Development Level

Tbio 2,981 | 11,445
Tdark 1,504 | 6,588
Tchem 310 | 1,598
Tclin 121 | 613

Collection

RFA-RM-18-021 24 | 328
Kinase: IDG Consortium (Target... 10 | 125
Ion Channel: IDG Consortium (T... 8 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 231 | 979
preweaning lethality, incomple... 134 | 499
abnormal behavior 81 | 298
embryonic lethality prior to t... 70 | 278
decreased total body fat amoun... 59 | 207
decreased vertical activity 58 | 208
enlarged heart 52 | 210
abnormal embryo size 51 | 220
abnormal bone structure 46 | 187
decreased body weight 45 | 161
increased lean body mass 45 | 172
abnormal heart morphology 43 | 162
decreased circulating glucose ... 40 | 126
embryonic lethality prior to o... 40 | 239
hypoactivity 37 | 132
hyperactivity 36 | 148
decreased circulating choleste... 35 | 93
increased total body fat amoun... 34 | 134
short tibia 32 | 97
decreased bone mineral content 31 | 151
decreased lean body mass 31 | 135
abnormal seminal vesicle morph... 30 | 114
embryonic growth retardation 30 | 106
impaired glucose tolerance 30 | 75
increased or absent threshold ... 30 | 101
increased startle reflex 29 | 112
decreased bone mineral density 28 | 126
decreased grip strength 28 | 116
decreased mean corpuscular vol... 27 | 79
decreased lymphocyte cell numb... 26 | 83
increased bone mineral content 26 | 108
increased circulating alkaline... 26 | 122
male infertility 26 | 123
decreased body length 25 | 101
decreased circulating serum al... 25 | 82
decreased leukocyte cell numbe... 25 | 73
increased monocyte cell number 24 | 63
prenatal lethality prior to he... 24 | 87
decreased circulating triglyce... 23 | 79
decreased prepulse inhibition 23 | 82
increased mean corpuscular hem... 23 | 96
abnormal eye morphology 22 | 68
abnormal gait 22 | 69
decreased startle reflex 22 | 75
decreased hemoglobin content 21 | 68
increased circulating HDL chol... 21 | 80
decreased blood urea nitrogen ... 20 | 51
decreased circulating insulin ... 19 | 76
improved glucose tolerance 19 | 79
increased bone mineral density 19 | 72
increased heart weight 19 | 62
increased mean corpuscular vol... 19 | 92
abnormal coat-hair pigmentatio... 18 | 64
increased circulating choleste... 18 | 66
decreased mean corpuscular hem... 17 | 50
decreased neutrophil cell numb... 17 | 42
increased circulating sodium l... 17 | 71
tremors 17 | 39
decreased circulating HDL chol... 16 | 68
decreased circulating aspartat... 16 | 34
decreased circulating total pr... 16 | 49
decreased erythrocyte cell num... 16 | 62
increased leukocyte cell numbe... 16 | 47
small testis 16 | 58
abnormal retina morphology 15 | 71
increased lymphocyte cell numb... 15 | 32
increased neutrophil cell numb... 15 | 46
thrombocytopenia 15 | 56
abnormal kidney morphology 14 | 65
abnormal spleen morphology 14 | 55
decreased fasted circulating g... 14 | 65
edema 14 | 59
increased hematocrit 14 | 46
abnormal behavioral response t... 13 | 66
abnormal skin morphology 13 | 50
abnormal tooth morphology 13 | 24
cataract 13 | 92
decreased circulating alanine ... 13 | 47
decreased hematocrit 13 | 46
enlarged spleen 13 | 41
increased blood urea nitrogen ... 13 | 48
increased mean platelet volume 13 | 45
persistence of hyaloid vascula... 13 | 33
abnormal lens morphology 12 | 81
abnormal sleep behavior 12 | 70
decreased red blood cell distr... 12 | 41
female infertility 12 | 60
increased fasted circulating g... 12 | 76
small superior vagus ganglion 12 | 74
abnormal testis morphology 11 | 43
decreased caudal vertebrae num... 11 | 53
decreased circulating alkaline... 11 | 46
decreased circulating amylase ... 11 | 28
decreased circulating iron lev... 11 | 32
impaired righting response 11 | 26
increased circulating calcium ... 11 | 34
increased circulating triglyce... 11 | 42
increased erythrocyte cell num... 11 | 39
increased grip strength 11 | 41
limb grasping 11 | 41

