Development Level

Tbio 194 | 11,651
Tdark 87 | 6,593
Tchem 5 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 26 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 5 | 220
abnormal behavior 4 | 298
embryonic growth retardation 4 | 106
increased mean corpuscular vol... 4 | 92
abnormal bone structure 3 | 187
decreased bone mineral density 3 | 126
increased fasted circulating g... 3 | 76
increased grip strength 3 | 41
preweaning lethality, incomple... 3 | 499
abnormal lens morphology 2 | 81
decreased circulating glucose ... 2 | 126
decreased circulating sodium l... 2 | 22
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
increased circulating chloride... 2 | 41
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
abnormal bone mineralization 1 | 38
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal tail morphology 1 | 25
aorta dilation 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QT interval 1 | 38
short tibia 1 | 97
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

ovarian cancer 154 | 8,520
lung cancer 96 | 4,740
osteosarcoma 92 | 7,950
Carcinoma 86 | 11,493
medulloblastoma, large-cell 72 | 6,241
Multiple myeloma 67 | 1,332
group 3 medulloblastoma 63 | 4,104
psoriasis 62 | 6,694
glioblastoma 53 | 5,792
atypical teratoid / rhabdoid tumor 47 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
Waldenstrons macroglobulinemia 40 | 765
acute quadriplegic myopathy 39 | 1,158
diabetes mellitus 39 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
Breast cancer 36 | 3,578
ependymoma 33 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
oligodendroglioma 31 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
malignant mesothelioma 29 | 3,232
acute myeloid leukemia 27 | 783
non primary Sjogren syndrome sicca 27 | 891
adult high grade glioma 26 | 3,801
primitive neuroectodermal tumor 26 | 3,035
Diamond-Blackfan anemia 25 | 31
astrocytic glioma 24 | 2,597
lung adenocarcinoma 22 | 2,716
subependymal giant cell astrocytoma 22 | 2,287
Pick disease 21 | 1,894
non-small cell lung cancer 21 | 2,890
invasive ductal carcinoma 20 | 2,951
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
astrocytoma 19 | 1,146
cystic fibrosis 19 | 1,696
dermatomyositis 19 | 966
Anemia 17 | 365
Disease Progression 17 | 136
colon cancer 17 | 1,478
pediatric high grade glioma 17 | 1,064
sonic hedgehog group medulloblastoma 17 | 467
Stomach Neoplasms 16 | 300
Cancer 15 | 2,499
Cleft Palate 15 | 271
juvenile dermatomyositis 15 | 1,187
Fatigue 14 | 182
Uranostaphyloschisis 14 | 167
breast carcinoma 14 | 1,638
Abnormality of the urinary system 13 | 21
Adenocarcinoma of lung 13 | 142
Amyotrophic lateral sclerosis 13 | 451
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Astrocytoma, Pilocytic 13 | 3,081
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Conduction disorder of the heart 13 | 79
Delayed Puberty 13 | 97
Disease Models, Animal 13 | 155
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Hand deformities 13 | 32
Intellectual disability 13 | 1,016
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
Rheumatoid arthritis 12 | 1,191
lung carcinoma 12 | 2,843
primary pancreatic ductal adenocarcinoma 11 | 1,109
progressive supranuclear palsy 11 | 676
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Kidney cancer 10 | 2,613
Mental and motor retardation 10 | 608
Short stature 10 | 531
pancreatic cancer 9 | 2,398
Autosomal recessive predisposition 8 | 1,442
Dull intelligence 8 | 645
Fetal Growth Retardation 8 | 189
Infant, Small for Gestational Age 8 | 176
Intrauterine retardation 8 | 176
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Osteoporosis 8 | 363
Poor school performance 8 | 645
Small head 8 | 374
adrenocortical carcinoma 8 | 1,428
atypical teratoid/rhabdoid tumor 8 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
pituitary cancer 8 | 1,972
Polycystic ovary syndrome 7 | 360
aldosterone-producing adenoma 7 | 665
group 4 medulloblastoma 7 | 1,855
mucosa-associated lymphoid tissue lymphoma 7 | 484
cutaneous lupus erythematosus 6 | 1,057

Tissue

Endocrine System 276 | 18,159
Digestive Tract 273 | 17,369
Blood and immune system 272 | 16,909
Male tissues 272 | 17,142
Skin and soft tissues 272 | 17,230
Cardiovascular System 271 | 15,192
Female tissues 271 | 17,400
Liver and Pancreas 271 | 16,750
Nervous System 271 | 16,725
Respiratory system 271 | 16,393
Urinary Tract 271 | 16,678

Target Family

Non-IDG 273 | 12,091
Enzyme 11 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

UniProt Keyword

Ribonucleoprotein 286 | 286
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
Heterogeneous nuclear ribonucleoprotein C-like 2 HNRNPCL2 Tdark Non-IDG 0.33 1.30 0
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
Heterogeneous nuclear ribonucleoprotein A0 HNRNPA0 Tbio Non-IDG -0.86935 6.45 110
U6 snRNA-associated Sm-like protein LSm5 LSM5 Tdark Non-IDG -0.98876 8.80 46
39S ribosomal protein L42, mitochondrial MRPL42 Tdark Non-IDG 0.02 0.40 139
H/ACA ribonucleoprotein complex subunit 1 GAR1 Tbio Non-IDG -0.33131 2.70 86
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
Protein argonaute-1 AGO1 Tbio Non-IDG -2.22336 158.4 203