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Target Filters...

Development Level

Tdark 529 | 7,003
Tbio 471 | 10,625
Tchem 273 | 1,890
Tclin 223 | 602

Collection

Eligible non-olfactory GPCR Proteins 141 | 143
Eligible Ion Channel Proteins 20 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, incomple... 24 | 260
preweaning lethality, complete... 23 | 633
enlarged heart 15 | 111
abnormal behavior 12 | 226
decreased lean body mass 12 | 195
decreased total body fat amoun... 12 | 186
decreased bone mineral content 11 | 157
decreased bone mineral density 11 | 126
embryonic lethality prior to t... 11 | 187
decreased body weight 10 | 174
increased or absent threshold ... 10 | 128
decreased grip strength 9 | 123
abnormal bone structure 8 | 131
decreased body length 8 | 108
decreased circulating alanine ... 8 | 53
increased circulating HDL chol... 8 | 63
increased circulating choleste... 8 | 53
decreased circulating glucose ... 7 | 121
increased circulating alkaline... 7 | 119
abnormal embryo size 6 | 112
abnormal seminal vesicle morph... 6 | 47
enlarged epididymis 6 | 27
hyperactivity 6 | 108
improved glucose tolerance 6 | 56
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
abnormal epididymis morphology 5 | 31
abnormal eye morphology 5 | 38
abnormal gait 5 | 51
decreased circulating choleste... 5 | 85
decreased heart weight 5 | 44
decreased hemoglobin content 5 | 53
decreased leukocyte cell numbe... 5 | 54
decreased prepulse inhibition 5 | 52
hypoactivity 5 | 89
impaired glucose tolerance 5 | 52
increased circulating calcium ... 5 | 32
increased circulating creatini... 5 | 29
increased circulating sodium l... 5 | 71
increased circulating triglyce... 5 | 24
increased grip strength 5 | 83
increased hematocrit 5 | 36
increased hemoglobin content 5 | 45
increased total body fat amoun... 5 | 57
abnormal heart morphology 4 | 51
abnormal kidney morphology 4 | 30
abnormal sleep behavior 4 | 63
cardiovascular system phenotyp... 4 | 35
decreased circulating creatini... 4 | 31
decreased circulating triglyce... 4 | 83
decreased fasted circulating g... 4 | 49
embryonic lethality prior to o... 4 | 148
female infertility 4 | 34
increased bone mineral content 4 | 92
increased circulating serum al... 4 | 25
increased exploration in new e... 4 | 56
increased leukocyte cell numbe... 4 | 37
small superior vagus ganglion 4 | 20
tremors 4 | 34
abnormal behavioral response t... 3 | 52
abnormal cranium morphology 3 | 32
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal pericardium morpholog... 3 | 11
abnormal retina morphology 3 | 100
absent pinna reflex 3 | 21
cataract 3 | 26
decreased CD8-positive, alpha-... 3 | 26
decreased T cell number 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating chloride... 3 | 32
decreased eosinophil cell numb... 3 | 41
decreased heart rate 3 | 10
decreased mean corpuscular hem... 3 | 34
decreased monocyte cell number 3 | 28
decreased neutrophil cell numb... 3 | 37
decreased rib number 3 | 59
decreased startle reflex 3 | 48
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating phosphat... 3 | 24
increased circulating total pr... 3 | 20
increased heart weight 3 | 37
limb grasping 3 | 35
male infertility 3 | 62
small testis 3 | 37
thrombocytopenia 3 | 46
decreased circulating glycerol... 2 | 19
decreased lumbar vertebrae num... 2 | 62
increased body weight 2 | 42
increased circulating aspartat... 2 | 17
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased respiratory quotient 2 | 12

