Development Level

Tbio 984 | 10,625
Tchem 494 | 1,890
Tdark 202 | 7,003
Tclin 89 | 602

Collection

Eligible Kinase Proteins 120 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 108 | 633
abnormal behavior 33 | 226
embryonic lethality prior to t... 32 | 187
preweaning lethality, incomple... 32 | 260
embryonic lethality prior to o... 31 | 148
decreased lean body mass 29 | 195
decreased body weight 28 | 174
decreased bone mineral content 22 | 157
abnormal embryo size 20 | 112
decreased body length 17 | 108
decreased total body fat amoun... 17 | 186
increased circulating alkaline... 17 | 119
abnormal bone structure 16 | 131
increased or absent threshold ... 16 | 128
abnormal retina morphology 14 | 100
decreased grip strength 14 | 123
increased grip strength 14 | 83
decreased bone mineral density 12 | 126
enlarged heart 12 | 111
increased blood urea nitrogen ... 12 | 44
increased mean corpuscular hem... 12 | 93
abnormal behavioral response t... 11 | 52
abnormal bone mineralization 11 | 55
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 11 | 121
decreased circulating triglyce... 11 | 83
hyperactivity 11 | 108
increased circulating HDL chol... 11 | 63
abnormal lens morphology 10 | 73
decreased circulating serum al... 10 | 79
increased bone mineral content 10 | 92
increased circulating choleste... 10 | 53
increased heart weight 10 | 37
increased lean body mass 10 | 107
abnormal retinal pigmentation 9 | 61
increased circulating sodium l... 9 | 71
increased mean corpuscular vol... 9 | 91
increased total body fat amoun... 9 | 57
male infertility 9 | 62
abnormal seminal vesicle morph... 8 | 47
increased circulating chloride... 8 | 43
increased erythrocyte cell num... 8 | 26
increased fasted circulating g... 8 | 68
abnormal gait 7 | 51
cardiovascular system phenotyp... 7 | 35
decreased blood urea nitrogen ... 7 | 31
decreased circulating HDL chol... 7 | 77
decreased leukocyte cell numbe... 7 | 54
decreased prepulse inhibition 7 | 52
improved glucose tolerance 7 | 56
increased circulating potassiu... 7 | 31
increased hemoglobin content 7 | 45
prenatal lethality prior to he... 7 | 64
short tibia 7 | 82
abnormal cranium morphology 6 | 32
abnormal hindbrain development 6 | 24
abnormal neural tube closure 6 | 37
abnormal sleep behavior 6 | 63
decreased circulating total pr... 6 | 41
decreased lumbar vertebrae num... 6 | 62
decreased mean corpuscular hem... 6 | 34
decreased mean corpuscular vol... 6 | 50
decreased startle reflex 6 | 48
small testis 6 | 37
abnormal coat/hair pigmentatio... 5 | 54
abnormal heart morphology 5 | 51
abnormal kidney morphology 5 | 30
abnormal midbrain development 5 | 22
abnormal snout morphology 5 | 18
anophthalmia 5 | 20
corneal opacity 5 | 25
decreased circulating alanine ... 5 | 53
decreased circulating amylase ... 5 | 24
decreased erythrocyte cell num... 5 | 43
decreased fasted circulating g... 5 | 49
decreased hemoglobin content 5 | 53
decreased neutrophil cell numb... 5 | 37
female infertility 5 | 34
hypoactivity 5 | 89
increased NK cell number 5 | 19
increased exploration in new e... 5 | 56
increased hematocrit 5 | 36
increased leukocyte cell numbe... 5 | 37
increased rib number 5 | 41
abnormal cornea morphology 4 | 24
abnormal epididymis morphology 4 | 31
abnormal locomotor activation 4 | 26
abnormal spleen morphology 4 | 36
abnormal tooth morphology 4 | 24
decreased NK T cell number 4 | 28
decreased circulating LDL chol... 4 | 37
decreased circulating free fat... 4 | 39
decreased heart weight 4 | 44
decreased rib number 4 | 59
impaired glucose tolerance 4 | 52
increased circulating iron lev... 4 | 25
increased sacral vertebrae num... 4 | 62
long tibia 4 | 13
persistence of hyaloid vascula... 4 | 22
thrombocytopenia 4 | 46

