Development Level

Tbio 116 | 10,625
Tdark 25 | 7,003
Tchem 23 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
preweaning lethality, incomple... 6 | 260
decreased circulating triglyce... 4 | 83
enlarged heart 4 | 111
abnormal behavior 3 | 226
increased circulating alkaline... 3 | 119
abnormal QRS complex 2 | 25
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased mean corpuscular hem... 2 | 34
hyperactivity 2 | 108
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased grip strength 2 | 83
increased heart weight 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
limb grasping 2 | 35
abnormal body wall morphology 1 | 7
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal craniofacial morpholo... 1 | 12
abnormal facial morphology 1 | 9
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal spine curvature 1 | 7
abnormal whole-body plethysmog... 1 | 4
anophthalmia 1 | 20
cleft palate 1 | 6
corneal opacity 1 | 25
decreased NK T cell number 1 | 28
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased bone mineral content 1 | 157
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased granulocyte number 1 | 8
decreased large unstained cell... 1 | 3
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased pre-pro B cell numbe... 1 | 2
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to t... 1 | 187
facial cleft 1 | 3
hydrometra 1 | 13
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
increased B cell number 1 | 23
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased cellular hemoglobin ... 1 | 2
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased plasma cell number 1 | 5
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
macrophthalmia 1 | 2
polycystic kidney 1 | 9
polydactyly 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 82 | 8,484
osteosarcoma 77 | 7,933
medulloblastoma, large-cell 76 | 6,234
psoriasis 73 | 6,685
glioblastoma 72 | 5,572
lung cancer 51 | 4,466
pilocytic astrocytoma 50 | 3,086
atypical teratoid / rhabdoid tumor 48 | 4,369
invasive ductal carcinoma 42 | 2,950
malignant mesothelioma 42 | 3,162
Pick disease 39 | 1,893
pediatric high grade glioma 39 | 2,712
oligodendroglioma 37 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
primitive neuroectodermal tumor 36 | 3,031
Breast cancer 35 | 3,094
lung carcinoma 35 | 2,844
ependymoma 34 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
lung adenocarcinoma 34 | 2,713
subependymal giant cell astrocytoma 34 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
non-small cell lung cancer 33 | 2,798
Cancer 28 | 2,346
adult high grade glioma 28 | 2,148
astrocytic glioma 28 | 2,241
astrocytoma 27 | 1,493
interstitial cystitis 27 | 2,299
pancreatic cancer 26 | 2,300
group 3 medulloblastoma 25 | 2,254
ulcerative colitis 25 | 2,087
ductal carcinoma in situ 22 | 1,745
pituitary cancer 22 | 1,972
Multiple myeloma 21 | 1,327
posterior fossa group A ependymoma 21 | 1,511
cystic fibrosis 20 | 1,665
medulloblastoma 20 | 1,524
primary pancreatic ductal adenocarcinoma 20 | 1,271
breast carcinoma 18 | 1,614
group 4 medulloblastoma 18 | 1,875
primary Sjogren syndrome 18 | 789
atypical teratoid/rhabdoid tumor 17 | 1,095
tuberculosis 16 | 1,557
acute quadriplegic myopathy 15 | 1,157
sonic hedgehog group medulloblastoma 15 | 1,482
Rheumatoid Arthritis 14 | 1,160
colon cancer 14 | 1,475
cutaneous lupus erythematosus 14 | 1,056
juvenile dermatomyositis 14 | 1,189
gastric carcinoma 13 | 832
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
posterior fossa group B ependymoma 13 | 1,530
spina bifida 13 | 1,064
active Crohn's disease 12 | 918
adrenocortical carcinoma 12 | 1,427
diabetes mellitus 12 | 1,663
nasopharyngeal carcinoma 12 | 1,056
Carcinoma 11 | 2,147
dermatomyositis 10 | 933
glioblastoma multiforme 10 | 347
Atopic dermatitis 9 | 944
Endometriosis 9 | 535
IGA Glomerulonephritis 9 | 454
aldosterone-producing adenoma 9 | 664
Duchenne muscular dystrophy 8 | 602
Oculocerebrorenal syndrome 8 | 23
Parkinson's disease 8 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
fibroadenoma 8 | 557
hereditary spastic paraplegia 8 | 313
non primary Sjogren syndrome sicca 8 | 840
Amyotrophic Lateral Sclerosis 7 | 431
Neurodegenerative disease 7 | 383
hepatocellular carcinoma 7 | 532
Alzheimer's disease 6 | 644
Choroideremia 6 | 13
Fundus dystrophy 6 | 77
Intellectual disability 6 | 573
Myocardial Ischemia 6 | 169
Schizophrenia 6 | 501
Waldenstrons macroglobulinemia 6 | 765
active ulcerative colitis 6 | 477
acute myeloid leukemia 6 | 780
esophageal adenocarcinoma 6 | 737
gastric cancer 6 | 430
non-small cell lung carcinoma 6 | 413
pancreatic carcinoma 6 | 567
sarcoidosis 6 | 358
Chronic Lymphocytic Leukemia 5 | 242
Epilepsy 5 | 346
Hermansky-Pudlak syndrome 5 | 43
Juvenile Myelomonocytic Leukemia 5 | 21
Lymphoma 5 | 56
Retinitis pigmentosa 5 | 153
Warburg micro syndrome 5 | 19
inflammatory breast cancer 5 | 404
mucosa-associated lymphoid tissue lymphoma 5 | 480
Prostatic Neoplasms 4 | 471
chronic rhinosinusitis 4 | 512
periodontitis 4 | 269

Tissue

Digestive Tract 166 | 18,473
Male tissues 165 | 17,969
Nervous System 165 | 18,561
Urinary Tract 165 | 18,444
Blood and immune system 164 | 17,995
Endocrine System 164 | 18,512
Female tissues 164 | 18,647
Liver and Pancreas 164 | 18,136
Cardiovascular System 163 | 17,958
Skin and soft tissues 162 | 18,115
Respiratory system 161 | 17,484

Target Family

Enzyme 118 | 4,146
Non-IDG 43 | 11,971
Kinase 6 | 634
GPCR 1 | 406

UniProt Keyword

Prenylation 168 | 168
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C Tclin Enzyme -1.36465 22.7 78
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.22946 184.9 247
Ras-related protein Rab-13 RAB13 Tbio Enzyme -1.35800 26.2 55
Ras-related protein Rab-28 RAB28 Tbio Enzyme -1.12829 14.9 57