Development Level

Tbio 470 | 11,445
Tdark 68 | 6,588
Tchem 50 | 1,598
Tclin 14 | 613

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 20 | 499
increased bone mineral content 9 | 108
abnormal behavior 8 | 298
abnormal bone structure 8 | 187
abnormal embryo size 8 | 220
decreased total body fat amoun... 8 | 207
decreased bone mineral density 7 | 126
increased startle reflex 7 | 112
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
increased circulating alkaline... 6 | 122
abnormal cornea morphology 5 | 31
decreased bone mineral content 5 | 151
decreased circulating HDL chol... 5 | 68
decreased circulating glucose ... 5 | 126
decreased heart left ventricle... 5 | 28
decreased lean body mass 5 | 135
decreased vertical activity 5 | 208
hyperactivity 5 | 148
increased bone mineral density 5 | 72
increased fasted circulating g... 5 | 76
increased lean body mass 5 | 172
increased mean corpuscular hem... 5 | 96
cataract 4 | 92
decreased blood urea nitrogen ... 4 | 51
decreased circulating choleste... 4 | 93
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
decreased leukocyte cell numbe... 4 | 73
embryonic lethality prior to o... 4 | 239
hypoactivity 4 | 132
increased body length 4 | 32
increased circulating HDL chol... 4 | 80
increased circulating chloride... 4 | 41
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased grip strength 4 | 41
increased mean corpuscular vol... 4 | 92
male infertility 4 | 123
abnormal coat-hair pigmentatio... 3 | 64
corneal opacity 3 | 32
decreased CD4-positive, alpha ... 3 | 7
decreased T cell number 3 | 15
decreased body length 3 | 101
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased mean platelet volume 3 | 25
decreased neutrophil cell numb... 3 | 42
embryonic growth retardation 3 | 106
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased B cell number 3 | 9
increased circulating creatini... 3 | 38
increased total body fat amoun... 3 | 134
persistence of hyaloid vascula... 3 | 33
small spleen 3 | 19
small superior vagus ganglion 3 | 74
thin ventricular wall 3 | 24
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal sleep behavior 2 | 70
abnormal snout morphology 2 | 23
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
absent startle reflex 2 | 24
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating glycerol... 2 | 16
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
edema 2 | 59
impaired glucose tolerance 2 | 75
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased hemoglobin content 2 | 45
increased lactate dehydrogenas... 2 | 3
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
increased vertical activity 2 | 24
long tibia 2 | 25
microphthalmia 2 | 26
small testis 2 | 58
syndactyly 2 | 23

