Development Level

Tbio 3,387 | 10,625
Tdark 1,186 | 7,003
Tchem 500 | 1,890
Tclin 83 | 602

Collection

Eligible Kinase Proteins 41 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 255 | 633
preweaning lethality, incomple... 88 | 260
embryonic lethality prior to t... 71 | 187
abnormal behavior 67 | 226
embryonic lethality prior to o... 59 | 148
decreased lean body mass 56 | 195
decreased body weight 52 | 174
decreased total body fat amoun... 50 | 186
decreased body length 41 | 108
abnormal embryo size 39 | 112
abnormal bone structure 37 | 131
decreased bone mineral content 36 | 157
decreased grip strength 36 | 123
increased or absent threshold ... 36 | 128
decreased bone mineral density 33 | 126
decreased circulating glucose ... 32 | 121
increased circulating alkaline... 30 | 119
increased lean body mass 30 | 107
hyperactivity 29 | 108
increased bone mineral content 29 | 92
increased mean corpuscular vol... 29 | 91
abnormal retina morphology 28 | 100
enlarged heart 28 | 111
decreased circulating choleste... 27 | 85
hypoactivity 27 | 89
increased grip strength 27 | 83
decreased circulating triglyce... 25 | 83
increased mean corpuscular hem... 24 | 93
abnormal lens morphology 23 | 73
decreased circulating serum al... 23 | 79
decreased lumbar vertebrae num... 23 | 62
increased sacral vertebrae num... 23 | 62
prenatal lethality prior to he... 23 | 64
decreased circulating HDL chol... 21 | 77
increased circulating sodium l... 20 | 71
increased fasted circulating g... 20 | 68
short tibia 20 | 82
abnormal coat/hair pigmentatio... 19 | 54
increased circulating HDL chol... 19 | 63
increased circulating choleste... 19 | 53
abnormal bone mineralization 18 | 55
decreased caudal vertebrae num... 17 | 49
decreased circulating insulin ... 17 | 75
decreased leukocyte cell numbe... 17 | 54
abnormal heart morphology 16 | 51
abnormal retinal pigmentation 16 | 61
decreased circulating alanine ... 16 | 53
decreased rib number 16 | 59
increased bone mineral density 16 | 52
abnormal gait 15 | 51
decreased fasted circulating g... 15 | 49
decreased hemoglobin content 15 | 53
thrombocytopenia 15 | 46
abnormal sleep behavior 14 | 63
decreased mean corpuscular vol... 14 | 50
increased exploration in new e... 14 | 56
increased startle reflex 14 | 38
male infertility 14 | 62
abnormal behavioral response t... 13 | 52
abnormal eye morphology 13 | 38
abnormal neural tube closure 13 | 37
decreased circulating LDL chol... 13 | 37
decreased erythrocyte cell num... 13 | 43
decreased prepulse inhibition 13 | 52
impaired glucose tolerance 13 | 52
increased circulating chloride... 13 | 43
increased total body fat amoun... 13 | 57
tremors 13 | 34
abnormal seminal vesicle morph... 12 | 47
decreased circulating alkaline... 12 | 41
decreased circulating total pr... 12 | 41
increased circulating triglyce... 12 | 24
abnormal cornea morphology 11 | 24
corneal opacity 11 | 25
decreased eosinophil cell numb... 11 | 41
improved glucose tolerance 11 | 56
increased body weight 11 | 42
increased circulating creatini... 11 | 29
increased hemoglobin content 11 | 45
abnormal hindbrain development 10 | 24
abnormal spleen morphology 10 | 36
abnormal tooth morphology 10 | 24
decreased B cell number 10 | 30
decreased T cell number 10 | 31
decreased circulating fructosa... 10 | 31
female infertility 10 | 34
increased mean corpuscular hem... 10 | 25
limb grasping 10 | 35
polydactyly 10 | 22
abnormal kidney morphology 9 | 30
abnormal locomotor activation 9 | 26
abnormal rib morphology 9 | 28
decreased circulating aspartat... 9 | 27
decreased circulating chloride... 9 | 32
decreased circulating iron lev... 9 | 25
decreased mean corpuscular hem... 9 | 34
increased heart weight 9 | 37
increased respiratory quotient 9 | 12
small testis 9 | 37
thrombocytosis 9 | 23

