Development Level

Tbio 437 | 10,625
Tdark 78 | 7,003
Tchem 60 | 1,890
Tclin 14 | 602

IMPC Phenotype

preweaning lethality, complete... 26 | 633
preweaning lethality, incomple... 14 | 260
increased circulating alkaline... 8 | 119
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
abnormal bone structure 6 | 131
decreased body weight 6 | 174
decreased bone mineral density 6 | 126
decreased grip strength 6 | 123
hyperactivity 6 | 108
increased bone mineral content 6 | 92
abnormal cornea morphology 5 | 24
decreased body length 5 | 108
decreased circulating HDL chol... 5 | 77
decreased circulating insulin ... 5 | 75
decreased circulating triglyce... 5 | 83
decreased total body fat amoun... 5 | 186
increased grip strength 5 | 83
abnormal coat-hair pigmentatio... 4 | 54
decreased caudal vertebrae num... 4 | 49
decreased circulating glucose ... 4 | 121
decreased rib number 4 | 59
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased lean body mass 4 | 107
increased or absent threshold ... 4 | 128
increased sacral vertebrae num... 4 | 62
abnormal eye morphology 3 | 38
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased CD4-positive, alpha ... 3 | 19
decreased T cell number 3 | 31
decreased bone mineral content 3 | 157
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased effector memory CD8-... 3 | 24
decreased leukocyte cell numbe... 3 | 54
decreased mature B cell number 3 | 25
decreased prepulse inhibition 3 | 52
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating creatini... 3 | 29
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
oligodactyly 3 | 14
abnormal bone mineralization 2 | 55
abnormal iris morphology 2 | 12
abnormal retina morphology 2 | 100
abnormal testis morphology 2 | 30
cataract 2 | 26
cyanosis 2 | 6
decreased CD8-positive, alpha-... 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
enlarged heart 2 | 111
increased B cell number 2 | 23
increased Ly6C low monocyte nu... 2 | 8
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating iron lev... 2 | 25
increased lactate dehydrogenas... 2 | 3
increased mean corpuscular vol... 2 | 91
irregularly shaped pupil 2 | 7
long tibia 2 | 13
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
small spleen 2 | 11
small testis 2 | 37
thin ventricular wall 2 | 5
trunk curl 2 | 15
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal tooth morphology 1 | 24
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
female infertility 1 | 34
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
prenatal lethality 1 | 16

