Development Level

Tchem 27 | 1,598
Tbio 26 | 11,445
Tclin 5 | 613
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
increased circulating alkaline... 2 | 122
increased hemoglobin content 2 | 45
increased startle reflex 2 | 112
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal vitreous body morphol... 1 | 10
absent testes 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
female infertility 1 | 60
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased fasted circulating g... 1 | 76
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33

Disease

ovarian cancer 43 | 8,520
Carcinoma 38 | 11,493
lung cancer 36 | 4,740
Cancer 34 | 2,499
glioblastoma 30 | 5,792
medulloblastoma, large-cell 28 | 6,241
psoriasis 28 | 6,694
osteosarcoma 26 | 7,950
ependymoma 24 | 4,679
atypical teratoid / rhabdoid tumor 22 | 5,112
pancreatic cancer 22 | 2,398
diabetes mellitus 20 | 1,728
group 3 medulloblastoma 20 | 4,104
Breast cancer 19 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
acute quadriplegic myopathy 18 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
lung adenocarcinoma 18 | 2,716
Multiple myeloma 16 | 1,332
breast carcinoma 16 | 1,638
Schizophrenia 15 | 1,160
oligodendroglioma 15 | 2,850
primitive neuroectodermal tumor 15 | 3,035
juvenile dermatomyositis 14 | 1,187
non-small cell lung cancer 14 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Vascular disease 13 | 319
adult high grade glioma 13 | 3,801
astrocytoma 13 | 1,146
dermatomyositis 13 | 966
ulcerative colitis 13 | 1,819
Alzheimer's disease 12 | 658
Astrocytoma, Pilocytic 12 | 3,081
Autosomal recessive predisposition 12 | 1,442
Liver Cirrhosis, Experimental 12 | 769
Prostatic Neoplasms 12 | 495
invasive ductal carcinoma 12 | 2,951
lung carcinoma 12 | 2,843
tuberculosis 12 | 2,010
Duchenne muscular dystrophy 11 | 601
Heart disease 11 | 306
Waldenstrons macroglobulinemia 10 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
malignant mesothelioma 10 | 3,232
subependymal giant cell astrocytoma 10 | 2,287
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
interstitial cystitis 9 | 2,312
pituitary cancer 9 | 1,972
Colonic Neoplasms 8 | 142
Down syndrome 8 | 499
Hypertension 8 | 396
Melanoma 8 | 711
Parkinson's disease 8 | 392
astrocytic glioma 8 | 2,597
gastric carcinoma 8 | 807
primary pancreatic ductal adenocarcinoma 8 | 1,109
Amyotrophic lateral sclerosis 7 | 451
Anemia 7 | 365
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Disease Models, Animal 7 | 155
Liver carcinoma 7 | 240
Mood Disorders 7 | 184
Neoplasm Metastasis 7 | 168
Obesity 7 | 678
Osteoarthritis 7 | 184
Rheumatoid arthritis 7 | 1,191
Squamous cell carcinoma 7 | 129
Stomach Neoplasms 7 | 300
Toxic encephalopathy 7 | 141
adrenocortical carcinoma 7 | 1,428
colon cancer 7 | 1,478
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
pancreatic carcinoma 7 | 562
Adenocarcinoma of lung 6 | 142
Arthritis 6 | 290
Becker muscular dystrophy 6 | 191
Cell Transformation, Neoplastic 6 | 97
Depressive disorder 6 | 409
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Diabetes Mellitus, Type 2 6 | 142
Hepatomegaly 6 | 285
Hyperglycemia 6 | 137
Kidney disease 6 | 430
Lung Neoplasms 6 | 232
Muscle hypotonia 6 | 571
Neoplasm Invasiveness 6 | 161
Neoplastic Cell Transformation 6 | 89
Neurodegenerative disease 6 | 414
Skin Neoplasms 6 | 69
Splenomegaly 6 | 190
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 459
group 4 medulloblastoma 6 | 1,855
pediatric high grade glioma 6 | 1,064
Bipolar Disorder 5 | 666

Tissue

Blood and immune system 58 | 16,909
Endocrine System 58 | 18,159
Female tissues 58 | 17,400
Skin and soft tissues 58 | 17,230
Digestive Tract 57 | 17,369
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Respiratory system 57 | 16,393
Cardiovascular System 56 | 15,192
Nervous System 56 | 16,725
Urinary Tract 56 | 16,678

Target Family

Non-IDG 24 | 12,091
Enzyme 19 | 4,145
Ion Channel 6 | 344
Epigenetic 3 | 242
Kinase 3 | 634
Transcription Factor 3 | 1,400
Transporter 1 | 473

UniProt Keyword

S-nitrosylation 59 | 59
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
Inward rectifier potassium channel 18 KCNJ18 Tdark Ion Channel 0.00000 43
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
ATP-sensitive inward rectifier potassium channel 14 KCNJ14 Tchem Ion Channel -1.15435 15.5 7
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Inward rectifier potassium channel 2 KCNJ2 Tchem Ion Channel -2.36978 224.8 221
Protein S100-A1 S100A1 Tbio Non-IDG -2.47381 296.0 704