Development Level

Tbio 88 | 11,651
Tchem 34 | 1,388
Tdark 12 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
preweaning lethality, complete... 7 | 979
abnormal bone structure 5 | 187
abnormal embryo size 5 | 220
decreased total body fat amoun... 5 | 207
increased lean body mass 5 | 172
decreased lean body mass 3 | 135
edema 3 | 59
abnormal behavior 2 | 298
abnormal coat appearance 2 | 31
abnormal coat-hair pigmentatio... 2 | 64
abnormal sleep behavior 2 | 70
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased circulating magnesiu... 2 | 13
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
limb grasping 2 | 41
male infertility 2 | 123
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 92 | 11,493
osteosarcoma 73 | 7,950
ovarian cancer 73 | 8,520
medulloblastoma, large-cell 60 | 6,241
glioblastoma 58 | 5,792
atypical teratoid / rhabdoid tumor 49 | 5,112
ependymoma 47 | 4,679
lung cancer 46 | 4,740
psoriasis 46 | 6,694
adult high grade glioma 42 | 3,801
group 3 medulloblastoma 39 | 4,104
malignant mesothelioma 38 | 3,232
Breast cancer 35 | 3,578
non-small cell lung cancer 29 | 2,890
astrocytic glioma 28 | 2,597
lung adenocarcinoma 28 | 2,716
Pick disease 27 | 1,894
interstitial cystitis 27 | 2,312
invasive ductal carcinoma 27 | 2,951
Astrocytoma, Pilocytic 26 | 3,081
group 4 medulloblastoma 26 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
oligodendroglioma 26 | 2,850
primitive neuroectodermal tumor 26 | 3,035
ulcerative colitis 26 | 1,819
Cancer 25 | 2,499
Kidney cancer 25 | 2,613
subependymal giant cell astrocytoma 24 | 2,287
colon cancer 21 | 1,478
tuberculosis 21 | 2,010
lung carcinoma 20 | 2,843
pituitary cancer 20 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pancreatic cancer 18 | 2,398
breast carcinoma 17 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
spina bifida 15 | 1,074
Multiple myeloma 13 | 1,332
Rheumatoid arthritis 13 | 1,191
acute quadriplegic myopathy 13 | 1,158
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Schizophrenia 12 | 1,160
adrenocortical carcinoma 12 | 1,428
juvenile dermatomyositis 12 | 1,187
pediatric high grade glioma 12 | 1,064
esophageal adenocarcinoma 11 | 737
Waldenstrons macroglobulinemia 10 | 765
cutaneous lupus erythematosus 10 | 1,057
diabetes mellitus 10 | 1,728
Autosomal recessive predisposition 9 | 1,442
Melanoma 9 | 711
Skin cancer 9 | 469
active Crohn's disease 9 | 922
dermatomyositis 9 | 966
gastric carcinoma 9 | 807
non primary Sjogren syndrome sicca 9 | 891
progressive supranuclear palsy 9 | 676
Duchenne muscular dystrophy 8 | 601
Liver Cirrhosis, Experimental 8 | 769
aldosterone-producing adenoma 8 | 665
astrocytoma 8 | 1,146
primary pancreatic ductal adenocarcinoma 8 | 1,109
Alzheimer's disease 7 | 658
Crohn's disease 7 | 321
Endometriosis 7 | 540
Epilepsy 7 | 792
Liver cancer 7 | 604
active ulcerative colitis 7 | 764
acute myeloid leukemia 7 | 783
hereditary spastic paraplegia 7 | 318
medulloblastoma 7 | 720
urothelial carcinoma 7 | 318
Bipolar Disorder 6 | 666
Chronic Lymphocytic Leukemia 6 | 262
Down syndrome 6 | 499
Endometrial cancer 6 | 311
Intellectual disability 6 | 1,016
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
gastric cancer 6 | 459
hepatocellular carcinoma 6 | 547
nasopharyngeal carcinoma 6 | 1,058
pancreatic carcinoma 6 | 562
Atopic dermatitis 5 | 952
Cognitive delay 5 | 608
Depressive disorder 5 | 409
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Low intelligence 5 | 645
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Myocardial Ischemia 5 | 169
Poor school performance 5 | 645
Short stature 5 | 531
chronic rhinosinusitis 5 | 512
fibroadenoma 5 | 559

Tissue

Endocrine System 132 | 18,159
Blood and immune system 130 | 16,909
Female tissues 130 | 17,400
Digestive Tract 129 | 17,369
Male tissues 129 | 17,142
Skin and soft tissues 129 | 17,230
Nervous System 128 | 16,725
Cardiovascular System 127 | 15,192
Liver and Pancreas 127 | 16,750
Urinary Tract 127 | 16,678
Respiratory system 126 | 16,393

Target Family

Enzyme 129 | 4,145
Non-IDG 5 | 12,091

UniProt Keyword

Protein phosphatase 134 | 134
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Protein phosphatase 1E PPM1E Tbio Enzyme -0.97004 9.49 44
Dual specificity protein phosphatase 10 DUSP10 Tbio Enzyme -1.51719 38.2 270
Dual specificity protein phosphatase 23 DUSP23 Tbio Enzyme -0.95671 11.5 109
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.45823 27.6 148
Dual specificity protein phosphatase CDC14A CDC14A Tbio Enzyme -2.31524 216.3 245
Protein tyrosine phosphatase domain-containing protein 1 PTPDC1 Tdark Enzyme 0.63 0.21 17
Dual specificity protein phosphatase 3 DUSP3 Tchem Enzyme -2.11925 133.6 222
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA Tchem Enzyme -2.17010 139.0 378