Development Level

Tbio 152 | 10,625
Tchem 27 | 1,890
Tdark 27 | 7,003
Tclin 9 | 602

Collection

Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

decreased body weight 7 | 174
decreased circulating choleste... 7 | 85
abnormal behavior 6 | 226
decreased circulating HDL chol... 6 | 77
decreased grip strength 6 | 123
preweaning lethality, complete... 6 | 633
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
increased or absent threshold ... 5 | 128
abnormal bone structure 4 | 131
preweaning lethality, incomple... 4 | 260
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased circulating triglyce... 3 | 83
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
abnormal bone mineralization 2 | 55
abnormal posture 2 | 5
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal testis morphology 2 | 30
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating aspartat... 2 | 27
decreased circulating bilirubi... 2 | 14
decreased exploration in new e... 2 | 9
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased respiratory quotient 2 | 12
shortened ST segment 2 | 9
small testis 2 | 37
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 8
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal vibrissa morphology 1 | 17
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cystolithiasis 1 | 1
decreased IgE level 1 | 3
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased effector memory CD8-... 1 | 24
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired righting response 1 | 19
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating total pr... 1 | 20
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
increased vertical activity 1 | 18
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
shortened PQ interval 1 | 6
small superior vagus ganglion 1 | 20
stereotypic behavior 1 | 3
tremors 1 | 34
trunk curl 1 | 15

Disease

osteosarcoma 118 | 7,933
ovarian cancer 102 | 8,492
glioblastoma 93 | 5,572
medulloblastoma, large-cell 92 | 6,234
psoriasis 91 | 6,685
atypical teratoid / rhabdoid tumor 69 | 4,369
lung cancer 66 | 4,473
pilocytic astrocytoma 59 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
interstitial cystitis 54 | 2,299
lung carcinoma 54 | 2,844
oligodendroglioma 54 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,988
invasive ductal carcinoma 52 | 2,950
subependymal giant cell astrocytoma 51 | 2,287
Carcinoma 50 | 2,147
malignant mesothelioma 49 | 3,163
non-small cell lung cancer 49 | 2,798
pediatric high grade glioma 49 | 2,712
primitive neuroectodermal tumor 48 | 3,031
ependymoma 47 | 2,514
Breast cancer 44 | 3,099
Cancer 40 | 2,346
pancreatic cancer 40 | 2,300
astrocytic glioma 39 | 2,241
group 4 medulloblastoma 37 | 1,875
spina bifida 36 | 1,064
adult high grade glioma 32 | 2,148
Pick disease 31 | 1,893
lung adenocarcinoma 31 | 2,714
medulloblastoma 31 | 1,524
pituitary cancer 31 | 1,972
ulcerative colitis 31 | 2,087
tuberculosis 30 | 1,563
astrocytoma 29 | 1,493
cutaneous lupus erythematosus 27 | 1,056
cystic fibrosis 27 | 1,670
juvenile dermatomyositis 27 | 1,189
ductal carcinoma in situ 24 | 1,745
esophageal adenocarcinoma 24 | 737
sonic hedgehog group medulloblastoma 24 | 1,482
group 3 medulloblastoma 22 | 2,254
primary pancreatic ductal adenocarcinoma 22 | 1,271
colon cancer 21 | 1,475
primary Sjogren syndrome 21 | 789
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
breast carcinoma 18 | 1,614
Blastic phase chronic myeloid leukemia 17 | 58
Chronic Myelocytic Leukemia Accelerated Phase 17 | 59
adrenocortical carcinoma 17 | 1,427
posterior fossa group A ependymoma 17 | 1,511
posterior fossa group B ependymoma 17 | 1,530
Rheumatoid Arthritis 16 | 1,171
Chronic phase chronic myeloid leukemia 15 | 45
Down syndrome 15 | 548
Intellectual disability 15 | 573
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 15 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 15 | 47
diabetes mellitus 15 | 1,663
gastric carcinoma 15 | 832
acute quadriplegic myopathy 13 | 1,157
Atopic dermatitis 12 | 944
IGA Glomerulonephritis 12 | 454
acute myeloid leukemia 12 | 785
atypical teratoid/rhabdoid tumor 12 | 1,095
dermatomyositis 12 | 967
mucosa-associated lymphoid tissue lymphoma 12 | 480
nasopharyngeal carcinoma 12 | 1,056
Waldenstrons macroglobulinemia 11 | 765
aldosterone-producing adenoma 11 | 664
progressive supranuclear palsy 11 | 674
Alzheimer's disease 10 | 644
Schizophrenia 10 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
fibroadenoma 10 | 557
tuberculosis and treatment for 6 months 10 | 686
active Crohn's disease 9 | 918
chronic lymphocytic leukemia 9 | 244
non primary Sjogren syndrome sicca 9 | 840
periodontitis 9 | 269
Autistic Disorder 8 | 320
Bipolar Disorder 8 | 266
Duchenne muscular dystrophy 8 | 602
Kidney disease 8 | 397
active ulcerative colitis 8 | 477
chronic lymphosyte leukemia 8 | 232
Kidney cancer 7 | 121
Multiple myeloma 7 | 1,328
inflammatory breast cancer 7 | 404
pancreatic carcinoma 7 | 567
tuberculosis and treatment for 3 months 6 | 327
Acquired immunodeficiency syndrome 5 | 164
Agammaglobulinemia 5 | 24
urothelial carcinoma 5 | 318
Arthritis 4 | 248
Crohn's disease 4 | 304
Multiple Sclerosis 4 | 498
Prostatic Neoplasms 4 | 471
nephrosclerosis 4 | 329

Tissue

Digestive Tract 212 | 18,473
Nervous System 212 | 18,561
Blood and immune system 211 | 17,995
Cardiovascular System 211 | 17,958
Endocrine System 211 | 18,512
Female tissues 211 | 18,647
Urinary Tract 210 | 18,444
Liver and Pancreas 209 | 18,136
Male tissues 209 | 17,969
Respiratory system 206 | 17,484
Skin and soft tissues 206 | 18,115

Target Family

Non-IDG 146 | 11,969
Enzyme 34 | 4,146
Kinase 30 | 634
Ion Channel 4 | 341
Epigenetic 1 | 242

UniProt Keyword

SH3 domain 215 | 215
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.72520 53.3 32
Sorting nexin-33 SNX33 Tbio Non-IDG -0.45756 4.34 87
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 BAIAP2L1 Tbio Non-IDG -1.08192 13.9 107
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.13158 14.2 196
NADPH oxidase activator 1 NOXA1 Tbio Enzyme -1.21837 16.1 76
Endophilin-B1 SH3GLB1 Tbio Non-IDG -1.09363 4.54 332
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.10835 131.7 114
RelA-associated inhibitor PPP1R13L Tbio Non-IDG -1.68215 55.1 175
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.81698 62.2 337
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.63547 43.1 338