Development Level

Tbio 1,015 | 11,445
Tchem 484 | 1,598
Tdark 183 | 6,588
Tclin 93 | 613

Collection

RFA-RM-18-021 118 | 328
Kinase: IDG Consortium (Target... 115 | 125
Kinase: IDG Consortium (Comple... 37 | 37
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 163 | 979
preweaning lethality, incomple... 60 | 499
embryonic lethality prior to o... 49 | 239
embryonic lethality prior to t... 48 | 278
abnormal behavior 38 | 298
abnormal embryo size 38 | 220
decreased body weight 28 | 161
abnormal bone structure 27 | 187
decreased bone mineral content 27 | 151
decreased lean body mass 23 | 135
embryonic growth retardation 20 | 106
enlarged heart 18 | 210
increased total body fat amoun... 18 | 134
decreased body length 17 | 101
decreased vertical activity 17 | 208
abnormal behavioral response t... 16 | 66
decreased total body fat amoun... 16 | 207
hyperactivity 16 | 148
decreased bone mineral density 15 | 126
increased startle reflex 15 | 112
abnormal lens morphology 14 | 81
increased or absent threshold ... 14 | 101
increased circulating alkaline... 13 | 122
increased heart weight 13 | 62
increased lean body mass 13 | 172
increased mean corpuscular hem... 13 | 96
male infertility 13 | 123
cataract 12 | 92
decreased circulating choleste... 12 | 93
decreased circulating glucose ... 12 | 126
decreased mean corpuscular vol... 12 | 79
decreased prepulse inhibition 12 | 82
increased bone mineral content 12 | 108
increased circulating HDL chol... 12 | 80
increased mean corpuscular vol... 12 | 92
abnormal retina morphology 11 | 71
abnormal seminal vesicle morph... 11 | 114
decreased grip strength 11 | 116
increased circulating choleste... 11 | 66
prenatal lethality prior to he... 11 | 87
abnormal heart morphology 10 | 162
decreased circulating serum al... 10 | 82
decreased circulating triglyce... 10 | 79
decreased leukocyte cell numbe... 10 | 73
decreased lymphocyte cell numb... 10 | 83
decreased mean corpuscular hem... 10 | 50
increased blood urea nitrogen ... 10 | 48
increased circulating sodium l... 10 | 71
increased fasted circulating g... 10 | 76
short tibia 10 | 97
decreased circulating total pr... 9 | 49
decreased fasted circulating g... 9 | 65
decreased neutrophil cell numb... 9 | 42
decreased startle reflex 9 | 75
increased bone mineral density 9 | 72
increased erythrocyte cell num... 9 | 39
increased hematocrit 9 | 46
abnormal cranium morphology 8 | 36
abnormal gait 8 | 69
abnormal sleep behavior 8 | 70
decreased hemoglobin content 8 | 68
hypoactivity 8 | 132
impaired glucose tolerance 8 | 75
improved glucose tolerance 8 | 79
prenatal lethality 8 | 28
abnormal coat-hair pigmentatio... 7 | 64
abnormal epididymis morphology 7 | 42
cardiovascular system phenotyp... 7 | 36
decreased blood urea nitrogen ... 7 | 51
decreased circulating HDL chol... 7 | 68
decreased circulating alanine ... 7 | 47
edema 7 | 59
enlarged lymph nodes 7 | 37
increased mean platelet volume 7 | 45
increased monocyte cell number 7 | 63
persistence of hyaloid vascula... 7 | 33
prolonged QT interval 7 | 38
small testis 7 | 58
abnormal bone mineralization 6 | 38
abnormal embryo turning 6 | 31
abnormal neural tube closure 6 | 46
abnormal skin morphology 6 | 50
abnormal spleen morphology 6 | 55
decreased circulating aspartat... 6 | 34
decreased erythrocyte cell num... 6 | 62
decreased heart left ventricle... 6 | 28
decreased hematocrit 6 | 46
decreased red blood cell distr... 6 | 41
enlarged spleen 6 | 41
impaired pupillary reflex 6 | 26
increased body length 6 | 32
increased circulating chloride... 6 | 41
increased circulating potassiu... 6 | 29
increased grip strength 6 | 41
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
prolonged ST segment 6 | 36
abnormal kidney morphology 5 | 65
corneal opacity 5 | 32
decreased circulating alkaline... 5 | 46

