Development Level

Tbio 60 | 11,445
Tchem 28 | 1,598
Tclin 13 | 613
Tdark 7 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal behavior 4 | 298
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
impaired righting response 2 | 26
increased lean body mass 2 | 172
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
anophthalmia 1 | 33
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased spleen weight 1 | 10
short tibia 1 | 97
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 81 | 11,493
osteosarcoma 74 | 7,950
ovarian cancer 59 | 8,520
Cancer 49 | 2,499
psoriasis 46 | 6,694
lung cancer 43 | 4,740
medulloblastoma, large-cell 39 | 6,241
interstitial cystitis 36 | 2,312
glioblastoma 32 | 5,792
invasive ductal carcinoma 32 | 2,951
lung carcinoma 32 | 2,843
Breast cancer 26 | 3,578
malignant mesothelioma 26 | 3,232
ependymoma 25 | 4,679
group 4 medulloblastoma 25 | 1,855
non-small cell lung cancer 25 | 2,890
tuberculosis 25 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
ulcerative colitis 23 | 1,819
Astrocytoma, Pilocytic 22 | 3,081
Kidney cancer 22 | 2,613
atypical teratoid / rhabdoid tumor 21 | 5,112
cutaneous lupus erythematosus 21 | 1,057
subependymal giant cell astrocytoma 21 | 2,287
lung adenocarcinoma 20 | 2,716
primary Sjogren syndrome 20 | 735
adult high grade glioma 19 | 3,801
group 3 medulloblastoma 19 | 4,104
pancreatic cancer 18 | 2,398
Blastic phase chronic myeloid leukemia 17 | 58
Chronic Myelocytic Leukemia Accelerated Phase 17 | 59
astrocytic glioma 17 | 2,597
astrocytoma 17 | 1,146
ductal carcinoma in situ 16 | 1,745
juvenile dermatomyositis 16 | 1,187
oligodendroglioma 16 | 2,850
Chronic phase chronic myeloid leukemia 15 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 15 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 15 | 47
cystic fibrosis 15 | 1,696
diabetes mellitus 14 | 1,728
pituitary cancer 14 | 1,972
Rheumatoid arthritis 13 | 1,191
Pick disease 12 | 1,894
colon cancer 12 | 1,478
primitive neuroectodermal tumor 12 | 3,035
Liver Cirrhosis, Experimental 11 | 769
breast carcinoma 11 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
spina bifida 11 | 1,074
Arthritis 10 | 290
Autosomal recessive predisposition 10 | 1,442
dermatomyositis 10 | 966
pediatric high grade glioma 10 | 1,064
Agammaglobulinemia 9 | 34
Atopic dermatitis 9 | 952
Diarrhea 9 | 253
active ulcerative colitis 9 | 764
adrenocortical carcinoma 9 | 1,428
pancreatic carcinoma 9 | 562
Anemia 8 | 365
Immunologic Deficiency Syndromes 8 | 113
Polycythemia vera 8 | 27
Waldenstrons macroglobulinemia 8 | 765
Asthma 7 | 385
Fatigue 7 | 182
Fever 7 | 138
Immune system cancer 7 | 140
Lymphoid leukemia 7 | 160
Multiple Sclerosis 7 | 540
Multiple myeloma 7 | 1,332
Recurrent respiratory infections 7 | 141
Short stature 7 | 531
gastric carcinoma 7 | 807
nasopharyngeal carcinoma 7 | 1,058
Breast Neoplasms 6 | 445
Chronic Lymphocytic Leukemia 6 | 262
Chronic graft-versus-host disease 6 | 6
Chronic lymphoid leukemia, disease 6 | 13
Failure to gain weight 6 | 365
Lymphoproliferative syndrome 6 | 58
Mammary Neoplasms 6 | 425
Mantle cell lymphoma 6 | 23
Melanoma 6 | 711
Obesity 6 | 678
Pediatric failure to thrive 6 | 365
Precancerous Conditions 6 | 80
Splenomegaly 6 | 190
Systemic lupus erythematosus 6 | 194
Waldenström macroglobulinemia 6 | 6
active Crohn's disease 6 | 922
esophageal adenocarcinoma 6 | 737
primary pancreatic ductal adenocarcinoma 6 | 1,109
Down syndrome 5 | 499
Schizophrenia 5 | 1,160
fibroadenoma 5 | 559
progressive supranuclear palsy 5 | 676
urothelial carcinoma 5 | 318

Tissue

Endocrine System 107 | 18,159
Blood and immune system 106 | 16,909
Digestive Tract 106 | 17,369
Liver and Pancreas 106 | 16,750
Male tissues 106 | 17,142
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Female tissues 105 | 17,400
Respiratory system 105 | 16,393
Nervous System 103 | 16,725
Cardiovascular System 102 | 15,192

Target Family

Non-IDG 62 | 12,091
Kinase 29 | 634
Enzyme 10 | 4,145
Transcription Factor 7 | 1,400

UniProt Keyword

SH2 domain 108 | 108
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of cytokine signaling 4 SOCS4 Tbio Non-IDG -1.22763 14.8 224
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Tyrosine-protein kinase FRK FRK Tchem Kinase -1.68365 49.2 394
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
SH2 domain-containing protein 3A SH2D3A Tbio Non-IDG -2.47559 291.4 103
GRB2-related adapter protein GRAP Tbio Non-IDG -1.51362 31.8 124
Tensin-1 TNS1 Tbio Non-IDG -2.74141 354.5 133
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418