Development Level

Tbio 2,780 | 10,625
Tdark 1,611 | 7,003
Tchem 394 | 1,890
Tclin 114 | 602

Collection

Eligible Kinase Proteins 13 | 134
Eligible Ion Channel Proteins 11 | 117
Eligible non-olfactory GPCR Proteins 8 | 143

IMPC Term

preweaning lethality, complete... 145 | 633
preweaning lethality, incomple... 77 | 260
abnormal behavior 62 | 226
decreased lean body mass 50 | 195
decreased total body fat amoun... 50 | 186
decreased body weight 48 | 174
embryonic lethality prior to t... 47 | 187
decreased bone mineral content 41 | 157
increased or absent threshold ... 40 | 128
decreased circulating glucose ... 37 | 121
decreased grip strength 34 | 123
increased circulating alkaline... 33 | 119
decreased bone mineral density 32 | 126
decreased circulating choleste... 31 | 85
increased bone mineral content 30 | 92
increased lean body mass 30 | 107
abnormal bone structure 29 | 131
hyperactivity 29 | 108
embryonic lethality prior to o... 28 | 148
abnormal embryo size 27 | 112
decreased body length 27 | 108
enlarged heart 27 | 111
decreased circulating HDL chol... 25 | 77
increased mean corpuscular hem... 25 | 93
decreased circulating triglyce... 24 | 83
hypoactivity 24 | 89
decreased leukocyte cell numbe... 23 | 54
increased grip strength 23 | 83
abnormal retina morphology 22 | 100
short tibia 22 | 82
decreased circulating serum al... 21 | 79
increased mean corpuscular vol... 21 | 91
impaired glucose tolerance 18 | 52
decreased circulating insulin ... 17 | 75
increased circulating sodium l... 17 | 71
prenatal lethality prior to he... 17 | 64
abnormal gait 16 | 51
abnormal lens morphology 16 | 73
decreased circulating alanine ... 16 | 53
decreased hemoglobin content 16 | 53
decreased mean corpuscular vol... 16 | 50
improved glucose tolerance 16 | 56
increased circulating HDL chol... 16 | 63
tremors 16 | 34
decreased prepulse inhibition 15 | 52
increased blood urea nitrogen ... 15 | 44
increased hemoglobin content 15 | 45
male infertility 15 | 62
abnormal coat/hair pigmentatio... 14 | 54
abnormal seminal vesicle morph... 14 | 47
decreased rib number 14 | 59
decreased circulating free fat... 13 | 39
decreased startle reflex 13 | 48
increased body weight 13 | 42
increased circulating calcium ... 13 | 32
persistence of hyaloid vascula... 13 | 22
abnormal heart morphology 12 | 51
abnormal neural tube closure 12 | 37
abnormal tooth morphology 12 | 24
decreased circulating total pr... 12 | 41
decreased mean corpuscular hem... 12 | 34
decreased neutrophil cell numb... 12 | 37
increased bone mineral density 12 | 52
increased circulating choleste... 12 | 53
thrombocytopenia 12 | 46
abnormal bone mineralization 11 | 55
abnormal retinal pigmentation 11 | 61
decreased blood urea nitrogen ... 11 | 31
decreased circulating amylase ... 11 | 24
decreased fasted circulating g... 11 | 49
decreased lumbar vertebrae num... 11 | 62
increased circulating chloride... 11 | 43
increased rib number 11 | 41
abnormal sleep behavior 10 | 63
absent pinna reflex 10 | 21
decreased circulating alkaline... 10 | 41
decreased heart weight 10 | 44
increased circulating potassiu... 10 | 31
increased exploration in new e... 10 | 56
increased hematocrit 10 | 36
increased monocyte cell number 10 | 27
increased total body fat amoun... 10 | 57
abnormal kidney morphology 9 | 30
decreased circulating aspartat... 9 | 27
decreased circulating chloride... 9 | 32
decreased erythrocyte cell num... 9 | 43
decreased threshold for audito... 9 | 32
enlarged spleen 9 | 26
impaired righting response 9 | 19
increased circulating phosphat... 9 | 24
increased leukocyte cell numbe... 9 | 37
increased startle reflex 9 | 38
small testis 9 | 37
abnormal epididymis morphology 8 | 31
abnormal heart left ventricle ... 8 | 20
abnormal spleen morphology 8 | 36
decreased circulating LDL chol... 8 | 37
decreased circulating iron lev... 8 | 25
increased fasted circulating g... 8 | 68
increased heart weight 8 | 37

