Development Level

Tbio 103 | 11,445
Tchem 19 | 1,598
Tdark 9 | 6,588

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
decreased bone mineral content 4 | 151
abnormal bone structure 3 | 187
abnormal retina morphology 3 | 71
decreased grip strength 3 | 116
embryonic growth retardation 3 | 106
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
abnormal cranium morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 30
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
impaired glucose tolerance 2 | 75
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
abnormal QT variability 1 | 10
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal snout morphology 1 | 23
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
decreased urine magnesium leve... 1 | 3
enlarged heart 1 | 210
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased NK cell number 1 | 3
increased bone mineral content 1 | 108
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9
increased urine magnesium leve... 1 | 2
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
vertebral transformation 1 | 12

Disease

Carcinoma 89 | 11,493
ovarian cancer 85 | 8,520
osteosarcoma 52 | 7,950
lung cancer 48 | 4,740
medulloblastoma, large-cell 45 | 6,241
psoriasis 39 | 6,694
Multiple myeloma 38 | 1,332
glioblastoma 32 | 5,792
Autosomal recessive predisposition 25 | 1,442
atypical teratoid / rhabdoid tumor 24 | 5,112
group 3 medulloblastoma 23 | 4,104
Cancer 21 | 2,499
ependymoma 21 | 4,679
Breast cancer 20 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Epilepsy 17 | 792
diabetes mellitus 17 | 1,728
oligodendroglioma 17 | 2,850
Waldenstrons macroglobulinemia 16 | 765
dermatomyositis 16 | 966
primitive neuroectodermal tumor 16 | 3,035
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
malignant mesothelioma 15 | 3,232
non-small cell lung cancer 15 | 2,890
Pick disease 14 | 1,894
acute quadriplegic myopathy 14 | 1,158
adult high grade glioma 14 | 3,801
Leigh disease 13 | 100
Neurodegenerative disease 13 | 414
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
tuberculosis 13 | 2,010
Kidney cancer 12 | 2,613
Muscle hypotonia 12 | 571
group 4 medulloblastoma 12 | 1,855
Seizures 11 | 596
astrocytoma 11 | 1,146
hereditary spastic paraplegia 11 | 318
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
sonic hedgehog group medulloblastoma 11 | 467
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
pancreatic cancer 10 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Myositis 9 | 30
Optic Atrophy 9 | 242
pediatric high grade glioma 9 | 1,064
Astrocytoma, Pilocytic 8 | 3,081
Leukodystrophy 8 | 55
Muscle Spasticity 8 | 195
Nystagmus 8 | 317
Small head 8 | 374
acute myeloid leukemia 8 | 783
breast carcinoma 8 | 1,638
colon cancer 8 | 1,478
subependymal giant cell astrocytoma 8 | 2,287
Charcot-Marie-Tooth disease 7 | 62
Combined oxidative phosphorylation deficiency 7 | 14
Distal sensory impairment 7 | 52
Dysarthria 7 | 192
Leukoencephalopathies 7 | 29
Leukoencephalopathy with vanishing white matter 7 | 20
Neuropathy 7 | 261
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
primary pancreatic ductal adenocarcinoma 7 | 1,109
Acidosis, Lactic 6 | 97
Anemia 6 | 365
Childhood Ataxia with Central Nervous System Hypomyelinization 6 | 6
Developmental regression 6 | 95
Failure to gain weight 6 | 365
Gait, Unsteady 6 | 29
Intellectual disability 6 | 1,016
Lactic acidemia 6 | 95
Lethargy 6 | 77
Loss of developmental milestones 6 | 95
Mental deterioration in childhood 6 | 95
Neurodevelopmental regression 6 | 95
OVARIOLEUKODYSTROPHY 6 | 6
Pediatric failure to thrive 6 | 365
Premature Menopause 6 | 31
Psychomotor regression 6 | 95
Psychomotor regression beginning in infancy 6 | 95
Psychomotor regression in infants 6 | 95
Psychomotor regression, progressive 6 | 95
Rheumatoid arthritis 6 | 1,191
cystic fibrosis 6 | 1,696
Amyotrophic lateral sclerosis 5 | 451
Cerebral atrophy 5 | 178
Decreased tendon reflex 5 | 122
Hypoplasia of corpus callosum 5 | 90
Increased head circumference 5 | 147
Increased size of skull 5 | 147
Personality change 5 | 23
Progressive disorder 5 | 142
Secondary physiologic amenorrhea 5 | 32
progressive supranuclear palsy 5 | 676
tuberculosis and treatment for 6 months 5 | 409

Tissue

Endocrine System 128 | 18,159
Male tissues 128 | 17,142
Nervous System 128 | 16,725
Blood and immune system 127 | 16,909
Cardiovascular System 127 | 15,192
Digestive Tract 127 | 17,369
Female tissues 127 | 17,400
Liver and Pancreas 127 | 16,750
Respiratory system 127 | 16,393
Skin and soft tissues 127 | 17,230
Urinary Tract 127 | 16,678

Target Family

Non-IDG 76 | 12,091
Enzyme 54 | 4,145
Kinase 1 | 634

UniProt Keyword

Protein biosynthesis 131 | 131
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121
Required for meiotic nuclear division protein 1 homolog RMND1 Tbio Non-IDG -0.98615 10.0 63
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Eukaryotic translation initiation factor 3 subunit C EIF3C Tbio Non-IDG -1.20680 14.1 159
Eukaryotic translation initiation factor 3 subunit B EIF3B Tbio Non-IDG -1.83618 70.5 84
Translation initiation factor eIF-2B subunit delta EIF2B4 Tbio Non-IDG -1.06082 11.3 145
Peptide deformylase, mitochondrial PDF Tchem Enzyme -1.62419 40.8 57