Development Level

Tbio 6,677 | 10,625
Tdark 3,500 | 7,003
Tchem 1,415 | 1,890
Tclin 447 | 602

Collection

Eligible Kinase Proteins 111 | 134
Eligible non-olfactory GPCR Proteins 96 | 143
Eligible Ion Channel Proteins 83 | 117

IMPC Term

preweaning lethality, complete... 383 | 633
preweaning lethality, incomple... 159 | 260
abnormal behavior 125 | 226
decreased body weight 117 | 174
decreased lean body mass 117 | 195
embryonic lethality prior to t... 116 | 187
decreased total body fat amoun... 115 | 186
decreased bone mineral content 96 | 157
embryonic lethality prior to o... 93 | 148
abnormal bone structure 81 | 131
increased or absent threshold ... 80 | 128
decreased circulating glucose ... 79 | 121
decreased bone mineral density 78 | 126
decreased body length 71 | 108
abnormal embryo size 70 | 112
increased circulating alkaline... 70 | 119
decreased grip strength 67 | 123
abnormal retina morphology 65 | 100
increased lean body mass 65 | 107
enlarged heart 64 | 111
increased mean corpuscular vol... 61 | 91
hyperactivity 59 | 108
increased bone mineral content 59 | 92
increased mean corpuscular hem... 58 | 93
abnormal lens morphology 55 | 73
decreased circulating choleste... 55 | 85
hypoactivity 55 | 89
decreased circulating triglyce... 50 | 83
increased grip strength 49 | 83
decreased circulating HDL chol... 47 | 77
decreased circulating serum al... 47 | 79
increased circulating sodium l... 46 | 71
male infertility 46 | 62
short tibia 46 | 82
increased sacral vertebrae num... 45 | 62
increased fasted circulating g... 44 | 68
improved glucose tolerance 43 | 56
abnormal sleep behavior 42 | 63
decreased circulating insulin ... 42 | 75
abnormal retinal pigmentation 39 | 61
decreased hemoglobin content 38 | 53
decreased lumbar vertebrae num... 38 | 62
increased exploration in new e... 38 | 56
impaired glucose tolerance 37 | 52
abnormal bone mineralization 36 | 55
abnormal coat/hair pigmentatio... 36 | 54
decreased leukocyte cell numbe... 36 | 54
increased circulating HDL chol... 36 | 63
decreased circulating alanine ... 35 | 53
prenatal lethality prior to he... 35 | 64
increased hemoglobin content 34 | 45
abnormal behavioral response t... 33 | 52
decreased rib number 33 | 59
increased total body fat amoun... 33 | 57
decreased heart weight 32 | 44
decreased mean corpuscular vol... 32 | 50
increased circulating choleste... 31 | 53
abnormal seminal vesicle morph... 30 | 47
decreased circulating free fat... 30 | 39
decreased caudal vertebrae num... 29 | 49
decreased eosinophil cell numb... 29 | 41
increased bone mineral density 29 | 52
abnormal heart morphology 28 | 51
decreased prepulse inhibition 28 | 52
decreased startle reflex 28 | 48
increased blood urea nitrogen ... 28 | 44
thrombocytopenia 28 | 46
decreased circulating alkaline... 27 | 41
decreased fasted circulating g... 27 | 49
increased body weight 27 | 42
abnormal spleen morphology 26 | 36
decreased erythrocyte cell num... 26 | 43
decreased mean corpuscular hem... 26 | 34
increased rib number 26 | 41
abnormal neural tube closure 25 | 37
increased heart weight 25 | 37
small testis 25 | 37
abnormal cranium morphology 24 | 32
abnormal eye morphology 24 | 38
abnormal gait 24 | 51
decreased circulating LDL chol... 24 | 37
increased startle reflex 24 | 38
decreased circulating creatini... 23 | 31
decreased circulating total pr... 23 | 41
cardiovascular system phenotyp... 22 | 35
increased circulating chloride... 22 | 43
increased circulating potassiu... 22 | 31
abnormal epididymis morphology 21 | 31
abnormal kidney morphology 21 | 30
decreased neutrophil cell numb... 21 | 37
decreased threshold for audito... 21 | 32
female infertility 21 | 34
increased circulating calcium ... 21 | 32
increased hematocrit 21 | 36
cataract 20 | 26
increased leukocyte cell numbe... 20 | 37
tremors 20 | 34
decreased circulating calcium ... 19 | 33
enlarged spleen 19 | 26
increased erythrocyte cell num... 19 | 26

