Development Level

Tbio 7 | 11,445
Tchem 2 | 1,598

Disease

Carcinoma 8 | 11,493
invasive ductal carcinoma 6 | 2,951
medulloblastoma, large-cell 5 | 6,241
ovarian cancer 5 | 8,520
Autosomal recessive predisposition 4 | 1,442
atypical teratoid / rhabdoid tumor 4 | 5,112
ductal carcinoma in situ 4 | 1,745
lung adenocarcinoma 4 | 2,716
osteosarcoma 4 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
Acidosis, Lactic 3 | 97
Lactic acidosis 3 | 51
Pyruvate decarboxylase deficiency 3 | 16
breast carcinoma 3 | 1,638
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
Anemia 2 | 365
Cancer 2 | 2,499
Cholelithiasis 2 | 33
Chronic hemolytic anemia 2 | 3
Cognitive delay 2 | 608
Congenital hemolytic anemia 2 | 32
Dull intelligence 2 | 645
Epilepsy 2 | 792
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Hyper-beta-alaninemia 2 | 9
Icterus 2 | 82
Increased blood alanine 2 | 9
Increased serum alanine 2 | 9
Increased serum lactate 2 | 60
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Lactic acidemia 2 | 95
Leigh disease 2 | 100
Liver Cirrhosis, Experimental 2 | 769
Low intelligence 2 | 645
Malaria 2 | 160
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Osteoporosis 2 | 363
Polycythemia 2 | 25
Poor school performance 2 | 645
Pyruvate Dehydrogenase Complex Deficiency Disease 2 | 2
Reticulocytosis 2 | 20
Seizures 2 | 596
Splenomegaly 2 | 190
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
ependymoma 2 | 4,679
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
pancreatic cancer 2 | 2,398
Abnormal amniotic fluid 1 | 6
Abnormality of the spleen 1 | 13
Adenosine Triphosphate, Elevated, Of Erythrocytes 1 | 1
Alpha thalassemia 1 | 10
Apneic episodes precipitated by illness, fatigue, stress 1 | 3
Atrichia with papular lesions 1 | 9
Autoimmune lymphoproliferative syndrome type 2B 1 | 9
Biotinidase deficiency 1 | 14
Choreoathetoid movements 1 | 32
Choreoathetosis 1 | 32
Clonus 1 | 18
Deficiency of pyruvate kinase 1 | 1
Foetal haemoglobin increased 1 | 7
Generalized hypotonia 1 | 37
Glucosephosphate dehydrogenase deficiency 1 | 15
Hemochromatosis 1 | 54
Holocarboxylase synthetase deficiency 1 | 6
Hyperferritinaemia 1 | 14
Hyperplasia of malar bones 1 | 4
Increased ferritin 1 | 14
Increased red cell osmotic fragility 1 | 4
Infection of bone 1 | 19
Iron deficiency anemia 1 | 12
Kernicterus 1 | 11
Leukocytosis 1 | 17
Malaria, Falciparum 1 | 3
Methemoglobinemia 1 | 17
Microcytic hypochromic anemia (disorder) 1 | 10
Priapism 1 | 5
Primary cutaneous amyloidosis 1 | 29
Prominent midface 1 | 4
Pyruvate kinase deficiency of red cells 1 | 1
Reduced erythrocyte 2,3-diphosphoglycerate concentration 1 | 2
Secondary progressive multiple sclerosis 1 | 10
Serum ferritin increased 1 | 14
Sleeping sickness 1 | 37
Splenic infarction 1 | 6
Susceptibility to viral and mycobacterial infections 1 | 11
Unconjugated hyperbilirubinemia 1 | 4
beta-Thalassemia 1 | 10

Tissue

Endocrine System 9 | 18,159
Blood and immune system 8 | 16,909
Digestive Tract 8 | 17,369
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Cardiovascular System 7 | 15,192
Female tissues 7 | 17,400
Respiratory system 7 | 16,393

Target Family

Enzyme 6 | 4,145
Kinase 2 | 634
Non-IDG 1 | 12,091

UniProt Keyword

Pyruvate 9 | 9
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.21826 1586.8 141
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749
Pyruvate carboxylase, mitochondrial PC Tbio Enzyme -2.57922 361.7 238
Phosphatidylserine decarboxylase proenzyme, mitochondrial PISD Tbio Enzyme -1.98575 94.1 143
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial PDHA2 Tbio Enzyme -1.11924 13.9 89
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB Tbio Enzyme -1.71672 48.4 149
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1 Tbio Enzyme -2.31887 204.2 436
Hemoglobin subunit beta HBB Tbio Non-IDG -3.58028 3708.1 236