Development Level

Tbio 234 | 10,625
Tchem 172 | 1,890
Tdark 104 | 7,003
Tclin 21 | 602

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 21 | 633
decreased lean body mass 12 | 195
abnormal behavior 11 | 226
preweaning lethality, incomple... 11 | 260
decreased body weight 10 | 174
decreased body length 9 | 108
increased circulating alkaline... 8 | 119
decreased total body fat amoun... 7 | 186
hyperactivity 6 | 108
abnormal bone structure 5 | 131
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating triglyce... 5 | 83
increased bone mineral content 5 | 92
abnormal bone mineralization 4 | 55
abnormal tail morphology 4 | 17
decreased B cell number 4 | 30
decreased T cell number 4 | 31
decreased bone mineral density 4 | 126
decreased gamma-delta T cell n... 4 | 18
decreased prepulse inhibition 4 | 52
embryonic lethality prior to t... 4 | 187
increased CD8-positive, alpha-... 4 | 11
increased NK cell number 4 | 19
increased T cell number 4 | 15
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
increased monocyte cell number 4 | 27
thrombocytopenia 4 | 46
abnormal cranium morphology 3 | 32
abnormal vibrissa morphology 3 | 17
decreased circulating calcium ... 3 | 33
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
decreased neutrophil cell numb... 3 | 37
enlarged heart 3 | 111
increased B cell number 3 | 23
increased CD4-positive, alpha ... 3 | 15
increased alpha-beta T cell nu... 3 | 9
increased circulating choleste... 3 | 53
increased circulating serum al... 3 | 25
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
increased sacral vertebrae num... 3 | 62
increased total body fat amoun... 3 | 57
short tibia 3 | 82
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal femur morphology 2 | 14
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal joint morphology 2 | 14
abnormal limb bud morphology 2 | 15
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal tibia morphology 2 | 14
abnormal vertebrae morphology 2 | 14
abnormal vertebral arch morpho... 2 | 9
decreased CD4-positive, CD25-p... 2 | 24
decreased CD4-positive, alpha ... 2 | 19
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased alpha-beta T cell nu... 2 | 12
decreased blood urea nitrogen ... 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating creatini... 2 | 31
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating phosphat... 2 | 15
decreased circulating total pr... 2 | 41
decreased effector memory CD4-... 2 | 6
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
decreased respiratory quotient 2 | 12
embryonic lethality prior to o... 2 | 148
female infertility 2 | 34
hemorrhage 2 | 12
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased KLRG1-positive NK ce... 2 | 9
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 43
increased circulating glucose ... 2 | 16
increased circulating sodium l... 2 | 71
increased effector memory CD4-... 2 | 15
increased granulocyte number 2 | 8
increased mature B cell number 2 | 12
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
male infertility 2 | 62
thrombocytosis 2 | 23

