Development Level

Tbio 5,526 | 11,178
Tdark 1,280 | 6,569
Tchem 1,071 | 1,885
Tclin 339 | 612

Collection

Kinase: IDG Consortium (Target... 90 | 125
Ion Channel: IDG Consortium (T... 41 | 99
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Targets) 14 | 126
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 642 | 979
preweaning lethality, incomple... 256 | 499
embryonic lethality prior to t... 170 | 278
abnormal behavior 157 | 298
embryonic lethality prior to o... 149 | 239
abnormal embryo size 141 | 220
decreased total body fat amoun... 115 | 207
abnormal bone structure 103 | 187
decreased body weight 100 | 161
increased lean body mass 95 | 172
enlarged heart 94 | 210
decreased vertical activity 85 | 208
hyperactivity 84 | 148
decreased bone mineral content 82 | 151
increased startle reflex 77 | 112
increased circulating alkaline... 75 | 122
decreased bone mineral density 73 | 126
decreased lean body mass 71 | 135
decreased circulating glucose ... 69 | 126
increased total body fat amoun... 69 | 134
hypoactivity 68 | 132
decreased grip strength 67 | 116
abnormal heart morphology 65 | 162
embryonic growth retardation 63 | 106
male infertility 60 | 123
increased bone mineral content 59 | 108
increased mean corpuscular hem... 58 | 96
decreased body length 57 | 101
decreased circulating choleste... 56 | 93
prenatal lethality prior to he... 56 | 87
abnormal seminal vesicle morph... 54 | 114
increased mean corpuscular vol... 52 | 92
increased or absent threshold ... 52 | 101
cataract 51 | 92
short tibia 49 | 97
decreased circulating triglyce... 48 | 79
decreased prepulse inhibition 48 | 82
improved glucose tolerance 47 | 79
decreased circulating serum al... 46 | 82
increased circulating HDL chol... 46 | 80
impaired glucose tolerance 44 | 75
abnormal lens morphology 43 | 81
decreased mean corpuscular vol... 43 | 79
decreased circulating insulin ... 42 | 76
increased bone mineral density 42 | 72
edema 41 | 59
abnormal retina morphology 40 | 71
decreased startle reflex 40 | 75
decreased circulating HDL chol... 39 | 68
decreased leukocyte cell numbe... 39 | 73
decreased lymphocyte cell numb... 39 | 83
increased fasted circulating g... 39 | 76
abnormal eye morphology 38 | 68
decreased hemoglobin content 38 | 68
small superior vagus ganglion 38 | 74
small testis 38 | 58
abnormal kidney morphology 36 | 65
increased heart weight 34 | 62
abnormal behavioral response t... 33 | 66
decreased erythrocyte cell num... 33 | 62
increased circulating choleste... 33 | 66
abnormal coat-hair pigmentatio... 32 | 64
abnormal sleep behavior 32 | 70
increased mean platelet volume 32 | 45
abnormal spleen morphology 31 | 55
decreased caudal vertebrae num... 31 | 53
decreased circulating total pr... 31 | 49
decreased fasted circulating g... 31 | 65
decreased blood urea nitrogen ... 30 | 51
decreased mean corpuscular hem... 30 | 50
increased hematocrit 30 | 46
increased monocyte cell number 30 | 63
thrombocytopenia 30 | 56
abnormal gait 29 | 69
abnormal neural tube closure 29 | 46
increased circulating sodium l... 29 | 71
decreased circulating alanine ... 28 | 47
increased hemoglobin content 28 | 45
decreased circulating LDL chol... 27 | 38
decreased circulating alkaline... 27 | 46
abnormal bone mineralization 26 | 38
decreased neutrophil cell numb... 26 | 42
hydrometra 26 | 53
increased blood urea nitrogen ... 26 | 48
increased erythrocyte cell num... 26 | 39
increased grip strength 26 | 41
abnormal testis morphology 25 | 43
enlarged spleen 25 | 41
female infertility 25 | 60
increased circulating chloride... 25 | 41
increased neutrophil cell numb... 25 | 46
abnormal craniofacial morpholo... 24 | 33
abnormal epididymis morphology 24 | 42
increased leukocyte cell numbe... 24 | 47
abnormal cranium morphology 23 | 36
abnormal skin morphology 23 | 50
decreased heart left ventricle... 23 | 28
decreased hematocrit 23 | 46
decreased red blood cell distr... 23 | 41
increased circulating creatini... 23 | 38

