Development Level

Tbio 7,330 | 11,651
Tdark 3,331 | 6,593
Tchem 1,077 | 1,388
Tclin 456 | 612

Collection

RFA-RM-18-021 247 | 328
Kinase: IDG Consortium (Target... 113 | 125
GPCR: IDG Consortium (Targets) 87 | 126
Ion Channel: IDG Consortium (T... 68 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 613 | 979
preweaning lethality, incomple... 304 | 499
embryonic lethality prior to t... 176 | 278
abnormal behavior 160 | 298
embryonic lethality prior to o... 153 | 239
abnormal embryo size 135 | 220
decreased total body fat amoun... 130 | 207
decreased vertical activity 130 | 208
enlarged heart 121 | 210
abnormal bone structure 113 | 187
decreased body weight 102 | 161
increased lean body mass 102 | 172
decreased bone mineral content 96 | 151
abnormal heart morphology 89 | 162
male infertility 89 | 123
decreased circulating glucose ... 84 | 126
decreased lean body mass 83 | 135
increased total body fat amoun... 81 | 134
decreased bone mineral density 78 | 126
hypoactivity 78 | 132
increased circulating alkaline... 78 | 122
hyperactivity 77 | 148
abnormal seminal vesicle morph... 72 | 114
decreased body length 70 | 101
decreased grip strength 69 | 116
increased startle reflex 69 | 112
embryonic growth retardation 68 | 106
increased or absent threshold ... 63 | 101
increased mean corpuscular hem... 62 | 96
cataract 61 | 92
increased bone mineral content 61 | 108
decreased circulating choleste... 59 | 93
improved glucose tolerance 59 | 79
abnormal lens morphology 58 | 81
increased mean corpuscular vol... 58 | 92
decreased lymphocyte cell numb... 57 | 83
impaired glucose tolerance 57 | 75
decreased mean corpuscular vol... 52 | 79
short tibia 52 | 97
decreased circulating triglyce... 50 | 79
increased fasted circulating g... 50 | 76
prenatal lethality prior to he... 50 | 87
decreased leukocyte cell numbe... 49 | 73
decreased startle reflex 49 | 75
increased circulating HDL chol... 49 | 80
abnormal retina morphology 48 | 71
abnormal sleep behavior 48 | 70
decreased circulating serum al... 48 | 82
increased circulating sodium l... 47 | 71
decreased hemoglobin content 46 | 68
abnormal eye morphology 45 | 68
decreased prepulse inhibition 45 | 82
increased monocyte cell number 44 | 63
abnormal kidney morphology 43 | 65
small superior vagus ganglion 43 | 74
decreased blood urea nitrogen ... 42 | 51
decreased circulating HDL chol... 42 | 68
abnormal coat-hair pigmentatio... 41 | 64
decreased fasted circulating g... 41 | 65
female infertility 41 | 60
increased bone mineral density 41 | 72
abnormal behavioral response t... 40 | 66
decreased erythrocyte cell num... 40 | 62
increased circulating choleste... 40 | 66
decreased circulating insulin ... 39 | 76
increased heart weight 39 | 62
small testis 39 | 58
abnormal spleen morphology 37 | 55
decreased mean corpuscular hem... 37 | 50
abnormal gait 35 | 69
abnormal skin morphology 33 | 50
decreased circulating alanine ... 33 | 47
increased neutrophil cell numb... 33 | 46
decreased caudal vertebrae num... 32 | 53
decreased circulating alkaline... 32 | 46
decreased hematocrit 32 | 46
thrombocytopenia 32 | 56
hydrometra 31 | 53
abnormal neural tube closure 29 | 46
increased blood urea nitrogen ... 29 | 48
increased circulating triglyce... 29 | 42
increased hematocrit 29 | 46
increased hemoglobin content 29 | 45
abnormal testis morphology 28 | 43
decreased circulating total pr... 28 | 49
decreased neutrophil cell numb... 28 | 42
increased leukocyte cell numbe... 28 | 47
increased mean platelet volume 28 | 45
edema 27 | 59
enlarged spleen 27 | 41
decreased circulating LDL chol... 26 | 38
decreased circulating creatini... 26 | 39
abnormal cranium morphology 25 | 36
abnormal epididymis morphology 25 | 42
decreased red blood cell distr... 25 | 41
increased circulating creatini... 25 | 38
increased erythrocyte cell num... 25 | 39
increased grip strength 25 | 41
increased prepulse inhibition 25 | 32
increased mean corpuscular hem... 24 | 36

