Development Level

Tbio 3,647 | 11,445
Tdark 1,084 | 6,588
Tchem 444 | 1,598
Tclin 84 | 613

Collection

RFA-RM-18-021 44 | 328
Kinase: IDG Consortium (Target... 41 | 125
Kinase: IDG Consortium (Comple... 19 | 37
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 420 | 979
preweaning lethality, incomple... 155 | 499
embryonic lethality prior to t... 111 | 278
embryonic lethality prior to o... 100 | 239
abnormal embryo size 87 | 220
abnormal behavior 83 | 298
enlarged heart 61 | 210
abnormal bone structure 58 | 187
decreased total body fat amoun... 58 | 207
increased lean body mass 56 | 172
decreased vertical activity 53 | 208
decreased body weight 52 | 161
abnormal heart morphology 51 | 162
hypoactivity 43 | 132
increased startle reflex 42 | 112
male infertility 40 | 123
decreased circulating glucose ... 39 | 126
decreased lean body mass 39 | 135
embryonic growth retardation 39 | 106
increased total body fat amoun... 37 | 134
decreased bone mineral density 35 | 126
hyperactivity 35 | 148
decreased bone mineral content 34 | 151
increased circulating alkaline... 33 | 122
prenatal lethality prior to he... 33 | 87
decreased grip strength 32 | 116
abnormal seminal vesicle morph... 31 | 114
decreased body length 31 | 101
decreased circulating triglyce... 31 | 79
increased bone mineral content 30 | 108
increased mean corpuscular vol... 30 | 92
decreased circulating choleste... 28 | 93
decreased prepulse inhibition 27 | 82
increased bone mineral density 27 | 72
increased mean corpuscular hem... 27 | 96
impaired glucose tolerance 26 | 75
increased fasted circulating g... 26 | 76
decreased circulating serum al... 25 | 82
increased or absent threshold ... 25 | 101
decreased hemoglobin content 24 | 68
decreased leukocyte cell numbe... 24 | 73
decreased lymphocyte cell numb... 24 | 83
female infertility 24 | 60
cataract 23 | 92
decreased mean corpuscular vol... 23 | 79
increased circulating HDL chol... 23 | 80
small superior vagus ganglion 23 | 74
abnormal coat-hair pigmentatio... 22 | 64
abnormal gait 22 | 69
abnormal lens morphology 22 | 81
improved glucose tolerance 22 | 79
increased circulating choleste... 21 | 66
abnormal kidney morphology 20 | 65
increased circulating sodium l... 20 | 71
short tibia 20 | 97
decreased circulating insulin ... 19 | 76
decreased erythrocyte cell num... 19 | 62
decreased fasted circulating g... 19 | 65
thrombocytopenia 19 | 56
tremors 19 | 39
abnormal eye morphology 18 | 68
decreased blood urea nitrogen ... 18 | 51
decreased caudal vertebrae num... 18 | 53
decreased circulating alanine ... 18 | 47
increased mean platelet volume 18 | 45
abnormal behavioral response t... 17 | 66
abnormal neural tube closure 17 | 46
abnormal retina morphology 17 | 71
hydrometra 17 | 53
small testis 17 | 58
abnormal spleen morphology 16 | 55
corneal opacity 16 | 32
edema 16 | 59
increased monocyte cell number 16 | 63
increased neutrophil cell numb... 16 | 46
abnormal bone mineralization 15 | 38
abnormal sleep behavior 15 | 70
decreased mean corpuscular hem... 15 | 50
decreased startle reflex 15 | 75
increased body length 15 | 32
increased circulating chloride... 15 | 41
increased grip strength 15 | 41
abnormal embryo turning 14 | 31
decreased circulating HDL chol... 14 | 68
decreased hematocrit 14 | 46
increased circulating triglyce... 14 | 42
abnormal cornea morphology 13 | 31
abnormal skin morphology 13 | 50
decreased circulating alkaline... 13 | 46
decreased circulating iron lev... 13 | 32
increased heart weight 13 | 62
increased hemoglobin content 13 | 45
abnormal craniofacial morpholo... 12 | 33
anophthalmia 12 | 33
decreased circulating LDL chol... 12 | 38
decreased circulating total pr... 12 | 49
increased circulating creatini... 12 | 38
abnormal forebrain development 11 | 20
increased mean corpuscular hem... 11 | 36
decreased circulating aspartat... 10 | 34

