Development Level

Tbio 72 | 11,445
Tchem 8 | 1,598
Tclin 5 | 613
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
increased lean body mass 4 | 172
increased or absent threshold ... 4 | 101
abnormal behavior 3 | 298
absent startle reflex 3 | 24
enlarged heart 3 | 210
hypoactivity 3 | 132
impaired righting response 3 | 26
limb grasping 3 | 41
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
absent pinna reflex 2 | 23
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased thermal nociceptive ... 2 | 9
increased total body fat amoun... 2 | 134
short tibia 2 | 97
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal ear morphology 1 | 9
abnormal kidney morphology 1 | 65
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal pupil morphology 1 | 2
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating lipase l... 1 | 3
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased coping response 1 | 8
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged urinary bladder 1 | 8
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
macrophthalmia 1 | 2
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Retinitis Pigmentosa 88 | 226
Carcinoma 69 | 11,493
Intellectual disability 56 | 1,016
Sensorineural Hearing Loss (disorder) 56 | 284
Cataract 55 | 297
Lens Opacities 54 | 231
Dull intelligence 53 | 645
Low intelligence 53 | 645
Mental Retardation 53 | 645
Mental deficiency 53 | 645
Poor school performance 53 | 645
Electroretinogram abnormal 52 | 95
Nystagmus 52 | 317
Obesity 51 | 678
Optic Atrophy 51 | 242
Abnormality of retinal pigmentation 49 | 111
Retinal pigment epithelial abnormality 49 | 111
Blind Vision 48 | 111
Blindness, Legal 48 | 110
Photodysphoria 48 | 121
Photophobia 48 | 121
Congenital hypoplasia of penis 47 | 176
Glaucoma 47 | 239
Abnormality of the retinal vasculature 46 | 59
Anteverted nostril 46 | 191
Atypical scarring of skin 46 | 62
Broad flat nasal bridge 46 | 236
Conductive hearing loss 46 | 123
Congenital anomaly of testis 46 | 52
Hyperinsulinism 46 | 133
Hypogonadism 46 | 173
Keratoconus 46 | 113
Nasal bridge wide 46 | 236
Night blindness, progressive 46 | 51
Ophthalmoplegia 46 | 106
Night Blindness 45 | 101
Difficulties with night vision 42 | 87
Autosomal recessive predisposition 41 | 1,442
osteosarcoma 38 | 7,950
psoriasis 37 | 6,694
medulloblastoma, large-cell 34 | 6,241
ovarian cancer 31 | 8,520
Low Vision 27 | 174
Visual Impairment 27 | 174
Fundus dystrophy 26 | 83
ependymoma 26 | 4,679
group 3 medulloblastoma 26 | 4,104
Retinal Degeneration 25 | 106
Blindness 24 | 88
Cone dystrophy 21 | 71
glioblastoma 19 | 5,792
lung cancer 18 | 4,740
lung carcinoma 18 | 2,843
Visual field constriction 17 | 36
cone-rod dystrophy 17 | 59
oligodendroglioma 17 | 2,850
Kidney cancer 16 | 2,613
Leber congenital amaurosis 16 | 69
astrocytic glioma 16 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Usher syndrome 15 | 32
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Reduced visual acuity 14 | 63
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
primitive neuroectodermal tumor 14 | 3,035
Attenuation of retinal blood vessels 13 | 16
Pallor of optic disc 13 | 39
atypical teratoid / rhabdoid tumor 13 | 5,112
malignant mesothelioma 13 | 3,232
pituitary cancer 13 | 1,972
Breast cancer 12 | 3,578
Cerebellar Ataxia 12 | 304
Epilepsy 12 | 792
Fundus with peripheral 'bony spicules' 12 | 12
Muscle hypotonia 12 | 571
Nonsyndromic deafness 11 | 142
lung adenocarcinoma 11 | 2,716
pancreatic cancer 11 | 2,398
Abnormal vision 10 | 52
Pigmentary iris degeneration 10 | 20
Scotoma 10 | 22
Seizures 10 | 596
Abnormal color vision 9 | 31
Astrocytoma, Pilocytic 9 | 3,081
Color vision defect 9 | 33
Color vision defect, severe 9 | 31
Extinguished electroretinogram 9 | 15
Melanoma 9 | 711
Neuropathy 9 | 261
Pick disease 9 | 1,894
Retinal blind spot 9 | 11
Sensorineural hearing loss 9 | 106
tuberculosis 9 | 2,010
Enhanced S-cone syndrome 8 | 17
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
invasive ductal carcinoma 8 | 2,951
non-small cell lung cancer 8 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962

Tissue

Endocrine System 87 | 18,159
Female tissues 86 | 17,400
Digestive Tract 85 | 17,369
Male tissues 84 | 17,142
Skin and soft tissues 84 | 17,230
Nervous System 83 | 16,725
Blood and immune system 81 | 16,909
Liver and Pancreas 81 | 16,750
Urinary Tract 81 | 16,678
Respiratory system 79 | 16,393
Cardiovascular System 69 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 26 | 4,145
Kinase 5 | 634
Transcription Factor 5 | 1,400
GPCR 3 | 408
Ion Channel 3 | 344
Transporter 3 | 473
Nuclear Receptor 1 | 48

UniProt Keyword

Retinitis pigmentosa 89 | 89
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protocadherin-15 PCDH15 Tbio Non-IDG -1.83877 74.3 42
Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 Tbio Transporter -2.63743 436.2 124
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Photoreceptor-specific nuclear receptor NR2E3 Tbio Nuclear Receptor 0.00000 261
Feline leukemia virus subgroup C receptor-related protein 1 FLVCR1 Tbio Non-IDG -1.54460 33.8 139
G-protein coupled receptor 98 ADGRV1 Tbio GPCR -2.51228 316.6 64
Cone-rod homeobox protein CRX Tbio Transcription Factor -2.44826 272.0 185
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Protein C8orf37 C8orf37 Tbio Non-IDG -2.10097 123.4 32