Development Level

Tbio 302 | 10,625
Tchem 147 | 1,890
Tdark 64 | 7,003
Tclin 58 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 26 | 633
abnormal behavior 9 | 226
decreased total body fat amoun... 8 | 186
embryonic lethality prior to o... 8 | 148
abnormal embryo size 7 | 112
abnormal lens morphology 7 | 73
preweaning lethality, incomple... 7 | 260
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 195
embryonic lethality prior to t... 6 | 187
abnormal retina morphology 5 | 100
abnormal sleep behavior 5 | 63
decreased circulating HDL chol... 5 | 77
decreased circulating triglyce... 5 | 83
decreased grip strength 5 | 123
hyperactivity 5 | 108
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased circulating insulin ... 4 | 75
decreased circulating iron lev... 4 | 25
decreased lactate dehydrogenas... 4 | 14
decreased lumbar vertebrae num... 4 | 62
decreased threshold for audito... 4 | 32
embryonic growth retardation 4 | 28
hypoactivity 4 | 89
increased fasted circulating g... 4 | 68
increased startle reflex 4 | 38
small kidney 4 | 10
abnormal QRS complex 3 | 25
abnormal behavioral response t... 3 | 52
abnormal embryo turning 3 | 15
abnormal epididymis morphology 3 | 31
abnormal neural tube closure 3 | 37
abnormal testis morphology 3 | 30
abnormal vocalization 3 | 21
decreased circulating alkaline... 3 | 41
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased mean corpuscular vol... 3 | 50
decreased spleen weight 3 | 13
impaired glucose tolerance 3 | 52
impaired righting response 3 | 19
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased circulating alkaline... 3 | 119
increased circulating potassiu... 3 | 31
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
persistence of hyaloid vascula... 3 | 22
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal coat appearance 2 | 25
abnormal coat/ hair morphology 2 | 18
abnormal craniofacial morpholo... 2 | 12
abnormal cranium morphology 2 | 32
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 51
abnormal lumbar vertebrae morp... 2 | 6
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal skin morphology 2 | 23
abnormal tail bud morphology 2 | 6
abnormal thoracic vertebrae mo... 2 | 16
anophthalmia 2 | 20
craniofacial phenotype 2 | 9
decreased CD8-positive, alpha-... 2 | 26
decreased Ly6C low monocyte nu... 2 | 23
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating total pr... 2 | 41
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased mean corpuscular hem... 2 | 34
decreased mean platelet volume 2 | 12
decreased rib number 2 | 59
decreased vertical activity 2 | 22
enlarged lymph nodes 2 | 27
increased body length 2 | 20
increased bone mineral content 2 | 92
increased circulating creatini... 2 | 29
increased circulating serum al... 2 | 25
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased heart weight 2 | 37
increased red blood cell distr... 2 | 21
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
mydriasis 2 | 9
small adrenal glands 2 | 15
small spleen 2 | 11
small testis 2 | 37

