Development Level

Tbio 504 | 11,445
Tdark 99 | 6,588
Tchem 9 | 1,598

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 72 | 979
preweaning lethality, incomple... 25 | 499
embryonic lethality prior to o... 16 | 239
abnormal behavior 15 | 298
embryonic lethality prior to t... 15 | 278
abnormal embryo size 12 | 220
decreased total body fat amoun... 12 | 207
decreased bone mineral content 10 | 151
hyperactivity 9 | 148
increased mean corpuscular hem... 9 | 96
increased circulating alkaline... 8 | 122
increased lean body mass 8 | 172
decreased bone mineral density 7 | 126
decreased circulating choleste... 7 | 93
decreased circulating glucose ... 7 | 126
increased or absent threshold ... 7 | 101
abnormal bone structure 6 | 187
cataract 6 | 92
decreased body weight 6 | 161
decreased circulating insulin ... 6 | 76
decreased circulating triglyce... 6 | 79
decreased grip strength 6 | 116
decreased vertical activity 6 | 208
enlarged heart 6 | 210
increased bone mineral content 6 | 108
abnormal heart morphology 5 | 162
abnormal lens morphology 5 | 81
abnormal retina morphology 5 | 71
abnormal seminal vesicle morph... 5 | 114
abnormal sleep behavior 5 | 70
decreased circulating serum al... 5 | 82
decreased mean corpuscular hem... 5 | 50
edema 5 | 59
increased bone mineral density 5 | 72
increased fasted circulating g... 5 | 76
increased mean corpuscular vol... 5 | 92
prenatal lethality prior to he... 5 | 87
thrombocytopenia 5 | 56
abnormal craniofacial morpholo... 4 | 33
abnormal kidney morphology 4 | 65
absent pinna reflex 4 | 23
decreased blood urea nitrogen ... 4 | 51
decreased caudal vertebrae num... 4 | 53
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased fasted circulating g... 4 | 65
decreased red blood cell distr... 4 | 41
embryonic growth retardation 4 | 106
hypoactivity 4 | 132
increased circulating HDL chol... 4 | 80
increased circulating free fat... 4 | 20
increased circulating serum al... 4 | 22
increased prepulse inhibition 4 | 32
increased total body fat amoun... 4 | 134
limb grasping 4 | 41
short tibia 4 | 97
abnormal behavioral response t... 3 | 66
abnormal body wall morphology 3 | 9
abnormal joint morphology 3 | 23
abnormal vertebrae morphology 3 | 18
decreased body length 3 | 101
decreased circulating amylase ... 3 | 28
decreased circulating free fat... 3 | 31
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
enlarged spleen 3 | 41
impaired glucose tolerance 3 | 75
increased circulating choleste... 3 | 66
increased circulating sodium l... 3 | 71
increased grip strength 3 | 41
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 36
increased startle reflex 3 | 112
pallor 3 | 34
prenatal lethality 3 | 28
syndactyly 3 | 23
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal liver morphology 2 | 17
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased circulating potassiu... 2 | 20
decreased hematocrit 2 | 46
decreased prepulse inhibition 2 | 82
impaired pupillary reflex 2 | 26
increased anti-nuclear antigen... 2 | 19
increased circulating aspartat... 2 | 15
increased circulating fructosa... 2 | 13
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
microphthalmia 2 | 26
small testis 2 | 58
tremors 2 | 39

