Development Level

Tbio 9 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal placenta size 1 | 20
decreased leukocyte cell numbe... 1 | 73
decreased threshold for audito... 1 | 26
impaired glucose tolerance 1 | 75
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
pallor 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 9 | 11,493
Cancer 6 | 2,499
Autosomal recessive predisposition 5 | 1,442
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Waardenburg's syndrome 4 | 17
ovarian cancer 4 | 8,520
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Melanoma 3 | 711
Mental and motor retardation 3 | 608
Microphthalmia 3 | 76
Short stature 3 | 531
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
spina bifida 3 | 1,074
Abnormality of vision 2 | 40
Alveolar rhabdomyosarcoma 2 | 7
Astrocytoma, Pilocytic 2 | 3,081
Atresia of vagina 2 | 10
Breast cancer 2 | 3,578
Cleft Lip 2 | 141
Cleft Palate 2 | 271
Coloboma 2 | 51
Coloboma of optic disc 2 | 9
Concave bridge of nose 2 | 195
Congenital neurologic anomalies 2 | 20
Craniofacial Abnormalities 2 | 151
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Delayed bone age 2 | 136
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Ectomesenchymoma 2 | 5
Highly variable severity 2 | 157
Hypoplasia of the maxilla 2 | 66
Hypoplastic mandible condyle 2 | 275
Hypotrophic maxilla 2 | 66
Kidney disease 2 | 430
Low Vision 2 | 174
Low set ears 2 | 181
Mandibular hypoplasia 2 | 275
Maxillary retrognathia 2 | 66
Micrognathism 2 | 275
Muscle hypotonia 2 | 571
Myopia 2 | 176
Nephrogenic adenoma 2 | 10
Nephrogenic adenoma of urinary bladder 2 | 2
Nervous System Malformations 2 | 10
Orbital separation excessive 2 | 244
Orofacial cleft 2 | 54
Renal coloboma syndrome 2 | 4
Retrusion of upper jaw bones 2 | 66
Rhabdomyosarcoma 2 | 39
Rhabdomyosarcoma, Alveolar 2 | 4
Sarcoma 2 | 62
Scapular weakness 2 | 23
Sensorineural Hearing Loss (disorder) 2 | 284
Small head 2 | 374
Variable expressivity 2 | 157
Visual Impairment 2 | 174
Winged scapula 2 | 23
atypical teratoid/rhabdoid tumor 2 | 357
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
psoriasis 2 | 6,694
Abnormality of the antihelix 1 | 10
Aniridia 1 | 25
Anterior Segment Dysgenesis 5 1 | 4
Athyreosis 1 | 4
Athyroidal hypothyroidism 1 | 5
Axenfeld-Rieger Syndrome, Type 1 1 | 3
CATARACT, AUTOSOMAL DOMINANT 1 | 4
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Type 1 1 | 43
Disorder of the optic nerve 1 | 1
HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS 1 | 4
Hoarse cry 1 | 5
Hypersomnia 1 | 8
Hypoplastic iris stoma 1 | 4
Hypothermia, natural 1 | 17
Keratopathy 1 | 12
Lacrimation abnormality 1 | 4
Maturity onset diabetes mellitus in young 1 | 11
Peters anomaly 1 | 16
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 1 | 12
Presenile cataract 1 | 1
Raised TSH level 1 | 8
Scanning speech 1 | 9
Scleral staphyloma 1 | 1
Thyroid Agenesis 1 | 5
Thyroid Hypoplasia 1 | 4
WAGR syndrome 1 | 10
blue iris (physical finding) 1 | 17

Tissue

Endocrine System 9 | 18,159
Digestive Tract 8 | 17,369
Male tissues 8 | 17,142
Blood and immune system 7 | 16,909
Female tissues 7 | 17,400
Nervous System 7 | 16,725
Skin and soft tissues 7 | 17,230
Urinary Tract 6 | 16,678
Liver and Pancreas 5 | 16,750
Respiratory system 5 | 16,393
Cardiovascular System 3 | 15,192

Target Family

Transcription Factor 9 | 1,400

UniProt Keyword

Paired box 9 | 9
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.68609 492.0 349
Paired box protein Pax-1 PAX1 Tbio Transcription Factor -2.03339 106.1 245
Paired box protein Pax-8 PAX8 Tbio Transcription Factor -2.64765 442.1 540
Paired box protein Pax-7 PAX7 Tbio Transcription Factor -2.70703 468.7 418
Paired box protein Pax-9 PAX9 Tbio Transcription Factor -2.09311 130.5 226
Paired box protein Pax-5 PAX5 Tbio Transcription Factor -2.76237 578.2 633
Paired box protein Pax-4 PAX4 Tbio Transcription Factor -2.13674 146.6 229
Paired box protein Pax-3 PAX3 Tbio Transcription Factor -2.83871 692.1 400