Development Level

Tbio 127 | 11,445
Tdark 21 | 6,588
Tchem 18 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 8 | 499
enlarged heart 5 | 210
decreased circulating serum al... 4 | 82
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
cataract 3 | 92
decreased bone mineral content 3 | 151
decreased mean corpuscular hem... 3 | 50
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased mean corpuscular hem... 3 | 96
prenatal lethality 3 | 28
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal craniofacial morpholo... 2 | 33
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
abnormal limb morphology 2 | 13
anophthalmia 2 | 33
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
edema 2 | 59
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
limb grasping 2 | 41
polydactyly 2 | 7
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal limb bud morphology 1 | 17
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
abnormal whole-body plethysmog... 1 | 4
brachydactyly 1 | 19
cleft palate 1 | 8
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
facial cleft 1 | 3
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
macrophthalmia 1 | 2
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small kidney 1 | 16
small superior vagus ganglion 1 | 74
syndactyly 1 | 23

Disease

glioblastoma 82 | 5,792
ovarian cancer 82 | 8,520
medulloblastoma, large-cell 77 | 6,241
osteosarcoma 77 | 7,950
psoriasis 74 | 6,694
Carcinoma 68 | 11,493
atypical teratoid / rhabdoid tumor 62 | 5,112
ependymoma 62 | 4,679
adult high grade glioma 53 | 3,801
lung cancer 51 | 4,740
Astrocytoma, Pilocytic 49 | 3,081
group 3 medulloblastoma 46 | 4,104
invasive ductal carcinoma 43 | 2,951
malignant mesothelioma 42 | 3,232
Breast cancer 39 | 3,578
Pick disease 39 | 1,894
oligodendroglioma 37 | 2,850
astrocytic glioma 36 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
primitive neuroectodermal tumor 36 | 3,035
lung carcinoma 35 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
lung adenocarcinoma 34 | 2,716
non-small cell lung cancer 34 | 2,890
subependymal giant cell astrocytoma 34 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
Cancer 30 | 2,499
interstitial cystitis 27 | 2,312
pancreatic cancer 26 | 2,398
ductal carcinoma in situ 23 | 1,745
group 4 medulloblastoma 23 | 1,855
pituitary cancer 22 | 1,972
Multiple myeloma 21 | 1,332
breast carcinoma 21 | 1,638
tuberculosis 21 | 2,010
cystic fibrosis 20 | 1,696
astrocytoma 19 | 1,146
primary pancreatic ductal adenocarcinoma 18 | 1,109
ulcerative colitis 18 | 1,819
primary Sjogren syndrome 17 | 735
Autosomal recessive predisposition 16 | 1,442
acute quadriplegic myopathy 15 | 1,158
juvenile dermatomyositis 15 | 1,187
Rheumatoid arthritis 14 | 1,191
colon cancer 14 | 1,478
cutaneous lupus erythematosus 14 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
pediatric high grade glioma 14 | 1,064
Intellectual disability 13 | 1,016
Kidney cancer 13 | 2,613
gastric carcinoma 13 | 807
spina bifida 13 | 1,074
Epilepsy 12 | 792
Griscelli syndrome 12 | 24
active Crohn's disease 12 | 922
active ulcerative colitis 12 | 764
adrenocortical carcinoma 12 | 1,428
diabetes mellitus 12 | 1,728
nasopharyngeal carcinoma 12 | 1,058
Short stature 11 | 531
dermatomyositis 11 | 966
Liver Cirrhosis, Experimental 10 | 769
Obesity 10 | 678
Parkinson's disease 10 | 392
Atopic dermatitis 9 | 952
Byzanthine arch palate 9 | 194
Duchenne muscular dystrophy 9 | 601
Dull intelligence 9 | 645
Endometriosis 9 | 540
Hypoplastic mandible condyle 9 | 275
Low intelligence 9 | 645
Mandibular hypoplasia 9 | 275
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Micrognathism 9 | 275
Muscle hypotonia 9 | 571
Nystagmus 9 | 317
Poor school performance 9 | 645
aldosterone-producing adenoma 9 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
hereditary spastic paraplegia 9 | 318
non primary Sjogren syndrome sicca 9 | 891
Abnormality of retinal pigmentation 8 | 111
Amyotrophic lateral sclerosis 8 | 451
Cerebral atrophy 8 | 178
Neurodegenerative disease 8 | 414
Optic Atrophy 8 | 242
Retinal Degeneration 8 | 106
Retinal pigment epithelial abnormality 8 | 111
Retinitis Pigmentosa 8 | 226
Schizophrenia 8 | 1,160
Seizures 8 | 596
Sensorineural Hearing Loss (disorder) 8 | 284
fibroadenoma 8 | 559
Alzheimer's disease 7 | 658
Anteverted nostril 7 | 191
Broad flat nasal bridge 7 | 236
Hepatomegaly 7 | 285
Nasal bridge wide 7 | 236
hepatocellular carcinoma 7 | 547

Tissue

Endocrine System 166 | 18,159
Blood and immune system 163 | 16,909
Digestive Tract 163 | 17,369
Skin and soft tissues 163 | 17,230
Male tissues 162 | 17,142
Female tissues 161 | 17,400
Nervous System 160 | 16,725
Respiratory system 160 | 16,393
Urinary Tract 160 | 16,678
Liver and Pancreas 158 | 16,750
Cardiovascular System 150 | 15,192

Target Family

Enzyme 118 | 4,145
Non-IDG 45 | 12,091
Kinase 6 | 634
GPCR 1 | 408

UniProt Keyword

Prenylation 170 | 170
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/LRR-repeat protein 2 FBXL2 Tbio Non-IDG -0.89339 8.63 129
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Ras-related protein Rab-20 RAB20 Tbio Enzyme -0.97781 11.5 171
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-19 RAB19 Tdark Enzyme -0.54731 3.31 75
Ras-related protein Rab-40C RAB40C Tbio Non-IDG -0.89913 7.57 111
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Ras-related protein Rab-36 RAB36 Tdark Enzyme -0.51688 3.97 90
Rhodopsin kinase GRK7 Tchem Kinase -1.83396 45.0 180