Development Level

Tbio 75 | 11,445
Tchem 13 | 1,598
Tdark 11 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased vertical activity 3 | 208
abnormal heart morphology 2 | 162
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased NK T cell number 1 | 2
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
shortened RR interval 1 | 17
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 61 | 11,493
ovarian cancer 56 | 8,520
osteosarcoma 43 | 7,950
psoriasis 41 | 6,694
medulloblastoma, large-cell 38 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
glioblastoma 31 | 5,792
Zellweger syndrome 30 | 37
atypical teratoid / rhabdoid tumor 29 | 5,112
Autosomal recessive predisposition 27 | 1,442
ependymoma 27 | 4,679
lung cancer 25 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Muscle hypotonia 23 | 571
Peroxisomal disease 21 | 22
Epilepsy 20 | 792
Infantile Refsum disease 20 | 23
invasive ductal carcinoma 20 | 2,951
malignant mesothelioma 20 | 3,232
Concave bridge of nose 19 | 195
Depressed nasal bridge 19 | 195
Depressed nasal root/bridge 19 | 195
Failure to gain weight 19 | 365
Hepatomegaly 19 | 285
Pediatric failure to thrive 19 | 365
Seizures 19 | 596
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
ulcerative colitis 19 | 1,819
Cataract 18 | 297
Optic Atrophy 18 | 242
Retinitis Pigmentosa 18 | 226
Short stature 18 | 531
adult high grade glioma 18 | 3,801
astrocytic glioma 18 | 2,597
Adrenoleukodystrophy 17 | 29
Chondrodysplasia punctata 17 | 41
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Low Vision 17 | 174
Mental and motor retardation 17 | 608
Nystagmus 17 | 317
Sensorineural Hearing Loss (disorder) 17 | 284
Visual Impairment 17 | 174
interstitial cystitis 17 | 2,312
Abnormality of metabolism/homeostasis 16 | 134
Blepharoptosis 16 | 231
Broad flat nasal bridge 16 | 236
Cerebellar Ataxia 16 | 304
Developmental regression 16 | 95
High forehead 16 | 102
Hypoplastic mandible condyle 16 | 275
Lens Opacities 16 | 231
Loss of developmental milestones 16 | 95
Mandibular hypoplasia 16 | 275
Mental deterioration in childhood 16 | 95
Micrognathism 16 | 275
Muscle Spasticity 16 | 195
Nasal bridge wide 16 | 236
Neurodevelopmental regression 16 | 95
Psychomotor regression 16 | 95
Psychomotor regression beginning in infancy 16 | 95
Psychomotor regression in infants 16 | 95
Psychomotor regression, progressive 16 | 95
Small head 16 | 374
Strabismus 16 | 270
Tall forehead 16 | 102
ductal carcinoma in situ 16 | 1,745
Abnormal skeletal development 15 | 60
Abnormality of retinal pigmentation 15 | 111
Addison Disease 15 | 18
Adrenal cortical hypofunction 15 | 23
Anteverted nostril 15 | 191
Big calvaria 15 | 147
Byzanthine arch palate 15 | 194
Congenital Epicanthus 15 | 177
Death in early childhood 15 | 82
Death in infancy 15 | 82
Difficulties with night vision 15 | 87
Electroencephalogram abnormal 15 | 101
Elevated levels of phytanic acid 15 | 15
Increased head circumference 15 | 147
Increased size of cranium 15 | 147
Increased size of skull 15 | 147
Liver Failure 15 | 73
Long narrow head 15 | 75
Narrow cranium shape 15 | 75
Narrow head shape 15 | 75
Narrow skull shape 15 | 75
Night Blindness 15 | 101
Osteochondrodysplasias 15 | 72
Respiratory Insufficiency 15 | 132
Respiratory function loss 15 | 121
Retinal pigment epithelial abnormality 15 | 111
Stippled epiphyses 15 | 28
Turridolichocephaly 15 | 75
Upward slant of palpebral fissure 15 | 75
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
oligodendroglioma 15 | 2,850
Feeding difficulties in infancy 14 | 175

Tissue

Digestive Tract 99 | 17,369
Endocrine System 99 | 18,159
Blood and immune system 98 | 16,909
Female tissues 98 | 17,400
Liver and Pancreas 98 | 16,750
Male tissues 98 | 17,142
Skin and soft tissues 98 | 17,230
Urinary Tract 98 | 16,678
Nervous System 96 | 16,725
Respiratory system 95 | 16,393
Cardiovascular System 92 | 15,192

Target Family

Enzyme 57 | 4,145
Non-IDG 37 | 12,091
Transporter 6 | 473

UniProt Keyword

Peroxisome 100 | 100
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Peroxisomal membrane protein 4 PXMP4 Tdark Non-IDG -0.51334 4.00 99
Dehydrogenase/reductase SDR family member 4 DHRS4 Tbio Enzyme -1.65486 46.6 122
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100
ATP-binding cassette sub-family D member 3 ABCD3 Tbio Transporter -1.82051 64.2 166
Malonyl-CoA decarboxylase, mitochondrial MLYCD Tchem Enzyme -1.70434 46.1 67
Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase URAD Tdark Enzyme -0.87506 7.00 6
Acyl-coenzyme A thioesterase 4 ACOT4 Tbio Enzyme -0.53787 2.87 58
Meiosis regulator and mRNA stability factor 1 MARF1 Tdark Non-IDG -0.82344 7.58 23
Peroxisomal targeting signal 1 receptor PEX5 Tbio Non-IDG -2.43126 272.8 138