Disease

Carcinoma 8,334 | 11,493
ovarian cancer 5,302 | 8,520
osteosarcoma 5,033 | 7,950
psoriasis 4,340 | 6,694
medulloblastoma, large-cell 3,858 | 6,241
glioblastoma 3,588 | 5,792
lung cancer 3,195 | 4,740
atypical teratoid / rhabdoid tumor 3,127 | 5,112
ependymoma 2,905 | 4,679
group 3 medulloblastoma 2,543 | 4,104
adult high grade glioma 2,350 | 3,801
Breast cancer 2,308 | 3,578
malignant mesothelioma 2,199 | 3,232
Kidney cancer 2,167 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 2,142 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 1,979 | 2,989
Astrocytoma, Pilocytic 1,965 | 3,081
lung carcinoma 1,964 | 2,843
non-small cell lung cancer 1,964 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 1,953 | 2,955
invasive ductal carcinoma 1,918 | 2,951
primitive neuroectodermal tumor 1,860 | 3,035
lung adenocarcinoma 1,824 | 2,716
Cancer 1,759 | 2,499
oligodendroglioma 1,712 | 2,850
interstitial cystitis 1,630 | 2,312
pancreatic cancer 1,614 | 2,398
astrocytic glioma 1,518 | 2,597
subependymal giant cell astrocytoma 1,429 | 2,287
tuberculosis 1,373 | 2,010
pituitary cancer 1,274 | 1,972
ulcerative colitis 1,255 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 1,236 | 1,962
diabetes mellitus 1,190 | 1,728
ductal carcinoma in situ 1,172 | 1,745
group 4 medulloblastoma 1,155 | 1,855
Pick disease 1,151 | 1,894
cystic fibrosis 1,132 | 1,696
Autosomal recessive predisposition 1,115 | 1,442
breast carcinoma 1,068 | 1,638
colon cancer 1,039 | 1,478
adrenocortical carcinoma 952 | 1,428
Schizophrenia 829 | 1,160
Rheumatoid arthritis 785 | 1,191
nasopharyngeal carcinoma 771 | 1,058
juvenile dermatomyositis 754 | 1,187
astrocytoma 744 | 1,146
cutaneous lupus erythematosus 737 | 1,057
acute quadriplegic myopathy 707 | 1,158
Intellectual disability 706 | 1,016
primary pancreatic ductal adenocarcinoma 686 | 1,109
Multiple myeloma 677 | 1,332
spina bifida 673 | 1,074
pediatric high grade glioma 669 | 1,064
Atopic dermatitis 658 | 952
active Crohn's disease 625 | 922
dermatomyositis 624 | 966
Melanoma 595 | 711
gastric carcinoma 559 | 807
Liver Cirrhosis, Experimental 542 | 769
Epilepsy 538 | 792
non primary Sjogren syndrome sicca 536 | 891
active ulcerative colitis 525 | 764
esophageal adenocarcinoma 523 | 737
primary Sjogren syndrome 523 | 735
Liver cancer 521 | 604
Obesity 513 | 678
acute myeloid leukemia 476 | 783
Bipolar Disorder 471 | 666
Dull intelligence 461 | 645
Low intelligence 461 | 645
Mental Retardation 461 | 645
Mental deficiency 461 | 645
Poor school performance 461 | 645
Waldenstrons macroglobulinemia 450 | 765
medulloblastoma 443 | 720
Alzheimer's disease 433 | 658
Seizures 425 | 596
progressive supranuclear palsy 425 | 676
Cognitive delay 421 | 608
Global developmental delay 421 | 608
Mental and motor retardation 421 | 608
Skin cancer 421 | 469
Muscle hypotonia 413 | 571
aldosterone-producing adenoma 402 | 665
Duchenne muscular dystrophy 401 | 601
Multiple Sclerosis 387 | 540
Endometriosis 381 | 540
fibroadenoma 379 | 559
Short stature 376 | 531
pancreatic carcinoma 363 | 562
chronic rhinosinusitis 356 | 512
mucosa-associated lymphoid tissue lymphoma 349 | 484
Prostatic Neoplasms 346 | 495
Kidney disease 336 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 335 | 510
hepatocellular carcinoma 328 | 547
Breast Neoplasms 327 | 445
Mammary Neoplasms 315 | 425
Hypertension 309 | 396

Tissue

Endocrine System 11,224 | 18,159
Female tissues 10,794 | 17,400
Digestive Tract 10,749 | 17,369
Skin and soft tissues 10,675 | 17,230
Male tissues 10,598 | 17,142
Blood and immune system 10,482 | 16,909
Liver and Pancreas 10,370 | 16,750
Urinary Tract 10,352 | 16,678
Nervous System 10,320 | 16,725
Respiratory system 10,146 | 16,393
Cardiovascular System 9,372 | 15,192

Target Family

Non-IDG 6,865 | 12,091
Enzyme 2,584 | 4,145
Transcription Factor 811 | 1,400
Kinase 536 | 634
Transporter 331 | 473
oGPCR 320 | 421
GPCR 299 | 408
Ion Channel 240 | 344
Epigenetic 156 | 242
Nuclear Receptor 26 | 48
TF/Epigenetic 26 | 38

UniProt Keyword

Polymorphism 12,194 | 12,194
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28