Development Level

Tbio 474 | 10,625
Tdark 113 | 7,003
Tchem 17 | 1,890

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 45 | 633
embryonic lethality prior to t... 12 | 187
abnormal behavior 11 | 226
decreased total body fat amoun... 10 | 186
embryonic lethality prior to o... 10 | 148
increased circulating alkaline... 10 | 119
decreased bone mineral content 9 | 157
increased mean corpuscular hem... 9 | 93
decreased circulating glucose ... 8 | 121
decreased lean body mass 8 | 195
increased or absent threshold ... 8 | 128
preweaning lethality, incomple... 8 | 260
abnormal retina morphology 7 | 100
abnormal retinal pigmentation 7 | 61
decreased circulating choleste... 7 | 85
decreased circulating triglyce... 7 | 83
hyperactivity 7 | 108
abnormal bone structure 6 | 131
abnormal embryo size 6 | 112
decreased bone mineral density 6 | 126
decreased circulating insulin ... 6 | 75
decreased grip strength 6 | 123
increased grip strength 6 | 83
short tibia 6 | 82
abnormal lens morphology 5 | 73
decreased body length 5 | 108
decreased body weight 5 | 174
decreased circulating HDL chol... 5 | 77
decreased circulating serum al... 5 | 79
increased circulating HDL chol... 5 | 63
increased lean body mass 5 | 107
increased mean corpuscular vol... 5 | 91
increased prepulse inhibition 5 | 21
increased sacral vertebrae num... 5 | 62
prenatal lethality prior to he... 5 | 64
decreased circulating LDL chol... 4 | 37
decreased circulating free fat... 4 | 39
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular hem... 4 | 34
decreased rib number 4 | 59
enlarged heart 4 | 111
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased fasted circulating g... 4 | 68
limb grasping 4 | 35
abnormal body wall morphology 3 | 7
abnormal sleep behavior 3 | 63
abnormal vertebrae morphology 3 | 14
absent pinna reflex 3 | 21
cardiovascular system phenotyp... 3 | 35
decreased CD8-positive, alpha-... 3 | 26
decreased Ly6C low monocyte nu... 3 | 23
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased circulating alanine ... 3 | 53
decreased effector memory CD8-... 3 | 24
decreased fasted circulating g... 3 | 49
decreased gamma-delta T cell n... 3 | 18
decreased mean corpuscular vol... 3 | 50
decreased monocyte cell number 3 | 28
decreased total retina thickne... 3 | 20
enlarged spleen 3 | 26
impaired glucose tolerance 3 | 52
increased B cell number 3 | 23
increased Ly6C high monocyte n... 3 | 12
increased bone mineral density 3 | 52
increased circulating choleste... 3 | 53
increased circulating free fat... 3 | 17
increased circulating serum al... 3 | 25
increased circulating sodium l... 3 | 71
increased erythrocyte cell num... 3 | 26
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
straub tail 3 | 26
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal cranium morphology 2 | 32
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal neural tube closure 2 | 37
abnormal retinal inner nuclear... 2 | 5
abnormal spleen morphology 2 | 36
abnormal testis morphology 2 | 30
abnormal thoracic vertebrae mo... 2 | 16
decreased NK cell number 2 | 16
decreased alpha-beta T cell nu... 2 | 12
decreased caudal vertebrae num... 2 | 49
decreased circulating potassiu... 2 | 17
decreased heart rate variabili... 2 | 11
decreased neutrophil cell numb... 2 | 37
increased CD4-positive, CD25-p... 2 | 18
increased body weight 2 | 42
increased circulating aspartat... 2 | 17
increased circulating chloride... 2 | 43
increased circulating glucose ... 2 | 16
increased circulating potassiu... 2 | 31
increased heart weight 2 | 37
increased mean corpuscular hem... 2 | 25