Disease

Carcinoma 3,333 | 11,493
ovarian cancer 2,703 | 8,520
osteosarcoma 2,491 | 7,950
medulloblastoma, large-cell 1,887 | 6,241
psoriasis 1,834 | 6,694
glioblastoma 1,667 | 5,792
lung cancer 1,563 | 4,740
group 3 medulloblastoma 1,491 | 4,104
atypical teratoid / rhabdoid tumor 1,486 | 5,112
ependymoma 1,192 | 4,679
Breast cancer 1,118 | 3,578
malignant mesothelioma 1,043 | 3,232
primitive neuroectodermal tumor 984 | 3,035
Cancer 964 | 2,499
adult high grade glioma 958 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 881 | 3,291
oligodendroglioma 828 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 813 | 2,989
invasive ductal carcinoma 793 | 2,951
Kidney cancer 777 | 2,613
non-small cell lung cancer 771 | 2,890
astrocytic glioma 704 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 698 | 2,955
lung adenocarcinoma 682 | 2,716
Astrocytoma, Pilocytic 652 | 3,081
pancreatic cancer 608 | 2,398
subependymal giant cell astrocytoma 585 | 2,287
Pick disease 552 | 1,894
group 4 medulloblastoma 540 | 1,855
lung carcinoma 522 | 2,843
Multiple myeloma 520 | 1,332
tuberculosis 491 | 2,010
pituitary cancer 478 | 1,972
breast carcinoma 465 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 463 | 1,962
ductal carcinoma in situ 452 | 1,745
adrenocortical carcinoma 441 | 1,428
colon cancer 437 | 1,478
interstitial cystitis 433 | 2,312
acute quadriplegic myopathy 412 | 1,158
diabetes mellitus 408 | 1,728
astrocytoma 405 | 1,146
ulcerative colitis 383 | 1,819
Rheumatoid arthritis 382 | 1,191
Intellectual disability 378 | 1,016
juvenile dermatomyositis 374 | 1,187
dermatomyositis 369 | 966
cystic fibrosis 352 | 1,696
Waldenstrons macroglobulinemia 341 | 765
pediatric high grade glioma 339 | 1,064
spina bifida 326 | 1,074
acute myeloid leukemia 300 | 783
nasopharyngeal carcinoma 290 | 1,058
Autosomal recessive predisposition 285 | 1,442
primary pancreatic ductal adenocarcinoma 278 | 1,109
Schizophrenia 274 | 1,160
non primary Sjogren syndrome sicca 266 | 891
cutaneous lupus erythematosus 246 | 1,057
Dull intelligence 237 | 645
Low intelligence 237 | 645
Mental Retardation 237 | 645
Mental deficiency 237 | 645
Poor school performance 237 | 645
progressive supranuclear palsy 229 | 676
Atopic dermatitis 227 | 952
primary Sjogren syndrome 218 | 735
Short stature 210 | 531
medulloblastoma 206 | 720
Cognitive delay 203 | 608
Global developmental delay 203 | 608
Mental and motor retardation 203 | 608
aldosterone-producing adenoma 200 | 665
Epilepsy 187 | 792
active Crohn's disease 187 | 922
Breast Neoplasms 186 | 445
hepatocellular carcinoma 185 | 547
Mammary Neoplasms 176 | 425
tuberculosis and treatment for 6 months 175 | 409
Endometriosis 173 | 540
Alzheimer's disease 170 | 658
gastric carcinoma 168 | 807
Obesity 166 | 678
Amyotrophic lateral sclerosis 165 | 451
Melanoma 164 | 711
Prostatic Neoplasms 164 | 495
Small head 162 | 374
gastric cancer 157 | 459
esophageal adenocarcinoma 155 | 737
pancreatic carcinoma 155 | 562
Muscle hypotonia 154 | 571
sonic hedgehog group medulloblastoma 154 | 467
Bipolar Disorder 153 | 666
Liver cancer 149 | 604
Seizures 146 | 596
Liver Cirrhosis, Experimental 145 | 769
active ulcerative colitis 145 | 764
Down syndrome 143 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 136 | 510
posterior fossa group A ependymoma 132 | 468
Cryptorchidism 131 | 296

Tissue

Endocrine System 5,076 | 18,159
Digestive Tract 4,928 | 17,369
Skin and soft tissues 4,921 | 17,230
Female tissues 4,917 | 17,400
Male tissues 4,896 | 17,142
Blood and immune system 4,846 | 16,909
Nervous System 4,838 | 16,725
Urinary Tract 4,815 | 16,678
Liver and Pancreas 4,810 | 16,750
Respiratory system 4,761 | 16,393
Cardiovascular System 4,596 | 15,192

Target Family

Non-IDG 2,502 | 12,091
Transcription Factor 1,372 | 1,400
Enzyme 844 | 4,145
Kinase 230 | 634
Epigenetic 204 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 37 | 38
Transporter 10 | 473
Ion Channel 8 | 344
GPCR 4 | 408

UniProt Keyword

Nucleus 5,259 | 5,259
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Y-box-binding protein 2 YBX2 Tbio Transcription Factor -1.99119 94.8 236
NmrA-like family domain-containing protein 1 NMRAL1 Tbio Non-IDG -0.93702 11.0 67
Protein timeless homolog TIMELESS Tbio Non-IDG -2.76871 578.0 138
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Coilin COIL Tbio Non-IDG -2.31847 206.5 227
Probable dimethyladenosine transferase DIMT1 Tbio Enzyme -0.37946 1.98 103
Zinc finger protein 140 ZNF140 Tdark Transcription Factor 0.08 0.97 39