Development Level

Tbio 26 | 11,651
Tchem 7 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
hyperactivity 2 | 148
increased red blood cell distr... 2 | 34
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
thrombocytosis 2 | 27
abnormal bone structure 1 | 187
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
tremors 1 | 39

Disease

Parkinson's disease 36 | 392
Neurodegenerative disease 31 | 414
Carcinoma 27 | 11,493
Parkinsonian Disorders 22 | 56
ovarian cancer 22 | 8,520
osteosarcoma 21 | 7,950
Muscle Rigidity 18 | 49
Bradykinesia 17 | 34
Autosomal recessive predisposition 16 | 1,442
Dystonia 16 | 164
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
Dysarthria 13 | 192
Postural instability 13 | 19
Tremor 13 | 113
group 3 medulloblastoma 13 | 4,104
Parkinson Disease 12 | 64
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
oligodendroglioma 12 | 2,850
psoriasis 12 | 6,694
Astrocytoma, Pilocytic 11 | 3,081
Dystonic disease 11 | 106
Nerve Degeneration 11 | 121
lung cancer 11 | 4,740
Dementia 10 | 175
Depressive disorder 10 | 409
Breast cancer 9 | 3,578
Deglutition Disorders 9 | 132
Epilepsy 9 | 792
Intellectual disability 9 | 1,016
Multiple system atrophy 9 | 29
PARKINSON DISEASE 19, JUVENILE-ONSET 9 | 10
PARKINSON DISEASE, LATE-ONSET 9 | 20
Pick disease 9 | 1,894
Young onset Parkinson disease 9 | 10
adult high grade glioma 9 | 3,801
Alzheimer's disease 8 | 658
Hyperreflexia 8 | 209
Schizophrenia 8 | 1,160
lung carcinoma 8 | 2,843
Amyotrophic lateral sclerosis 7 | 451
Autosomal dominant late onset Parkinson disease 7 | 7
Brain disease 7 | 96
Cancer 7 | 2,499
Kidney cancer 7 | 2,613
Progressive disorder 7 | 142
Toxic encephalopathy 7 | 141
diabetes mellitus 7 | 1,728
primitive neuroectodermal tumor 7 | 3,035
Adult onset 6 | 82
Bipolar Disorder 6 | 666
Gait Ataxia 6 | 51
Multiple myeloma 6 | 1,332
Neurodegenerative Disorders 6 | 79
Pyramidal sign 6 | 29
Resting Tremor 6 | 9
Seizures 6 | 596
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
Akinesia 5 | 13
Anxiety 5 | 136
Anxiety disease 5 | 113
Babinski Reflex 5 | 100
Cerebral atrophy 5 | 178
Cognitive delay 5 | 608
Congenital pes cavus 5 | 88
Degenerative brain disorder 5 | 100
Dull intelligence 5 | 645
Fatigue 5 | 182
Favorable response to levodopa 5 | 6
Global developmental delay 5 | 608
Hypokinesia 5 | 19
Infantile onset 5 | 238
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Motor delay 5 | 147
Movement disease 5 | 11
Muscle Spasticity 5 | 195
Myoclonus 5 | 74
No development of motor milestones 5 | 147
Poor school performance 5 | 645
Rapidly progressive 5 | 27
Rapidly progressive disorder 5 | 27
Slow progression 5 | 89
colon cancer 5 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
non primary Sjogren syndrome sicca 5 | 891
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
aldosterone-producing adenoma 4 | 665
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 676
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Endocrine System 36 | 18,159
Digestive Tract 35 | 17,369
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Nervous System 35 | 16,725
Blood and immune system 34 | 16,909
Male tissues 34 | 17,142
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678
Cardiovascular System 33 | 15,192
Respiratory system 33 | 16,393

Target Family

Non-IDG 16 | 12,091
Enzyme 10 | 4,145
Transporter 5 | 473
Kinase 4 | 634
Ion Channel 1 | 344

UniProt Keyword

Parkinsonism 36 | 36
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 CHCHD2 Tbio Non-IDG -1.33813 39.8 99
Synphilin-1 SNCAIP Tbio Non-IDG -1.92755 92.1 157
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Serine/threonine-protein kinase PINK1, mitochondrial PINK1 Tbio Kinase -2.81574 706.5 546
F-box only protein 7 FBXO7 Tbio Non-IDG -2.07231 118.6 100
Ataxin-2 ATXN2 Tbio Non-IDG -2.32523 224.6 194
Alpha-synuclein SNCA Tchem Non-IDG -3.63937 4224.9 1813
Tyrosine 3-monooxygenase TH Tclin Enzyme -3.49790 2144.6 1203
Leucine-rich repeat serine/threonine-protein kinase 2 LRRK2 Tchem Kinase -3.07199 1241.4 740
Microtubule-associated protein tau MAPT Tchem Non-IDG -3.88207 7239.3 3951