Disease

Carcinoma 1,343 | 11,493
ovarian cancer 949 | 8,520
osteosarcoma 872 | 7,950
medulloblastoma, large-cell 746 | 6,241
psoriasis 695 | 6,694
glioblastoma 668 | 5,792
atypical teratoid / rhabdoid tumor 589 | 5,112
lung cancer 588 | 4,740
ependymoma 517 | 4,679
group 3 medulloblastoma 466 | 4,104
Breast cancer 434 | 3,578
Kidney cancer 432 | 2,613
adult high grade glioma 429 | 3,801
malignant mesothelioma 401 | 3,232
primitive neuroectodermal tumor 373 | 3,035
non-small cell lung cancer 355 | 2,890
Cancer 352 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 343 | 3,291
Astrocytoma, Pilocytic 338 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 330 | 2,989
invasive ductal carcinoma 328 | 2,951
oligodendroglioma 316 | 2,850
astrocytic glioma 297 | 2,597
lung carcinoma 297 | 2,843
lung adenocarcinoma 294 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 293 | 2,955
pancreatic cancer 264 | 2,398
Pick disease 253 | 1,894
subependymal giant cell astrocytoma 238 | 2,287
Autosomal recessive predisposition 231 | 1,442
interstitial cystitis 210 | 2,312
ulcerative colitis 203 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 198 | 1,962
group 4 medulloblastoma 197 | 1,855
tuberculosis 194 | 2,010
pituitary cancer 190 | 1,972
ductal carcinoma in situ 188 | 1,745
colon cancer 183 | 1,478
breast carcinoma 181 | 1,638
Multiple myeloma 178 | 1,332
adrenocortical carcinoma 170 | 1,428
diabetes mellitus 165 | 1,728
cystic fibrosis 164 | 1,696
juvenile dermatomyositis 158 | 1,187
Intellectual disability 157 | 1,016
acute quadriplegic myopathy 143 | 1,158
astrocytoma 143 | 1,146
dermatomyositis 137 | 966
Rheumatoid arthritis 134 | 1,191
Schizophrenia 134 | 1,160
Epilepsy 130 | 792
nasopharyngeal carcinoma 130 | 1,058
pediatric high grade glioma 124 | 1,064
Dull intelligence 118 | 645
Low intelligence 118 | 645
Mental Retardation 118 | 645
Mental deficiency 118 | 645
Poor school performance 118 | 645
primary pancreatic ductal adenocarcinoma 116 | 1,109
Liver cancer 112 | 604
Waldenstrons macroglobulinemia 111 | 765
primary Sjogren syndrome 109 | 735
Melanoma 108 | 711
spina bifida 106 | 1,074
cutaneous lupus erythematosus 103 | 1,057
Cognitive delay 102 | 608
Global developmental delay 102 | 608
Mental and motor retardation 102 | 608
Seizures 102 | 596
Muscle hypotonia 93 | 571
active Crohn's disease 91 | 922
progressive supranuclear palsy 91 | 676
Small head 90 | 374
medulloblastoma 90 | 720
Short stature 87 | 531
Atopic dermatitis 86 | 952
Bipolar Disorder 85 | 666
Renal Cell Carcinoma 82 | 214
Skin cancer 82 | 469
acute myeloid leukemia 81 | 783
Liver Cirrhosis, Experimental 75 | 769
esophageal adenocarcinoma 75 | 737
non primary Sjogren syndrome sicca 75 | 891
Neurodegenerative disease 74 | 414
Obesity 74 | 678
Endometriosis 72 | 540
Failure to gain weight 71 | 365
Pediatric failure to thrive 71 | 365
aldosterone-producing adenoma 71 | 665
gastric carcinoma 69 | 807
Alzheimer's disease 68 | 658
Breast Neoplasms 63 | 445
Colorectal Neoplasms 63 | 243
active ulcerative colitis 63 | 764
Amyotrophic lateral sclerosis 62 | 451
Endometrial cancer 61 | 311
Parkinson's disease 61 | 392
Down syndrome 60 | 499
Mammary Neoplasms 60 | 425
pancreatic carcinoma 59 | 562

Tissue

Endocrine System 1,738 | 18,159
Digestive Tract 1,701 | 17,369
Female tissues 1,696 | 17,400
Skin and soft tissues 1,696 | 17,230
Male tissues 1,693 | 17,142
Blood and immune system 1,672 | 16,909
Liver and Pancreas 1,671 | 16,750
Urinary Tract 1,669 | 16,678
Nervous System 1,666 | 16,725
Respiratory system 1,655 | 16,393
Cardiovascular System 1,589 | 15,192

Target Family

Kinase 602 | 634
Enzyme 564 | 4,145
Non-IDG 478 | 12,091
Transporter 86 | 473
Ion Channel 26 | 344
Epigenetic 19 | 242

UniProt Keyword

Nucleotide-binding 1,775 | 1,775
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150