Development Level

Tbio 5,329 | 10,625
Tdark 1,464 | 7,003
Tchem 1,071 | 1,890
Tclin 330 | 602

Collection

Eligible Kinase Proteins 97 | 134
Eligible Ion Channel Proteins 43 | 117
Eligible non-olfactory GPCR Proteins 16 | 143

IMPC Term

preweaning lethality, complete... 414 | 633
preweaning lethality, incomple... 144 | 260
abnormal behavior 125 | 226
decreased lean body mass 118 | 195
decreased total body fat amoun... 118 | 186
embryonic lethality prior to t... 110 | 187
decreased body weight 107 | 174
embryonic lethality prior to o... 91 | 148
decreased bone mineral content 86 | 157
increased or absent threshold ... 75 | 128
decreased grip strength 74 | 123
abnormal bone structure 73 | 131
abnormal embryo size 71 | 112
increased circulating alkaline... 69 | 119
decreased body length 68 | 108
decreased bone mineral density 65 | 126
hyperactivity 62 | 108
abnormal retina morphology 61 | 100
decreased circulating glucose ... 61 | 121
increased bone mineral content 59 | 92
increased lean body mass 58 | 107
increased mean corpuscular hem... 58 | 93
decreased circulating choleste... 53 | 85
enlarged heart 50 | 111
increased grip strength 49 | 83
decreased circulating HDL chol... 47 | 77
increased mean corpuscular vol... 47 | 91
abnormal lens morphology 46 | 73
decreased circulating triglyce... 46 | 83
hypoactivity 44 | 89
decreased circulating serum al... 43 | 79
prenatal lethality prior to he... 42 | 64
short tibia 42 | 82
decreased circulating insulin ... 41 | 75
increased sacral vertebrae num... 38 | 62
abnormal retinal pigmentation 37 | 61
decreased lumbar vertebrae num... 37 | 62
improved glucose tolerance 36 | 56
abnormal bone mineralization 35 | 55
decreased hemoglobin content 34 | 53
increased circulating HDL chol... 33 | 63
decreased leukocyte cell numbe... 32 | 54
decreased caudal vertebrae num... 31 | 49
increased circulating choleste... 31 | 53
increased fasted circulating g... 31 | 68
decreased mean corpuscular vol... 30 | 50
increased circulating sodium l... 30 | 71
increased hemoglobin content 30 | 45
decreased circulating alanine ... 29 | 53
decreased rib number 29 | 59
increased bone mineral density 29 | 52
decreased circulating total pr... 28 | 41
abnormal sleep behavior 27 | 63
decreased circulating LDL chol... 27 | 37
decreased prepulse inhibition 27 | 52
impaired glucose tolerance 27 | 52
male infertility 27 | 62
abnormal behavioral response t... 26 | 52
abnormal coat/hair pigmentatio... 26 | 54
decreased circulating free fat... 26 | 39
increased circulating chloride... 26 | 43
abnormal neural tube closure 25 | 37
decreased neutrophil cell numb... 25 | 37
decreased startle reflex 25 | 48
increased body weight 25 | 42
increased total body fat amoun... 25 | 57
decreased circulating alkaline... 24 | 41
decreased eosinophil cell numb... 24 | 41
decreased fasted circulating g... 24 | 49
increased startle reflex 24 | 38
abnormal spleen morphology 23 | 36
increased blood urea nitrogen ... 23 | 44
increased hematocrit 23 | 36
decreased erythrocyte cell num... 22 | 43
decreased heart weight 22 | 44
increased leukocyte cell numbe... 22 | 37
thrombocytopenia 22 | 46
cardiovascular system phenotyp... 21 | 35
decreased circulating calcium ... 21 | 33
decreased mean corpuscular hem... 21 | 34
small testis 21 | 37
tremors 21 | 34
abnormal cranium morphology 20 | 32
abnormal eye morphology 20 | 38
increased heart weight 20 | 37
increased rib number 20 | 41
abnormal gait 19 | 51
abnormal seminal vesicle morph... 19 | 47
decreased threshold for audito... 19 | 32
increased circulating creatini... 19 | 29
increased exploration in new e... 19 | 56
abnormal epididymis morphology 18 | 31
abnormal heart morphology 18 | 51
abnormal hindbrain development 18 | 24
enlarged spleen 18 | 26
increased erythrocyte cell num... 18 | 26
decreased circulating chloride... 17 | 32
increased circulating calcium ... 17 | 32
increased circulating iron lev... 17 | 25
increased circulating triglyce... 17 | 24

