Development Level

Tbio 62 | 11,651
Tdark 15 | 6,593
Tchem 5 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
increased mean corpuscular vol... 2 | 92
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 56 | 11,493
osteosarcoma 49 | 7,950
ovarian cancer 38 | 8,520
glioblastoma 27 | 5,792
medulloblastoma, large-cell 26 | 6,241
group 3 medulloblastoma 25 | 4,104
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
lung cancer 20 | 4,740
primitive neuroectodermal tumor 20 | 3,035
malignant mesothelioma 19 | 3,232
Breast cancer 15 | 3,578
Cancer 15 | 2,499
invasive ductal carcinoma 15 | 2,951
adult high grade glioma 14 | 3,801
ependymoma 14 | 4,679
Astrocytoma, Pilocytic 13 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
non-small cell lung cancer 13 | 2,890
Kidney cancer 12 | 2,613
Autosomal recessive predisposition 11 | 1,442
tuberculosis 11 | 2,010
astrocytic glioma 10 | 2,597
juvenile dermatomyositis 10 | 1,187
subependymal giant cell astrocytoma 10 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
acute myeloid leukemia 8 | 783
colon cancer 8 | 1,478
lung carcinoma 8 | 2,843
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Multiple myeloma 7 | 1,332
Pick disease 7 | 1,894
adrenocortical carcinoma 7 | 1,428
group 4 medulloblastoma 7 | 1,855
hepatocellular carcinoma 7 | 547
lung adenocarcinoma 7 | 2,716
primary Sjogren syndrome 7 | 735
Cerebellar Ataxia 6 | 304
Waldenstrons macroglobulinemia 6 | 765
cystic fibrosis 6 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pediatric high grade glioma 6 | 1,064
spina bifida 6 | 1,074
ulcerative colitis 6 | 1,819
Highly variable clinical phenotype 5 | 150
Highly variable phenotype and severity 5 | 150
Highly variable phenotype, even within families 5 | 150
Intellectual disability 5 | 1,016
Myopia 5 | 176
Phenotypic variability 5 | 150
Short stature 5 | 531
Xeroderma pigmentosum 5 | 43
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
pituitary cancer 5 | 1,972
Deglutition Disorders 4 | 132
Dull intelligence 4 | 645
Dysarthria 4 | 192
Highly variable severity 4 | 157
Influenza 4 | 142
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Microphthalmia with limb anomalies 4 | 40
Muscle hypotonia 4 | 571
Poor school performance 4 | 645
Primary hypogonadism 4 | 37
Progressive disorder 4 | 142
Sleeping sickness 4 | 37
Small head 4 | 374
Systemic lupus erythematosus 4 | 194
Variable expressivity 4 | 157
acute quadriplegic myopathy 4 | 1,158
gastric cancer 4 | 459
nasopharyngeal carcinoma 4 | 1,058
progressive supranuclear palsy 4 | 676
Atopic dermatitis 3 | 952
Attention deficit hyperactivity disorder 3 | 278
Cockayne syndrome 3 | 60
Creatine phosphokinase serum increased 3 | 110
Elevated creatine kinase 3 | 110
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Hepatomegaly 3 | 285
Impaired exercise tolerance 3 | 42
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Pediatric failure to thrive 3 | 365
Seizures 3 | 596
medulloblastoma 3 | 720
pancreatic carcinoma 3 | 562
posterior fossa group B ependymoma 3 | 416
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 74 | 18,159
Blood and immune system 73 | 16,909
Digestive Tract 73 | 17,369
Male tissues 72 | 17,142
Cardiovascular System 71 | 15,192
Female tissues 71 | 17,400
Liver and Pancreas 71 | 16,750
Nervous System 71 | 16,725
Respiratory system 71 | 16,393
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678

Target Family

Enzyme 75 | 4,145
Non-IDG 10 | 12,091

UniProt Keyword

Nucleotidyltransferase 85 | 85
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mannose-1-phosphate guanyltransferase beta GMPPB Tbio Enzyme -1.17283 16.0 118
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31765 20.1 141
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 PAPSS1 Tbio Enzyme -2.41857 281.0 125
CCA tRNA nucleotidyltransferase 1, mitochondrial TRNT1 Tbio Enzyme -1.38172 23.2 33
DNA polymerase subunit gamma-2, mitochondrial POLG2 Tbio Enzyme -1.34785 20.3 105
2'-5'-oligoadenylate synthase 2 OAS2 Tbio Enzyme -1.41496 20.8 293
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.22644 169.3 112
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138