Disease

psoriasis 487 | 6,685
osteosarcoma 476 | 7,933
ovarian cancer 403 | 8,484
medulloblastoma, large-cell 378 | 6,234
glioblastoma 332 | 5,572
lung cancer 308 | 4,466
lung carcinoma 293 | 2,844
interstitial cystitis 263 | 2,299
atypical teratoid / rhabdoid tumor 251 | 4,369
Cancer 247 | 2,346
pilocytic astrocytoma 238 | 3,086
invasive ductal carcinoma 223 | 2,950
lung adenocarcinoma 221 | 2,713
Carcinoma 213 | 2,147
non-small cell lung cancer 212 | 2,798
malignant mesothelioma 202 | 3,162
ulcerative colitis 196 | 2,087
diabetes mellitus 190 | 1,663
Breast cancer 181 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 180 | 3,289
pediatric high grade glioma 179 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 172 | 2,956
primitive neuroectodermal tumor 170 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 165 | 2,988
oligodendroglioma 163 | 2,849
pancreatic cancer 163 | 2,300
pituitary cancer 153 | 1,972
ductal carcinoma in situ 146 | 1,745
tuberculosis 145 | 1,557
adult high grade glioma 140 | 2,148
subependymal giant cell astrocytoma 139 | 2,287
cutaneous lupus erythematosus 137 | 1,056
ependymoma 131 | 2,514
breast carcinoma 123 | 1,614
astrocytic glioma 116 | 2,241
group 4 medulloblastoma 114 | 1,875
cystic fibrosis 113 | 1,665
posterior fossa group A ependymoma 111 | 1,511
group 3 medulloblastoma 110 | 2,254
colon cancer 108 | 1,475
astrocytoma 103 | 1,493
adrenocortical carcinoma 94 | 1,427
Rheumatoid Arthritis 93 | 1,160
Schizophrenia 92 | 501
Pick disease 85 | 1,893
Obesity 84 | 616
pancreatic ductal adenocarcinoma liver metastasis 84 | 1,795
medulloblastoma 83 | 1,524
sonic hedgehog group medulloblastoma 82 | 1,482
primary Sjogren syndrome 79 | 789
Asthma 77 | 349
mucosa-associated lymphoid tissue lymphoma 73 | 480
gastric carcinoma 72 | 832
posterior fossa group B ependymoma 72 | 1,530
Multiple Sclerosis 71 | 498
primary pancreatic ductal adenocarcinoma 70 | 1,271
Atopic dermatitis 65 | 944
atypical teratoid/rhabdoid tumor 64 | 1,095
Alzheimer's disease 63 | 644
non-small cell lung carcinoma 60 | 413
Epilepsy 59 | 346
Endometriosis 58 | 535
nasopharyngeal carcinoma 54 | 1,056
Autistic Disorder 53 | 320
esophageal adenocarcinoma 52 | 737
pancreatic carcinoma 52 | 567
fibroadenoma 51 | 557
spina bifida 49 | 1,064
active Crohn's disease 48 | 918
juvenile dermatomyositis 48 | 1,189
Hypersensitivity reaction type II disease 47 | 235
acute quadriplegic myopathy 47 | 1,157
Atherosclerosis 46 | 275
Parkinson's disease 46 | 364
Kidney disease 45 | 396
Down syndrome 44 | 548
Duchenne muscular dystrophy 44 | 602
Bipolar Disorder 43 | 266
IGA Glomerulonephritis 43 | 454
Mammary Neoplasms 43 | 410
Prostatic Neoplasms 43 | 471
non primary Sjogren syndrome sicca 43 | 840
dermatomyositis 41 | 933
Hypertension 40 | 287
General anesthesia 39 | 53
Cerebrovascular disease 38 | 231
aldosterone-producing adenoma 38 | 664
acute myeloid leukemia 37 | 780
head and neck cancer and chronic obstructive pulmonary disease 37 | 237
Multiple myeloma 35 | 1,327
Alcohol dependence 34 | 107
Peripheral Neuropathy 34 | 303
Vascular disease 34 | 281
chronic lymphosyte leukemia 34 | 232
Allergic rhinitis 32 | 91
Human immunodeficiency virus infectious disease 32 | 92
Inflammatory bowel disease 32 | 142
Waldenstrons macroglobulinemia 32 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 499
hepatocellular carcinoma 32 | 532

Tissue

Female tissues 1,344 | 18,647
Urinary Tract 1,314 | 18,444
Nervous System 1,266 | 18,561
Endocrine System 1,259 | 18,512
Digestive Tract 1,236 | 18,473
Skin and soft tissues 1,189 | 18,115
Liver and Pancreas 1,115 | 18,136
Blood and immune system 1,095 | 17,995
Cardiovascular System 1,085 | 17,958
Male tissues 1,049 | 17,969
Respiratory system 1,021 | 17,484

Target Family

Non-IDG 448 | 11,971
oGPCR 421 | 421
GPCR 403 | 406
Ion Channel 69 | 341
Kinase 69 | 634
Nuclear Receptor 48 | 48
Enzyme 26 | 4,146
Transporter 10 | 473
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Receptor 1,496 | 1,496
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell receptor beta chain V region CTL-L17 TCRB Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region HPB-MLT N/A Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
T cell receptor gamma variable 3 TRGV3 Tdark Non-IDG 0.00000 0
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Interferon lambda receptor 1 IFNLR1 Tchem Non-IDG -1.48464 33.1 128