Development Level

Tbio 18 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613

IMPC Phenotype

decreased body weight 3 | 161
decreased lean body mass 3 | 135
preweaning lethality, incomple... 3 | 499
abnormal cranium morphology 2 | 36
abnormal head morphology 2 | 10
decreased bone mineral content 2 | 151
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal eye morphology 1 | 68
abnormal eye pigmentation 1 | 3
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged testis 1 | 6
female infertility 1 | 60
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Microcephaly 23 | 166
Carcinoma 21 | 11,493
ovarian cancer 18 | 8,520
Intellectual disability 17 | 1,016
group 3 medulloblastoma 16 | 4,104
osteosarcoma 16 | 7,950
MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 1 15 | 16
glioblastoma 13 | 5,792
Kidney cancer 12 | 2,613
medulloblastoma, large-cell 12 | 6,241
atypical teratoid / rhabdoid tumor 11 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
primitive neuroectodermal tumor 11 | 3,035
psoriasis 11 | 6,694
Sloping forehead 10 | 46
Small head 10 | 374
Autosomal recessive predisposition 9 | 1,442
Cognitive delay 9 | 608
Dilated ventricles (finding) 9 | 121
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Severe mental retardation (I.Q. 20-34) 9 | 99
Short stature 9 | 531
adult high grade glioma 9 | 3,801
malignant mesothelioma 9 | 3,232
Upward slant of palpebral fissure 8 | 75
lung cancer 8 | 4,740
Abnormal cortical bone morphology 7 | 22
Agenesis of corpus callosum 7 | 83
Ectopic Tissue 7 | 14
Frontal lobe hypoplasia 7 | 9
Hyperreflexia 7 | 209
Pachygyria 7 | 41
Thin upper lip vermilion 7 | 67
Unilateral agenesis of kidney 7 | 20
Vesico-Ureteral Reflux 7 | 33
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
Breast cancer 6 | 3,578
Epilepsy 6 | 792
adrenocortical carcinoma 6 | 1,428
ductal carcinoma in situ 6 | 1,745
ependymoma 6 | 4,679
Astrocytoma, Pilocytic 5 | 3,081
Cortical gyral simplification 5 | 19
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Seizures 5 | 596
colon cancer 5 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
nasopharyngeal carcinoma 5 | 1,058
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
Atopic dermatitis 4 | 952
Cancer 4 | 2,499
Microcephalic osteodysplastic primordial dwarfism type II 4 | 13
Seckel syndrome 4 | 34
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Endometriosis 3 | 540
Fetal Growth Retardation 3 | 189
Glaucoma 3 | 239
Hypoplasia of corpus callosum 3 | 90
Hypoplastic mandible condyle 3 | 275
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
acute myeloid leukemia 3 | 783
gastric carcinoma 3 | 807
posterior fossa group A ependymoma 3 | 468
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Bilateral fifth finger clinodactyly 2 | 110
Broad flat nasal bridge 2 | 236
Craniosynostosis 2 | 74
Curvature of little finger 2 | 110
Delayed bone age 2 | 136
Nasal bridge wide 2 | 236
Neurodevelopmental Disorders 2 | 70
Physical aggression 2 | 76
Polycystic ovary syndrome 2 | 360
Strabismus 2 | 270
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
spina bifida 2 | 1,074

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400

UniProt Keyword

Primary microcephaly 23 | 23
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Sodium-dependent lysophosphatidylcholine symporter 1 MFSD2A Tbio Non-IDG -1.40175 26.3 73
Centrosomal protein of 152 kDa CEP152 Tbio Non-IDG -1.23896 18.1 117
CDK5 regulatory subunit-associated protein 2 CDK5RAP2 Tbio Non-IDG -1.70804 54.4 81
WD repeat-containing protein 62 WDR62 Tbio Non-IDG -1.43806 35.5 33
Abnormal spindle-like microcephaly-associated protein ASPM Tbio Non-IDG -1.52453 32.7 40
Kinetochore scaffold 1 KNL1 Tbio Non-IDG -2.20924 151.8 85
Centrosomal protein of 135 kDa CEP135 Tbio Non-IDG -1.20552 16.3 87
Citron Rho-interacting kinase CIT Tchem Kinase -0.69610 4.69 117
Centromere-associated protein E CENPE Tchem Non-IDG -2.14817 140.2 166