Disease

ovarian cancer 273 | 8,484
psoriasis 247 | 6,685
osteosarcoma 235 | 7,933
medulloblastoma, large-cell 182 | 6,234
lung cancer 163 | 4,466
pancreatic ductal adenocarcinoma liver metastasis 162 | 1,795
glioblastoma 159 | 5,572
non-small cell lung cancer 135 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,289
malignant mesothelioma 127 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,956
invasive ductal carcinoma 116 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 114 | 2,988
atypical teratoid / rhabdoid tumor 113 | 4,369
interstitial cystitis 111 | 2,299
lung adenocarcinoma 107 | 2,713
Cancer 105 | 2,346
lung carcinoma 104 | 2,844
Breast cancer 96 | 3,094
pancreatic cancer 96 | 2,300
pilocytic astrocytoma 96 | 3,086
ulcerative colitis 93 | 2,087
ductal carcinoma in situ 92 | 1,745
primitive neuroectodermal tumor 90 | 3,031
oligodendroglioma 87 | 2,849
tuberculosis 79 | 1,557
pediatric high grade glioma 77 | 2,712
adrenocortical carcinoma 76 | 1,427
subependymal giant cell astrocytoma 76 | 2,287
ependymoma 75 | 2,514
cystic fibrosis 74 | 1,665
astrocytic glioma 70 | 2,241
breast carcinoma 67 | 1,614
Pick disease 65 | 1,893
adult high grade glioma 63 | 2,148
group 4 medulloblastoma 63 | 1,875
diabetes mellitus 62 | 1,663
pituitary cancer 61 | 1,972
posterior fossa group A ependymoma 60 | 1,511
group 3 medulloblastoma 59 | 2,254
colon cancer 57 | 1,475
Multiple myeloma 55 | 1,327
active Crohn's disease 51 | 918
Prostatic Neoplasms 50 | 471
astrocytoma 48 | 1,493
esophageal adenocarcinoma 47 | 737
primary pancreatic ductal adenocarcinoma 47 | 1,271
medulloblastoma 46 | 1,524
Atopic dermatitis 45 | 944
atypical teratoid/rhabdoid tumor 44 | 1,095
nasopharyngeal carcinoma 43 | 1,056
sonic hedgehog group medulloblastoma 43 | 1,482
posterior fossa group B ependymoma 42 | 1,530
Obesity 41 | 616
acute quadriplegic myopathy 38 | 1,157
Rheumatoid Arthritis 34 | 1,160
aldosterone-producing adenoma 34 | 664
Carcinoma 33 | 2,147
cutaneous lupus erythematosus 33 | 1,056
Alzheimer's disease 32 | 644
acute myeloid leukemia 32 | 780
gastric carcinoma 32 | 832
nephrosclerosis 32 | 329
Hypertension 31 | 287
fibroadenoma 31 | 557
Endometriosis 30 | 535
Mammary Neoplasms 30 | 410
Waldenstrons macroglobulinemia 30 | 765
spina bifida 29 | 1,064
Liver carcinoma 27 | 217
Intellectual disability 26 | 573
pancreatic carcinoma 26 | 567
Atherosclerosis 25 | 275
Kidney disease 25 | 396
Schizophrenia 25 | 501
non primary Sjogren syndrome sicca 25 | 840
Polycystic Ovary Syndrome 24 | 332
chronic rhinosinusitis 24 | 512
dermatomyositis 24 | 933
Autistic Disorder 22 | 320
Leigh disease 21 | 81
Liver disease 21 | 219
Stomach Neoplasms 21 | 282
juvenile dermatomyositis 21 | 1,189
Colorectal Neoplasms 20 | 217
Diabetes Mellitus, Experimental 20 | 106
Peripheral Neuropathy 20 | 303
inflammatory breast cancer 20 | 404
primary Sjogren syndrome 20 | 789
Down syndrome 19 | 548
active ulcerative colitis 19 | 477
Asthma 18 | 349
Duchenne muscular dystrophy 18 | 602
Hypertensive disease 18 | 193
Liver Cirrhosis, Experimental 18 | 108
progressive supranuclear palsy 18 | 674
Neurodegenerative disease 17 | 383
Vascular disease 17 | 281
head and neck cancer 17 | 270
head and neck cancer and chronic obstructive pulmonary disease 17 | 237

Tissue

Digestive Tract 566 | 18,473
Endocrine System 566 | 18,512
Female tissues 566 | 18,647
Liver and Pancreas 566 | 18,136
Nervous System 566 | 18,561
Urinary Tract 565 | 18,444
Blood and immune system 563 | 17,995
Cardiovascular System 563 | 17,958
Male tissues 563 | 17,969
Skin and soft tissues 561 | 18,115
Respiratory system 556 | 17,484

Target Family

Enzyme 458 | 4,146
Non-IDG 84 | 11,971
Epigenetic 22 | 242
TF/Epigenetic 4 | 38
Ion Channel 3 | 341

UniProt Keyword

Oxidoreductase 571 | 571
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Dimethylaniline monooxygenase [N-oxide-forming] 5 FMO5 Tbio Enzyme -0.93021 9.11 128
Indoleamine 2,3-dioxygenase 2 IDO2 Tchem Enzyme -1.88853 82.2 208