Disease

ovarian cancer 5,259 | 8,484
osteosarcoma 5,008 | 7,933
psoriasis 4,326 | 6,685
medulloblastoma, large-cell 3,847 | 6,234
glioblastoma 3,443 | 5,572
lung cancer 2,971 | 4,466
atypical teratoid / rhabdoid tumor 2,650 | 4,369
malignant mesothelioma 2,143 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 2,142 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 1,977 | 2,988
lung carcinoma 1,964 | 2,844
pilocytic astrocytoma 1,961 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,954 | 2,956
Breast cancer 1,940 | 3,094
invasive ductal carcinoma 1,919 | 2,950
non-small cell lung cancer 1,892 | 2,798
primitive neuroectodermal tumor 1,858 | 3,031
lung adenocarcinoma 1,809 | 2,713
Carcinoma 1,806 | 2,147
oligodendroglioma 1,706 | 2,849
pediatric high grade glioma 1,702 | 2,712
Cancer 1,650 | 2,346
interstitial cystitis 1,612 | 2,299
pancreatic cancer 1,526 | 2,300
ependymoma 1,492 | 2,514
group 3 medulloblastoma 1,428 | 2,254
subependymal giant cell astrocytoma 1,427 | 2,287
ulcerative colitis 1,419 | 2,087
astrocytic glioma 1,312 | 2,241
adult high grade glioma 1,309 | 2,148
pituitary cancer 1,270 | 1,972
ductal carcinoma in situ 1,169 | 1,745
Pick disease 1,150 | 1,893
group 4 medulloblastoma 1,150 | 1,875
diabetes mellitus 1,139 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 1,125 | 1,795
cystic fibrosis 1,108 | 1,665
tuberculosis 1,062 | 1,557
breast carcinoma 1,041 | 1,614
colon cancer 1,030 | 1,475
posterior fossa group B ependymoma 991 | 1,530
posterior fossa group A ependymoma 988 | 1,511
adrenocortical carcinoma 950 | 1,427
astrocytoma 937 | 1,493
sonic hedgehog group medulloblastoma 924 | 1,482
medulloblastoma 914 | 1,524
primary pancreatic ductal adenocarcinoma 789 | 1,271
nasopharyngeal carcinoma 770 | 1,056
Rheumatoid Arthritis 759 | 1,160
juvenile dermatomyositis 754 | 1,189
cutaneous lupus erythematosus 732 | 1,056
acute quadriplegic myopathy 705 | 1,157
atypical teratoid/rhabdoid tumor 692 | 1,095
Multiple myeloma 666 | 1,327
spina bifida 664 | 1,064
Atopic dermatitis 653 | 944
active Crohn's disease 621 | 918
dermatomyositis 590 | 933
gastric carcinoma 582 | 832
primary Sjogren syndrome 555 | 789
esophageal adenocarcinoma 526 | 737
non primary Sjogren syndrome sicca 502 | 840
acute myeloid leukemia 474 | 780
Obesity 463 | 616
Waldenstrons macroglobulinemia 453 | 765
progressive supranuclear palsy 425 | 674
Alzheimer's disease 420 | 644
tuberculosis and treatment for 6 months 411 | 686
aldosterone-producing adenoma 401 | 664
Duchenne muscular dystrophy 400 | 602
Intellectual disability 384 | 573
Endometriosis 378 | 535
fibroadenoma 377 | 557
pancreatic carcinoma 368 | 567
Multiple Sclerosis 363 | 498
Schizophrenia 354 | 501
chronic rhinosinusitis 354 | 512
mucosa-associated lymphoid tissue lymphoma 344 | 480
Down syndrome 342 | 548
active ulcerative colitis 332 | 477
Prostatic Neoplasms 331 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 328 | 499
hepatocellular carcinoma 316 | 532
Kidney disease 309 | 396
IGA Glomerulonephritis 303 | 454
Mammary Neoplasms 302 | 410
non-small cell lung carcinoma 291 | 413
Amyotrophic Lateral Sclerosis 288 | 431
Asthma 271 | 349
gastric cancer 263 | 430
Neurodegenerative disease 259 | 383
sarcoidosis 249 | 358
Peripheral Neuropathy 244 | 303
Parkinson's disease 243 | 364
inflammatory breast cancer 241 | 404
nephrosclerosis 239 | 329
Epilepsy 226 | 346
Atherosclerosis 223 | 275
Hypertension 222 | 287
tuberculosis and treatment for 3 months 220 | 327

Tissue

Female tissues 11,600 | 18,647
Nervous System 11,530 | 18,561
Urinary Tract 11,519 | 18,444
Endocrine System 11,501 | 18,512
Digestive Tract 11,476 | 18,473
Skin and soft tissues 11,295 | 18,115
Liver and Pancreas 11,271 | 18,136
Blood and immune system 11,173 | 17,995
Cardiovascular System 11,161 | 17,958
Male tissues 11,127 | 17,969
Respiratory system 10,879 | 17,484

Target Family

Non-IDG 6,725 | 11,971
Enzyme 2,585 | 4,146
Transcription Factor 804 | 1,400
Kinase 534 | 634
Transporter 330 | 473
oGPCR 320 | 421
GPCR 297 | 406
Ion Channel 238 | 341
Epigenetic 155 | 242
Nuclear Receptor 26 | 48
TF/Epigenetic 25 | 38

UniProt Keyword

Polymorphism 12,039 | 12,039
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248