Development Level

Tdark 10 | 6,588
Tbio 1 | 11,445
Tchem 1 | 1,598

Disease

Abnormal blistering of the skin 1 | 54
Abnormality of female internal genitalia 1 | 13
Abnormality of the fingernails 1 | 51
Abnormality of the lymphatic system 1 | 14
Abnormality of the pharynx 1 | 19
Adenocarcinoma 1 | 122
Anemia, Aplastic 1 | 7
Anorectal Malformations 1 | 8
Aplasia/Hypoplasia of the skin 1 | 16
Aplastic Anemia 1 | 21
Aplastic anemia, idiopathic 1 | 4
Atrophic condition of skin 1 | 25
Basal cell carcinoma 1 | 54
Blister of skin 1 | 54
Bone marrow hypocellularity 1 | 20
Brain cancer 1 | 30
Bronchioloalveolar Adenocarcinoma 1 | 14
Carcinoma, Basal Cell 1 | 28
Carcinoma, Non-Small-Cell Lung 1 | 107
Cholangiocarcinoma 1 | 35
Clear cell sarcoma of kidney 1 | 6
Cri-Du-Chat syndrome 1 | 16
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 1 | 2
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2 1 | 1
Dental caries 1 | 164
Dry skin 1 | 75
Dyskeratosis congenita 1 | 24
Dyskeratosis congenita autosomal dominant 1 | 3
Dyskeratosis congenita autosomal recessive 1 1 | 3
Dyspnea on exertion 1 | 24
Early tooth exfoliation 1 | 17
Esophageal Stenosis 1 | 15
Esophagitis 1 | 35
Excessive wrinkled skin 1 | 16
Freckles 1 | 33
Generalized hyperpigmentation 1 | 22
Generalized hypopigmentation of hair 1 | 5
Gingival Diseases 1 | 19
Glioma 1 | 74
Globulin gamma serum plasma increased result 1 | 9
HOYERAAL-HREIDARSSON SYNDROME 1 | 6
Hair shaft abnormalities 1 | 30
Hereditary Melanoma 1 | 12
Hoyeraal Hreidarsson syndrome 1 | 1
Hypergammaglobulinemia 1 | 10
Hyperglobulinemia 1 | 9
Hyperpigmented macules 1 | 42
Hypodontia 1 | 81
Hypoplastic-absent toenails 1 | 11
Idiopathic pulmonary arterial hypertension 1 | 40
Idiopathic pulmonary fibrosis 1 | 23
Immunologic Deficiency Syndromes 1 | 113
Large elongated pulp chamber 1 | 14
Leukemia, Lymphoid 1 | 8
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 | 20
Leukokeratosis 1 | 19
Leukoplakia, Oral 1 | 20
Lupus Erythematosus, Systemic 1 | 67
Lymphatic Diseases 1 | 14
Lymphoid leukemia 1 | 160
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 9 1 | 1
Malignant glioma 1 | 26
Myeloid Leukemia, Chronic 1 | 23
Neoplasms 1 | 63
Nevus 1 | 19
Ovarian Neoplasms 1 | 102
PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 1 1 | 1
Periodontal Diseases 1 | 21
Pitting of nails 1 | 6
Pneumonia, Interstitial 1 | 5
Premature canities 1 | 24
Premature tooth loss 1 | 17
Pulmonary Fibrosis 1 | 106
Pulmonary Fibrosis, Idiopathic 1 | 12
Pulmonary hypertension 1 | 85
Raised level of immunoglobulins NOS 1 | 9
Reticulate hyperpigmentation 1 | 5
Ridged nails 1 | 14
Rotting teeth 1 | 73
Rough bone trabeculation 1 | 11
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Sparse scalp hair 1 | 42
Squamous cell carcinoma of skin 1 | 11
Taurodontism 1 | 14
Telangiectasia of the skin 1 | 39
Testicular cancer 1 | 25
Thyroid Neoplasm 1 | 37
Thyroid Neoplasms 1 | 34
Tracheoesophageal Fistula 1 | 36
Urethral Stricture 1 | 18
Xerosis 1 | 75
familial melanoma 1 | 10
gamma globulins increased 1 | 9
hair abnormalities (non-specific) 1 | 30
hypopigmented skin patch 1 | 59
interstitial lung disease 1 | 298
non-small cell lung carcinoma 1 | 317
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 1 | 16,909
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159

Target Family

Enzyme 10 | 4,145
Non-IDG 2 | 12,091

UniProt Keyword

RNA-directed DNA polymerase 12 | 12
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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