Development Level

Tdark 518 | 6,588
Tbio 492 | 11,445
Tchem 265 | 1,598
Tclin 227 | 613

Collection

GPCR: IDG Consortium (Targets) 124 | 126
RFA-RM-18-021 113 | 328
GPCR: IDG Consortium (Complete... 25 | 25
Ion Channel: IDG Consortium (T... 13 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 35 | 979
preweaning lethality, incomple... 31 | 499
decreased vertical activity 28 | 208
enlarged heart 22 | 210
abnormal behavior 17 | 298
abnormal bone structure 16 | 187
decreased total body fat amoun... 16 | 207
embryonic lethality prior to t... 15 | 278
abnormal heart morphology 14 | 162
abnormal seminal vesicle morph... 13 | 114
decreased bone mineral content 12 | 151
increased lean body mass 11 | 172
decreased heart weight 10 | 27
increased total body fat amoun... 10 | 134
abnormal embryo size 9 | 220
hyperactivity 9 | 148
improved glucose tolerance 9 | 79
increased bone mineral content 9 | 108
increased circulating choleste... 9 | 66
abnormal gait 8 | 69
abnormal kidney morphology 8 | 65
decreased body weight 8 | 161
decreased lean body mass 8 | 135
decreased startle reflex 8 | 75
embryonic lethality prior to o... 8 | 239
impaired glucose tolerance 8 | 75
increased or absent threshold ... 8 | 101
increased startle reflex 8 | 112
small superior vagus ganglion 8 | 74
abnormal epididymis morphology 7 | 42
abnormal eye morphology 7 | 68
decreased bone mineral density 7 | 126
decreased mean corpuscular vol... 7 | 79
decreased prepulse inhibition 7 | 82
increased circulating sodium l... 7 | 71
increased mean corpuscular vol... 7 | 92
prolonged QT interval 7 | 38
decreased circulating glucose ... 6 | 126
decreased lymphocyte cell numb... 6 | 83
female infertility 6 | 60
hypoactivity 6 | 132
increased circulating HDL chol... 6 | 80
increased circulating triglyce... 6 | 42
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
limb grasping 6 | 41
abnormal pericardium morpholog... 5 | 26
abnormal sleep behavior 5 | 70
cataract 5 | 92
decreased grip strength 5 | 116
decreased leukocyte cell numbe... 5 | 73
increased circulating alkaline... 5 | 122
increased circulating creatini... 5 | 38
increased fasted circulating g... 5 | 76
male infertility 5 | 123
prolonged ST segment 5 | 36
abnormal behavioral response t... 4 | 66
abnormal eye anterior chamber ... 4 | 9
abnormal skin morphology 4 | 50
cardiovascular system phenotyp... 4 | 36
decreased blood urea nitrogen ... 4 | 51
decreased circulating alanine ... 4 | 47
decreased fasted circulating g... 4 | 65
decreased mean corpuscular hem... 4 | 50
decreased neutrophil cell numb... 4 | 42
embryonic growth retardation 4 | 106
enlarged epididymis 4 | 31
increased bone mineral density 4 | 72
increased lymphocyte cell numb... 4 | 32
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
pale yolk sac 4 | 25
small testis 4 | 58
tremors 4 | 39
abnormal embryo turning 3 | 31
abnormal midbrain development 3 | 20
abnormal neural tube closure 3 | 46
abnormal skin coloration 3 | 25
abnormal spleen morphology 3 | 55
absent pinna reflex 3 | 23
decreased T cell number 3 | 15
decreased body length 3 | 101
decreased circulating alkaline... 3 | 46
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased hemoglobin content 3 | 68
enlarged lymph nodes 3 | 37
hydrometra 3 | 53
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating iron lev... 3 | 30
increased circulating total pr... 3 | 28
increased erythrocyte cell num... 3 | 39
increased heart weight 3 | 62
increased hematocrit 3 | 46
microphthalmia 3 | 26
pallor 3 | 34
short tibia 3 | 97

