Development Level

Tbio 339 | 11,445
Tchem 116 | 1,598
Tclin 58 | 613
Tdark 58 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 37 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 15 | 298
embryonic lethality prior to o... 11 | 239
decreased total body fat amoun... 10 | 207
abnormal embryo size 9 | 220
embryonic lethality prior to t... 9 | 278
hypoactivity 9 | 132
increased lean body mass 9 | 172
decreased bone mineral density 8 | 126
abnormal heart morphology 7 | 162
abnormal lens morphology 7 | 81
cataract 7 | 92
decreased vertical activity 7 | 208
abnormal seminal vesicle morph... 6 | 114
decreased lean body mass 6 | 135
enlarged heart 6 | 210
hyperactivity 6 | 148
increased startle reflex 6 | 112
abnormal bone structure 5 | 187
decreased circulating choleste... 5 | 93
decreased circulating iron lev... 5 | 32
embryonic growth retardation 5 | 106
increased body length 5 | 32
increased circulating alkaline... 5 | 122
abnormal neural tube closure 4 | 46
abnormal retinal vasculature m... 4 | 27
abnormal sleep behavior 4 | 70
decreased blood urea nitrogen ... 4 | 51
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
decreased circulating insulin ... 4 | 76
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
decreased grip strength 4 | 116
decreased mean corpuscular vol... 4 | 79
improved glucose tolerance 4 | 79
increased fasted circulating g... 4 | 76
increased monocyte cell number 4 | 63
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
small kidney 4 | 16
abnormal craniofacial morpholo... 3 | 33
abnormal embryo turning 3 | 31
abnormal epididymis morphology 3 | 42
abnormal retinal blood vessel ... 3 | 26
abnormal skin morphology 3 | 50
abnormal vocalization 3 | 21
decreased body length 3 | 101
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating phosphat... 3 | 27
decreased erythrocyte cell num... 3 | 62
decreased hemoglobin content 3 | 68
decreased lactate dehydrogenas... 3 | 16
decreased lymphocyte cell numb... 3 | 83
decreased threshold for audito... 3 | 26
hydrometra 3 | 53
increased blood urea nitrogen ... 3 | 48
increased circulating HDL chol... 3 | 80
increased circulating potassiu... 3 | 29
increased circulating sodium l... 3 | 71
male infertility 3 | 123
persistence of hyaloid vascula... 3 | 33
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
small superior vagus ganglion 3 | 74
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal locomotor behavior 2 | 24
abnormal neural tube morpholog... 2 | 12
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating serum al... 2 | 82
decreased hematocrit 2 | 46
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
edema 2 | 59
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
pallor 2 | 34
small spleen 2 | 19
small testis 2 | 58
trunk curl 2 | 16

