade glioma 68 | 3,701
Kidney cancer 67 | 2,548
Astrocytoma, Pilocytic 63 | 3,006
interstitial cystitis 61 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,872
lung carcinoma 59 | 2,755
oligodendroglioma 59 | 2,768
Breast cancer 57 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,204
group 3 medulloblastoma 54 | 4,002
intraductal papillary-mucinous carcinoma (IPMC) 54 | 2,902
invasive ductal carcinoma 53 | 2,867
malignant mesothelioma 53 | 3,135
non-small cell lung cancer 53 | 2,799
astrocytic glioma 52 | 2,530
subependymal giant cell astrocytoma 52 | 2,230
primitive neuroectodermal tumor 51 | 2,957
Cancer 46 | 2,388
pancreatic cancer 45 | 2,322
group 4 medulloblastoma 44 | 1,806
spina bifida 37 | 1,053
tuberculosis 37 | 1,963
Pick disease 33 | 1,856
lung adenocarcinoma 33 | 2,627
pituitary cancer 33 | 1,915
cystic fibrosis 30 | 1,629
ulcerative colitis 29 | 1,765
cutaneous lupus erythematosus 27 | 1,016
juvenile dermatomyositis 27 | 1,147
ductal carcinoma in situ 26 | 1,686
esophageal adenocarcinoma 26 | 696
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,911
Schizophrenia 22 | 1,136
astrocytoma 21 | 1,113
colon cancer 21 | 1,428
primary Sjogren syndrome 20 | 710
Autosomal recessive predisposition 19 | 1,407
Intellectual disability 19 | 998
Liver cancer 19 | 589
breast carcinoma 19 | 1,589
primary pancreatic ductal adenocarcinoma 19 | 1,071
adrenocortical carcinoma 18 | 1,385
Blastic phase chronic myeloid leukemia 17 | 58
Chronic Myelocytic Leukemia Accelerated Phase 17 | 59
Rheumatoid arthritis 16 | 1,156
gastric carcinoma 16 | 781
pediatric high grade glioma 16 | 1,035
Chronic phase chronic myeloid leukemia 15 | 45
Down syndrome 15 | 480
Melanoma 15 | 689
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 15 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 15 | 47
diabetes mellitus 15 | 1,683
acute quadriplegic myopathy 14 | 1,133
medulloblastoma 14 | 702
Atopic dermatitis 13 | 915
Bipolar Disorder 13 | 646
nasopharyngeal carcinoma 13 | 1,024
Liver Cirrhosis, Experimental 12 | 733
Waldenstrons macroglobulinemia 12 | 742
acute myeloid leukemia 12 | 760
dermatomyositis 12 | 941
mucosa-associated lymphoid tissue lymphoma 12 | 473
Endometrial cancer 11 | 301
Skin cancer 11 | 451
active ulcerative colitis 11 | 736
aldosterone-producing adenoma 11 | 646
progressive supranuclear palsy 11 | 656
Alzheimer's disease 10 | 640
Chronic Lymphocytic Leukemia 10 | 254
active Crohn's disease 10 | 882
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 492
fibroadenoma 10 | 538
non primary Sjogren syndrome sicca 10 | 861
posterior fossa group A ependymoma 10 | 456
Familial hypocalciuric hypercalcemia 9 | 20
Kidney disease 9 | 411
periodontitis 9 | 280
Autistic Disorder 8 | 358
Cognitive delay 8 | 596
Duchenne muscular dystrophy 8 | 587
Global developmental delay 8 | 596
Mental and motor retardation 8 | 596
Cerebellar Ataxia 7 | 302
Dull intelligence 7 | 634
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Multiple myeloma 7 | 1,296
Poor school performance 7 | 634
sonic hedgehog group medulloblastoma 7 | 459

Tissue

Endocrine System 218 | 18,159
Female tissues 218 | 17,400
Digestive Tract 217 | 17,369
Male tissues 217 | 17,142
Blood and immune system 216 | 16,909
Skin and soft tissues 216 | 17,230
Urinary Tract 214 | 16,678
Liver and Pancreas 213 | 16,750
Respiratory system 213 | 16,393
Nervous System 212 | 16,725
Cardiovascular System 204 | 15,192

Target Family

Non-IDG 155 | 12,091
Enzyme 35 | 4,145
Kinase 30 | 634
Ion Channel 4 | 344
Epigenetic 1 | 242

UniProt Keyword

SH3 domain 225 | 225
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tight junction protein ZO-3 TJP3 Tbio Non-IDG -1.36150 19.9 173
Mitogen-activated protein kinase kinase kinase 9 MAP3K9 Tchem Kinase -1.42881 24.7 265
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Disks large homolog 5 DLG5 Tbio Non-IDG -1.71553 56.2 60
RIMS-binding protein 3B RIMBP3B Tdark Non-IDG 0.00000 0
ABI gene family member 3 ABI3 Tbio Non-IDG -1.91619 82.1 63
SH3 domain and tetratricopeptide repeat-containing protein 1 SH3TC1 Tdark Non-IDG 0.48 0.08 77
Epidermal growth factor receptor kinase substrate 8-like protein 3 EPS8L3 Tdark Enzyme -0.23449 1.72 101
Melanoma-derived growth regulatory protein MIA Tbio Non-IDG -2.06006 104.4 123
SH3 domain and tetratricopeptide repeat-containing protein 2 SH3TC2 Tbio Non-IDG -2.27646 182.7 36