Disease

ovarian cancer 2,187 | 8,484
osteosarcoma 2,176 | 7,933
psoriasis 1,845 | 6,685
medulloblastoma, large-cell 1,733 | 6,234
glioblastoma 1,567 | 5,572
atypical teratoid / rhabdoid tumor 1,281 | 4,369
lung cancer 1,245 | 4,466
Carcinoma 1,100 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 912 | 3,289
malignant mesothelioma 903 | 3,162
pilocytic astrocytoma 902 | 3,086
lung carcinoma 894 | 2,844
primitive neuroectodermal tumor 876 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 861 | 2,956
Breast cancer 855 | 3,094
oligodendroglioma 855 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 847 | 2,988
invasive ductal carcinoma 809 | 2,950
pediatric high grade glioma 771 | 2,712
lung adenocarcinoma 762 | 2,713
non-small cell lung cancer 754 | 2,798
ependymoma 726 | 2,514
subependymal giant cell astrocytoma 652 | 2,287
interstitial cystitis 646 | 2,299
pancreatic cancer 644 | 2,300
group 3 medulloblastoma 638 | 2,254
Cancer 632 | 2,346
astrocytic glioma 621 | 2,241
group 4 medulloblastoma 619 | 1,875
pituitary cancer 591 | 1,972
adult high grade glioma 590 | 2,148
Pick disease 565 | 1,893
ulcerative colitis 553 | 2,087
cystic fibrosis 478 | 1,665
astrocytoma 448 | 1,493
ductal carcinoma in situ 445 | 1,745
breast carcinoma 444 | 1,614
sonic hedgehog group medulloblastoma 443 | 1,482
posterior fossa group A ependymoma 441 | 1,511
medulloblastoma 421 | 1,524
posterior fossa group B ependymoma 416 | 1,530
colon cancer 409 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 406 | 1,795
tuberculosis 403 | 1,557
adrenocortical carcinoma 396 | 1,427
diabetes mellitus 382 | 1,663
primary pancreatic ductal adenocarcinoma 365 | 1,271
juvenile dermatomyositis 363 | 1,189
Rheumatoid Arthritis 358 | 1,160
acute quadriplegic myopathy 350 | 1,157
spina bifida 316 | 1,064
nasopharyngeal carcinoma 299 | 1,056
cutaneous lupus erythematosus 292 | 1,056
atypical teratoid/rhabdoid tumor 288 | 1,095
dermatomyositis 282 | 933
Atopic dermatitis 280 | 944
gastric carcinoma 253 | 832
Multiple myeloma 247 | 1,327
Duchenne muscular dystrophy 224 | 602
active Crohn's disease 217 | 918
primary Sjogren syndrome 217 | 789
non primary Sjogren syndrome sicca 213 | 840
esophageal adenocarcinoma 211 | 737
acute myeloid leukemia 198 | 780
Alzheimer's disease 195 | 644
progressive supranuclear palsy 194 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 188 | 499
Intellectual disability 185 | 573
tuberculosis and treatment for 6 months 181 | 686
Waldenstrons macroglobulinemia 176 | 765
aldosterone-producing adenoma 176 | 664
pancreatic carcinoma 158 | 567
fibroadenoma 152 | 557
Down syndrome 150 | 548
Amyotrophic Lateral Sclerosis 148 | 431
mucosa-associated lymphoid tissue lymphoma 145 | 480
chronic rhinosinusitis 144 | 512
Obesity 143 | 616
Schizophrenia 138 | 501
Multiple Sclerosis 133 | 498
non-small cell lung carcinoma 130 | 413
Endometriosis 127 | 535
hepatocellular carcinoma 122 | 532
Kidney disease 120 | 396
active ulcerative colitis 120 | 477
gastric cancer 120 | 430
interstitial lung disease 117 | 291
Mammary Neoplasms 115 | 410
IGA Glomerulonephritis 113 | 454
Prostatic Neoplasms 111 | 471
sarcoidosis 110 | 358
glioblastoma multiforme 105 | 347
urothelial carcinoma 99 | 318
Autistic Disorder 96 | 320
Peripheral Neuropathy 95 | 303
Neurodegenerative disease 94 | 383
facioscapulohumeral dystrophy 93 | 286
inflammatory breast cancer 91 | 404
tuberculosis and treatment for 3 months 91 | 327
Crohn's disease 89 | 304

Tissue

Female tissues 4,732 | 18,647
Digestive Tract 4,720 | 18,473
Nervous System 4,706 | 18,561
Endocrine System 4,688 | 18,512
Urinary Tract 4,675 | 18,444
Liver and Pancreas 4,658 | 18,136
Blood and immune system 4,641 | 17,995
Skin and soft tissues 4,634 | 18,115
Male tissues 4,632 | 17,969
Cardiovascular System 4,628 | 17,958
Respiratory system 4,512 | 17,484

Target Family

Non-IDG 3,180 | 11,971
Transcription Factor 749 | 1,400
Enzyme 529 | 4,146
Kinase 128 | 634
Epigenetic 98 | 242
Transporter 98 | 473
Ion Channel 63 | 341
TF/Epigenetic 27 | 38
GPCR 26 | 406
Nuclear Receptor 1 | 48

UniProt Keyword

Repeat 4,899 | 4,899
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788