Disease

ovarian cancer 4,595 | 8,484
osteosarcoma 4,115 | 7,933
medulloblastoma, large-cell 3,347 | 6,234
psoriasis 3,143 | 6,685
glioblastoma 3,031 | 5,572
lung cancer 2,482 | 4,466
atypical teratoid / rhabdoid tumor 2,385 | 4,369
malignant mesothelioma 1,734 | 3,162
primitive neuroectodermal tumor 1,707 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 1,678 | 3,289
Breast cancer 1,628 | 3,094
oligodendroglioma 1,557 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,543 | 2,988
pilocytic astrocytoma 1,543 | 3,086
invasive ductal carcinoma 1,536 | 2,950
pediatric high grade glioma 1,526 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 1,470 | 2,956
non-small cell lung cancer 1,469 | 2,798
ependymoma 1,427 | 2,514
Cancer 1,384 | 2,346
lung adenocarcinoma 1,368 | 2,713
Carcinoma 1,329 | 2,147
lung carcinoma 1,281 | 2,844
subependymal giant cell astrocytoma 1,267 | 2,287
group 3 medulloblastoma 1,218 | 2,254
pancreatic cancer 1,163 | 2,300
astrocytic glioma 1,159 | 2,241
Pick disease 1,096 | 1,893
adult high grade glioma 1,052 | 2,148
ulcerative colitis 1,019 | 2,087
group 4 medulloblastoma 1,008 | 1,875
interstitial cystitis 1,004 | 2,299
pituitary cancer 948 | 1,972
astrocytoma 937 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 904 | 1,795
ductal carcinoma in situ 893 | 1,745
medulloblastoma 823 | 1,524
breast carcinoma 818 | 1,614
Multiple myeloma 807 | 1,327
colon cancer 807 | 1,475
sonic hedgehog group medulloblastoma 792 | 1,482
acute quadriplegic myopathy 773 | 1,157
diabetes mellitus 769 | 1,663
tuberculosis 761 | 1,557
posterior fossa group A ependymoma 757 | 1,511
adrenocortical carcinoma 747 | 1,427
cystic fibrosis 723 | 1,665
juvenile dermatomyositis 709 | 1,189
primary pancreatic ductal adenocarcinoma 699 | 1,271
Rheumatoid Arthritis 654 | 1,160
posterior fossa group B ependymoma 634 | 1,530
dermatomyositis 621 | 933
atypical teratoid/rhabdoid tumor 603 | 1,095
spina bifida 588 | 1,064
Waldenstrons macroglobulinemia 517 | 765
cutaneous lupus erythematosus 484 | 1,056
nasopharyngeal carcinoma 478 | 1,056
gastric carcinoma 436 | 832
acute myeloid leukemia 431 | 780
Atopic dermatitis 426 | 944
primary Sjogren syndrome 409 | 789
progressive supranuclear palsy 408 | 674
tuberculosis and treatment for 6 months 408 | 686
active Crohn's disease 407 | 918
non primary Sjogren syndrome sicca 401 | 840
Intellectual disability 373 | 573
Alzheimer's disease 364 | 644
aldosterone-producing adenoma 363 | 664
esophageal adenocarcinoma 354 | 737
Down syndrome 334 | 548
Duchenne muscular dystrophy 296 | 602
pancreatic carcinoma 294 | 567
Obesity 292 | 616
Schizophrenia 282 | 501
Endometriosis 278 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 276 | 499
Amyotrophic Lateral Sclerosis 275 | 431
hepatocellular carcinoma 275 | 532
IGA Glomerulonephritis 274 | 454
Prostatic Neoplasms 267 | 471
Mammary Neoplasms 261 | 410
Neurodegenerative disease 237 | 383
Multiple Sclerosis 231 | 498
fibroadenoma 231 | 557
gastric cancer 227 | 430
mucosa-associated lymphoid tissue lymphoma 222 | 480
chronic rhinosinusitis 217 | 512
Parkinson's disease 210 | 364
Kidney disease 208 | 396
active ulcerative colitis 206 | 477
hereditary spastic paraplegia 199 | 313
Epilepsy 194 | 346
inflammatory breast cancer 189 | 404
non-small cell lung carcinoma 184 | 413
interstitial lung disease 178 | 291
Autistic Disorder 176 | 320
Polycystic Ovary Syndrome 176 | 332
Peripheral Neuropathy 169 | 303
glioblastoma multiforme 167 | 347
Crohn's disease 164 | 304

Tissue

Nervous System 8,110 | 18,561
Digestive Tract 8,102 | 18,473
Female tissues 8,099 | 18,647
Endocrine System 8,090 | 18,512
Urinary Tract 8,076 | 18,444
Blood and immune system 8,075 | 17,995
Liver and Pancreas 8,073 | 18,136
Male tissues 8,066 | 17,969
Cardiovascular System 8,059 | 17,958
Skin and soft tissues 8,004 | 18,115
Respiratory system 7,986 | 17,484

Target Family

Non-IDG 4,789 | 11,971
Enzyme 1,663 | 4,146
Transcription Factor 525 | 1,400
Kinase 515 | 634
Transporter 201 | 473
Epigenetic 182 | 242
Ion Channel 165 | 341
GPCR 105 | 406
TF/Epigenetic 25 | 38
Nuclear Receptor 24 | 48

UniProt Keyword

Phosphoprotein 8,194 | 8,194
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955