Disease

Carcinoma 5,651 | 11,192
ovarian cancer 4,521 | 8,297
osteosarcoma 4,047 | 7,766
medulloblastoma, large-cell 3,287 | 6,086
psoriasis 3,086 | 6,514
glioblastoma 3,084 | 5,635
atypical teratoid / rhabdoid tumor 2,741 | 4,971
lung cancer 2,569 | 4,607
ependymoma 2,366 | 4,559
group 3 medulloblastoma 2,223 | 4,002
adult high grade glioma 1,957 | 3,701
Breast cancer 1,840 | 3,469
malignant mesothelioma 1,742 | 3,135
primitive neuroectodermal tumor 1,668 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 1,659 | 3,204
Kidney cancer 1,570 | 2,548
oligodendroglioma 1,527 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 1,519 | 2,902
invasive ductal carcinoma 1,514 | 2,867
Astrocytoma, Pilocytic 1,506 | 3,006
non-small cell lung cancer 1,471 | 2,799
intraductal papillary-mucinous adenoma (IPMA) 1,450 | 2,872
Cancer 1,426 | 2,388
astrocytic glioma 1,348 | 2,530
lung adenocarcinoma 1,347 | 2,627
lung carcinoma 1,261 | 2,755
subependymal giant cell astrocytoma 1,243 | 2,230
pancreatic cancer 1,189 | 2,322
Pick disease 1,083 | 1,856
interstitial cystitis 982 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 979 | 1,911
tuberculosis 977 | 1,963
group 4 medulloblastoma 950 | 1,806
pituitary cancer 941 | 1,915
ductal carcinoma in situ 881 | 1,686
ulcerative colitis 880 | 1,765
breast carcinoma 824 | 1,589
Multiple myeloma 791 | 1,296
diabetes mellitus 789 | 1,683
colon cancer 788 | 1,428
acute quadriplegic myopathy 760 | 1,133
Autosomal recessive predisposition 733 | 1,407
adrenocortical carcinoma 726 | 1,385
cystic fibrosis 713 | 1,629
astrocytoma 710 | 1,113
juvenile dermatomyositis 689 | 1,147
Rheumatoid arthritis 648 | 1,156
Schizophrenia 643 | 1,136
Intellectual disability 623 | 998
dermatomyositis 608 | 941
primary pancreatic ductal adenocarcinoma 596 | 1,071
spina bifida 587 | 1,053
pediatric high grade glioma 573 | 1,035
Waldenstrons macroglobulinemia 500 | 742
cutaneous lupus erythematosus 471 | 1,016
nasopharyngeal carcinoma 465 | 1,024
Epilepsy 441 | 775
acute myeloid leukemia 424 | 760
Atopic dermatitis 418 | 915
non primary Sjogren syndrome sicca 416 | 861
gastric carcinoma 410 | 781
active Crohn's disease 399 | 882
progressive supranuclear palsy 398 | 656
Dull intelligence 386 | 634
Low intelligence 386 | 634
Mental Retardation 386 | 634
Mental deficiency 386 | 634
Poor school performance 386 | 634
medulloblastoma 379 | 702
Liver cancer 376 | 589
primary Sjogren syndrome 373 | 710
Alzheimer's disease 361 | 640
aldosterone-producing adenoma 358 | 646
Cognitive delay 356 | 596
Global developmental delay 356 | 596
Mental and motor retardation 356 | 596
Bipolar Disorder 350 | 646
Melanoma 347 | 689
Liver Cirrhosis, Experimental 344 | 733
Seizures 341 | 584
esophageal adenocarcinoma 338 | 696
Muscle hypotonia 333 | 562
active ulcerative colitis 324 | 736
Obesity 318 | 655
Short stature 312 | 514
Down syndrome 302 | 480
Duchenne muscular dystrophy 291 | 587
Amyotrophic lateral sclerosis 288 | 437
pancreatic carcinoma 284 | 555
Prostatic Neoplasms 277 | 472
autosomal dominant Emery-Dreifuss muscular dystrophy 276 | 492
hepatocellular carcinoma 276 | 536
Breast Neoplasms 274 | 423
Endometriosis 272 | 521
Mammary Neoplasms 258 | 403
Neurodegenerative disease 251 | 402
Small head 244 | 366
tuberculosis and treatment for 6 months 244 | 399
Multiple Sclerosis 239 | 527
Skin cancer 238 | 451

Tissue

Endocrine System 8,078 | 18,159
Digestive Tract 7,977 | 17,369
Female tissues 7,971 | 17,400
Skin and soft tissues 7,957 | 17,230
Male tissues 7,939 | 17,142
Nervous System 7,884 | 16,725
Blood and immune system 7,865 | 16,909
Liver and Pancreas 7,864 | 16,750
Urinary Tract 7,854 | 16,678
Respiratory system 7,771 | 16,393
Cardiovascular System 7,511 | 15,192

Target Family

Non-IDG 4,797 | 12,091
Enzyme 1,668 | 4,145
Transcription Factor 530 | 1,400
Kinase 512 | 634
Transporter 202 | 473
Epigenetic 182 | 242
Ion Channel 167 | 344
GPCR 108 | 408
Nuclear Receptor 25 | 48
TF/Epigenetic 25 | 38

UniProt Keyword

Phosphoprotein 8,216 | 8,216
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148