Development Level

Tbio 163 | 11,651
Tchem 32 | 1,388
Tclin 27 | 612
Tdark 10 | 6,593

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
decreased leukocyte cell numbe... 7 | 73
decreased vertical activity 7 | 208
preweaning lethality, incomple... 7 | 499
abnormal embryo size 6 | 220
abnormal bone structure 5 | 187
abnormal seminal vesicle morph... 5 | 114
impaired glucose tolerance 5 | 75
abnormal behavior 4 | 298
decreased lymphocyte cell numb... 4 | 83
enlarged heart 4 | 210
hyperactivity 4 | 148
increased lean body mass 4 | 172
increased startle reflex 4 | 112
thrombocytopenia 4 | 56
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased prepulse inhibition 3 | 82
decreased total body fat amoun... 3 | 207
increased circulating HDL chol... 3 | 80
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
edema 2 | 59
embryonic lethality prior to t... 2 | 278
enlarged seminal vesicle 2 | 10
female infertility 2 | 60
increased blood urea nitrogen ... 2 | 48
increased circulating LDL chol... 2 | 13
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
male infertility 2 | 123
prenatal lethality 2 | 28
small spleen 2 | 19
thrombocytosis 2 | 27
tremors 2 | 39
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
microphthalmia 1 | 26
pallor 1 | 34
small kidney 1 | 16
small testis 1 | 58
thin ventricular wall 1 | 24
trunk curl 1 | 16

Disease

Cancer 229 | 2,499
Carcinoma 166 | 11,493
ovarian cancer 147 | 8,520
osteosarcoma 141 | 7,950
glioblastoma 110 | 5,792
medulloblastoma, large-cell 107 | 6,241
psoriasis 107 | 6,694
lung cancer 106 | 4,740
Breast cancer 94 | 3,578
atypical teratoid / rhabdoid tumor 80 | 5,112
group 3 medulloblastoma 72 | 4,104
ependymoma 67 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 64 | 2,989
lung adenocarcinoma 64 | 2,716
invasive ductal carcinoma 63 | 2,951
non-small cell lung cancer 63 | 2,890
malignant mesothelioma 62 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,291
Kidney cancer 57 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
pancreatic cancer 55 | 2,398
adult high grade glioma 54 | 3,801
primitive neuroectodermal tumor 54 | 3,035
subependymal giant cell astrocytoma 52 | 2,287
oligodendroglioma 49 | 2,850
tuberculosis 47 | 2,010
Astrocytoma, Pilocytic 46 | 3,081
lung carcinoma 46 | 2,843
astrocytic glioma 45 | 2,597
pituitary cancer 44 | 1,972
breast carcinoma 39 | 1,638
interstitial cystitis 39 | 2,312
ulcerative colitis 38 | 1,819
colon cancer 37 | 1,478
adrenocortical carcinoma 35 | 1,428
Breast Neoplasms 34 | 445
astrocytoma 34 | 1,146
Rheumatoid arthritis 33 | 1,191
Mammary Neoplasms 32 | 425
Pick disease 32 | 1,894
Multiple myeloma 31 | 1,332
ductal carcinoma in situ 31 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
Leukemia, Myelocytic, Acute 29 | 120
acute quadriplegic myopathy 29 | 1,158
group 4 medulloblastoma 29 | 1,855
cutaneous lupus erythematosus 28 | 1,057
juvenile dermatomyositis 28 | 1,187
cystic fibrosis 27 | 1,696
Autosomal recessive predisposition 25 | 1,442
Intellectual disability 25 | 1,016
Schizophrenia 25 | 1,160
Prostatic Neoplasms 24 | 495
Waldenstrons macroglobulinemia 24 | 765
pediatric high grade glioma 24 | 1,064
primary Sjogren syndrome 24 | 735
spina bifida 24 | 1,074
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
primary pancreatic ductal adenocarcinoma 23 | 1,109
Atopic dermatitis 22 | 952
Leukemia 22 | 104
Renal Cell Carcinoma 22 | 214
Stomach Neoplasms 22 | 300
acute myeloid leukemia 22 | 783
diabetes mellitus 22 | 1,728
Melanoma 21 | 711
Somatic mutation 21 | 61
dermatomyositis 21 | 966
Leukemia, Myeloid, Acute 20 | 105
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Immune system cancer 19 | 140
Mental and motor retardation 19 | 608
Orbital separation excessive 19 | 244
aldosterone-producing adenoma 19 | 665
Liver carcinoma 18 | 240
Lymphoid leukemia 18 | 160
gastric carcinoma 18 | 807
Carcinoma, Hepatocellular 17 | 228
Downward slant of palpebral fissure 17 | 158
Liver Cirrhosis, Experimental 17 | 769
Lung Neoplasms 17 | 232
Obesity 17 | 678
Short stature 17 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 510
Chronic Lymphocytic Leukemia 16 | 262
Hypoplastic mandible condyle 16 | 275
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
Papillary thyroid carcinoma 16 | 43
Splenomegaly 16 | 190
Bipolar Disorder 15 | 666
Epilepsy 15 | 792
Precursor Cell Lymphoblastic Leukemia-Lymphoma 15 | 49
gastric cancer 15 | 459
nasopharyngeal carcinoma 15 | 1,058

Tissue

Endocrine System 226 | 18,159
Digestive Tract 223 | 17,369
Female tissues 223 | 17,400
Male tissues 222 | 17,142
Skin and soft tissues 222 | 17,230
Nervous System 219 | 16,725
Blood and immune system 218 | 16,909
Urinary Tract 217 | 16,678
Liver and Pancreas 216 | 16,750
Respiratory system 214 | 16,393
Cardiovascular System 207 | 15,192

Target Family

Non-IDG 102 | 12,091
Transcription Factor 52 | 1,400
Kinase 41 | 634
Enzyme 24 | 4,145
Epigenetic 7 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38
GPCR 1 | 408

UniProt Keyword

Proto-oncogene 232 | 232
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Nuclear receptor coactivator 4 NCOA4 Tbio Non-IDG -2.20245 136.0 283
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
T-cell leukemia/lymphoma protein 1B TCL1B Tdark Non-IDG -1.17863 16.3 34
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.61667 619.4 476
Protein C-ets-2 ETS2 Tbio Transcription Factor -2.40902 253.3 272
NCK-interacting protein with SH3 domain NCKIPSD Tbio Non-IDG -1.01986 16.6 99
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS Tbio Non-IDG -2.63356 1389.7 509
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Protein kinase C iota type PRKCI Tchem Kinase -1.71694 51.2 148