Development Level
Tdark | 518 | 6,588 | |
Tbio | 492 | 11,445 | |
Tchem | 265 | 1,598 | |
Tclin | 227 | 613 |
Collection
GPCR: IDG Consortium (Targets) | 124 | 126 | |
RFA-RM-18-021 | 113 | 328 | |
GPCR: IDG Consortium (Complete... | 25 | 25 | |
Ion Channel: IDG Consortium (T... | 13 | 99 | |
Kinase: IDG Consortium (Target... | 1 | 125 |
IMPC Phenotype
preweaning lethality, complete... | 35 | 979 | |
preweaning lethality, incomple... | 31 | 499 | |
decreased vertical activity | 28 | 208 | |
enlarged heart | 22 | 210 | |
abnormal behavior | 17 | 298 | |
abnormal bone structure | 16 | 187 | |
decreased total body fat amoun... | 16 | 207 | |
embryonic lethality prior to t... | 15 | 278 | |
abnormal heart morphology | 14 | 162 | |
abnormal seminal vesicle morph... | 13 | 114 | |
decreased bone mineral content | 12 | 151 | |
increased lean body mass | 11 | 172 | |
decreased heart weight | 10 | 27 | |
increased total body fat amoun... | 10 | 134 | |
abnormal embryo size | 9 | 220 | |
hyperactivity | 9 | 148 | |
improved glucose tolerance | 9 | 79 | |
increased bone mineral content | 9 | 108 | |
increased circulating choleste... | 9 | 66 | |
abnormal gait | 8 | 69 | |
abnormal kidney morphology | 8 | 65 | |
decreased body weight | 8 | 161 | |
decreased lean body mass | 8 | 135 | |
decreased startle reflex | 8 | 75 | |
embryonic lethality prior to o... | 8 | 239 | |
impaired glucose tolerance | 8 | 75 | |
increased or absent threshold ... | 8 | 101 | |
increased startle reflex | 8 | 112 | |
small superior vagus ganglion | 8 | 74 | |
abnormal epididymis morphology | 7 | 42 | |
abnormal eye morphology | 7 | 68 | |
decreased bone mineral density | 7 | 126 | |
decreased mean corpuscular vol... | 7 | 79 | |
decreased prepulse inhibition | 7 | 82 | |
increased circulating sodium l... | 7 | 71 | |
increased mean corpuscular vol... | 7 | 92 | |
prolonged QT interval | 7 | 38 | |
decreased circulating glucose ... | 6 | 126 | |
decreased lymphocyte cell numb... | 6 | 83 | |
female infertility | 6 | 60 | |
hypoactivity | 6 | 132 | |
increased circulating HDL chol... | 6 | 80 | |
increased circulating triglyce... | 6 | 42 | |
increased hemoglobin content | 6 | 45 | |
increased leukocyte cell numbe... | 6 | 47 | |
limb grasping | 6 | 41 | |
abnormal pericardium morpholog... | 5 | 26 | |
abnormal sleep behavior | 5 | 70 | |
cataract | 5 | 92 | |
decreased grip strength | 5 | 116 | |
decreased leukocyte cell numbe... | 5 | 73 | |
increased circulating alkaline... | 5 | 122 | |
increased circulating creatini... | 5 | 38 | |
increased fasted circulating g... | 5 | 76 | |
male infertility | 5 | 123 | |
prolonged ST segment | 5 | 36 | |
abnormal behavioral response t... | 4 | 66 | |
abnormal eye anterior chamber ... | 4 | 9 | |
abnormal skin morphology | 4 | 50 | |
cardiovascular system phenotyp... | 4 | 36 | |
decreased blood urea nitrogen ... | 4 | 51 | |
decreased circulating alanine ... | 4 | 47 | |
decreased fasted circulating g... | 4 | 65 | |
decreased mean corpuscular hem... | 4 | 50 | |
decreased neutrophil cell numb... | 4 | 42 | |
embryonic growth retardation | 4 | 106 | |
enlarged epididymis | 4 | 31 | |
increased bone mineral density | 4 | 72 | |
increased lymphocyte cell numb... | 4 | 32 | |
increased monocyte cell number | 4 | 63 | |
increased neutrophil cell numb... | 4 | 46 | |
pale yolk sac | 4 | 25 | |
small testis | 4 | 58 | |
tremors | 4 | 39 | |
abnormal embryo turning | 3 | 31 | |
abnormal midbrain development | 3 | 20 | |
abnormal neural tube closure | 3 | 46 | |
abnormal skin coloration | 3 | 25 | |
abnormal spleen morphology | 3 | 55 | |
absent pinna reflex | 3 | 23 | |
decreased T cell number | 3 | 15 | |
decreased body length | 3 | 101 | |
decreased circulating alkaline... | 3 | 46 | |
decreased circulating choleste... | 3 | 93 | |
decreased circulating creatini... | 3 | 39 | |
decreased circulating serum al... | 3 | 82 | |
decreased circulating triglyce... | 3 | 79 | |
decreased hemoglobin content | 3 | 68 | |
enlarged lymph nodes | 3 | 37 | |
hydrometra | 3 | 53 | |
increased circulating calcium ... | 3 | 34 | |
increased circulating chloride... | 3 | 41 | |
increased circulating iron lev... | 3 | 30 | |