Disease

ovarian cancer 2,650 | 8,484
osteosarcoma 2,431 | 7,933
medulloblastoma, large-cell 1,851 | 6,234
psoriasis 1,808 | 6,685
glioblastoma 1,569 | 5,572
lung cancer 1,469 | 4,466
atypical teratoid / rhabdoid tumor 1,248 | 4,369
malignant mesothelioma 1,013 | 3,162
Breast cancer 969 | 3,094
primitive neuroectodermal tumor 969 | 3,031
Cancer 895 | 2,346
group 3 medulloblastoma 870 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 863 | 3,289
oligodendroglioma 816 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 799 | 2,988
invasive ductal carcinoma 781 | 2,950
pediatric high grade glioma 775 | 2,712
non-small cell lung cancer 751 | 2,798
ependymoma 715 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 684 | 2,956
lung adenocarcinoma 671 | 2,713
pilocytic astrocytoma 641 | 3,086
Carcinoma 613 | 2,147
astrocytic glioma 608 | 2,241
group 4 medulloblastoma 583 | 1,875
subependymal giant cell astrocytoma 578 | 2,287
pancreatic cancer 564 | 2,300
Pick disease 546 | 1,893
lung carcinoma 511 | 2,844
Multiple myeloma 510 | 1,327
adult high grade glioma 500 | 2,148
astrocytoma 478 | 1,493
pituitary cancer 468 | 1,972
sonic hedgehog group medulloblastoma 459 | 1,482
breast carcinoma 447 | 1,614
ductal carcinoma in situ 445 | 1,745
adrenocortical carcinoma 437 | 1,427
colon cancer 433 | 1,475
medulloblastoma 432 | 1,524
interstitial cystitis 425 | 2,299
ulcerative colitis 419 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 418 | 1,795
acute quadriplegic myopathy 407 | 1,157
diabetes mellitus 386 | 1,663
Rheumatoid Arthritis 377 | 1,160
tuberculosis 370 | 1,557
posterior fossa group A ependymoma 367 | 1,511
juvenile dermatomyositis 366 | 1,189
dermatomyositis 360 | 933
cystic fibrosis 341 | 1,665
Waldenstrons macroglobulinemia 337 | 765
atypical teratoid/rhabdoid tumor 317 | 1,095
spina bifida 312 | 1,064
posterior fossa group B ependymoma 306 | 1,530
primary pancreatic ductal adenocarcinoma 305 | 1,271
acute myeloid leukemia 293 | 780
nasopharyngeal carcinoma 284 | 1,056
tuberculosis and treatment for 6 months 255 | 686
non primary Sjogren syndrome sicca 249 | 840
cutaneous lupus erythematosus 243 | 1,056
primary Sjogren syndrome 228 | 789
progressive supranuclear palsy 226 | 674
Atopic dermatitis 222 | 944
Intellectual disability 211 | 573
aldosterone-producing adenoma 197 | 664
active Crohn's disease 181 | 918
hepatocellular carcinoma 178 | 532
Endometriosis 171 | 535
gastric carcinoma 169 | 832
Mammary Neoplasms 166 | 410
Alzheimer's disease 163 | 644
pancreatic carcinoma 155 | 567
Amyotrophic Lateral Sclerosis 153 | 431
Down syndrome 152 | 548
esophageal adenocarcinoma 150 | 737
gastric cancer 147 | 430
Prostatic Neoplasms 146 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 134 | 499
inflammatory breast cancer 133 | 404
IGA Glomerulonephritis 125 | 454
Obesity 124 | 616
Schizophrenia 115 | 501
Stomach Neoplasms 114 | 282
fibroadenoma 107 | 557
Duchenne muscular dystrophy 106 | 602
chronic rhinosinusitis 106 | 512
Neurodegenerative disease 105 | 383
active ulcerative colitis 99 | 477
Crohn's disease 97 | 304
Multiple Sclerosis 97 | 498
glioblastoma multiforme 96 | 347
Melanoma 95 | 261
sarcoidosis 93 | 358
tuberculosis and treatment for 3 months 93 | 327
Polycystic Ovary Syndrome 92 | 332
hereditary spastic paraplegia 90 | 313
non-small cell lung carcinoma 90 | 413
Peripheral Neuropathy 88 | 303
Parkinson's disease 86 | 364
Acquired metabolic disease 84 | 267

Tissue

Female tissues 5,041 | 18,647
Nervous System 5,022 | 18,561
Endocrine System 5,017 | 18,512
Digestive Tract 5,008 | 18,473
Urinary Tract 4,976 | 18,444
Male tissues 4,974 | 17,969
Blood and immune system 4,972 | 17,995
Liver and Pancreas 4,954 | 18,136
Cardiovascular System 4,929 | 17,958
Skin and soft tissues 4,923 | 18,115
Respiratory system 4,815 | 17,484

Target Family

Non-IDG 2,419 | 11,971
Transcription Factor 1,371 | 1,400
Enzyme 829 | 4,146
Kinase 228 | 634
Epigenetic 202 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 37 | 38
Transporter 10 | 473
Ion Channel 8 | 341
GPCR 4 | 406

UniProt Keyword

Nucleus 5,156 | 5,156
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345