Disease

Carcinoma 1,095 | 11,493
psoriasis 489 | 6,694
osteosarcoma 476 | 7,950
ovarian cancer 409 | 8,520
medulloblastoma, large-cell 378 | 6,241
glioblastoma 355 | 5,792
lung cancer 355 | 4,740
atypical teratoid / rhabdoid tumor 296 | 5,112
lung carcinoma 293 | 2,843
Cancer 274 | 2,499
interstitial cystitis 264 | 2,312
ependymoma 261 | 4,679
adult high grade glioma 258 | 3,801
Astrocytoma, Pilocytic 238 | 3,081
Breast cancer 230 | 3,578
Kidney cancer 227 | 2,613
non-small cell lung cancer 225 | 2,890
invasive ductal carcinoma 224 | 2,951
lung adenocarcinoma 223 | 2,716
group 3 medulloblastoma 218 | 4,104
malignant mesothelioma 213 | 3,232
diabetes mellitus 196 | 1,728
ulcerative colitis 183 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 182 | 3,291
Schizophrenia 181 | 1,160
tuberculosis 175 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 173 | 2,955
pancreatic cancer 172 | 2,398
primitive neuroectodermal tumor 171 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 167 | 2,989
oligodendroglioma 165 | 2,850
pituitary cancer 154 | 1,972
ductal carcinoma in situ 147 | 1,745
astrocytic glioma 145 | 2,597
subependymal giant cell astrocytoma 139 | 2,287
cutaneous lupus erythematosus 137 | 1,057
Autosomal recessive predisposition 128 | 1,442
breast carcinoma 124 | 1,638
cystic fibrosis 116 | 1,696
Bipolar Disorder 111 | 666
colon cancer 109 | 1,478
Rheumatoid arthritis 97 | 1,191
group 4 medulloblastoma 96 | 1,855
adrenocortical carcinoma 95 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 91 | 1,962
Depressive disorder 90 | 409
Obesity 90 | 678
Pick disease 85 | 1,894
Melanoma 82 | 711
Epilepsy 79 | 792
astrocytoma 79 | 1,146
Multiple Sclerosis 78 | 540
Asthma 76 | 385
primary Sjogren syndrome 76 | 735
mucosa-associated lymphoid tissue lymphoma 73 | 484
Alcoholic Intoxication, Chronic 72 | 289
Mental Depression 71 | 333
Skin cancer 69 | 469
Alzheimer's disease 68 | 658
Atopic dermatitis 66 | 952
gastric carcinoma 66 | 807
Liver cancer 65 | 604
primary pancreatic ductal adenocarcinoma 63 | 1,109
Liver Cirrhosis, Experimental 62 | 769
Major Depressive Disorder 62 | 301
pediatric high grade glioma 61 | 1,064
Endometriosis 59 | 540
nasopharyngeal carcinoma 55 | 1,058
Autistic Disorder 53 | 364
Hypertension 53 | 396
Mood Disorders 53 | 184
esophageal adenocarcinoma 53 | 737
spina bifida 53 | 1,074
Hypersensitivity reaction type II disease 51 | 253
Intellectual disability 51 | 1,016
fibroadenoma 51 | 559
pancreatic carcinoma 51 | 562
Seizures 49 | 596
juvenile dermatomyositis 49 | 1,187
Atherosclerosis 48 | 291
active Crohn's disease 48 | 922
Kidney disease 47 | 430
Parkinson's disease 47 | 392
Unipolar Depression 47 | 250
acute quadriplegic myopathy 47 | 1,158
non primary Sjogren syndrome sicca 47 | 891
Breast Neoplasms 45 | 445
Duchenne muscular dystrophy 45 | 601
Prostatic Neoplasms 45 | 495
non-small cell lung carcinoma 45 | 317
Mammary Neoplasms 44 | 425
active ulcerative colitis 42 | 764
medulloblastoma 42 | 720
Dull intelligence 41 | 645
Low intelligence 41 | 645
Mental Retardation 41 | 645
Mental deficiency 41 | 645
Poor school performance 41 | 645
Cerebrovascular disease 40 | 238
dermatomyositis 40 | 966

Tissue

Endocrine System 1,093 | 18,159
Female tissues 991 | 17,400
Digestive Tract 973 | 17,369
Skin and soft tissues 956 | 17,230
Blood and immune system 953 | 16,909
Male tissues 950 | 17,142
Nervous System 937 | 16,725
Urinary Tract 911 | 16,678
Liver and Pancreas 908 | 16,750
Respiratory system 884 | 16,393
Cardiovascular System 788 | 15,192

Target Family

Non-IDG 451 | 12,091
oGPCR 421 | 421
GPCR 405 | 408
Kinase 70 | 634
Ion Channel 69 | 344
Nuclear Receptor 48 | 48
Enzyme 26 | 4,145
Transporter 10 | 473
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Receptor 1,502 | 1,502
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Sodium/bile acid cotransporter SLC10A1 Tchem Transporter -2.69150 476.1 163
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Fibrocystin-L PKHD1L1 Tdark Non-IDG -0.48112 3.05 17
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304