Development Level

Tbio 8 | 11,445
Tchem 3 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydroencephaly 1 | 14
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979

Disease

glioblastoma 6 | 5,792
ovarian cancer 6 | 8,520
osteosarcoma 5 | 7,950
Pellagra 4 | 26
adult high grade glioma 4 | 3,801
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Carcinoma 3 | 11,493
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung carcinoma 3 | 2,843
medulloblastoma, large-cell 3 | 6,241
subependymal giant cell astrocytoma 3 | 2,287
Breast cancer 2 | 3,578
Dermatitis, Allergic Contact 2 | 67
Liver Cirrhosis, Experimental 2 | 769
Macular degeneration 2 | 65
Major Depressive Disorder 2 | 301
Pick disease 2 | 1,894
Polycystic ovary syndrome 2 | 360
Unipolar Depression 2 | 250
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
group 4 medulloblastoma 2 | 1,855
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
ulcerative colitis 2 | 1,819
urothelial carcinoma 2 | 318
Arthritis 1 | 290
Atherosclerosis 1 | 291
Atopic dermatitis 1 | 952
Attention deficit hyperactivity disorder 1 | 278
Blindness 1 | 88
Cancer 1 | 2,499
Colitis 1 | 54
Colorectal Neoplasms 1 | 243
Comatose 1 | 56
Congenital deafness 1 | 185
Deafness 1 | 198
Down syndrome 1 | 499
Fatty liver disease 1 | 103
Fundus dystrophy 1 | 83
Hearing Loss, Partial 1 | 185
Huntington's disease 1 | 76
Hyperandrogenism 1 | 34
Hypertension 1 | 396
Inflammation 1 | 120
Leber congenital amaurosis 1 | 69
Mouth Neoplasms 1 | 55
Multiple Sclerosis 1 | 540
Muscle Hypertonia 1 | 88
Narcolepsy 1 | 72
Neurodegenerative Disorders 1 | 79
Rectal prolapse 1 | 19
Retinal Degeneration 1 | 106
Systemic lupus erythematosus 1 | 194
Tachycardia 1 | 43
Type 2 diabetes mellitus 1 | 272
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute myeloid leukemia 1 | 783
acute quadriplegic myopathy 1 | 1,158
aldosterone-producing adenoma 1 | 665
chronic lymphosyte leukemia 1 | 204
chronic rhinosinusitis 1 | 512
dermatomyositis 1 | 966
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 559
head and neck cancer 1 | 271
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
hearing impairment 1 | 199
hepatocellular carcinoma 1 | 547
interstitial lung disease 1 | 298
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
mucosa-associated lymphoid tissue lymphoma 1 | 484
nephrosclerosis 1 | 333
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
posterior fossa group A ependymoma 1 | 468
primary pancreatic ductal adenocarcinoma 1 | 1,109
progressive supranuclear palsy 1 | 676

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Nervous System 11 | 16,725

Target Family

Enzyme 10 | 4,145
Kinase 2 | 634

UniProt Keyword

Pyridine nucleotide biosynthes... 12 | 12
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 NMNAT2 Tbio Enzyme -1.54038 36.0 111
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173
3-hydroxyanthranilate 3,4-dioxygenase HAAO Tbio Enzyme -1.76359 56.1 114
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Putative L-aspartate dehydrogenase ASPDH Tdark Enzyme -0.74689 5.85 36
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31765 20.1 141
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.15501 134.1 127
Nicotinate phosphoribosyltransferase NAPRT Tbio Enzyme -1.26235 18.2 103
Nicotinamide riboside kinase 2 NMRK2 Tbio Kinase -1.91893 79.0 77