Development Level

Tbio 5,661 | 11,445
Tdark 1,282 | 6,588
Tchem 933 | 1,598
Tclin 340 | 613

Collection

RFA-RM-18-021 145 | 328
Kinase: IDG Consortium (Target... 90 | 125
Ion Channel: IDG Consortium (T... 41 | 99
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Targets) 14 | 126
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 642 | 979
preweaning lethality, incomple... 256 | 499
embryonic lethality prior to t... 170 | 278
abnormal behavior 157 | 298
embryonic lethality prior to o... 149 | 239
abnormal embryo size 141 | 220
decreased total body fat amoun... 115 | 207
abnormal bone structure 103 | 187
decreased body weight 100 | 161
increased lean body mass 95 | 172
enlarged heart 94 | 210
decreased vertical activity 85 | 208
hyperactivity 84 | 148
decreased bone mineral content 82 | 151
increased startle reflex 77 | 112
increased circulating alkaline... 75 | 122
decreased bone mineral density 73 | 126
decreased lean body mass 71 | 135
decreased circulating glucose ... 69 | 126
increased total body fat amoun... 69 | 134
hypoactivity 68 | 132
decreased grip strength 67 | 116
abnormal heart morphology 65 | 162
embryonic growth retardation 63 | 106
male infertility 60 | 123
increased bone mineral content 59 | 108
increased mean corpuscular hem... 58 | 96
decreased body length 57 | 101
decreased circulating choleste... 56 | 93
prenatal lethality prior to he... 56 | 87
abnormal seminal vesicle morph... 54 | 114
increased mean corpuscular vol... 52 | 92
increased or absent threshold ... 52 | 101
cataract 51 | 92
short tibia 49 | 97
decreased circulating triglyce... 48 | 79
decreased prepulse inhibition 48 | 82
improved glucose tolerance 47 | 79
decreased circulating serum al... 46 | 82
increased circulating HDL chol... 46 | 80
impaired glucose tolerance 44 | 75
abnormal lens morphology 43 | 81
decreased mean corpuscular vol... 43 | 79
decreased circulating insulin ... 42 | 76
increased bone mineral density 42 | 72
edema 41 | 59
abnormal retina morphology 40 | 71
decreased startle reflex 40 | 75
decreased circulating HDL chol... 39 | 68
decreased leukocyte cell numbe... 39 | 73
decreased lymphocyte cell numb... 39 | 83
increased fasted circulating g... 39 | 76
abnormal eye morphology 38 | 68
decreased hemoglobin content 38 | 68
small superior vagus ganglion 38 | 74
small testis 38 | 58
abnormal kidney morphology 36 | 65
increased heart weight 34 | 62
abnormal behavioral response t... 33 | 66
decreased erythrocyte cell num... 33 | 62
increased circulating choleste... 33 | 66
abnormal coat-hair pigmentatio... 32 | 64
abnormal sleep behavior 32 | 70
increased mean platelet volume 32 | 45
abnormal spleen morphology 31 | 55
decreased caudal vertebrae num... 31 | 53
decreased circulating total pr... 31 | 49
decreased fasted circulating g... 31 | 65
decreased blood urea nitrogen ... 30 | 51
decreased mean corpuscular hem... 30 | 50
increased hematocrit 30 | 46
increased monocyte cell number 30 | 63
thrombocytopenia 30 | 56
abnormal gait 29 | 69
abnormal neural tube closure 29 | 46
increased circulating sodium l... 29 | 71
decreased circulating alanine ... 28 | 47
increased hemoglobin content 28 | 45
decreased circulating LDL chol... 27 | 38
decreased circulating alkaline... 27 | 46
abnormal bone mineralization 26 | 38
decreased neutrophil cell numb... 26 | 42
hydrometra 26 | 53
increased blood urea nitrogen ... 26 | 48
increased erythrocyte cell num... 26 | 39
increased grip strength 26 | 41
abnormal testis morphology 25 | 43
enlarged spleen 25 | 41
female infertility 25 | 60
increased circulating chloride... 25 | 41
increased neutrophil cell numb... 25 | 46
abnormal craniofacial morpholo... 24 | 33
abnormal epididymis morphology 24 | 42
increased leukocyte cell numbe... 24 | 47
abnormal cranium morphology 23 | 36
abnormal skin morphology 23 | 50
decreased heart left ventricle... 23 | 28
decreased hematocrit 23 | 46
decreased red blood cell distr... 23 | 41
increased circulating creatini... 23 | 38

