Development Level

Tbio 437 | 10,625
Tdark 78 | 7,003
Tchem 60 | 1,890
Tclin 14 | 602

IMPC Term

preweaning lethality, complete... 26 | 633
preweaning lethality, incomple... 14 | 260
increased circulating alkaline... 8 | 119
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
abnormal bone structure 6 | 131
decreased body weight 6 | 174
decreased bone mineral density 6 | 126
decreased grip strength 6 | 123
hyperactivity 6 | 108
increased bone mineral content 6 | 92
abnormal cornea morphology 5 | 24
decreased body length 5 | 108
decreased circulating HDL chol... 5 | 77
decreased circulating insulin ... 5 | 75
decreased circulating triglyce... 5 | 83
decreased total body fat amoun... 5 | 186
increased grip strength 5 | 83
abnormal coat/hair pigmentatio... 4 | 54
decreased caudal vertebrae num... 4 | 49
decreased circulating glucose ... 4 | 121
decreased rib number 4 | 59
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased lean body mass 4 | 107
increased or absent threshold ... 4 | 128
increased sacral vertebrae num... 4 | 62
abnormal eye morphology 3 | 38
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased CD4-positive, alpha ... 3 | 19
decreased T cell number 3 | 31
decreased bone mineral content 3 | 157
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased effector memory CD8-... 3 | 24
decreased leukocyte cell numbe... 3 | 54
decreased mature B cell number 3 | 25
decreased prepulse inhibition 3 | 52
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating creatini... 3 | 29
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 93
increased startle reflex 3 | 38
oligodactyly 3 | 14
abnormal bone mineralization 2 | 55
abnormal iris morphology 2 | 12
abnormal retina morphology 2 | 100
abnormal testis morphology 2 | 30
cataract 2 | 26
cyanosis 2 | 6
decreased CD8-positive, alpha-... 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
enlarged heart 2 | 111
increased B cell number 2 | 23
increased Ly6C low monocyte nu... 2 | 8
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating iron lev... 2 | 25
increased lactate dehydrogenas... 2 | 3
increased mean corpuscular vol... 2 | 91
irregularly shaped pupil 2 | 7
long tibia 2 | 13
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
small spleen 2 | 11
small testis 2 | 37
thin ventricular wall 2 | 5
trunk curl 2 | 15
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal tooth morphology 1 | 24
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
female infertility 1 | 34
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
prenatal lethality 1 | 16

Disease

ovarian cancer 328 | 8,484
osteosarcoma 319 | 7,933
medulloblastoma, large-cell 253 | 6,234
psoriasis 228 | 6,685
glioblastoma 223 | 5,572
atypical teratoid / rhabdoid tumor 195 | 4,369
lung cancer 187 | 4,466
Cancer 144 | 2,346
primitive neuroectodermal tumor 138 | 3,031
Breast cancer 136 | 3,094
malignant mesothelioma 129 | 3,162
invasive ductal carcinoma 117 | 2,950
oligodendroglioma 114 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 113 | 2,988
pediatric high grade glioma 111 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 108 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 108 | 3,289
group 4 medulloblastoma 105 | 1,875
ependymoma 103 | 2,514
pilocytic astrocytoma 102 | 3,086
Carcinoma 94 | 2,147
group 3 medulloblastoma 93 | 2,254
non-small cell lung cancer 90 | 2,798
pituitary cancer 84 | 1,972
subependymal giant cell astrocytoma 84 | 2,287
pancreatic cancer 83 | 2,300
Pick disease 81 | 1,893
lung adenocarcinoma 81 | 2,713
astrocytic glioma 79 | 2,241
astrocytoma 79 | 1,493
lung carcinoma 77 | 2,844
adult high grade glioma 75 | 2,148
juvenile dermatomyositis 70 | 1,189
sonic hedgehog group medulloblastoma 70 | 1,482
Multiple myeloma 69 | 1,327
acute quadriplegic myopathy 68 | 1,157
ductal carcinoma in situ 67 | 1,745
Rheumatoid Arthritis 65 | 1,160
interstitial cystitis 65 | 2,299
cystic fibrosis 64 | 1,665
medulloblastoma 64 | 1,524
ulcerative colitis 64 | 2,087
primary pancreatic ductal adenocarcinoma 63 | 1,271
breast carcinoma 62 | 1,614
posterior fossa group A ependymoma 62 | 1,511
adrenocortical carcinoma 58 | 1,427
tuberculosis 56 | 1,557
spina bifida 53 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,795
dermatomyositis 50 | 933
diabetes mellitus 49 | 1,663
atypical teratoid/rhabdoid tumor 43 | 1,095
aldosterone-producing adenoma 42 | 664
tuberculosis and treatment for 6 months 42 | 686
Waldenstrons macroglobulinemia 40 | 765
acute myeloid leukemia 40 | 780
colon cancer 39 | 1,475
Intellectual disability 36 | 573
Mammary Neoplasms 35 | 410
posterior fossa group B ependymoma 34 | 1,530
gastric carcinoma 33 | 832
primary Sjogren syndrome 33 | 789
nasopharyngeal carcinoma 30 | 1,056
Amyotrophic Lateral Sclerosis 29 | 431
cutaneous lupus erythematosus 29 | 1,056
non primary Sjogren syndrome sicca 29 | 840
active Crohn's disease 28 | 918
Prostatic Neoplasms 27 | 471
progressive supranuclear palsy 27 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 499
Atopic dermatitis 25 | 944
hepatocellular carcinoma 24 | 532
Alzheimer's disease 23 | 644
active ulcerative colitis 21 | 477
Down syndrome 20 | 548
sarcoidosis 20 | 358
Endometriosis 19 | 535
esophageal adenocarcinoma 19 | 737
tuberculosis and treatment for 3 months 19 | 327
Crohn's disease 18 | 304
Duchenne muscular dystrophy 18 | 602
Stomach Neoplasms 18 | 282
fibroadenoma 18 | 557
Chronic Lymphocytic Leukemia 17 | 242
Obesity 17 | 616
Craniofacial Abnormalities 16 | 147
Polycystic Ovary Syndrome 16 | 332
Schizophrenia 16 | 501
gastric cancer 16 | 430
inflammatory breast cancer 16 | 404
pancreatic carcinoma 16 | 567
Melanoma 15 | 261
Acquired metabolic disease 14 | 267
Neoplasm Invasiveness 14 | 127
Peripheral T-cell lymphoma 14 | 24
urothelial carcinoma 14 | 318
IGA Glomerulonephritis 13 | 454
Multiple Sclerosis 13 | 498
glioblastoma multiforme 13 | 347
non-small cell lung carcinoma 13 | 413

Tissue

Nervous System 585 | 18,561
Endocrine System 582 | 18,512
Female tissues 582 | 18,647
Liver and Pancreas 581 | 18,136
Digestive Tract 580 | 18,473
Male tissues 579 | 17,969
Urinary Tract 579 | 18,444
Blood and immune system 578 | 17,995
Cardiovascular System 578 | 17,958
Skin and soft tissues 577 | 18,115
Respiratory system 569 | 17,484

Target Family

Transcription Factor 254 | 1,400
Non-IDG 222 | 11,971
Epigenetic 62 | 242
Enzyme 27 | 4,146
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38
Kinase 2 | 634
Ion Channel 1 | 341

UniProt Keyword

Repressor 589 | 589
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Class A basic helix-loop-helix protein 15 BHLHA15 Tbio Transcription Factor -1.24086 19.1 70
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567