1. Home
  2. Targets
Target Filters...

Development Level

Tbio 82 | 10,625
Tdark 32 | 7,003
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Phenotype

abnormal coping response 1 | 12
abnormal digit morphology 1 | 13
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal humerus morphology 1 | 11
abnormal limb position 1 | 3
abnormal nail morphology 1 | 7
abnormal retinal blood vessel ... 1 | 18
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating bilirubi... 1 | 14
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
enlarged epididymis 1 | 27
head bobbing 1 | 3
improved glucose tolerance 1 | 56
increased CD5-positive Ly6C-po... 1 | 4
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating phosphat... 1 | 24
increased hematocrit 1 | 36
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
male infertility 1 | 62
polydactyly 1 | 22
premature death 1 | 5
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
tail dragging 1 | 1

Disease

psoriasis 66 | 6,685
ovarian cancer 46 | 8,491
lung cancer 39 | 4,473
osteosarcoma 37 | 7,933
medulloblastoma, large-cell 31 | 6,234
lung adenocarcinoma 30 | 2,714
lung carcinoma 30 | 2,844
pancreatic cancer 30 | 2,300
Cancer 29 | 2,346
non-small cell lung cancer 29 | 2,798
interstitial cystitis 27 | 2,299
glioblastoma 26 | 5,572
ulcerative colitis 26 | 2,087
malignant mesothelioma 25 | 3,163
cystic fibrosis 24 | 1,670
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,289
Atopic dermatitis 22 | 944
invasive ductal carcinoma 22 | 2,950
primary pancreatic ductal adenocarcinoma 22 | 1,271
atypical teratoid / rhabdoid tumor 20 | 4,369
pilocytic astrocytoma 20 | 3,086
Breast cancer 19 | 3,098
Kidney disease 16 | 397
ductal carcinoma in situ 16 | 1,745
nasopharyngeal carcinoma 16 | 1,056
posterior fossa group A ependymoma 16 | 1,511
breast carcinoma 15 | 1,614
colon cancer 15 | 1,475
esophageal adenocarcinoma 15 | 737
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
subependymal giant cell astrocytoma 15 | 2,287
Carcinoma 14 | 2,147
pediatric high grade glioma 14 | 2,712
adult high grade glioma 13 | 2,148
cutaneous lupus erythematosus 13 | 1,056
diabetes mellitus 13 | 1,663
gastric carcinoma 13 | 832
pituitary cancer 13 | 1,972
primitive neuroectodermal tumor 13 | 3,031
tuberculosis 13 | 1,563
acute quadriplegic myopathy 11 | 1,157
astrocytic glioma 11 | 2,241
sonic hedgehog group medulloblastoma 11 | 1,482
Alzheimer's disease 10 | 644
Duchenne muscular dystrophy 10 | 602
juvenile dermatomyositis 10 | 1,189
oligodendroglioma 10 | 2,849
Vascular disease 9 | 281
adrenocortical carcinoma 9 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
ependymoma 9 | 2,514
fibroadenoma 9 | 557
spina bifida 9 | 1,064
Cerebrovascular disease 8 | 231
astrocytoma 8 | 1,493
group 3 medulloblastoma 8 | 2,254
non-small cell lung carcinoma 8 | 413
posterior fossa group B ependymoma 8 | 1,530
Asthma 7 | 349
Dementia 7 | 129
Heart disease 7 | 279
Liver carcinoma 7 | 217
Liver disease 7 | 219
Lung disease 7 | 136
Prostatic Neoplasms 7 | 471
Stomach Neoplasms 7 | 282
primary Sjogren syndrome 7 | 788
Atherosclerosis 6 | 275
Chronic obstructive pulmonary disease 6 | 147
Coronary artery disease 6 | 240
Disseminated intravascular coagulation 6 | 32
Endometriosis 6 | 535
Mammary Neoplasms 6 | 410
Spontaneous abortion 6 | 108
uncontrolled asthma 6 | 67
Amyloidosis 5 | 68
Arthritis 5 | 248
Colorectal Neoplasms 5 | 217
Down syndrome 5 | 548
Hypertension 5 | 293
IGA Glomerulonephritis 5 | 454
Multiple Sclerosis 5 | 498
Neoplasm Invasiveness 5 | 127
Pancreatitis 5 | 97
Pick disease 5 | 1,893
Polycystic Ovary Syndrome 5 | 334
active Crohn's disease 5 | 918
group 4 medulloblastoma 5 | 1,875
head and neck cancer 5 | 270
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
non-inflammatory breast cancer 5 | 208
Becker muscular dystrophy 4 | 187
Multiple myeloma 4 | 1,327
dermatomyositis 4 | 966
nephrosclerosis 4 | 329
pancreatic carcinoma 4 | 567
pterygium 4 | 74
urothelial carcinoma 4 | 318

Tissue

Urinary Tract 117 | 18,443
Digestive Tract 116 | 18,472
Endocrine System 116 | 18,511
Nervous System 116 | 18,560
Female tissues 115 | 18,646
Skin and soft tissues 113 | 18,114
Male tissues 111 | 17,968
Respiratory system 109 | 17,483
Liver and Pancreas 108 | 18,135
Cardiovascular System 103 | 17,957
Blood and immune system 101 | 17,994

Target Family

Non-IDG 92 | 11,969
Enzyme 31 | 4,146

UniProt Keyword

Protease inhibitor 123 | 123
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serpin A9 SERPINA9 Tbio Non-IDG -1.93591 84.3 121
Alpha-1-antichymotrypsin SERPINA3 Tchem Non-IDG -2.94207 803.8 261
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Alpha-2-macroglobulin A2M Tbio Non-IDG -2.95602 802.7 553
Cystatin-SN CST1 Tbio Non-IDG -1.44230 27.4 105
Cystatin-S CST4 Tbio Non-IDG -1.82088 50.6 143
Cystatin-C CST3 Tbio Non-IDG -3.48935 3020.7 756
Metalloproteinase inhibitor 1 TIMP1 Tbio Enzyme -3.55219 3513.4 673
Serpin B9 SERPINB9 Tbio Non-IDG -2.47183 283.3 276
Serpin B8 SERPINB8 Tbio Non-IDG -2.37655 220.8 146