increased circulating total pr... | 3 | 28 | |
increased erythrocyte cell num... | 3 | 39 | |
increased heart weight | 3 | 62 | |
increased hematocrit | 3 | 46 | |
microphthalmia | 3 | 26 | |
pallor | 3 | 34 | |
short tibia | 3 | 97 |
Disease
Tissue
Endocrine System | 1,093 | 18,159 | |
Female tissues | 991 | 17,400 | |
Digestive Tract | 973 | 17,369 | |
Skin and soft tissues | 956 | 17,230 | |
Blood and immune system | 953 | 16,909 | |
Male tissues | 950 | 17,142 | |
Nervous System | 937 | 16,725 | |
Urinary Tract | 911 | 16,678 | |
Liver and Pancreas | 908 | 16,750 | |
Respiratory system | 884 | 16,393 | |
Cardiovascular System | 788 | 15,192 |
Target Family
Non-IDG | 451 | 12,091 | |
oGPCR | 421 | 421 | |
GPCR | 405 | 408 | |
Kinase | 70 | 634 | |
Ion Channel | 69 | 344 | |
Nuclear Receptor | 48 | 48 | |
Enzyme | 26 | 4,145 | |
Transporter | 10 | 473 | |
Epigenetic | 1 | 242 | |
Transcription Factor | 1 | 1,400 |
UniProt Keyword
Receptor | 1,502 | 1,502 | |
Complete proteome | 20,231 | 20,231 | |
Reference proteome | 20,231 | 20,231 | |
Polymorphism | 12,194 | 12,194 | |
Alternative splicing | 10,528 | 10,528 | |
Phosphoprotein | 8,216 | 8,216 | |
Membrane | 7,361 | 7,361 | |
3D-structure | 6,226 | 6,226 | |
Nucleus | 5,259 | 5,259 | |
Transmembrane | 5,228 | 5,228 | |
Transmembrane helix | 5,207 | 5,207 | |
Cytoplasm | 4,952 | 4,952 | |
Repeat | 4,916 | 4,916 | |
Glycoprotein | 4,623 | 4,623 | |
Metal-binding | 3,672 | 3,672 | |
Disulfide bond | 3,599 | 3,599 | |
Signal | 3,561 | 3,561 | |
Acetylation | 3,409 | 3,409 | |
Cell membrane | 3,390 | 3,390 | |
Direct protein sequencing | 2,872 | 2,872 | |
Disease mutation | 2,804 | 2,804 | |
Ubl conjugation | 2,439 | 2,439 | |
Transcription | 2,402 | 2,402 | |
Zinc | 2,356 | 2,356 | |
Transcription regulation | 2,336 | 2,336 | |
Coiled coil | 2,153 | 2,153 | |
Secreted | 2,041 | 2,041 | |
DNA-binding | 2,008 | 2,008 | |
Transport | 1,985 | 1,985 | |
Zinc-finger | 1,785 | 1,785 | |
Transferase | 1,782 | 1,782 | |
Nucleotide-binding | 1,775 | 1,775 | |
Isopeptide bond | 1,739 | 1,739 | |
Hydrolase | 1,654 | 1,654 | |
ATP-binding | 1,380 | 1,380 | |
Cytoskeleton | 1,182 | 1,182 | |
Mitochondrion | 1,147 | 1,147 | |
Endoplasmic reticulum | 1,119 | 1,119 | |
Methylation | 973 | 973 | |
Developmental protein | 965 | 965 | |
Transducer | 887 | 887 | |
Calcium | 875 | 875 | |
Golgi apparatus | 838 | 838 | |
G-protein coupled receptor | 830 | 830 | |
Cell projection | 826 | 826 | |
Lipoprotein | 825 | 825 | |
Immunity | 717 | 717 | |
Cell junction | 709 | 709 | |
Differentiation | 703 | 703 | |
Ubl conjugation pathway | 684 | 684 | |
RNA-binding | 682 | 682 | |
Activator | 672 | 672 | |
Cell cycle | 647 | 647 | |
Kinase | 637 | 637 | |
Ion transport | 631 | 631 | |
Immunoglobulin domain | 625 | 625 | |
Protein transport | 612 | 612 | |
Repressor | 602 | 602 | |
Sensory transduction | 600 | 600 | |
Oxidoreductase | 571 | 571 | |
Magnesium | 558 | 558 | |
Transit peptide | 544 | 544 | |
Cytoplasmic vesicle | 535 | 535 | |
Protease | 535 | 535 | |
Apoptosis | 533 | 533 | |
Endosome | 525 | 525 | |
Cell adhesion | 482 | 482 | |
Host-virus interaction | 472 | 472 | |
Signal-anchor | 458 | 458 | |
Olfaction | 435 | 435 | |
Lipid metabolism | 432 | 432 | |
Chromosome | 388 | 388 | |
Serine-threonine-protein kinas... | 388 | 388 | |
Cell division | 383 | 383 | |
Synapse | 378 | 378 | |
DNA damage | 366 | 366 | |
Mental retardation | 362 | 362 | |
Ion channel | 348 | 348 | |
mRNA processing | 340 | 340 | |
GTP-binding | 339 | 339 | |
Palmitate | 331 | 331 | |
Chromosomal rearrangement | 324 | 324 | |
Iron | 319 | 319 | |
Neurodegeneration | 318 | 318 | |
Leucine-rich repeat | 312 | 312 | |
DNA repair | 306 | 306 | |
Lysosome | 301 | 301 | |
Cleavage on pair of basic resi... | 298 | 298 | |
Innate immunity | 291 | 291 | |
Chromatin regulator | 290 | 290 | |
Ribonucleoprotein | 286 | 286 | |
Microtubule | 281 | 281 | |
Adaptive immunity | 280 | 280 | |
WD repeat | 277 | 277 | |
Mitochondrion inner membrane | 276 | 276 | |
Mitosis | 273 | 273 | |
Actin-binding | 272 | 272 | |
mRNA splicing | 264 | 264 | |
Neurogenesis | 260 | 260 | |
ANK repeat | 258 | 258 |
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