Disease

Carcinoma 3,684 | 11,493
ovarian cancer 2,211 | 8,520
osteosarcoma 2,183 | 7,950
psoriasis 1,850 | 6,694
medulloblastoma, large-cell 1,736 | 6,241
glioblastoma 1,641 | 5,792
atypical teratoid / rhabdoid tumor 1,478 | 5,112
lung cancer 1,368 | 4,740
ependymoma 1,355 | 4,679
Kidney cancer 1,258 | 2,613
group 3 medulloblastoma 1,195 | 4,104
Breast cancer 1,085 | 3,578
adult high grade glioma 1,077 | 3,801
malignant mesothelioma 936 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 915 | 3,291
Astrocytoma, Pilocytic 900 | 3,081
lung carcinoma 898 | 2,843
primitive neuroectodermal tumor 880 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 863 | 2,955
oligodendroglioma 858 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 850 | 2,989
invasive ductal carcinoma 811 | 2,951
non-small cell lung cancer 783 | 2,890
lung adenocarcinoma 764 | 2,716
astrocytic glioma 740 | 2,597
pancreatic cancer 715 | 2,398
Cancer 680 | 2,499
subependymal giant cell astrocytoma 655 | 2,287
interstitial cystitis 651 | 2,312
pituitary cancer 592 | 1,972
group 4 medulloblastoma 584 | 1,855
Pick disease 569 | 1,894
tuberculosis 518 | 2,010
ulcerative colitis 493 | 1,819
cystic fibrosis 488 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 461 | 1,962
breast carcinoma 451 | 1,638
ductal carcinoma in situ 446 | 1,745
colon cancer 412 | 1,478
adrenocortical carcinoma 397 | 1,428
diabetes mellitus 397 | 1,728
Autosomal recessive predisposition 396 | 1,442
Rheumatoid arthritis 368 | 1,191
juvenile dermatomyositis 363 | 1,187
acute quadriplegic myopathy 350 | 1,158
Liver cancer 347 | 604
astrocytoma 335 | 1,146
Melanoma 325 | 711
Schizophrenia 323 | 1,160
spina bifida 315 | 1,074
primary pancreatic ductal adenocarcinoma 313 | 1,109
nasopharyngeal carcinoma 298 | 1,058
Intellectual disability 297 | 1,016
cutaneous lupus erythematosus 294 | 1,057
pediatric high grade glioma 288 | 1,064
dermatomyositis 284 | 966
Atopic dermatitis 283 | 952
Skin cancer 267 | 469
gastric carcinoma 252 | 807
Multiple myeloma 243 | 1,332
non primary Sjogren syndrome sicca 230 | 891
Duchenne muscular dystrophy 224 | 601
active Crohn's disease 217 | 922
esophageal adenocarcinoma 212 | 737
medulloblastoma 208 | 720
Endometrial cancer 203 | 311
primary Sjogren syndrome 202 | 735
Alzheimer's disease 201 | 658
acute myeloid leukemia 200 | 783
Liver Cirrhosis, Experimental 198 | 769
progressive supranuclear palsy 195 | 676
autosomal dominant Emery-Dreifuss muscular dystrophy 190 | 510
active ulcerative colitis 187 | 764
Dull intelligence 180 | 645
Low intelligence 180 | 645
Mental Retardation 180 | 645
Mental deficiency 180 | 645
Poor school performance 180 | 645
Bipolar Disorder 177 | 666
Waldenstrons macroglobulinemia 177 | 765
aldosterone-producing adenoma 176 | 665
Epilepsy 172 | 792
Short stature 167 | 531
Amyotrophic lateral sclerosis 160 | 451
Obesity 158 | 678
pancreatic carcinoma 157 | 562
fibroadenoma 153 | 559
mucosa-associated lymphoid tissue lymphoma 147 | 484
Muscle hypotonia 145 | 571
Cognitive delay 144 | 608
Global developmental delay 144 | 608
Mental and motor retardation 144 | 608
chronic rhinosinusitis 144 | 512
sonic hedgehog group medulloblastoma 144 | 467
Down syndrome 142 | 499
Multiple Sclerosis 142 | 540
Endometriosis 131 | 540
Kidney disease 131 | 430
hepatocellular carcinoma 131 | 547
posterior fossa group A ependymoma 130 | 468

Tissue

Endocrine System 4,621 | 18,159
Female tissues 4,484 | 17,400
Digestive Tract 4,472 | 17,369
Skin and soft tissues 4,430 | 17,230
Male tissues 4,419 | 17,142
Nervous System 4,361 | 16,725
Blood and immune system 4,356 | 16,909
Liver and Pancreas 4,327 | 16,750
Urinary Tract 4,318 | 16,678
Respiratory system 4,262 | 16,393
Cardiovascular System 3,973 | 15,192

Target Family

Non-IDG 3,192 | 12,091
Transcription Factor 749 | 1,400
Enzyme 534 | 4,145
Kinase 128 | 634
Epigenetic 98 | 242
Transporter 98 | 473
Ion Channel 63 | 344
TF/Epigenetic 27 | 38
GPCR 26 | 408
Nuclear Receptor 1 | 48

UniProt Keyword

Repeat 4,916 | 4,916
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158