Disease

ovarian cancer 374 | 8,484
osteosarcoma 292 | 7,933
medulloblastoma, large-cell 235 | 6,234
glioblastoma 210 | 5,572
psoriasis 203 | 6,685
atypical teratoid / rhabdoid tumor 163 | 4,369
lung cancer 153 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 103 | 3,289
oligodendroglioma 103 | 2,849
Breast cancer 102 | 3,094
pediatric high grade glioma 100 | 2,712
pilocytic astrocytoma 100 | 3,086
primitive neuroectodermal tumor 99 | 3,031
ependymoma 95 | 2,514
malignant mesothelioma 92 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 91 | 2,956
invasive ductal carcinoma 91 | 2,950
astrocytic glioma 90 | 2,241
Pick disease 87 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 84 | 2,988
Multiple myeloma 82 | 1,327
non-small cell lung cancer 81 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 75 | 1,795
group 3 medulloblastoma 72 | 2,254
subependymal giant cell astrocytoma 72 | 2,287
group 4 medulloblastoma 71 | 1,875
lung carcinoma 66 | 2,844
pancreatic cancer 65 | 2,300
lung adenocarcinoma 64 | 2,713
Carcinoma 62 | 2,147
astrocytoma 60 | 1,493
adult high grade glioma 59 | 2,148
ulcerative colitis 58 | 2,087
medulloblastoma 57 | 1,524
acute quadriplegic myopathy 56 | 1,157
tuberculosis 55 | 1,557
diabetes mellitus 54 | 1,663
dermatomyositis 52 | 933
interstitial cystitis 48 | 2,299
posterior fossa group B ependymoma 48 | 1,530
breast carcinoma 47 | 1,614
juvenile dermatomyositis 47 | 1,189
colon cancer 43 | 1,475
pituitary cancer 43 | 1,972
ductal carcinoma in situ 42 | 1,745
sonic hedgehog group medulloblastoma 42 | 1,482
Rheumatoid Arthritis 40 | 1,160
primary pancreatic ductal adenocarcinoma 39 | 1,271
posterior fossa group A ependymoma 38 | 1,511
Waldenstrons macroglobulinemia 37 | 765
Cancer 34 | 2,346
progressive supranuclear palsy 34 | 674
non primary Sjogren syndrome sicca 33 | 840
spina bifida 33 | 1,064
acute myeloid leukemia 32 | 780
cystic fibrosis 31 | 1,665
tuberculosis and treatment for 6 months 31 | 686
adrenocortical carcinoma 30 | 1,427
pancreatic carcinoma 29 | 567
Intellectual disability 27 | 573
active Crohn's disease 27 | 918
atypical teratoid/rhabdoid tumor 27 | 1,095
Alzheimer's disease 25 | 644
IGA Glomerulonephritis 25 | 454
gastric carcinoma 24 | 832
aldosterone-producing adenoma 22 | 664
cutaneous lupus erythematosus 22 | 1,056
Obesity 20 | 616
hepatocellular carcinoma 20 | 532
hereditary spastic paraplegia 20 | 313
Atopic dermatitis 19 | 944
Neurodegenerative disease 18 | 383
gastric cancer 17 | 430
Gaucher disease type 1 16 | 171
active ulcerative colitis 16 | 477
esophageal adenocarcinoma 16 | 737
primary Sjogren syndrome 16 | 789
nasopharyngeal carcinoma 15 | 1,056
Ciliopathy 14 | 57
Hermansky-Pudlak syndrome 14 | 43
Parkinson's disease 14 | 364
Down syndrome 13 | 548
Duchenne muscular dystrophy 13 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
Bardet-Biedl Syndrome 12 | 40
Polycystic Ovary Syndrome 12 | 332
Polydactyly 12 | 93
mucosa-associated lymphoid tissue lymphoma 12 | 480
Amyotrophic Lateral Sclerosis 11 | 431
Retinitis pigmentosa 11 | 153
head and neck cancer and chronic obstructive pulmonary disease 11 | 237
inflammatory breast cancer 11 | 404
tuberculosis and treatment for 3 months 11 | 327
Multiple Sclerosis 10 | 498
Paraplegia 10 | 71
interstitial lung disease 10 | 291
Autistic Disorder 9 | 320
Cardiovascular system disease 9 | 194
Crohn's disease 9 | 304
Schizophrenia 9 | 501

Tissue

Nervous System 601 | 18,561
Cardiovascular System 600 | 17,958
Digestive Tract 600 | 18,473
Endocrine System 600 | 18,512
Female tissues 600 | 18,647
Liver and Pancreas 600 | 18,136
Male tissues 600 | 17,969
Blood and immune system 599 | 17,995
Urinary Tract 599 | 18,444
Respiratory system 598 | 17,484
Skin and soft tissues 593 | 18,115

Target Family

Non-IDG 474 | 11,971
Enzyme 115 | 4,146
Transporter 7 | 473
Transcription Factor 3 | 1,400
Ion Channel 2 | 341
Kinase 2 | 634
Epigenetic 1 | 242

UniProt Keyword

Protein transport 604 | 604
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
A-kinase anchor protein 8 AKAP8 Tbio Enzyme -1.32097 22.6 240
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Cysteine protease ATG4A ATG4A Tbio Enzyme -0.98696 7.89 199