Disease

ovarian cancer 933 | 8,484
osteosarcoma 872 | 7,933
medulloblastoma, large-cell 741 | 6,234
psoriasis 692 | 6,685
glioblastoma 640 | 5,572
lung cancer 552 | 4,466
atypical teratoid / rhabdoid tumor 489 | 4,369
malignant mesothelioma 391 | 3,162
Carcinoma 377 | 2,147
primitive neuroectodermal tumor 370 | 3,031
Breast cancer 362 | 3,094
non-small cell lung cancer 350 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 343 | 3,289
pilocytic astrocytoma 339 | 3,086
Cancer 337 | 2,346
pediatric high grade glioma 336 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 330 | 2,988
invasive ductal carcinoma 325 | 2,950
oligodendroglioma 315 | 2,849
lung carcinoma 296 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 294 | 2,956
lung adenocarcinoma 293 | 2,713
ependymoma 285 | 2,514
Pick disease 252 | 1,893
group 3 medulloblastoma 252 | 2,254
astrocytic glioma 246 | 2,241
pancreatic cancer 244 | 2,300
subependymal giant cell astrocytoma 233 | 2,287
ulcerative colitis 231 | 2,087
adult high grade glioma 212 | 2,148
interstitial cystitis 207 | 2,299
astrocytoma 190 | 1,493
pituitary cancer 187 | 1,972
ductal carcinoma in situ 185 | 1,745
group 4 medulloblastoma 185 | 1,875
medulloblastoma 183 | 1,524
colon cancer 181 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 177 | 1,795
Multiple myeloma 175 | 1,327
posterior fossa group B ependymoma 173 | 1,530
breast carcinoma 171 | 1,614
adrenocortical carcinoma 168 | 1,427
sonic hedgehog group medulloblastoma 167 | 1,482
cystic fibrosis 160 | 1,665
juvenile dermatomyositis 158 | 1,189
diabetes mellitus 157 | 1,663
posterior fossa group A ependymoma 150 | 1,511
tuberculosis 148 | 1,557
acute quadriplegic myopathy 143 | 1,157
dermatomyositis 136 | 933
primary pancreatic ductal adenocarcinoma 135 | 1,271
Rheumatoid Arthritis 133 | 1,160
atypical teratoid/rhabdoid tumor 133 | 1,095
nasopharyngeal carcinoma 126 | 1,056
Waldenstrons macroglobulinemia 111 | 765
primary Sjogren syndrome 110 | 789
spina bifida 105 | 1,064
cutaneous lupus erythematosus 103 | 1,056
progressive supranuclear palsy 91 | 674
active Crohn's disease 88 | 918
tuberculosis and treatment for 6 months 86 | 686
Atopic dermatitis 84 | 944
Intellectual disability 79 | 573
acute myeloid leukemia 79 | 780
Renal Cell Carcinoma 74 | 199
non primary Sjogren syndrome sicca 74 | 840
esophageal adenocarcinoma 73 | 737
aldosterone-producing adenoma 71 | 664
Endometriosis 70 | 535
IGA Glomerulonephritis 70 | 454
Neurodegenerative disease 69 | 383
gastric carcinoma 68 | 832
Alzheimer's disease 67 | 644
Obesity 66 | 616
Down syndrome 65 | 548
Colorectal Neoplasms 61 | 217
Amyotrophic Lateral Sclerosis 60 | 431
pancreatic carcinoma 60 | 567
Peripheral Neuropathy 58 | 303
Mammary Neoplasms 56 | 410
Parkinson's disease 56 | 364
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
Blastic phase chronic myeloid leukemia 54 | 58
chronic rhinosinusitis 54 | 512
Schizophrenia 53 | 501
hepatocellular carcinoma 53 | 532
non-small cell lung carcinoma 53 | 413
fibroadenoma 52 | 557
gastric cancer 51 | 430
Duchenne muscular dystrophy 48 | 602
Gastrointestinal stromal tumor 47 | 61
Prostatic Neoplasms 46 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 499
sarcoidosis 46 | 358
Epilepsy 43 | 346
Philadelphia chromosome-positive acute lymphoblastic leukemia 43 | 47
hereditary spastic paraplegia 43 | 313
Pancreatic Neuroendocrine Tumor 42 | 45
Vascular disease 42 | 281
inflammatory breast cancer 41 | 404

Tissue

Digestive Tract 1,735 | 18,473
Nervous System 1,735 | 18,561
Blood and immune system 1,734 | 17,995
Endocrine System 1,732 | 18,512
Female tissues 1,732 | 18,647
Liver and Pancreas 1,732 | 18,136
Male tissues 1,731 | 17,969
Urinary Tract 1,731 | 18,444
Cardiovascular System 1,728 | 17,958
Respiratory system 1,713 | 17,484
Skin and soft tissues 1,713 | 18,115

Target Family

Kinase 602 | 634
Enzyme 561 | 4,146
Non-IDG 476 | 11,971
Transporter 86 | 473
Ion Channel 25 | 341
Epigenetic 19 | 242

UniProt Keyword

Nucleotide-binding 1,769 | 1,769
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67