Disease

ovarian cancer 328 | 8,491
osteosarcoma 319 | 7,933
medulloblastoma, large-cell 253 | 6,234
psoriasis 228 | 6,685
glioblastoma 223 | 5,572
atypical teratoid / rhabdoid tumor 195 | 4,369
lung cancer 188 | 4,473
Cancer 144 | 2,346
primitive neuroectodermal tumor 138 | 3,031
Breast cancer 136 | 3,098
malignant mesothelioma 129 | 3,163
invasive ductal carcinoma 117 | 2,950
oligodendroglioma 114 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 113 | 2,988
pediatric high grade glioma 111 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 108 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 108 | 3,289
group 4 medulloblastoma 105 | 1,875
ependymoma 103 | 2,514
pilocytic astrocytoma 102 | 3,086
Carcinoma 94 | 2,147
group 3 medulloblastoma 93 | 2,254
non-small cell lung cancer 90 | 2,798
pituitary cancer 84 | 1,972
subependymal giant cell astrocytoma 84 | 2,287
pancreatic cancer 83 | 2,300
Pick disease 81 | 1,893
lung adenocarcinoma 81 | 2,714
astrocytic glioma 79 | 2,241
astrocytoma 79 | 1,493
lung carcinoma 77 | 2,844
adult high grade glioma 75 | 2,148
juvenile dermatomyositis 70 | 1,189
sonic hedgehog group medulloblastoma 70 | 1,482
Multiple myeloma 69 | 1,327
acute quadriplegic myopathy 68 | 1,157
ductal carcinoma in situ 67 | 1,745
Rheumatoid Arthritis 65 | 1,170
interstitial cystitis 65 | 2,299
cystic fibrosis 64 | 1,670
medulloblastoma 64 | 1,524
ulcerative colitis 64 | 2,087
primary pancreatic ductal adenocarcinoma 63 | 1,271
breast carcinoma 62 | 1,614
posterior fossa group A ependymoma 62 | 1,511
adrenocortical carcinoma 58 | 1,427
tuberculosis 57 | 1,563
spina bifida 53 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,795
dermatomyositis 50 | 966
diabetes mellitus 49 | 1,663
atypical teratoid/rhabdoid tumor 43 | 1,095
aldosterone-producing adenoma 42 | 664
tuberculosis and treatment for 6 months 42 | 686
Waldenstrons macroglobulinemia 40 | 764
acute myeloid leukemia 40 | 785
colon cancer 39 | 1,475
Intellectual disability 36 | 573
Mammary Neoplasms 35 | 410
posterior fossa group B ependymoma 34 | 1,530
gastric carcinoma 33 | 832
primary Sjogren syndrome 33 | 788
nasopharyngeal carcinoma 30 | 1,056
Amyotrophic Lateral Sclerosis 29 | 432
cutaneous lupus erythematosus 29 | 1,056
non primary Sjogren syndrome sicca 29 | 840
active Crohn's disease 28 | 918
Prostatic Neoplasms 27 | 471
progressive supranuclear palsy 27 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 499
hepatocellular carcinoma 26 | 550
Atopic dermatitis 25 | 944
Alzheimer's disease 23 | 644
active ulcerative colitis 21 | 477
Down syndrome 20 | 548
sarcoidosis 20 | 368
Endometriosis 19 | 535
esophageal adenocarcinoma 19 | 737
tuberculosis and treatment for 3 months 19 | 327
Crohn's disease 18 | 304
Duchenne muscular dystrophy 18 | 602
Stomach Neoplasms 18 | 282
fibroadenoma 18 | 557
Obesity 17 | 616
chronic lymphocytic leukemia 17 | 244
gastric cancer 17 | 436
Craniofacial Abnormalities 16 | 147
Polycystic Ovary Syndrome 16 | 334
Schizophrenia 16 | 503
inflammatory breast cancer 16 | 404
pancreatic carcinoma 16 | 567
Melanoma 15 | 261
Acquired metabolic disease 14 | 267
Neoplasm Invasiveness 14 | 127
Peripheral T-cell lymphoma 14 | 24
urothelial carcinoma 14 | 318
IGA Glomerulonephritis 13 | 454
Multiple Sclerosis 13 | 498
glioblastoma multiforme 13 | 347
non-small cell lung carcinoma 13 | 413

Tissue

Nervous System 585 | 18,560
Endocrine System 582 | 18,511
Female tissues 582 | 18,646
Liver and Pancreas 581 | 18,135
Digestive Tract 580 | 18,472
Male tissues 579 | 17,968
Urinary Tract 579 | 18,443
Blood and immune system 578 | 17,994
Cardiovascular System 578 | 17,957
Skin and soft tissues 577 | 18,114
Respiratory system 569 | 17,483

Target Family

Transcription Factor 254 | 1,400
Non-IDG 222 | 11,969
Epigenetic 62 | 242
Enzyme 27 | 4,146
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38
Kinase 2 | 634
Ion Channel 1 | 341

UniProt Keyword

Repressor 589 | 589
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 606 ZNF606 Tdark Transcription Factor 0.00000 1.48 76
SKI family transcriptional corepressor 2 SKOR2 Tbio Non-IDG -0.51537 4.32 50
Ribosomal RNA-processing protein 8 RRP8 Tbio Enzyme -2.24766 174.5 99
Transcription factor HES-2 HES2 Tdark Transcription Factor -0.19957 1.87 203
Dachshund homolog 2 DACH2 Tbio Non-IDG -0.93745 8.59 121
Zinc finger protein RFP TRIM27 Tbio Non-IDG -1.50884 32.8 154
Transcription regulator protein BACH2 BACH2 Tbio Transcription Factor -1.84608 77.3 159
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
Msx2-interacting protein SPEN Tbio Non-IDG -2.91140 781.7 40