Disease

ovarian cancer 239 | 8,484
osteosarcoma 212 | 7,933
psoriasis 178 | 6,685
glioblastoma 141 | 5,572
medulloblastoma, large-cell 134 | 6,234
lung cancer 119 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,289
atypical teratoid / rhabdoid tumor 106 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 102 | 2,956
Cancer 98 | 2,346
malignant mesothelioma 92 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 90 | 2,988
lung adenocarcinoma 83 | 2,713
lung carcinoma 83 | 2,844
non-small cell lung cancer 83 | 2,798
Breast cancer 82 | 3,094
invasive ductal carcinoma 81 | 2,950
pancreatic cancer 81 | 2,300
ulcerative colitis 80 | 2,087
diabetes mellitus 75 | 1,663
cystic fibrosis 73 | 1,665
oligodendroglioma 71 | 2,849
pilocytic astrocytoma 71 | 3,086
interstitial cystitis 70 | 2,299
pediatric high grade glioma 63 | 2,712
subependymal giant cell astrocytoma 61 | 2,287
Carcinoma 59 | 2,147
primitive neuroectodermal tumor 59 | 3,031
adult high grade glioma 58 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 58 | 1,795
ependymoma 55 | 2,514
astrocytic glioma 51 | 2,241
cutaneous lupus erythematosus 47 | 1,056
tuberculosis 46 | 1,557
Atopic dermatitis 45 | 944
primary pancreatic ductal adenocarcinoma 45 | 1,271
Multiple myeloma 44 | 1,327
group 3 medulloblastoma 44 | 2,254
pituitary cancer 43 | 1,972
posterior fossa group A ependymoma 42 | 1,511
Alzheimer's disease 40 | 644
active Crohn's disease 40 | 918
colon cancer 40 | 1,475
juvenile dermatomyositis 39 | 1,189
breast carcinoma 38 | 1,614
group 4 medulloblastoma 37 | 1,875
ductal carcinoma in situ 36 | 1,745
medulloblastoma 36 | 1,524
adrenocortical carcinoma 34 | 1,427
Pick disease 33 | 1,893
Rheumatoid Arthritis 33 | 1,160
esophageal adenocarcinoma 33 | 737
posterior fossa group B ependymoma 30 | 1,530
spina bifida 29 | 1,064
astrocytoma 28 | 1,493
sonic hedgehog group medulloblastoma 28 | 1,482
Waldenstrons macroglobulinemia 27 | 765
gastric carcinoma 27 | 832
nasopharyngeal carcinoma 27 | 1,056
primary Sjogren syndrome 27 | 789
Hypertension 26 | 287
dermatomyositis 25 | 933
Atherosclerosis 23 | 275
Kidney disease 23 | 396
Cerebrovascular disease 21 | 231
acute myeloid leukemia 21 | 780
acute quadriplegic myopathy 21 | 1,157
atypical teratoid/rhabdoid tumor 21 | 1,095
Prostatic Neoplasms 20 | 471
non-small cell lung carcinoma 20 | 413
progressive supranuclear palsy 20 | 674
Obesity 19 | 616
Pancreatitis 19 | 97
Coronary artery disease 18 | 240
Neurodegenerative disease 18 | 383
Parkinson's disease 18 | 364
Vascular disease 18 | 281
inflammatory breast cancer 18 | 404
non primary Sjogren syndrome sicca 18 | 840
Down syndrome 17 | 548
Duchenne muscular dystrophy 17 | 602
Endometriosis 17 | 535
IGA Glomerulonephritis 17 | 454
head and neck cancer and chronic obstructive pulmonary disease 17 | 237
Arthritis 16 | 248
Asthma 16 | 349
active ulcerative colitis 16 | 477
periodontitis 16 | 269
Heart disease 15 | 279
Hypertensive disease 15 | 193
Liver carcinoma 15 | 217
aldosterone-producing adenoma 15 | 664
fibroadenoma 15 | 557
mucosa-associated lymphoid tissue lymphoma 15 | 480
tuberculosis and treatment for 6 months 15 | 686
Lung disease 13 | 132
Multiple Sclerosis 13 | 498
Myocardial Infarction 13 | 126
glioblastoma multiforme 13 | 347
sarcoidosis 13 | 358

Tissue

Female tissues 507 | 18,647
Nervous System 504 | 18,561
Blood and immune system 498 | 17,995
Digestive Tract 492 | 18,473
Endocrine System 491 | 18,512
Urinary Tract 490 | 18,444
Male tissues 489 | 17,969
Skin and soft tissues 488 | 18,115
Liver and Pancreas 486 | 18,136
Cardiovascular System 482 | 17,958
Respiratory system 475 | 17,484

Target Family

Enzyme 464 | 4,146
Non-IDG 62 | 11,971
Ion Channel 3 | 341
Transcription Factor 2 | 1,400

UniProt Keyword

Protease 531 | 531
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 Tbio Enzyme -1.30374 25.3 78
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 USP17L1 Tdark Enzyme 10.9 3