Development Level

Tbio 31 | 11,651
Tchem 2 | 1,388

IMPC Phenotype

decreased vertical activity 3 | 208
abnormal vibrissa morphology 2 | 25
decreased circulating insulin ... 2 | 76
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal limb position 1 | 3
abnormal liver morphology 1 | 17
abnormal nail morphology 1 | 8
abnormal retinal outer nuclear... 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
decreased basophil cell number 1 | 16
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
female infertility 1 | 60
hydrometra 1 | 53
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating phosphat... 1 | 26
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
prenatal lethality 1 | 28
short tibia 1 | 97
small testis 1 | 58

Disease

Palmoplantar keratosis 33 | 74
Carcinoma 24 | 11,493
psoriasis 20 | 6,694
ovarian cancer 17 | 8,520
Autosomal recessive predisposition 15 | 1,442
Keratosis 15 | 37
Dystrophia unguium 13 | 53
non-small cell lung cancer 12 | 2,890
osteosarcoma 12 | 7,950
Breast cancer 11 | 3,578
Cancer 10 | 2,499
breast carcinoma 10 | 1,638
lung adenocarcinoma 10 | 2,716
pancreatic cancer 10 | 2,398
spina bifida 10 | 1,074
Abnormal blistering of the skin 9 | 54
Alopecia 9 | 115
Blister of skin 9 | 54
Erythema 9 | 58
Flushing 9 | 60
Hyperhidrosis disorder 9 | 81
Ichthyoses 9 | 41
Increased sweating 9 | 81
Skin bulla 9 | 54
Sweating 9 | 81
medulloblastoma, large-cell 9 | 6,241
Atopic dermatitis 8 | 952
cystic fibrosis 8 | 1,696
esophageal adenocarcinoma 8 | 737
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
malignant mesothelioma 8 | 3,232
Leukokeratosis 7 | 19
Leukoplakia, Oral 7 | 20
Nail dysplasia 7 | 52
Onychogryposis 7 | 13
Sparse eyebrow 7 | 42
lung cancer 7 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Clouston syndrome 6 | 9
Dental caries 6 | 164
Erythrokeratodermia variabilis 6 | 10
Ichthyosis 6 | 56
Pachyonychia congenita 6 | 10
Rotting teeth 6 | 73
Sparse eyelashes 6 | 31
adult high grade glioma 6 | 3,801
ductal carcinoma in situ 6 | 1,745
glioblastoma 6 | 5,792
invasive ductal carcinoma 6 | 2,951
nasopharyngeal carcinoma 6 | 1,058
Abnormality of nail color 5 | 5
Abnormality of the fingernails 5 | 51
Astrocytoma, Pilocytic 5 | 3,081
Dystrophic fingernails 5 | 18
Epidermolytic hyperkeratosis 5 | 14
Hyperkeratosis, generalized 5 | 14
Skin Neoplasms 5 | 69
Skin disease 5 | 66
Squamous cell carcinoma 5 | 129
atypical teratoid / rhabdoid tumor 5 | 5,112
cutaneous lupus erythematosus 5 | 1,057
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung carcinoma 5 | 2,843
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Carcinoma, Squamous Cell 4 | 110
Congenital ichthyosiform erythroderma 4 | 28
Deafness 4 | 198
Dull intelligence 4 | 645
Exfoliative dermatitis 4 | 24
Fissured tongue 4 | 25
Hyperkeratosis, Epidermolytic 4 | 7
Hypohidrosis 4 | 34
Hypotrichosis 4 | 47
Infantile onset 4 | 238
Intellectual disability 4 | 1,016
Keratitis 4 | 62
Keratoderma, Palmoplantar, Diffuse 4 | 4
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Monilethrix 4 | 18
Nail Diseases 4 | 24
Nail abnormality 4 | 22
Nonsyndromic deafness 4 | 142
Oculodentodigital dysplasia 4 | 14
Poor school performance 4 | 645
Sensorineural Hearing Loss (disorder) 4 | 284
Sensorineural hearing loss 4 | 106
Short stature 4 | 531
Small head 4 | 374
Sparse scalp hair 4 | 42
ependymoma 4 | 4,679
group 4 medulloblastoma 4 | 1,855
Congenital deafness 3 | 185
Hearing Loss, Partial 3 | 185

Tissue

Digestive Tract 33 | 17,369
Female tissues 33 | 17,400
Skin and soft tissues 33 | 17,230
Blood and immune system 32 | 16,909
Endocrine System 31 | 18,159
Liver and Pancreas 30 | 16,750
Urinary Tract 30 | 16,678
Male tissues 29 | 17,142
Nervous System 28 | 16,725
Respiratory system 27 | 16,393
Cardiovascular System 20 | 15,192

Target Family

Non-IDG 27 | 12,091
Enzyme 5 | 4,145
Ion Channel 1 | 344

UniProt Keyword

Palmoplantar keratoderma 33 | 33
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Membrane-bound transcription factor site-2 protease MBTPS2 Tbio Enzyme -1.94015 86.1 119
Tyrosine aminotransferase TAT Tbio Enzyme -3.06741 1138.7 162
Gap junction beta-4 protein GJB4 Tbio Non-IDG -1.60100 40.2 125
Synaptosomal-associated protein 29 SNAP29 Tbio Non-IDG -1.47467 28.0 125
Transient receptor potential cation channel subfamily V member 3 TRPV3 Tchem Ion Channel -2.11149 133.2 273
Junction plakoglobin JUP Tbio Non-IDG -2.01808 101.8 719
R-spondin-1 RSPO1 Tbio Non-IDG -2.26774 188.7 164
Keratin, type II cytoskeletal 6C KRT6C Tbio Non-IDG -0.47272 2.11 89