Disease

Carcinoma 426 | 11,493
ovarian cancer 335 | 8,520
osteosarcoma 327 | 7,950
medulloblastoma, large-cell 259 | 6,241
glioblastoma 236 | 5,792
psoriasis 234 | 6,694
atypical teratoid / rhabdoid tumor 219 | 5,112
group 3 medulloblastoma 200 | 4,104
lung cancer 198 | 4,740
ependymoma 172 | 4,679
Breast cancer 161 | 3,578
Cancer 159 | 2,499
adult high grade glioma 143 | 3,801
primitive neuroectodermal tumor 139 | 3,035
malignant mesothelioma 134 | 3,232
invasive ductal carcinoma 120 | 2,951
oligodendroglioma 117 | 2,850
Kidney cancer 116 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 114 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 109 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 108 | 2,955
Astrocytoma, Pilocytic 102 | 3,081
astrocytic glioma 99 | 2,597
non-small cell lung cancer 94 | 2,890
group 4 medulloblastoma 90 | 1,855
pancreatic cancer 90 | 2,398
pituitary cancer 87 | 1,972
subependymal giant cell astrocytoma 87 | 2,287
lung adenocarcinoma 85 | 2,716
tuberculosis 85 | 2,010
Pick disease 83 | 1,894
lung carcinoma 79 | 2,843
Multiple myeloma 71 | 1,332
acute quadriplegic myopathy 71 | 1,158
juvenile dermatomyositis 70 | 1,187
ductal carcinoma in situ 68 | 1,745
cystic fibrosis 67 | 1,696
interstitial cystitis 67 | 2,312
Rheumatoid arthritis 66 | 1,191
astrocytoma 65 | 1,146
breast carcinoma 65 | 1,638
Intellectual disability 61 | 1,016
adrenocortical carcinoma 60 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,962
ulcerative colitis 57 | 1,819
primary pancreatic ductal adenocarcinoma 56 | 1,109
spina bifida 55 | 1,074
diabetes mellitus 53 | 1,728
dermatomyositis 52 | 966
pediatric high grade glioma 46 | 1,064
Schizophrenia 43 | 1,160
aldosterone-producing adenoma 43 | 665
Waldenstrons macroglobulinemia 42 | 765
acute myeloid leukemia 39 | 783
colon cancer 39 | 1,478
Breast Neoplasms 36 | 445
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mammary Neoplasms 35 | 425
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Poor school performance 35 | 645
non primary Sjogren syndrome sicca 35 | 891
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Mental and motor retardation 34 | 608
gastric carcinoma 34 | 807
Short stature 32 | 531
cutaneous lupus erythematosus 31 | 1,057
Amyotrophic lateral sclerosis 30 | 451
Epilepsy 30 | 792
Muscle hypotonia 30 | 571
Prostatic Neoplasms 30 | 495
medulloblastoma 30 | 720
nasopharyngeal carcinoma 30 | 1,058
active ulcerative colitis 29 | 764
primary Sjogren syndrome 29 | 735
active Crohn's disease 28 | 922
Liver cancer 27 | 604
Seizures 27 | 596
progressive supranuclear palsy 27 | 676
Alzheimer's disease 26 | 658
Obesity 26 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 510
hepatocellular carcinoma 26 | 547
Atopic dermatitis 25 | 952
Melanoma 25 | 711
Autosomal recessive predisposition 24 | 1,442
Bipolar Disorder 23 | 666
Small head 23 | 374
atypical teratoid/rhabdoid tumor 23 | 357
posterior fossa group A ependymoma 23 | 468
Cryptorchidism 22 | 296
Crohn's disease 21 | 321
Liver Cirrhosis, Experimental 21 | 769
esophageal adenocarcinoma 21 | 737
tuberculosis and treatment for 6 months 21 | 409
Endometriosis 20 | 540
sarcoidosis 20 | 370
sonic hedgehog group medulloblastoma 19 | 467

Tissue

Endocrine System 595 | 18,159
Female tissues 583 | 17,400
Skin and soft tissues 581 | 17,230
Digestive Tract 579 | 17,369
Male tissues 579 | 17,142
Nervous System 577 | 16,725
Blood and immune system 573 | 16,909
Liver and Pancreas 573 | 16,750
Urinary Tract 573 | 16,678
Respiratory system 571 | 16,393
Cardiovascular System 549 | 15,192

Target Family

Transcription Factor 262 | 1,400
Non-IDG 227 | 12,091
Epigenetic 62 | 242
Enzyme 27 | 4,145
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38
Kinase 2 | 634
Ion Channel 1 | 344

UniProt Keyword

Repressor 602 | 602
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Zinc finger protein 140 ZNF140 Tdark Transcription Factor 0.08 0.97 39
Zinc finger protein 138 ZNF138 Tdark Transcription Factor 1.15 0.03 69
Y-box-binding protein 3 YBX3 Tbio Transcription Factor -2.13168 143.1 204
E3 ubiquitin-protein ligase TRIM33 TRIM33 Tbio Epigenetic -3.10754 1197.2 297
Transcription regulator protein BACH2 BACH2 Tbio Transcription Factor -1.90906 89.8 184
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.25853 1689.4 685
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
Coiled-coil and C2 domain-containing protein 1A CC2D1A Tbio Non-IDG -1.65526 46.8 118
ETS domain-containing protein Elk-3 ELK3 Tbio Transcription Factor -0.17124 0.86 225