Disease

Carcinoma 5,768 | 11,493
ovarian cancer 4,617 | 8,520
osteosarcoma 4,129 | 7,950
medulloblastoma, large-cell 3,358 | 6,241
psoriasis 3,154 | 6,694
glioblastoma 3,152 | 5,792
atypical teratoid / rhabdoid tumor 2,807 | 5,112
lung cancer 2,620 | 4,740
ependymoma 2,416 | 4,679
group 3 medulloblastoma 2,264 | 4,104
adult high grade glioma 1,999 | 3,801
Breast cancer 1,886 | 3,578
malignant mesothelioma 1,781 | 3,232
primitive neuroectodermal tumor 1,708 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 1,685 | 3,291
Kidney cancer 1,599 | 2,613
oligodendroglioma 1,557 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,547 | 2,989
invasive ductal carcinoma 1,543 | 2,951
Astrocytoma, Pilocytic 1,541 | 3,081
non-small cell lung cancer 1,508 | 2,890
Cancer 1,478 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 1,473 | 2,955
lung adenocarcinoma 1,378 | 2,716
astrocytic glioma 1,373 | 2,597
lung carcinoma 1,292 | 2,843
subependymal giant cell astrocytoma 1,271 | 2,287
pancreatic cancer 1,214 | 2,398
Pick disease 1,103 | 1,894
interstitial cystitis 1,006 | 2,312
tuberculosis 1,005 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 997 | 1,962
group 4 medulloblastoma 971 | 1,855
pituitary cancer 957 | 1,972
ductal carcinoma in situ 898 | 1,745
ulcerative colitis 895 | 1,819
breast carcinoma 839 | 1,638
Multiple myeloma 809 | 1,332
diabetes mellitus 808 | 1,728
colon cancer 805 | 1,478
acute quadriplegic myopathy 774 | 1,158
adrenocortical carcinoma 750 | 1,428
Autosomal recessive predisposition 744 | 1,442
cystic fibrosis 735 | 1,696
astrocytoma 726 | 1,146
juvenile dermatomyositis 710 | 1,187
Rheumatoid arthritis 668 | 1,191
Schizophrenia 653 | 1,160
Intellectual disability 634 | 1,016
dermatomyositis 626 | 966
primary pancreatic ductal adenocarcinoma 614 | 1,109
spina bifida 593 | 1,074
pediatric high grade glioma 586 | 1,064
Waldenstrons macroglobulinemia 515 | 765
cutaneous lupus erythematosus 486 | 1,057
nasopharyngeal carcinoma 476 | 1,058
Epilepsy 448 | 792
acute myeloid leukemia 437 | 783
Atopic dermatitis 429 | 952
non primary Sjogren syndrome sicca 425 | 891
gastric carcinoma 417 | 807
active Crohn's disease 412 | 922
progressive supranuclear palsy 410 | 676
Dull intelligence 392 | 645
Low intelligence 392 | 645
Mental Retardation 392 | 645
Mental deficiency 392 | 645
Poor school performance 392 | 645
medulloblastoma 386 | 720
primary Sjogren syndrome 385 | 735
Liver cancer 384 | 604
Alzheimer's disease 372 | 658
aldosterone-producing adenoma 364 | 665
Liver Cirrhosis, Experimental 363 | 769
Cognitive delay 362 | 608
Global developmental delay 362 | 608
Mental and motor retardation 362 | 608
Bipolar Disorder 357 | 666
Melanoma 353 | 711
esophageal adenocarcinoma 353 | 737
Seizures 347 | 596
Muscle hypotonia 337 | 571
active ulcerative colitis 334 | 764
Obesity 327 | 678
Short stature 317 | 531
Down syndrome 313 | 499
Duchenne muscular dystrophy 299 | 601
Amyotrophic lateral sclerosis 294 | 451
Prostatic Neoplasms 289 | 495
pancreatic carcinoma 288 | 562
Breast Neoplasms 285 | 445
autosomal dominant Emery-Dreifuss muscular dystrophy 284 | 510
hepatocellular carcinoma 283 | 547
Endometriosis 282 | 540
Mammary Neoplasms 269 | 425
Neurodegenerative disease 257 | 414
tuberculosis and treatment for 6 months 251 | 409
Small head 249 | 374
Multiple Sclerosis 245 | 540
gastric cancer 245 | 459

Tissue

Endocrine System 8,078 | 18,159
Digestive Tract 7,977 | 17,369
Female tissues 7,971 | 17,400
Skin and soft tissues 7,957 | 17,230
Male tissues 7,939 | 17,142
Nervous System 7,884 | 16,725
Blood and immune system 7,865 | 16,909
Liver and Pancreas 7,864 | 16,750
Urinary Tract 7,854 | 16,678
Respiratory system 7,771 | 16,393
Cardiovascular System 7,511 | 15,192

Target Family

Non-IDG 4,797 | 12,091
Enzyme 1,668 | 4,145
Transcription Factor 530 | 1,400
Kinase 512 | 634
Transporter 202 | 473
Epigenetic 182 | 242
Ion Channel 167 | 344
GPCR 108 | 408
Nuclear Receptor 25 | 48
TF/Epigenetic 25 | 38

UniProt Keyword

Phosphoprotein 8,216 | 8,216
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103