Disease

ovarian cancer 380 | 8,520
Carcinoma 360 | 11,493
osteosarcoma 295 | 7,950
medulloblastoma, large-cell 240 | 6,241
glioblastoma 217 | 5,792
psoriasis 205 | 6,694
atypical teratoid / rhabdoid tumor 186 | 5,112
ependymoma 161 | 4,679
lung cancer 156 | 4,740
group 3 medulloblastoma 131 | 4,104
adult high grade glioma 122 | 3,801
Breast cancer 116 | 3,578
astrocytic glioma 105 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 105 | 3,291
oligodendroglioma 105 | 2,850
Astrocytoma, Pilocytic 100 | 3,081
primitive neuroectodermal tumor 100 | 3,035
invasive ductal carcinoma 94 | 2,951
malignant mesothelioma 94 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 92 | 2,955
Pick disease 89 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,989
Kidney cancer 84 | 2,613
non-small cell lung cancer 84 | 2,890
Multiple myeloma 82 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 78 | 1,962
tuberculosis 76 | 2,010
group 4 medulloblastoma 73 | 1,855
subependymal giant cell astrocytoma 73 | 2,287
lung carcinoma 68 | 2,843
pancreatic cancer 66 | 2,398
lung adenocarcinoma 64 | 2,716
Autosomal recessive predisposition 57 | 1,442
acute quadriplegic myopathy 56 | 1,158
diabetes mellitus 56 | 1,728
dermatomyositis 55 | 966
breast carcinoma 51 | 1,638
ulcerative colitis 51 | 1,819
interstitial cystitis 49 | 2,312
juvenile dermatomyositis 49 | 1,187
astrocytoma 47 | 1,146
colon cancer 44 | 1,478
ductal carcinoma in situ 44 | 1,745
pituitary cancer 44 | 1,972
Intellectual disability 43 | 1,016
pediatric high grade glioma 40 | 1,064
Rheumatoid arthritis 39 | 1,191
Cancer 37 | 2,499
Waldenstrons macroglobulinemia 37 | 765
primary pancreatic ductal adenocarcinoma 37 | 1,109
Cognitive delay 35 | 608
Global developmental delay 35 | 608
Mental and motor retardation 35 | 608
progressive supranuclear palsy 34 | 676
spina bifida 34 | 1,074
acute myeloid leukemia 33 | 783
non primary Sjogren syndrome sicca 33 | 891
adrenocortical carcinoma 32 | 1,428
cystic fibrosis 31 | 1,696
active Crohn's disease 29 | 922
pancreatic carcinoma 29 | 562
Short stature 27 | 531
medulloblastoma 27 | 720
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
Schizophrenia 26 | 1,160
active ulcerative colitis 24 | 764
gastric carcinoma 24 | 807
Alzheimer's disease 23 | 658
Epilepsy 23 | 792
Muscle hypotonia 23 | 571
aldosterone-producing adenoma 22 | 665
cutaneous lupus erythematosus 22 | 1,057
Obesity 21 | 678
hereditary spastic paraplegia 21 | 318
Atopic dermatitis 20 | 952
Nystagmus 20 | 317
hepatocellular carcinoma 20 | 547
Liver Cirrhosis, Experimental 19 | 769
Neurodegenerative disease 19 | 414
Cerebellar Ataxia 18 | 304
Gaucher disease type 1 18 | 180
Liver cancer 18 | 604
Retinitis Pigmentosa 18 | 226
Seizures 18 | 596
Small head 18 | 374
primary Sjogren syndrome 18 | 735
esophageal adenocarcinoma 17 | 737
gastric cancer 17 | 459
Broad flat nasal bridge 16 | 236
Nasal bridge wide 16 | 236
Optic Atrophy 16 | 242
Bipolar Disorder 15 | 666
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
nasopharyngeal carcinoma 15 | 1,058
tuberculosis and treatment for 6 months 15 | 409
Duchenne muscular dystrophy 14 | 601

Tissue

Female tissues 607 | 17,400
Digestive Tract 606 | 17,369
Endocrine System 606 | 18,159
Liver and Pancreas 606 | 16,750
Skin and soft tissues 606 | 17,230
Male tissues 605 | 17,142
Urinary Tract 605 | 16,678
Nervous System 604 | 16,725
Blood and immune system 603 | 16,909
Respiratory system 601 | 16,393
Cardiovascular System 587 | 15,192

Target Family

Non-IDG 479 | 12,091
Enzyme 117 | 4,145
Transporter 7 | 473
Ion Channel 3 | 344
Transcription Factor 3 | 1,400
Kinase 2 | 634
Epigenetic 1 | 242

UniProt Keyword

Protein transport 612 | 612
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
NTF2-related export protein 1 NXT1 Tbio Non-IDG -1.49831 29.4 91
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Exportin-6 XPO6 Tbio Non-IDG -1.53980 34.5 29
DnaJ homolog subfamily C member 15 DNAJC15 Tbio Non-IDG -1.67016 50.2 31
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Sorting nexin-13 SNX13 Tbio Non-IDG -0.67169 5.24 65
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72