Development Level

Tdark 24 | 6,593
Tbio 6 | 11,651

IMPC Phenotype

decreased grip strength 1 | 116

Disease

lung cancer 4 | 4,740
osteosarcoma 4 | 7,950
ovarian cancer 3 | 8,520
Breast cancer 2 | 3,578
Carcinoma 2 | 11,493
atypical teratoid / rhabdoid tumor 2 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
psoriasis 2 | 6,694
Abnormal urinary amino-acid findings 1 | 38
Abnormality of the menstrual cycle 1 | 4
Acute hepatitis 1 | 2
Aminoaciduria 1 | 38
Anemia 1 | 365
Anemia, Hemolytic 1 | 55
Arthralgia 1 | 90
Back Pain 1 | 7
Bone pain 1 | 42
Breast Neoplasms 1 | 445
Calcium pyrophosphate deposition disease 1 | 13
Carcinoma, squamous cell of head and neck 1 | 31
Chromosome 9p deletion syndrome 1 | 13
Colorectal Neoplasms 1 | 243
Comatose 1 | 56
Decreased platelet count 1 | 111
Degenerative polyarthritis 1 | 115
Deglutition Disorders 1 | 132
Dementia 1 | 175
Difficulty walking 1 | 28
Disease Models, Animal 1 | 155
Disease Progression 1 | 136
Drooling 1 | 27
Dysarthria 1 | 192
Dyslipidemias 1 | 27
Dystonia 1 | 164
Dystonic disease 1 | 106
Ecchymosis 1 | 66
Elevated hepatic transaminases 1 | 81
Esophageal Varices 1 | 6
Fatty Liver 1 | 70
Fatty liver disease 1 | 103
Glycosuria 1 | 29
Hand deformities 1 | 32
Hemoglobin low 1 | 124
Hepatic enzyme increased 1 | 81
Hepatitis 1 | 67
Hepatolenticular Degeneration 1 | 24
Hereditary spastic paraplegia 17 1 | 16
Hypercalciuria 1 | 27
Hyperphosphaturia 1 | 21
Hypoparathyroidism 1 | 41
Icterus 1 | 82
Increased tendency to bruise 1 | 66
Inflammation 1 | 120
Joint swelling 1 | 26
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Liver Cirrhosis 1 | 181
Liver Dysfunction 1 | 99
Liver Failure 1 | 73
Liver Failure, Acute 1 | 29
Liver Neoplasms, Experimental 1 | 59
Liver diseases 1 | 87
Liver enzymes abnormal 1 | 81
Liver function test increased 1 | 81
Liver function tests abnormal finding 1 | 81
Liver neoplasms 1 | 130
MEDNIK syndrome 1 | 8
Mammary Neoplasms 1 | 425
Menkes disease 1 | 19
Mouth Neoplasms 1 | 55
Multiple personality disorder 1 | 8
Oral squamous cell carcinoma 1 | 11
Osteomalacia 1 | 35
Osteoporosis 1 | 363
Ovarian Neoplasms 1 | 102
Pathological fracture 1 | 20
Personality change 1 | 23
Poor motor coordination 1 | 2
Primary ciliary dyskinesia 1 | 76
Proteinuria 1 | 144
Pruritus 1 | 58
Range of joint movement increased 1 | 32
Renal tubular disorder 1 | 12
Retinopathy of prematurity 1 | 22
Sialorrhea 1 | 28
Squamous cell carcinoma of the head and neck 1 | 29
Steatohepatitis 1 | 44
Subclinical abnormal liver function tests 1 | 81
Thrombocytopenia 1 | 197
Transaminases increased 1 | 81
Tremor 1 | 113
Urine phosphorous concentration above normal 1 | 21
Weight Gain 1 | 100
Weight decreased 1 | 103
Wilson disease 1 | 16
atypical teratoid/rhabdoid tumor 1 | 357
menstrual abnormality 1 | 4
non-small cell lung carcinoma 1 | 317
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 11 | 12,091

UniProt Keyword

Ribosomal frameshifting 30 | 30
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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