Disease

Carcinoma 365 | 11,493
ovarian cancer 273 | 8,520
psoriasis 247 | 6,694
osteosarcoma 236 | 7,950
medulloblastoma, large-cell 184 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 168 | 1,962
lung cancer 167 | 4,740
glioblastoma 166 | 5,792
atypical teratoid / rhabdoid tumor 146 | 5,112
ependymoma 144 | 4,679
non-small cell lung cancer 136 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,291
malignant mesothelioma 128 | 3,232
group 3 medulloblastoma 127 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,955
Cancer 117 | 2,499
invasive ductal carcinoma 116 | 2,951
Autosomal recessive predisposition 115 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 114 | 2,989
Breast cancer 111 | 3,578
interstitial cystitis 111 | 2,312
adult high grade glioma 108 | 3,801
lung adenocarcinoma 107 | 2,716
lung carcinoma 104 | 2,843
pancreatic cancer 96 | 2,398
Astrocytoma, Pilocytic 95 | 3,081
ductal carcinoma in situ 92 | 1,745
tuberculosis 91 | 2,010
primitive neuroectodermal tumor 90 | 3,035
oligodendroglioma 87 | 2,850
astrocytic glioma 77 | 2,597
subependymal giant cell astrocytoma 77 | 2,287
cystic fibrosis 76 | 1,696
adrenocortical carcinoma 75 | 1,428
ulcerative colitis 73 | 1,819
breast carcinoma 68 | 1,638
diabetes mellitus 67 | 1,728
Pick disease 66 | 1,894
Epilepsy 63 | 792
Schizophrenia 62 | 1,160
pituitary cancer 61 | 1,972
Liver Cirrhosis, Experimental 58 | 769
Intellectual disability 57 | 1,016
Seizures 57 | 596
colon cancer 57 | 1,478
Muscle hypotonia 55 | 571
Multiple myeloma 54 | 1,332
Cognitive delay 52 | 608
Global developmental delay 52 | 608
Mental and motor retardation 52 | 608
Prostatic Neoplasms 52 | 495
active Crohn's disease 51 | 922
Kidney cancer 50 | 2,613
group 4 medulloblastoma 50 | 1,855
esophageal adenocarcinoma 47 | 737
Atopic dermatitis 45 | 952
Dull intelligence 44 | 645
Low intelligence 44 | 645
Mental Retardation 44 | 645
Mental deficiency 44 | 645
Poor school performance 44 | 645
nasopharyngeal carcinoma 43 | 1,058
Hypertension 42 | 396
Obesity 42 | 678
astrocytoma 42 | 1,146
primary pancreatic ductal adenocarcinoma 41 | 1,109
active ulcerative colitis 40 | 764
acute quadriplegic myopathy 40 | 1,158
Failure to gain weight 37 | 365
Pediatric failure to thrive 37 | 365
Bipolar Disorder 36 | 666
Depressive disorder 34 | 409
Rheumatoid arthritis 34 | 1,191
aldosterone-producing adenoma 34 | 665
pediatric high grade glioma 34 | 1,064
Breast Neoplasms 33 | 445
Cerebellar Ataxia 33 | 304
Chemical and Drug Induced Liver Injury 33 | 195
cutaneous lupus erythematosus 33 | 1,057
Alzheimer's disease 32 | 658
Mammary Neoplasms 32 | 425
acute myeloid leukemia 32 | 783
gastric carcinoma 32 | 807
nephrosclerosis 32 | 333
fibroadenoma 31 | 559
spina bifida 31 | 1,074
Endometriosis 30 | 540
Alcoholic Intoxication, Chronic 29 | 289
Hypertensive disease 29 | 292
Waldenstrons macroglobulinemia 29 | 765
Carcinoma, Hepatocellular 28 | 228
Short stature 28 | 531
Liver carcinoma 27 | 240
Hypoglycemia 26 | 152
Kidney disease 26 | 430
Osteoarthritis 26 | 184
pancreatic carcinoma 26 | 562
Polycystic ovary syndrome 25 | 360
dermatomyositis 25 | 966
non primary Sjogren syndrome sicca 25 | 891

Tissue

Endocrine System 559 | 18,159
Digestive Tract 550 | 17,369
Female tissues 549 | 17,400
Skin and soft tissues 545 | 17,230
Liver and Pancreas 544 | 16,750
Male tissues 543 | 17,142
Urinary Tract 539 | 16,678
Blood and immune system 538 | 16,909
Nervous System 527 | 16,725
Respiratory system 526 | 16,393
Cardiovascular System 479 | 15,192

Target Family

Enzyme 456 | 4,145
Non-IDG 86 | 12,091
Epigenetic 22 | 242
TF/Epigenetic 4 | 38
Ion Channel 3 | 344

UniProt Keyword

Oxidoreductase 571 | 571
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Putative fatty acid desaturase 2-like protein FADS2P1 FADS2P1 Tdark Enzyme 0.00000 0
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Fatty acyl-CoA reductase 1 FAR1 Tbio Enzyme -1.65427 43.8 27
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Nucleic acid dioxygenase ALKBH1 ALKBH1 Tbio Enzyme -2.09946 119.6 149
Peroxidasin-like protein PXDNL Tbio Non-IDG -1.10753 14.4 0
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 ALKBH6 Tdark Enzyme 0.38 0.31 58